LOCUS       NM_001042421            6961 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus kinetochore associated 1 (Kntc1), mRNA.
ACCESSION   NM_001042421 XM_001000208 XM_916900 XM_924553 XM_924555 XM_977852
VERSION     NM_001042421.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6961)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6961)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6961)
  AUTHORS   Fairfield,H., Srivastava,A., Ananda,G., Liu,R., Kircher,M.,
            Lakshminarayana,A., Harris,B.S., Karst,S.Y., Dionne,L.A.,
            Kane,C.C., Curtain,M., Berry,M.L., Ward-Bailey,P.F., Greenstein,I.,
            Byers,C., Czechanski,A., Sharp,J., Palmer,K., Gudis,P., Martin,W.,
            Tadenev,A., Bogdanik,L., Pratt,C.H., Chang,B., Schroeder,D.G.,
            Cox,G.A., Cliften,P., Milbrandt,J., Murray,S., Burgess,R.,
            Bergstrom,D.E., Donahue,L.R., Hamamy,H., Masri,A., Santoni,F.A.,
            Makrythanasis,P., Antonarakis,S.E., Shendure,J. and Reinholdt,L.G.
  TITLE     Exome sequencing reveals pathogenic mutations in 91 strains of mice
            with Mendelian disorders
  JOURNAL   Genome Res 25 (7), 948-957 (2015)
   PUBMED   25917818
REFERENCE   4  (bases 1 to 6961)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 6961)
  AUTHORS   Jerome-Majewska,L.A., Achkar,T., Luo,L., Lupu,F. and Lacy,E.
  TITLE     The trafficking protein Tmed2/p24beta(1) is required for
            morphogenesis of the mouse embryo and placenta
  JOURNAL   Dev Biol 341 (1), 154-166 (2010)
   PUBMED   20178780
REFERENCE   6  (bases 1 to 6961)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   7  (bases 1 to 6961)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY010626.1, AK172905.1 and AC129582.10.
            
            On or before Jun 21, 2006 this sequence version replaced
            XM_916900.2, XM_924555.2, XM_924553.2, XM_977852.1, XM_001000208.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BY010626.1         2-27
            27-6953             AK172905.1         1-6927
            6954-6961           AC129582.10        57816-57823         c
FEATURES             Location/Qualifiers
     source          1..6961
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.17 cM"
     gene            1..6961
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /note="kinetochore associated 1"
                     /db_xref="GeneID:208628"
                     /db_xref="MGI:MGI:2673709"
     exon            1..99
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            100..274
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..6769
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /codon_start=1
                     /product="kinetochore-associated protein 1"
                     /protein_id="NP_001035886.1"
                     /db_xref="CCDS:CCDS39274.1"
                     /db_xref="GeneID:208628"
                     /db_xref="MGI:MGI:2673709"
                     /translation="MWNNIELLTSDDTGSGCLSVGSRKENVTALYQADLLGKISSEKT
                     SLSPKIQAFSLSHGFIIVADQSVILLDSICRSLQLFLIFDTDVDVVGLCQEGKFLFVG
                     ERSGNFHLIYVTSKQTLFTKAFVEKALDESQRTYRNLIIEKDGSNEGTYYMLLLTNNG
                     FFYITNLQLSQIEQAIENTDLDSAKKLQGQFKCSFISTENYHSCLSLVASQSGTFASK
                     TSVIIGGTGSCAFSKWEPDSTKKEMSLKNFVGTDIIKGAKSFQLIDNLLFVLDTDNVL
                     SLWDAYTLTPVWNWPSLPVEQFVLTTEADSPSSVTWQGITNLKLVTLTATAKEKMRSL
                     IIYSLPSMETLYSLEVSSVSSLVQTGISTDTIYLLEGIHKNDPNLCEDSVSDLVLRYL
                     TEVLPENRLSRLLHKHRFAEAESFAIQFGLDVELVYKVKSNDMLEKLALISSDKSEQS
                     KWQQLVDEAKENLCKIQDDDFVVNFCLKAQWVTYETTQEMLSYAKTRLMKKEDRALPA
                     SSDAFMEVLKAHAKLTTFYGAFGPEKFSGSSWIEFLNNEDDLRDVFLQLSEGNFACAQ
                     YLWLRHRADFESKFDVKMLENLLNSISTQFPLENLCSWFKNEVIPFVRRIVPEGQNIL
