LOCUS       NM_008466               4167 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus karyopherin subunit alpha 3 (Kpna3), mRNA.
ACCESSION   NM_008466
VERSION     NM_008466.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4167)
  AUTHORS   Aomine,Y., Sakurai,K., Macpherson,T., Ozawa,T., Miyamoto,Y.,
            Yoneda,Y., Oka,M. and Hikida,T.
  TITLE     Importin alpha3 (KPNA3) Deficiency Augments Effortful
            Reward-Seeking Behavior in Mice
  JOURNAL   Front Neurosci 16, 905991 (2022)
   PUBMED   35844217
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4167)
  AUTHORS   Miyamoto,Y., Sasaki,M., Miyata,H., Monobe,Y., Nagai,M., Otani,M.,
            Whiley,P.A.F., Morohoshi,A., Oki,S., Matsuda,J., Akagi,K.I.,
            Adachi,J., Okabe,M., Ikawa,M., Yoneda,Y., Loveland,K.L. and Oka,M.
  TITLE     Genetic loss of importin alpha4 causes abnormal sperm morphology
            and impacts on male fertility in mouse
  JOURNAL   FASEB J 34 (12), 16224-16242 (2020)
   PUBMED   33058343
REFERENCE   3  (bases 1 to 4167)
  AUTHORS   Marvaldi,L., Panayotis,N., Alber,S., Dagan,S.Y., Okladnikov,N.,
            Koppel,I., Di Pizio,A., Song,D.A., Tzur,Y., Terenzio,M., Rishal,I.,
            Gordon,D., Rother,F., Hartmann,E., Bader,M. and Fainzilber,M.
  TITLE     Importin alpha3 regulates chronic pain pathways in peripheral
            sensory neurons
  JOURNAL   Science 369 (6505), 842-846 (2020)
   PUBMED   32792398
REFERENCE   4  (bases 1 to 4167)
  AUTHORS   Thiele,S., Stanelle-Bertram,S., Beck,S., Kouassi,N.M., Zickler,M.,
            Muller,M., Tuku,B., Resa-Infante,P., van Riel,D., Alawi,M.,
            Gunther,T., Rother,F., Hugel,S., Reimering,S., McHardy,A.,
            Grundhoff,A., Brune,W., Osterhaus,A., Bader,M., Hartmann,E. and
            Gabriel,G.
  TITLE     Cellular Importin-alpha3 Expression Dynamics in the Lung Regulate
            Antiviral Response Pathways against Influenza A Virus Infection
  JOURNAL   Cell Rep 31 (3), 107549 (2020)
   PUBMED   32320654
  REMARK    Erratum:[Cell Rep. 2024 Apr 23;43(4):114023. doi:
            10.1016/j.celrep.2024.114023.. PMID: 38520692]
REFERENCE   5  (bases 1 to 4167)
  AUTHORS   Panayotis,N., Sheinin,A., Dagan,S.Y., Tsoory,M.M., Rother,F.,
            Vadhvani,M., Meshcheriakova,A., Koley,S., Marvaldi,L., Song,D.A.,
            Reuveny,E., Eickholt,B.J., Hartmann,E., Bader,M., Michaelevski,I.
            and Fainzilber,M.
  TITLE     Importin alpha5 Regulates Anxiety through MeCP2 and Sphingosine
            Kinase 1
  JOURNAL   Cell Rep 25 (11), 3169-3179 (2018)
   PUBMED   30540948
REFERENCE   6  (bases 1 to 4167)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 4167)
  AUTHORS   Kobayashi,M., Kishida,S., Fukui,A., Michiue,T., Miyamoto,Y.,
            Okamoto,T., Yoneda,Y., Asashima,M. and Kikuchi,A.
  TITLE     Nuclear localization of Duplin, a beta-catenin-binding protein, is
            essential for its inhibitory activity on the Wnt signaling pathway
  JOURNAL   J Biol Chem 277 (8), 5816-5822 (2002)
   PUBMED   11744694
REFERENCE   8  (bases 1 to 4167)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 4167)
  AUTHORS   Kamei,Y., Yuba,S., Nakayama,T. and Yoneda,Y.
  TITLE     Three distinct classes of the alpha-subunit of the nuclear
            pore-targeting complex (importin-alpha) are differentially
            expressed in adult mouse tissues
  JOURNAL   J Histochem Cytochem 47 (3), 363-372 (1999)
   PUBMED   10026238
REFERENCE   10 (bases 1 to 4167)
  AUTHORS   Tsuji,L., Takumi,T., Imamoto,N. and Yoneda,Y.
  TITLE     Identification of novel homologues of mouse importin alpha, the
            alpha subunit of the nuclear pore-targeting complex, and their
            tissue-specific expression
  JOURNAL   FEBS Lett 416 (1), 30-34 (1997)
   PUBMED   9369227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AV581906.1, AK049373.1 and AC154435.2.
