LOCUS       NP_001403647             538 aa            linear   ROD 01-MAY-2025
DEFINITION  importin subunit alpha-5 isoform 1 [Mus musculus].
ACCESSION   NP_001403647 XP_006521877
VERSION     NP_001403647.1
DBSOURCE    REFSEQ: accession NM_001416718.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 538)
  AUTHORS   Nomiya,H., Sakurai,K., Miyamoto,Y., Oka,M., Yoneda,Y., Hikida,T.
            and Yamada,M.
  TITLE     A Kpna1-deficient psychotropic drug-induced schizophrenia model
            mouse for studying gene-environment interactions
  JOURNAL   Sci Rep 14 (1), 3376 (2024)
   PUBMED   38336912
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 538)
  AUTHORS   Sakurai,K., Itou,T., Morita,M., Kasahara,E., Moriyama,T.,
            Macpherson,T., Ozawa,T., Miyamoto,Y., Yoneda,Y., Sekiyama,A.,
            Oka,M. and Hikida,T.
  TITLE     Effects of Importin alpha1/KPNA1 deletion and adolescent social
            isolation stress on psychiatric disorder-associated behaviors in
            mice
  JOURNAL   PLoS One 16 (11), e0258364 (2021)
   PUBMED   34767585
  REMARK    GeneRIF: Effects of Importin alpha1/KPNA1 deletion and adolescent
            social isolation stress on psychiatric disorder-associated
            behaviors in mice.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 538)
  AUTHORS   de Oliveira,H.C., da Silva,T.D., Salvador,G.H.M., Moraes,I.R.,
            Fukuda,C.A., de Barros,A.C. and Fontes,M.R.M.
  TITLE     Structural and calorimetric studies reveal specific determinants
            for the binding of a high-affinity NLS to mammalian importin-alpha
  JOURNAL   Biochem J 478 (13), 2715-2732 (2021)
   PUBMED   34195786
  REMARK    GeneRIF: Structural and calorimetric studies reveal specific
            determinants for the binding of a high-affinity NLS to mammalian
            importin-alpha.
REFERENCE   4  (residues 1 to 538)
  AUTHORS   Marvaldi,L., Panayotis,N., Alber,S., Dagan,S.Y., Okladnikov,N.,
            Koppel,I., Di Pizio,A., Song,D.A., Tzur,Y., Terenzio,M., Rishal,I.,
            Gordon,D., Rother,F., Hartmann,E., Bader,M. and Fainzilber,M.
  TITLE     Importin alpha3 regulates chronic pain pathways in peripheral
            sensory neurons
  JOURNAL   Science 369 (6505), 842-846 (2020)
   PUBMED   32792398
REFERENCE   5  (residues 1 to 538)
  AUTHORS   Panayotis,N., Sheinin,A., Dagan,S.Y., Tsoory,M.M., Rother,F.,
            Vadhvani,M., Meshcheriakova,A., Koley,S., Marvaldi,L., Song,D.A.,
            Reuveny,E., Eickholt,B.J., Hartmann,E., Bader,M., Michaelevski,I.
            and Fainzilber,M.
  TITLE     Importin alpha5 Regulates Anxiety through MeCP2 and Sphingosine
            Kinase 1
  JOURNAL   Cell Rep 25 (11), 3169-3179 (2018)
   PUBMED   30540948
  REMARK    GeneRIF: importin alpha5 influences sphingosine-sensitive anxiety
            pathways by regulating MeCP2 nuclear import in hippocampal neurons.
REFERENCE   6  (residues 1 to 538)
  AUTHORS   Tsuji,L., Takumi,T., Imamoto,N. and Yoneda,Y.
  TITLE     Identification of novel homologues of mouse importin alpha, the
            alpha subunit of the nuclear pore-targeting complex, and their
            tissue-specific expression
  JOURNAL   FEBS Lett 416 (1), 30-34 (1997)
   PUBMED   9369227
REFERENCE   7  (residues 1 to 538)
  AUTHORS   Matsuda,Y., Hamatani,K., Itoh,M., Takahashi,E.I., Araki,R. and
            Abe,M.
  TITLE     Localization of the importin-beta gene to mouse chromosome 11D and
            rat chromosome 10q32.1
  JOURNAL   Genomics 36 (1), 213-215 (1996)
   PUBMED   8812441
REFERENCE   8  (residues 1 to 538)
  AUTHORS   Prieve,M.G., Guttridge,K.L., Munguia,J.E. and Waterman,M.L.