                     AKWLEQASRNLELTDKANWPENGLQLAEVFFTAEKTDRFGFASSWHWISLDYQNTEEV
                     RQLRTLVSKLRELIILHRKYNCKLALSDFEKENATTVVFRMFDRVSAPELIPSVLEKS
                     VRVYIREQNLQEEELLLLYIEDLLKRCSSKSMTLFDTAWEAKAMAVIRCLSDTDLIFD
                     AVLKIMYKAVVPWSAAVEQLVKQHLEMDHPKVKLLQESYKLMEMKKLLRGYGIREVNL
                     LNKEIMRVIRYILKQDIPSSLEDALKVAQGYRLSDDEIYSLRIIDLIDREQGGDCLLL
                     LKSLPAAEAEKTAERVIIWARLALQEEPDGSEEDKAWRISVAKTSVDILKILCDIRKD
                     NLQKKDESEEFLKRFQMVASLQENFEVFLPFEDYSNTALVAGLREQYIKAQEAAQAEH
                     KHRGPPGPTPARGTHLSIKSKLHRQALALQVSEQELEAELTLRALKDGKVVAALSKCR
                     DLLKHYCNADTGRLLFVVCQKLCQMLADDVPMVAPGGLSLPSEIHDLACHAVTICSPD
                     YLLDVLELSKYTLTAVELCRQCQMDDCGMLMKAALGTHKDPYEEWSFSDFFSEDGIVL
                     ESQVVLPVIYELISSVMPPAESKRHPLDSISLPYCSTSEGENRILPLVSSISALLRSL
                     QECSQWELALRFVVGSFGTCLQHSMSNVMSISLSKQLLGKNTLANSRHIIMELKEKSI
                     TFIRENATTLLHKVFNCRVVDLDLALAYCTLLPQKDVFDNLWKFIDKAWQNYDKILAL
                     SLVGSQLANLYQDIETGLWFHELSIDAKWGIRLGKLGISFQPAFRQNFLTKKDLIKAL
                     VNNIDMDTSLILEYCSTFQLDSDAALRLFIETLLRNTSSQSQGDAAPESTKHQHSKLL
                     AKATELVPLLKNTKDLVISLSEILYKLDPYDYEMIDVVLKVLEQANEKITSVNINQAL
                     NLLRHLKSYRRISPPVDHEYQYALEHMITLPPAAHTRLPFHLILFGTAQNFWKILSSE
                     LSEESLPTLLLIAKLMKFSLDTLYVSTAKHLFEKNLKPKLLKSAQARSSTLMSKEVDK
                     LMQTLESYLLSIVNPEWAVAIAISLTQEVPEGPFKMSSLKFCLYLAERWLQNIPPQDE
                     TCEKAKALQKKLCLQVRLSGTEAVLIAHKLNDQEYLRVIGKPAHLIVSLYEHPSISER
                     LCTTSGKDYPDIHTAAKEIAEVNEVNLEKIWDMLLEKWLCPSTVPSEKASEFFELEED
                     EVLHRVVYLLQARPVDYCSRMLFVFATSATSTLGMRQLTFAHKARALQCLLYLADKET
                     IESLFKKPIKEMKSYLKCITFLASFETLNIPITYELFCNSPKEGMIKGLWKNHSHEPM
                     AVRLVAELCLEYKIYDLQLWNGLLQKLLGFNMIPYLRKVLSCISSIHSLWQVPYFSKA
                     WQRVIQIPLLSASCPLRPSQLADCCDSLVAILECPVSDDLDMMGVAKQYVQLDLPAFA
                     LTCLTLMPHSEKRHQQIKNFLNSCDARIILQQIEEHMNTGQLAGFSHQIGSLVLNHVV
                     NKKEFGILAKTKYFQLLKCHVINTGNVTELVNYLANDFSVDEASALINEYSKHCGKPV
                     PADAAPCEILQTFLGGS"
     exon            275..395
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            396..511
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            512..590
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            591..668
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            669..703
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            704..817
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            818..911
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            912..964
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1080
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1135
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1234
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1278
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1344
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1420
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1546
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1636
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1690
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1752
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1864
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..2008
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2065
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2167
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2284
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2285..2428
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2429..2527
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2631
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2731
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2866