            
            On Mar 24, 2009 this sequence version replaced NM_008466.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026885.1, AK161664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               AV581906.1         1-130
            131-2125            AK049373.1         2-1996
            2126-4167           AC154435.2         71091-73132
FEATURES             Location/Qualifiers
     source          1..4167
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 32.76 cM"
     gene            1..4167
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /note="karyopherin subunit alpha 3"
                     /db_xref="GeneID:16648"
                     /db_xref="MGI:MGI:1100863"
     exon            1..225
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1722
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /note="importin subunit alpha-3; qip2; importin alpha Q2;
                     karyopherin (importin) alpha 3; importin alpha 4"
                     /codon_start=1
                     /product="importin subunit alpha-4"
                     /protein_id="NP_032492.1"
                     /db_xref="CCDS:CCDS36942.1"
                     /db_xref="GeneID:16648"
                     /db_xref="MGI:MGI:1100863"
                     /translation="MAENPGLENHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEH
                     LLKKRNVPQEESLEDSDVDADFKAQNVTLEAILQNATSDNPVVQLSAVQAARKLLSSD
                     RNPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVP
                     LFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLR
                     NVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQ
                     IQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNL
                     LSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAI
                     SNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAGDEASTIA
                     EIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPSLIPEATQGGTYNF
                     DPTANLQTKEFNF"
     exon            226..270
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            271..360
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            361..390
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            391..443
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..539
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            540..625
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            626..712
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            713..882
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            883..927
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1059
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1188
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1293
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1365
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1528
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1623
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..4167
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2274..2279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /note="hexamer: ATTAAA"
     polyA_site      2302
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
     regulatory      4116..4121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /note="hexamer: AATAAA"
     polyA_site      4146
                     /gene="Kpna3"
                     /gene_synonym="IPOA4"
                     /note="major polyA site"
ORIGIN      
        1 cttctccggc gcgcgcctct cctcagcgcc gcccccgcgc cgcggccacc tcgcgctcca
       61 ggcgtcacgg agcgcgcgct cctccccctt cgtcccctcc cgctcgactc gccgccgccg
      121 ccgcaggagc agacgcctcc ggagccgcgc gcagccatgg ccgagaaccc cggcttggag
      181 aaccaccgca tcaagagctt caagaacaag ggccgcgatg tggagacgat gcgaagacac
      241 agaaatgaag tgacagttga actccggaag aacaaaagag acgaacactt actgaaaaag
      301 agaaatgttc cccaagaaga aagcttagaa gattcagatg ttgatgctga ttttaaagca
      361 caaaatgtaa cactagaagc tatattacag aatgccacaa gtgataatcc tgtagtccag
      421 ttgagtgctg tgcaggcagc aaggaaacta ttatccagtg acagaaatcc accaattgat
      481 gacctaataa aatctgggat tttaccaatt ctagtcaaat gtctagaaag agatgataat
      541 ccttcattac agtttgaagc tgcttgggca ctaactaata tagcatcggg aacttctgca
      601 cagactcaag ctgttgtaca gtctaatgca gtaccacttt ttctgcgact cctccattcc
