LOCUS       NM_010655               2071 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus karyopherin subunit alpha 2 (Kpna2), mRNA.
ACCESSION   NM_010655 XM_987865
VERSION     NM_010655.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2071)
  AUTHORS   Rother,F., Abu Hweidi,D., Hartmann,E. and Bader,M.
  TITLE     Normal male fertility in a mouse model of KPNA2 deficiency
  JOURNAL   PLoS One 19 (10), e0304189 (2024)
   PUBMED   39423201
  REMARK    GeneRIF: Normal male fertility in a mouse model of KPNA2
            deficiency.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2071)
  AUTHORS   Rother,F., Depping,R., Popova,E., Huegel,S., Heiler,A., Hartmann,E.
            and Bader,M.
  TITLE     Karyopherin alpha2 is a maternal effect gene required for early
            embryonic development and female fertility in mice
  JOURNAL   FASEB J 38 (8), e23623 (2024)
   PUBMED   38656660
  REMARK    GeneRIF: Karyopherin alpha2 is a maternal effect gene required for
            early embryonic development and female fertility in mice.
REFERENCE   3  (bases 1 to 2071)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2071)
  AUTHORS   Indrigo,M., Morella,I., Orellana,D., d'Isa,R., Papale,A., Parra,R.,
            Gurgone,A., Lecca,D., Cavaccini,A., Tigaret,C.M., Cagnotto,A.,
            Jones,K., Brooks,S., Ratto,G.M., Allen,N.D., Lelos,M.J., Middei,S.,
            Giustetto,M., Carta,A.R., Tonini,R., Salmona,M., Hall,J.,
            Thomas,K., Brambilla,R. and Fasano,S.
  TITLE     Nuclear ERK1/2 signaling potentiation enhances neuroprotection and
            cognition via Importinalpha1/KPNA2
  JOURNAL   EMBO Mol Med 15 (11), e15984 (2023)
   PUBMED   37792911
  REMARK    GeneRIF: Nuclear ERK1/2 signaling potentiation enhances
            neuroprotection and cognition via Importinalpha1/KPNA2.
REFERENCE   5  (bases 1 to 2071)
  AUTHORS   Navarrete-Lopez,P., Maroto,M., Pericuesta,E.,
            Fernandez-Gonzalez,R., Lombo,M., Ramos-Ibeas,P. and
            Gutierrez-Adan,A.
  TITLE     Loss of the importin Kpna2 causes infertility in male mice by
            disrupting the translocation of testis-specific transcription
            factors
  JOURNAL   iScience 26 (7), 107134 (2023)
   PUBMED   37456838
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2071)
  AUTHORS   Gage,P.J. and Camper,S.A.
  TITLE     Pituitary homeobox 2, a novel member of the bicoid-related family
            of homeobox genes, is a potential regulator of anterior structure
            formation
  JOURNAL   Hum Mol Genet 6 (3), 457-464 (1997)
   PUBMED   9147650
REFERENCE   7  (bases 1 to 2071)
  AUTHORS   Prieve,M.G., Guttridge,K.L., Munguia,J.E. and Waterman,M.L.
  TITLE     The nuclear localization signal of lymphoid enhancer factor-1 is
            recognized by two differentially expressed Srp1-nuclear
            localization sequence receptor proteins
  JOURNAL   J Biol Chem 271 (13), 7654-7658 (1996)
   PUBMED   8631802
REFERENCE   8  (bases 1 to 2071)
  AUTHORS   Kussel,P. and Frasch,M.
  TITLE     Yeast Srp1, a nuclear protein related to Drosophila and mouse
            pendulin, is required for normal migration, division, and integrity
            of nuclei during mitosis
  JOURNAL   Mol Gen Genet 248 (3), 351-363 (1995)
   PUBMED   7565597
REFERENCE   9  (bases 1 to 2071)
  AUTHORS   Imamoto,N., Shimamoto,T., Takao,T., Tachibana,T., Kose,S.,
            Matsubae,M., Sekimoto,T., Shimonishi,Y. and Yoneda,Y.
  TITLE     In vivo evidence for involvement of a 58 kDa component of nuclear
            pore-targeting complex in nuclear protein import
  JOURNAL   EMBO J 14 (15), 3617-3626 (1995)
   PUBMED   7641681
REFERENCE   10 (bases 1 to 2071)
  AUTHORS   Gorlich,D., Kostka,S., Kraft,R., Dingwall,C., Laskey,R.A.,
            Hartmann,E. and Prehn,S.