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2867..2986
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3059
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            3060..3127
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3408
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            3409..3581
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            3582..3679
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            3680..3818
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            3819..3875
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..4039
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            4040..4144
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4273
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            4274..4390
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4500
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..4705
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..4795
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4967
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            4968..5026
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            5027..5243
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            5244..5317
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            5318..5528
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            5529..5638
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            5639..5685
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            5686..5764
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            5765..5883
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            5884..6019
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            6020..6115
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            6116..6172
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            6173..6227
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            6228..6291
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            6292..6421
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            6422..6511
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            6512..6657
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            6658..6748
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     exon            6749..6961
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6936..6941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /note="hexamer: AATAAA"
     polyA_site      6954
                     /gene="Kntc1"
                     /gene_synonym="D330012D13; jgl"
                     /note="major polyA site"
ORIGIN      
        1 agtggcaggg aaggtaaaat gagtaggggc ggttgtgtcc gtcgggaaga agtgtgagac
       61 acttgagaat tctcttttta atttcgtcag ctgctgcagg aaagatagtg gttccttcct
      121 tcttctgaaa gacaatctca gaaacatgtg gaacaatatt gagctgctaa caagcgatga
      181 cactggaagt ggatgcctga gtgttggctc aagaaaagaa aacgtgactg cactgtacca
      241 agccgacttg cttgggaaga tctcctctga gaagacctca ctgagtccga agatccaagc
      301 attcagctta agccatgggt ttataatcgt tgcagaccag tcagtgatat tgcttgacag
      361 tatatgcaga tcactccagt tgtttcttat cttcgatact gacgtggatg tggtcggcct
      421 gtgtcaagaa ggaaagtttc tctttgtggg ggagagaagc ggcaacttcc accttatcta
      481 cgtcacatcg aagcaaacgc tgttcaccaa ggcttttgtg gagaaagctt tggacgagag
      541 tcagcgaacg taccggaatc tcattattga gaaagatggt tcaaatgaag gtacctatta
      601 tatgttgctt ctaacgaaca atggattttt ttatattaca aacctccagc tttcacaaat
      661 tgaacaggcc attgagaaca cggacttgga ttcagccaag aagttacaag gacaattcaa
      721 atgtagtttt atttctactg aaaattacca cagttgtctc agtcttgtgg catctcaatc
      781 tggaacattt gcaagtaaaa cttctgtgat aattggggga accggtagtt gtgcattctc