      661 ccacatcaga atgtttgtga acaagcggtg tgggctttgg gaaacattat aggtgatggt
      721 cctcaatgta gagattatgt catatcactg ggagttgtca aacctcttct gtccttcatc
      781 aatccctcca ttcccatcac cttccttcgg aacgtcacat gggtcattgt caatctctgc
      841 aggaataaag accccccacc gcctatggag acagttcagg agattttgcc agctttgtgt
      901 gtgctcatct accatacgga cataaatatt cttgtagaca ctgtttgggc gctgtcatac
      961 ttgacagacg ggggaaatga gcaaatacag atggttattg attcaggggt tgtacccttc
     1021 ctcgtacccc ttctgagcca ccaggaagtc aaagttcaaa ctgcagcact cagagcggtt
     1081 gggaacatag tgactggcac tgatgagcag acccaggtgg ttctcaactg tgatgtcctg
     1141 tcccacttcc caaacctctt gtcacaccca aaagagaaaa taaataagga agcagtatgg
     1201 ttcctttcca atataacagc aggcaatcag cagcaagttc aagctgtaat agatgctggg
     1261 ttaatcccta tgattattca tcagctcgct aagggggact ttggaacaca aaaggaagct
     1321 gcttgggcaa ttagcaactt aacgataagt ggcagaaaag atcaagttga ataccttgta
     1381 cagcagaacg taataccacc attctgtaac ttactgtcag taaaagattc tcaagtggtg
     1441 caggtggttc tagatggtct taaaaacatc ctgataatgg ctggtgatga agcaagcaca
     1501 atagctgaga tcatagaaga gtgtggaggt ttggagaaaa ttgaagtttt gcagcaacat
     1561 gaaaatgaag acatatataa attagcattt gaaatcatag atcaatattt ctctggtgat
     1621 gatattgatg aagatcctag cctcattcca gaagcaacac aaggaggtac ttacaatttt
     1681 gacccaacag ccaaccttca aacaaaagaa tttaatttct aaggtcaatt aagtgcagca
     1741 tctttcattc aatatgaaac accaccagat ggccaccaag cgataagaca gcaagcaaca
     1801 gaaggctccc agcactcttg cctcttcatt ttgatgcttc taaagcaagc catgtctcag
     1861 tcactttgca gttgccaaaa gtcactctca catggactgt aaatgcatat gcatgatttc
     1921 ctaaactgtt ttagaattct ccttaaccat ctcaactccc ctatattttc catgttccct
     1981 ggtgccacat gctgacaact gcagtctcca gttagaatat tccatagtgg tggtatatca
     2041 gctgcccact gatacgcctt tggaaaaagg tgcgctgtgg atcaagacac tttggtatga
     2101 tgtatattca tgttggaaga ctacagaggt gcagtgtgat ctgagcctcc atcattgtcc
     2161 tccacaaaca tattttcata ttcttatgtg gaagaattaa aagtacaagc caaatgattt
     2221 tcattggtga aactgacaca aaagtaactt aaaaacaaga aacttggttg ttgattaaaa
     2281 agataagttt tttaaaactg tacttcacct accattaatt gatgtgttta ttatctgcct
     2341 cagaagccag ggttggagga agagctttag atatcaatgg taatgctttc gccattatac
     2401 ctaatttttt gagaacagca aatcctattt gaccactcac ttcagcctgt gtgttcctgc
     2461 tgttttgaat aatcaaatgc tgtgcatggt ctctacctga gctgcaacct gttacagact
     2521 tgaacttctg ttaagttgaa agcaagagtc cttgactaca aaaatacaca aataaataag
     2581 tcaaaacaag aatggaaaag gtttaaatac tgattggtaa ggttttaaga caaagtcttg
     2641 ctttcagctt ccaggggtta attttatttt tgttttaatt tgataattgg atatggttga
     2701 tttatattgg gtttaaactg tggagctttc atgtttactg taatttagtc ttaaaatatt
     2761 ttttacttag taaccagtac ttttgataat gtggtggcaa caaaccagca actatctaga
     2821 agtgttacaa gacttcattc ttgagtattg gagttcattc agatctcact caaagcatct
     2881 gcacacatta aaagataaac caaggatctg tgtagaggaa tggtctgcag ttatttaact
     2941 cagcctgatt tgcagtgatc ttaagctctg caaaatctgg ccttactatg taaagtcatt
     3001 gcttatggca aatggtctga cccagttatt aatgaatgaa tagggatttg aaatttttta
     3061 aactaaataa tttgtgctgt cacagaaatg gttttgttgc tcttgttcac tgggtataat
     3121 ttcccaatgc attgatgtga agggatagaa atctaaacta agatagtttt cagatggggg
     3181 gtgtatttac tgtgatgaag aagagacaga tgccatcaga gctttgtgaa acagctgggg
     3241 tgttttcact gataaacaac acatagcagg tgtgcttcat tacaaatata tgtatctgcc
     3301 aaggtggagc cactttaaag agtgagtttt gtcttgtatc taaaatggat acaagcgtat
     3361 gtttaaactg caagattttt acttgctaga gaatctgttt taatatagtg gtttggcctc
     3421 tgattattta taggttttat aaattttaga atcaatttct ctttaaggtg gctcagattt
     3481 ttcaactctt gtgcacataa aattgagttg aagttcattg tgcctttttt ctttacccaa
     3541 attttgagtt aaagcttcat atggtaactg catcctgttc aaacacttgt ctaaattttg
     3601 aaactgtgta gtgttcacta aaagtaggag taacaaagtc agaatgaatt aaggtcacac
     3661 actctggtga aacccttaaa gtcacaacct tcttgatagt gtgaattgtc cccttccagt
     3721 tacttccttc tggtctctcc ctacttaact gacagttacc ttttaaattt tgcacacatt
     3781 gagattaaaa ttgggcttct actgtgatga ttcctatttc ctctcgcgtc ttaagtgcaa
     3841 actaaccgtt aagtaacgtt ggcatcaagt agtgcagact ccgtgcctct gcttgagcgg
     3901 tttgccgtga cctgaccagt tttgagttgg aatcacacca tttcgtagat aaggaaactg
     3961 agtgtattgc tgcactttta agttttcaaa acagtgtttt aaaattgcat tgtttttttt
     4021 ttttaaactc agtttaaaaa aagactaaaa tgttctttca aaagaggcat ctaaacgtgt
     4081 tcctaatttt gtatatgggc ttaggttttg taaccaataa aaaagctgct atcaaatatg
     4141 ataaaacatt gaaagactta tttctgg
//
