LOCUS       NM_001416718            7161 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus karyopherin subunit alpha 1 (Kpna1), transcript
            variant 2, mRNA.
ACCESSION   NM_001416718 XM_006521814
VERSION     NM_001416718.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7161)
  AUTHORS   Nomiya,H., Sakurai,K., Miyamoto,Y., Oka,M., Yoneda,Y., Hikida,T.
            and Yamada,M.
  TITLE     A Kpna1-deficient psychotropic drug-induced schizophrenia model
            mouse for studying gene-environment interactions
  JOURNAL   Sci Rep 14 (1), 3376 (2024)
   PUBMED   38336912
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7161)
  AUTHORS   Sakurai,K., Itou,T., Morita,M., Kasahara,E., Moriyama,T.,
            Macpherson,T., Ozawa,T., Miyamoto,Y., Yoneda,Y., Sekiyama,A.,
            Oka,M. and Hikida,T.
  TITLE     Effects of Importin alpha1/KPNA1 deletion and adolescent social
            isolation stress on psychiatric disorder-associated behaviors in
            mice
  JOURNAL   PLoS One 16 (11), e0258364 (2021)
   PUBMED   34767585
  REMARK    GeneRIF: Effects of Importin alpha1/KPNA1 deletion and adolescent
            social isolation stress on psychiatric disorder-associated
            behaviors in mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7161)
  AUTHORS   de Oliveira,H.C., da Silva,T.D., Salvador,G.H.M., Moraes,I.R.,
            Fukuda,C.A., de Barros,A.C. and Fontes,M.R.M.
  TITLE     Structural and calorimetric studies reveal specific determinants
            for the binding of a high-affinity NLS to mammalian importin-alpha
  JOURNAL   Biochem J 478 (13), 2715-2732 (2021)
   PUBMED   34195786
  REMARK    GeneRIF: Structural and calorimetric studies reveal specific
            determinants for the binding of a high-affinity NLS to mammalian
            importin-alpha.
REFERENCE   4  (bases 1 to 7161)
  AUTHORS   Marvaldi,L., Panayotis,N., Alber,S., Dagan,S.Y., Okladnikov,N.,
            Koppel,I., Di Pizio,A., Song,D.A., Tzur,Y., Terenzio,M., Rishal,I.,
            Gordon,D., Rother,F., Hartmann,E., Bader,M. and Fainzilber,M.
  TITLE     Importin alpha3 regulates chronic pain pathways in peripheral
            sensory neurons
  JOURNAL   Science 369 (6505), 842-846 (2020)
   PUBMED   32792398
REFERENCE   5  (bases 1 to 7161)
  AUTHORS   Panayotis,N., Sheinin,A., Dagan,S.Y., Tsoory,M.M., Rother,F.,
            Vadhvani,M., Meshcheriakova,A., Koley,S., Marvaldi,L., Song,D.A.,
            Reuveny,E., Eickholt,B.J., Hartmann,E., Bader,M., Michaelevski,I.
            and Fainzilber,M.
  TITLE     Importin alpha5 Regulates Anxiety through MeCP2 and Sphingosine
            Kinase 1
  JOURNAL   Cell Rep 25 (11), 3169-3179 (2018)
   PUBMED   30540948
  REMARK    GeneRIF: importin alpha5 influences sphingosine-sensitive anxiety
            pathways by regulating MeCP2 nuclear import in hippocampal neurons.
REFERENCE   6  (bases 1 to 7161)
  AUTHORS   Tsuji,L., Takumi,T., Imamoto,N. and Yoneda,Y.
  TITLE     Identification of novel homologues of mouse importin alpha, the
            alpha subunit of the nuclear pore-targeting complex, and their
            tissue-specific expression
  JOURNAL   FEBS Lett 416 (1), 30-34 (1997)
   PUBMED   9369227
REFERENCE   7  (bases 1 to 7161)
  AUTHORS   Matsuda,Y., Hamatani,K., Itoh,M., Takahashi,E.I., Araki,R. and
            Abe,M.
  TITLE     Localization of the importin-beta gene to mouse chromosome 11D and
            rat chromosome 10q32.1
  JOURNAL   Genomics 36 (1), 213-215 (1996)
   PUBMED   8812441
REFERENCE   8  (bases 1 to 7161)
  AUTHORS   Prieve,M.G., Guttridge,K.L., Munguia,J.E. and Waterman,M.L.