      841 aaaatgggaa cccgattcta ccaagaaaga aatgtctctt aagaactttg tgggcacaga
      901 cattattaaa ggtgcaaagt catttcagct gatcgacaac ctgctttttg tgctggatac
      961 tgataatgtg ctgagcttgt gggatgctta cactctcact cctgtgtgga actggccctc
     1021 tcttcccgta gagcagtttg ttctcacgac agaagcggat tctccctcat ctgttacctg
     1081 gcaaggaatt acaaatctca aattagtcac cctgacagca acagcgaagg agaagatgag
     1141 aagcctcatc atttactctc tgccttcgat ggaaacactg tactctttgg aagtatctag
     1201 tgtttcttct ttagttcaaa caggaatcag cacggacact atatatcttc tggaaggaat
     1261 tcacaaaaat gatcctaacc tatgtgaaga ctctgtgtct gacttagtac ttaggtacct
     1321 cacagaggtg ttaccagaaa acagactgag ccggttactt cacaagcaca gatttgccga
     1381 agccgagagc tttgccattc agttcggact ggatgttgag cttgtttata aggtcaaatc
     1441 aaatgatatg ttggagaagc tggctttgat ttcctcggac aagagtgagc agtccaaatg
     1501 gcagcaactt gtagatgaag ctaaagaaaa cctatgcaaa atccaggacg atgacttcgt
     1561 ggtgaatttc tgcctcaagg cccaatgggt aacctatgaa accacccagg aaatgctcag
     1621 ttatgccaaa accaggctca tgaagaaaga agacagagct ctacctgcct cttctgatgc
     1681 cttcatggag gtgctaaaag ctcatgcaaa gttaactaca ttttatggag catttggacc
     1741 agaaaaattc agtggtagct cttggattga gttcctgaat aacgaagatg acctcaggga
     1801 tgtttttttg cagctaagtg aaggaaactt cgcttgtgct cagtatcttt ggcttagaca
     1861 tcgggctgac tttgaaagca agtttgacgt gaaaatgctg gagaatttgc tgaattcaat
     1921 atctacacaa ttccccttgg aaaacctttg ttcctggttt aaaaatgaag tgattccgtt
     1981 tgtgaggagg attgtgcccg aaggacaaaa cattcttgca aaatggctag aacaagcatc
     2041 aaggaaccta gagttaactg ataaggcaaa ctggccagaa aatggacttc agctggcaga
     2101 ggtgttcttc actgcagaaa aaacagaccg gtttggattc gcatcttctt ggcactggat
     2161 ttccttggat tatcaaaaca cagaggaagt ccgccagtta cggacactgg tgagcaagtt
     2221 gcgggagctg atcattctgc ataggaaata caactgcaag ctggccctct cggactttga
     2281 gaaggaaaat gccaccactg tggtgttccg catgttcgac agggtctcgg ccccagagct
     2341 gatcccttcg gtcttagaga agtctgtgag agtttacatt cgcgaacaga atctgcaaga
     2401 ggaggagctg ctgttgctct atatagagga tttactgaag aggtgtagct caaagtcaat
     2461 gactctcttc gacacagcgt gggaagcaaa ggccatggcc gtgataagat gcttgtctga
     2521 cacagatctc atctttgatg ctgtgctgaa gataatgtac aaggcggtgg ttccctggag
     2581 tgcagccgtg gagcagctgg tgaaacagca cctggaaatg gaccacccca aagtcaagtt
     2641 attgcaggaa agctacaaac tgatggagat gaagaaactt ttgcgagggt atgggataag
     2701 agaggtgaat ctcctgaaca aggaaataat gagagtgatc cgatacattc taaagcagga
     2761 catcccgtct tctttagaag atgctctgaa ggtggcccag gggtacaggc tgtctgatga
     2821 cgaaatctac agcctgagaa tcatcgatct gattgacagg gagcaggggg gagattgcct
     2881 cctgctactg aagtctctgc ctgccgctga agccgagaag actgcagaaa gggttatcat
     2941 ctgggctcga ctggcactgc aggaggagcc tgacggctct gaggaggaca aggcctggag
     3001 aatatctgtg gcgaagacat cggtggatat tctcaagatc ctgtgtgata ttcgaaaaga
     3061 caatctgcag aagaaggatg aatctgaaga attcctgaag cgatttcaaa tggttgctag
     3121 tttacaggag aactttgagg tcttccttcc atttgaagac tacagcaaca ccgccttggt
     3181 agctggcctt cgagaacagt atattaaggc acaggaagct gcacaggctg agcacaaaca
     3241 caggggaccc cccgggccca ccccggctag ggggacacac ctgagcatca agtcaaagct
     3301 gcaccgacag gcactggccc tgcaggtgtc tgaacaggag ctggaggcag agctgacctt
     3361 gagagcctta aaggacggga aggtggtggc cgccctgagc aaatgcagag atttacttaa
     3421 gcattactgc aatgccgaca ctgggaggtt actgtttgtg gtgtgtcaga agctctgtca
     3481 gatgttggct gacgatgtcc caatggtggc cccaggagga ctcagccttc cttctgagat
     3541 ccatgacctc gcatgccacg ctgtcaccat ctgcagtcca gattatttgc tggatgtttt
     3601 agaactaagt aaatacactt taaccgctgt ggagctttgc agacaatgcc agatggatga
     3661 ctgtggaatg ctgatgaagg ccgctcttgg aactcacaag gatccctatg aagagtggtc
     3721 ctttagtgac ttcttcagtg aagatggaat tgttctcgag tcccaggtgg tgctgcctgt
     3781 catctatgaa ttgatctcat cagtgatgcc ccctgcagaa agcaaaagac atcctttgga
     3841 ttctataagt ttgccatact gctccactag tgaaggagaa aaccgtattc tccctcttgt