  TITLE     The nuclear localization signal of lymphoid enhancer factor-1 is
            recognized by two differentially expressed Srp1-nuclear
            localization sequence receptor proteins
  JOURNAL   J Biol Chem 271 (13), 7654-7658 (1996)
   PUBMED   8631802
REFERENCE   9  (residues 1 to 538)
  AUTHORS   Moroianu,J., Blobel,G. and Radu,A.
  TITLE     Previously identified protein of uncertain function is karyopherin
            alpha and together with karyopherin beta docks import substrate at
            nuclear pore complexes
  JOURNAL   Proc Natl Acad Sci U S A 92 (6), 2008-2011 (1995)
   PUBMED   7892216
REFERENCE   10 (residues 1 to 538)
  AUTHORS   Cortes,P., Ye,Z.S. and Baltimore,D.
  TITLE     RAG-1 interacts with the repeated amino acid motif of the human
            homologue of the yeast protein SRP1
  JOURNAL   Proc Natl Acad Sci U S A 91 (16), 7633-7637 (1994)
   PUBMED   8052633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133464.11 and CT573031.6.
            
            On Feb 15, 2023 this sequence version replaced XP_006521877.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.16959.1,
                                           SRR13422598.481121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..538
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.43 cM"
     Protein         1..538
                     /product="importin subunit alpha-5 isoform 1"
                     /note="importin subunit alpha-1; NPI-1; SRP1-beta;
                     importin alpha-S1; RAG cohort protein 2; nucleoprotein
                     interactor 1; m-importin-alpha-S1; importin subunit
                     alpha-5; importin alpha 5; karyopherin (importin) alpha 1"
                     /calculated_mol_wt=60052
     Region          1..41
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P52294; propagated from
                     UniProtKB/Swiss-Prot (Q60960.2)"
     Site            3
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P52294; propagated from
                     UniProtKB/Swiss-Prot (Q60960.2)"
     Region          33..516
                     /region_name="SRP1"
                     /note="Karyopherin (importin) alpha [Intracellular
                     trafficking and secretion]; COG5064"
                     /db_xref="CDD:227396"
     Region          42..51
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250|UniProtKB:P52293"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52294; propagated from
                     UniProtKB/Swiss-Prot (Q60960.2)"
     Region          77..117
                     /region_name="ARM 1, truncated"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     Region          118..161
                     /region_name="ARM 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     Region          128..154
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Site            order(145,149,153,187,191,195,230,234,238)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          149..241
                     /region_name="NLS binding site (major).
                     /evidence=ECO:0000250|UniProtKB:P52293"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     Region          162..198
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          204..239
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          207..245
                     /region_name="ARM 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     Region          245..437
                     /region_name="Binding to RAG1.
                     /evidence=ECO:0000250|UniProtKB:P52294"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     Region          256..281
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          289..325
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          318..406
                     /region_name="NLS binding site (minor).
                     /evidence=ECO:0000250|UniProtKB:P52293"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     Site            order(356,360,364,398,402,406,441,445,449)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:293788"
     Region          373..409
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          413..457
                     /region_name="ARM 9"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     Region          416..450
                     /region_name="armadillo repeat"
                     /note="armadillo repeat [structural motif]"
                     /db_xref="CDD:293788"
     Region          460..504
                     /region_name="ARM 10, atypical"
                     /note="propagated from UniProtKB/Swiss-Prot (Q60960.2)"
     CDS             1..538
                     /gene="Kpna1"
                     /gene_synonym="IPOA5; mSRP1; NPI1; Rch2"
                     /coded_by="NM_001416718.1:344..1960"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /db_xref="GeneID:16646"
                     /db_xref="MGI:MGI:103560"
ORIGIN      
        1 mstpgkenfr lksyknksln pdemrrrree eglqlrkqkr eeqlfkrrnv ataeeeteee
       61 vmsdggfhea qinnmemapg gvitsdmtdm ifsnspeqql satqkfrkll skepnppide
      121 vintpgvvar fveflkrken ctlqfesawv ltniasgnsl qtrnviqaga vpifiellss
      181 efedvqeqav walgniagds tmcrdyvlnc nilppllqlf skqnrltmtr navwalsnlc
      241 rgkspppefa kvspclnvls wllfvsdtdv ladacwalsy lsdgpndkiq avidagvcrr
      301 lvellmhndy kvvspalrav gnivtgddiq tqvilncsal qsllhllssp kesikkeacw
      361 tisnitagnr aqiqtvidan mfpalisilq taefrtrkea awaitnatsg gsaeqikylv
      421 elgcikplcd lltvmdakiv qvalngleni lrlgeqeakr ngsginpyca lieeaygldk
      481 ieflqshenq eiyqkafdli ehyfgteded ssiapqvdls qqqyifqqce apmegfql
//