  TITLE     The nuclear localization signal of lymphoid enhancer factor-1 is
            recognized by two differentially expressed Srp1-nuclear
            localization sequence receptor proteins
  JOURNAL   J Biol Chem 271 (13), 7654-7658 (1996)
   PUBMED   8631802
REFERENCE   9  (bases 1 to 7161)
  AUTHORS   Moroianu,J., Blobel,G. and Radu,A.
  TITLE     Previously identified protein of uncertain function is karyopherin
            alpha and together with karyopherin beta docks import substrate at
            nuclear pore complexes
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2008-2011 (1995)
   PUBMED   7892216
REFERENCE   10 (bases 1 to 7161)
  AUTHORS   Cortes,P., Ye,Z.S. and Baltimore,D.
  TITLE     RAG-1 interacts with the repeated amino acid motif of the human
            homologue of the yeast protein SRP1
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7633-7637 (1994)
   PUBMED   8052633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133464.11 and CT573031.6.
            
            On Feb 15, 2023 this sequence version replaced XM_006521814.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.16959.1,
                                           SRR13422598.481121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-338               AC133464.11        43953-44290         c
            339-472             AC133464.11        27298-27431         c
            473-580             AC133464.11        24663-24770         c
            581-680             AC133464.11        18198-18297         c
            681-775             AC133464.11        14626-14720         c
            776-907             AC133464.11        8224-8355           c
            908-996             AC133464.11        7369-7457           c
            997-1096            AC133464.11        6826-6925           c
            1097-1260           AC133464.11        5965-6128           c
            1261-1339           AC133464.11        4360-4438           c
            1340-1465           CT573031.6         21351-21476
            1466-1593           CT573031.6         22999-23126
            1594-1772           CT573031.6         25081-25259
            1773-7161           CT573031.6         25550-30938
FEATURES             Location/Qualifiers
     source          1..7161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.43 cM"
     gene            1..7161
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /note="karyopherin subunit alpha 1"
                     /db_xref="GeneID:16646"
                     /db_xref="MGI:MGI:103560"
     exon            1..338
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            339..472
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     CDS             344..1960
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /note="isoform 1 is encoded by transcript variant 2;
                     importin subunit alpha-1; NPI-1; SRP1-beta; importin
                     alpha-S1; RAG cohort protein 2; nucleoprotein interactor
                     1; m-importin-alpha-S1; importin subunit alpha-5; importin
                     alpha 5; karyopherin (importin) alpha 1"
                     /codon_start=1
                     /product="importin subunit alpha-5 isoform 1"
                     /protein_id="NP_001403647.1"
                     /db_xref="GeneID:16646"
                     /db_xref="MGI:MGI:103560"
                     /translation="MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQL
                     FKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMTDMIFSNSPEQQLSA
                     TQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSL
                     QTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLNCNILPPLLQ
                     LFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACW
                     ALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVI
                     LNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTA
                     EFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENI
                     LRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTED
                     EDSSIAPQVDLSQQQYIFQQCEAPMEGFQL"
     exon            473..580
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..680
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            681..775
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..907
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            908..996
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1096
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1260
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1339
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1465
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1593
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1772
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..7161
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4044..4049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /note="hexamer: AGTAAA"
     polyA_site      4069
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /note="major polyA site"
     regulatory      5140..5145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /note="hexamer: AATAAA"
     polyA_site      5168
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /note="major polyA site"
     polyA_site      5188
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /note="major polyA site"
     regulatory      7140..7145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /note="hexamer: AATACA"
     polyA_site      7161
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
ORIGIN      
        1 gcagtgcgca cgccggctga gctgggtctc gcggctctgt gagcggcagc ggagagcgag
       61 gcctggtgag cgccgccgtg gtgcgcgccg gctggtcaag gttgtgcgca gaagaggcgc
      121 agcgggcggg ccaagagcga gcgtctccct cttcgtagtg gcaccgggac cggtcgcctg
      181 gagccggtga gtgggggcac ctcgcggccc ctccccctcg gcgggcggct ctgggtcccc
      241 ctccgcggac ccgagggagg ccccggggcg aaggcggacg cgggcggaag ccggagctgg
      301 ctcgggcgcg ccggggaccg gaccctcgcg tcgctccgaa atcatgtcca caccaggaaa
      361 agagaacttt cgcctgaaaa gttacaagaa caaatctctg aatcctgatg agatgcgcag
      421 gaggagggag gaagaaggac tgcagttacg gaagcagaaa agagaagagc agttattcaa
      481 gagaagaaat gttgctacag cagaagaaga aacagaagaa gaagttatgt ctgatggtgg
      541 ctttcatgag gcccagataa ataacatgga gatggcacca gggggtgtca tcacctctga
      601 catgactgat atgatattct cgaatagccc agagcagcag ctctctgcaa cacagaagtt
      661 taggaaacta ctttcaaaag aacctaatcc tccaattgat gaagtcatca acacaccagg
      721 agtagtggcc aggtttgtgg agttcctcaa acgaaaagaa aattgtacac tgcagtttga
      781 atcagcttgg gtcctgacaa atattgcttc aggaaactct cttcagaccc ggaatgtgat
      841 tcaggcagga gctgtgccta ttttcatcga gttgcttagc tcagagtttg aagatgtcca
      901 ggagcaggca gtttgggctc ttggcaacat tgctggagat agtaccatgt gcagggacta
      961 tgtcttaaac tgcaatatcc ttcctcctct tctgcagtta ttttcaaagc aaaaccgctt
     1021 gaccatgacc cggaatgcag tatgggcttt atctaatctc tgtagaggga agagcccacc
     1081 tccagaattt gctaaggttt ctccctgtct gaatgtcctt tcttggttac tgtttgtcag
     1141 tgacactgat gtactagctg atgcttgctg ggctctctca tacctgtcag atggacccaa
     1201 tgataaaatc caagcagtca tcgatgcagg agtctgcagg aggcttgtgg aacttctgat
     1261 gcataatgac tataaagtag tttctcctgc tttgcgggct gtgggaaaca ttgtcacagg