     3901 aagctccatc tctgctctgc tccggagcct ccaggaatgt agtcagtggg agctagccct
     3961 gaggttcgtg gtgggctcct ttggtacctg cctgcagcac tctatgtcaa acgtcatgag
     4021 tatcagcttg agtaaacagt tacttgggaa gaacacattg gcgaactcca ggcatatcat
     4081 tatggaattg aaagagaagt ccatcacatt tatcagagaa aatgctacga cactcctgca
     4141 taaagtgttt aactgtcggg tggtggatct ggacctcgcc ttggcttact gcactctctt
     4201 acctcaaaag gatgtattcg acaacctctg gaagttcata gataaagcgt ggcagaatta
     4261 cgacaaaatt ctggcattat ctttggtggg ctctcagctg gcaaatctct accaggatat
     4321 tgaaacagga ctttggttcc acgagctcag tatcgatgcc aagtggggta ttcgtcttgg
     4381 taaacttggt atttcttttc agcctgcttt tagacaaaat tttctcacca agaaagacct
     4441 tatcaaagct cttgtgaata acatagacat ggacaccagc ctcattctgg agtattgcag
     4501 cacatttcag ctggactctg acgctgccct tcggctgttc attgaaactc tgctccgcaa
     4561 cactagcagc cagagccagg gagatgctgc cccggagtcc acaaagcatc agcattccaa
     4621 actcctggcg aaagccactg agctggtccc tttactgaag aacacaaagg atctggtgat
     4681 cagtcttagt gagatcctct ataagctgga cccatatgat tatgaaatga ttgatgttgt
     4741 cctgaaagtt ttagaacaag ctaacgaaaa gataaccagt gtgaacatca atcaggcgct
     4801 gaatcttctg agacacttga agtcatacag aaggatctcc ccgccagtgg accacgaata
     4861 ccagtacgcg ctggagcaca tgatcactct gccaccggct gctcacacta gactgccctt
     4921 tcacctaata ctgtttggca cagcacagaa cttctggaaa attctctcct cagagctcag
     4981 cgaagagtcg ctgccaaccc tgctcttaat cgcgaagctg atgaagttct ccctagatac
     5041 tctctatgtg tctaccgcca aacacttgtt tgaaaaaaac ctgaagccaa agctcctgaa
     5101 gtcggcacaa gccaggtcct ccaccctgat gagcaaggaa gtggataagc tcatgcagac
     5161 gctggagtcg tacctcctgt ccatcgtcaa ccccgagtgg gctgtcgcca ttgccatcag
     5221 cctcacccag gaagtcccag aaggcccctt caagatgtct agtttgaagt tctgcctgta
     5281 tttagctgag agatggctac aaaacatccc acctcaggat gagacgtgtg aaaaggccaa
     5341 agccttgcag aagaagctct gcctccaggt ccggctctca ggaacggaag ccgtgctcat
     5401 agcccacaag ctgaacgatc aggaatattt aagagtgata gggaagccag cgcacctcat
     5461 cgtgagcctc tacgaacatc ccagcataag cgaaaggctt tgtaccacat ctggcaaaga
     5521 ttatcccgat atccatacag ccgctaaaga aatagccgaa gtcaatgaag ttaatttgga
     5581 aaaaatctgg gacatgttgt tggagaaatg gctgtgcccc tcaacggtgc ccagtgagaa
     5641 agcatcggag ttctttgagc tggaagagga tgaagtgctg catagagtcg tgtatctcct
     5701 ccaggctcgt cctgttgatt attgttcgag aatgctgttt gtatttgcca cttcagctac
     5761 aagtacactg ggcatgcgcc agctaacgtt tgcccacaaa gcacgagctc tgcagtgtct
     5821 cctctatttg gctgacaagg aaacaattga atctctcttc aaaaagccca ttaaagaaat
     5881 gaaatcctat ctgaaatgta taactttcct ggcatcattt gagacattga atattcccat
     5941 cacatatgaa ttattctgca acagtcccaa agaaggcatg attaagggct tgtggaagaa
     6001 ccacagccac gaacctatgg cagtacgatt ggttgcagag ctttgcttag aatacaaaat
     6061 ctatgacctg cagctttgga atgggctctt gcagaagctt ctgggcttca acatgattcc
     6121 ttacctgagg aaagtgttat cctgcatttc tagcatccat tcgttatggc aggtgcccta
     6181 cttcagcaaa gcgtggcagc gcgtgatcca gatccctctg ctctcggctt cctgtccttt
     6241 aagacccagt cagttagcag actgctgtga cagtctcgtc gccatccttg aatgtccagt
     6301 ttcagatgac ctggacatga tgggagtcgc caagcagtac gtccagttag accttcccgc
     6361 ttttgctctg acctgcctga cgctcatgcc ccactctgaa aaaagacacc agcagatcaa
     6421 gaattttctg aattcctgtg atgctcggat cattttacag cagatagaag aacatatgaa
     6481 cactggccag ctagcagggt tttcacatca gattggaagt ctggttctga atcatgttgt
     6541 aaataagaag gaatttggga ttttggcaaa gacaaagtat tttcagttgt tgaaatgcca
     6601 cgtgataaac accggcaacg tcactgaatt ggtaaactat ttggcaaatg acttcagtgt
     6661 agatgaagca tcagcgttga taaatgagta ttcaaagcat tgtgggaagc ctgtgccagc
     6721 agatgcagct ccctgtgaga tcctgcagac atttcttggt ggatcatagt aaaacaaaca
     6781 agttttcaaa acaagaggaa gtctggagtc tgccgctaat taatcttatt tattgcagct
     6841 tataaattgt gcaatctcta tttcattatc ctgtaaggaa taaataagac attcaatatt
     6901 gacctaacta acttgaatgt ctcatatgat gaatcaataa actatgtgca catagctttg
     6961 a
//