  TITLE     Two different subunits of importin cooperate to recognize nuclear
            localization signals and bind them to the nuclear envelope
  JOURNAL   Curr Biol 5 (4), 383-392 (1995)
   PUBMED   7627554
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI664586.1, AK075952.1 and BC086789.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_987865.1, NM_010655.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC086789.1, SRR1660817.155589.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN02415136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AI664586.1         1-110
            111-811             AK075952.1         50-750
            812-1080            BC086789.1         729-997
            1081-1729           AK075952.1         1021-1669
            1730-2071           BC086789.1         1645-1986
FEATURES             Location/Qualifiers
     source          1..2071
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 70.08 cM"
     gene            1..2071
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /note="karyopherin subunit alpha 2"
                     /db_xref="GeneID:16647"
                     /db_xref="MGI:MGI:103561"
     exon            1..167
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..265
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            266..403
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..492
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            493..761
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            762..856
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1120
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1354
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1537
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1687
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..2038
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2007..2012
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
     polyA_site      2038
                     /gene="Kpna2"
                     /gene_synonym="2410044B12Rik; IPOA1; PTAC58; Rch1"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 aatcagccaa tcggaacgcg gcgtcaccgg gaaatttaaa tcgcgccggc cggcagcacg
       61 aggcacaaaa tctgagggct gaagggtagc agacgtttcc acagccgccg acccgcagct
      121 tgagtgtcct gcaccacctt tcgtggaaat ctgagccggc tgtacagctt tcctccttgt
      181 tcctgcagcc atgtccacga acgagaatgc taacttacca gctgcccgac ttaacaggtt
      241 caagaacaag gggaaggaca gcacagaaat gcgtcgccgc cgaatagaag ttaatgtgga
      301 actcaggaaa gctaaaaaag atgagcagat gctgaaaaga agaaacgtca gctcctttcc
      361 tgatgatgct acttctccgc tacaggaaaa ccggaacaac cagggtactg taaattggtc
      421 tgttgaggac attgttaaag gcataaacag taacaatttg gaaagccagc tccaagctac
      481 tcaagctgct cggaaattgc tttctagaga gaaacagcct cctatagaca acatcatccg
      541 ggctggtttg atcccaaaat ttgtgtcctt cttgggcaaa actgattgta gtcctattca
      601 gtttgagtct gcttgggcac tcaccaacat tgcttctgga acatctgaac agaccaaagc
      661 tgtggtggat ggaggtgcta tcccagcgtt tatttctctc ttggcatctc ctcatgctca
      721 catcagcgag caagctgttt gggctcttgg aaacattgca ggtgatggtt cagctttccg
      781 agacttagtt atcaaacacg gtgcgattga cccactgttg gcacttcttg cagttcccga
      841 tctgtctacc ttggcatgtg gttacttacg taatcttacc tggacacttt caaacctttg
      901 tcgaaacaag aaccctgcac ctcccttaga cgccgttgag cagattcttc ctacgttagt
      961 tcgactcctg caccacaatg atccagaagt attggcagat tcctgctggg ccatttccta
     1021 cctgactgat ggtccaaatg agcgcattga gatggttgtg aagaaaggag ttgttcccca
     1081 acttgtgaag cttctaggag ctactgaact gcccattgtg actcccgcac taagagccat
     1141 agggaatatt gtcactggaa cagatgagca gactcagaaa gtgatcgatg caggagcact
     1201 tgcagtcttt cccagcctgc taacaaaccc caaaactaat attcagaagg aggccacatg
     1261 gacaatgtcg aacattacag ctggacgcca ggaccagata cagcaagttg tgaatcacgg
     1321 cctagtcccc tttcttgttg gtgtcctctc taaggcggac tttaagacac agaaggaggc
     1381 cgcgtgggct ataaccaact ataccagcgg tgggactgtt gagcagattg tgtatctcgt
     1441 tcactgtggg ataatagaac ctttgatgaa cctcctgagt gcaaaagata ccaagattat
     1501 tcaggttatt cttgacgcca tttcaaatat ctttcaggct gcagagaaac taggtgagac
     1561 agaaaagctc agtataatga ttgaagagtg tggaggcttg gataaaattg aagcactaca
     1621 gaggcatgaa aacgagtctg tatacaaggc ctcattgaac ttaattgaga agtacttctc
     1681 agtggaggaa gaggaagatc aaaatgtggt gccagaaact acctctgaag gcttcgcctt
     1741 ccaagttcag gatggagctc ctgggacctt taacttctaa tgtccagcta aggcacaaag
     1801 ttgttagcta tgtgctgtgc tattctgtgt tctcatagat ttgtcttact gtttctctac
     1861 taagaactct ttttaaatgt ggtttgttat tgtagcactt tttacaaaag aaactatact
     1921 tgaacagtta taaactgtac atactctatg aagctgtcct ctgaatttat ttctatgtgg
     1981 aatttcgtac cctgtcatgt cctgtaaata aagattaaag ttccattctt tactctgaaa
     2041 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa a
//