     1321 ggatgatatt cagacacagg taattttgaa ttgctcagct cttcaaagtt tattgcatct
     1381 gctgagtagc ccaaaggaat ctatcaaaaa agaagcctgt tggacaatct ctaatattac
     1441 agctggaaat agggcacaga tccagactgt gatagatgct aacatgttcc cagctcttat
     1501 tagtatattg caaacagcag agttccggac aaggaaggaa gctgcttggg ccatcacaaa
     1561 tgcaacttct ggaggatcag ctgagcagat caagtaccta gtagaactgg gttgtatcaa
     1621 gccactctgt gatctcctca ctgtcatgga tgcaaaaatt gtacaggttg ccctaaatgg
     1681 cttagaaaac atcctgaggc ttggagaaca agaagccaaa cgaaacggct caggcattaa
     1741 tccttactgt gctttgattg aggaagcata tggtctggat aaaattgagt tcttacagag
     1801 tcatgaaaac caggagatct atcaaaaggc ttttgatctt attgagcatt actttgggac
     1861 cgaagatgag gacagcagca tcgcacccca ggttgatctt agccagcagc agtacatctt
     1921 ccagcagtgt gaagctccta tggaaggttt ccagctttga agcaatcctc tccttcttgt
     1981 tcctgtgtca gaccaggcta tccagtcaag tcctcttgtg gagcccacag tcctcatgga
     2041 gctaatctct caaatgtttt ccataatact gtttgcgctc atttgcttgc cttgcgcacc
     2101 tgctctctta cacacatctg gaaaacctct ggctctctgt ggtggaatac ccttttatta
     2161 caagggtaac cagaacggcc cactctctta tggaaaaatc cctaagcttt ggagatccgc
     2221 acttacatta gagtcatggg aatatataca catactaatg tggctccctt ttttgtgggg
     2281 gaaaaaagag gactcttcct cattccgtaa agtggggaaa atgacattga aagataaaac
     2341 taaaaccttt atcttgaatt ttacacaact acaagggaga tatttagact tgtgtataca
     2401 tcagagtact cttctcgagt tcttccacag tgaatcaacc cttggagtac ctggtggctt
     2461 tttctagcca catttgcatt aatccttatt gagatgggat ggttttcttt cctctaatgg
     2521 agtcattttc ttcagatatt aaagttaaac catccaatcc ctcaccttca gccttcagtg
     2581 aatgtgcttc tagttgtcag gaatgctgaa gaattaacac tttgactttt aaatgtgatc
     2641 ctggcttggc agatttcctt aaagcaggaa ggagagaagc atatattagt ttgtatggct
     2701 tttgcttctc tttgtttttg tttcttagga tttggaagtg gttcagtttt aacgctggta
     2761 tgaaggctaa aagtccttaa gtaaaaccat gttcaaaaat ccaattaaag actaagaaca
     2821 taaaacccat cactttgttt aaaccggtgt gacgagaggc tgtgtttctg cattacaaat
     2881 gatcctcagg ctttgtggtc ctgaccaagg gcctggtaaa ttggagtcac cctaggtgct
     2941 tttcctcttc gtgactggca gataacacat atttaaatgt tacttaggga tttttttttc
     3001 ctttgttgag tgcagctcga ttctaatgta atcatgctgc atacatgctt ttgctgtgca
     3061 gcatccttat ctttaaaagc atactagtct cctcagtgtg acctctagac taaaagggca
     3121 gtgatccaat aacctcagta tcccctgttt ttatttcatc tcctactagt accctacctc
     3181 ccctaggaag aacatgccca cctcctgctt atttaatgat gactgtaatg tacctgcaaa
     3241 tggcgcttcc agtactgtgt tcactgacat ttgtgcttgg actagaaggg gaaagaaaca
     3301 agaaaaaaag gataattgcc aagagaactg caaatgagtt caatgtgact tctcggtgct
     3361 agttggccat cttggctcaa tgttgggaca cactatcaga gagaggagtc tttttttttt
     3421 tccccaatga tattctgttc aaaatgaatt ctgaaggaaa agttgctcat gtctgtttca
     3481 gagcataccc ttttaaatct ttttagacta ctcttctaga attcatcata accccaaaat
     3541 agataaaagc tatctagaag ttgccctgac aagctattgc acatctctgg taaatcctgc
     3601 tgaatgtaag gaatattcag agctctcata cctcatcatg atgttattta agcagccaat
     3661 ttacacgacc tgatttactt tgaaaaattt gtttcattca aactagaaag ttccagagac
     3721 aaaggacatt tctcagccaa gagtgtgatg cattcttgcc ctagtcttta cttgtgtctg
     3781 ctctgggatg gatgctgtct gatgtctgtt accaatggag cagataccac aaaactagtc
     3841 aactcccgtc tgtcctgttg ttttctagtg ctgctttgtg ctgagagaac atgttagttt
     3901 actgaacttg acctgtacaa gactgattct ttgtaatttt agggttaaat taggtggtta
     3961 atttaaagat gaactttcaa tgttgccttt acatcacatt acagtatcac ttctttgaga
     4021 aggtaataga agcactgatt catagtaaaa atcttgtttt tagctttgac ttttcttgtg
     4081 gctgatttct ttttaaattg taaattactg gtaacatgtt atttctatag aatgttttaa
     4141 attatgtacc ttctattgga tagttaaaac ctttgcatct tataaaggag tttgaatgaa
     4201 aagaaataga aagcacacag agttgtcacc tcaccttacc aagagcatac agctggaact
     4261 tttgtagcaa tatcagggtg gcccaatgag ttcaggtcca ttaatcagtg tgagctcttt
     4321 tatcttaagc ctgaccagaa gttcatgaac tttaaatatt ctgaactttg tttttatagt
     4381 aaaatgattg tttcagtgta aacatggcat tcagctaaac cctggcaagt tcagatgttc
     4441 tggaactgag tacttacaaa gaagactttt gtttcttaac gcaagtggaa tcttaggggt
     4501 tacttgtaaa tcctattttt agtctttcac ctggcaaagt ctattaattt aatcttttga
     4561 agatttttat cagaaaggtg ttacttatta cagaagcatg ttagtattta taacataaaa
     4621 cctcttaagg attttagata gtgatcaggg caaagtggct ttgttgtttt ccttctctgt
     4681 ctccttccag actttccaag tatgtatttt atactgagaa ctttgatttt taaagaagca
     4741 ttcagagact ttgagatgta aaggtacctg gtacctgaag caccaaaagg taaagagccg
     4801 ggtggagaaa caccccagaa cattcagatg ccaggtacag aacacagtta ggagacttgg
     4861 ctgtgggaca cgggttcttg ccaccagtca aagccatctt tagattgccc tcgttagccc
     4921 cctgctggaa actctgctgc accagggttg tttcttccac acaccagact aagctgttgg
     4981 actccgggtg tttctcagcc ttactgtcct ataataaatc tgaattattc cagttgctgc
     5041 tgactatgcc taagaaaaca tatgtaagta taatttgtca accaaattct gttgtacatg
     5101 actacctacc ggcaactttg attgatttct gtagtgctaa ataaacattt cagctgtctg
     5161 accccaaacg tggggctgta ttgtaaaaca ggttttcctt gggttatggg atttatttta
     5221 tgtctgatta aatttggggg aaattttcat atcagtaagc aagccatttt agctgttttt
     5281 aggggctgga actttttatt taagttggaa agtgtgttga gtaatgtgcc ataagaaaaa
     5341 ggagtcagtt tttgagcggg gattgtttct tttcagggtg catacatacc ttccaaatta
     5401 gaaagtttgc tcacttgcag tttcattttg aaatcctaaa ttagtagagc catttttttt
     5461 tgtttgaggt agacaaatta actatctgtc tgcagagttg gaagtattta gactcctatc
     5521 attcaaaatt agttaaatat aatatttgcc tgtatataaa tgatattcta tattctttat
     5581 tgttacaaaa gaacagctta tgagtactaa gacatcaggg taatgtttaa taaagtagag
     5641 gtttaatgtt ttaaaaatat cacattgcta gagctggagg gagacctctt gtgttaggag
     5701 gtcatctgtt acgggaagtc actaccctcg aggaagatgg gagtgtggct cccagcaccc
     5761 acatcagcac ccatcttgct ttgactccag ctacagtgga tccggagctc tcttctggct
     5821 ttcccgggac acatggtgtg cacgcatacc tatgagcaag cacttccaga taaaaacaaa
     5881 ccttaatttt tttcaaagta ccaaattact attggtcata agatcatcca gaagcttgag
     5941 gtaagaaaga atgaaggaat actaggtcct gttttcagct aagtgtagac aaatttctgt
     6001 cctcctttag gtcaaataat aaaaaagtca tatttagtgt ctattttgtt tcagggcatt
     6061 cccttaatca gtcctttagt tgctatttaa gatggataat tccgactgta ttataaatag
     6121 aggctcaaaa cttaatggag tacttggctt agatagatgg tggctgtcca gaggagagag
     6181 ccttgcaagc tctgcatcag accattgttc ccaactgttc ctaactggcg atactttgaa
     6241 gtggctccat ctcataatca caattgccat tgatttgcat attctgatag atgaattgac
     6301 tcccttgttc ctaagcatcc ttccccttct gcagtactaa cattcagaca agtgcaacac
     6361 tttaaaagaa attcaggcag ttgattgtga atttagtgac agaagtgaaa acagatattg
     6421 acgtaggaaa actctttggg gtgcaaagta acagctcttc tgatcagcac catgggtgtg
     6481 acactagccc agcctgctct taaacataga tcctgtgccc tttctccaga gtgtttgtac
     6541 acttgatcta gaatggctat tgatactttg tactgaatgc actctgccag ccgtgggtga
     6601 atgaatgctt tgcacacggt caattttcaa taaatagtgg atgaggagta tacacctgtg
     6661 gtagtaatgg gtgcacagct gaatccagaa ttgacaactg ttaaaagcaa atgtatcaac
     6721 agagtgtttc atttgtagtt actgttgagg atagagagag ggtcctgaag tttatgaaaa
     6781 acattttcac accaggagtc tgtgacatca aagcagtaag gaagaggaaa agctgctggt
     6841 ttattctgca agtagcacac actgcagtgc atttgataca agttttgtta ctgtacgtcc
     6901 acctgaggtg ggagcccagt ggctaggctg ttgaggtttc cggttttcac atattatata
     6961 tattgcagaa gaatgctttt tttattcctc taggcttata aaacaaatga aaagaaaaag
     7021 ttggtatatt ctttactctg acagtttcac tccttgtgag gtttactggc ccagtatttt
     7081 tgtgaaaaga actttaaatc aaaacagctt cagtttctgt gaactcttgt ttcatatcca
     7141 atacaaaaat tgtggactct a
//
