LOCUS       NM_026412               3118 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus kinetochore-localized astrin/SPAG5 binding (Knstrn),
            mRNA.
ACCESSION   NM_026412
VERSION     NM_026412.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3118)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3118)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3118)
  AUTHORS   Lau,E.O., Damiani,D., Chehade,G., Ruiz-Reig,N., Saade,R.,
            Jossin,Y., Aittaleb,M., Schakman,O., Tajeddine,N., Gailly,P. and
            Tissir,F.
  TITLE     DIAPH3 deficiency links microtubules to mitotic errors, defective
            neurogenesis, and brain dysfunction
  JOURNAL   Elife 10, e61974 (2021)
   PUBMED   33899739
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3118)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3118)
  AUTHORS   Cindric Vranesic,A., Reiche,J., Hoischen,C., Wohlmann,A.,
            Bratsch,J., Friedrich,K., Gunes,B., Cappallo-Obermann,H.,
            Kirchhoff,C., Diekmann,S., Gunes,C. and Huber,O.
  TITLE     Characterization of SKAP/kinastrin isoforms: the N-terminus defines
            tissue specificity and Pontin binding
  JOURNAL   Hum Mol Genet 25 (13), 2838-2852 (2016)
   PUBMED   27170314
REFERENCE   6  (bases 1 to 3118)
  AUTHORS   Grey,C., Espeut,J., Ametsitsi,R., Kumar,R., Luksza,M., Brun,C.,
            Verlhac,M.H., Suja,J.A. and de Massy,B.
  TITLE     SKAP, an outer kinetochore protein, is required for mouse germ cell
            development
  JOURNAL   Reproduction 151 (3), 239-251 (2016)
   PUBMED   26667018
  REMARK    GeneRIF: important role in the successful outcome of male
            gametogenesis
REFERENCE   7  (bases 1 to 3118)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3118)
  AUTHORS   Suzuki,H., Fukunishi,Y., Kagawa,I., Saito,R., Oda,H., Endo,T.,
            Kondo,S., Bono,H., Okazaki,Y. and Hayashizaki,Y.
  TITLE     Protein-protein interaction panel using mouse full-length cDNAs
  JOURNAL   Genome Res 11 (10), 1758-1765 (2001)
   PUBMED   11591653
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK006328.1, AK036374.1 and AK028590.1.
            
            On Apr 29, 2009 this sequence version replaced NM_026412.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028590.1, SRR1660817.14208.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-725               AK006328.1         2-726
            726-3042            AK036374.1         515-2831
            3043-3118           AK028590.1         2844-2919
FEATURES             Location/Qualifiers
     source          1..3118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.46 cM"
     gene            1..3118
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="kinetochore-localized astrin/SPAG5 binding"
                     /db_xref="GeneID:51944"
                     /db_xref="MGI:MGI:1289298"
     exon            1..307
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1037
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="TRAF4 associated factor 1 homolog; putative
                     TRAF4-associated factor 1; kinetochore-localized
                     astrin/SPAG5-binding protein; kinastrin;
                     kinetochore-localized astrin-binding protein"
                     /codon_start=1
                     /product="small kinetochore-associated protein"
                     /protein_id="NP_080688.2"
                     /db_xref="CCDS:CCDS16585.1"
                     /db_xref="GeneID:51944"
                     /db_xref="MGI:MGI:1289298"
                     /translation="MAAPEAEAQETAFRTTGPPTDSEPRPFPPSSRKFPFESAAADSN
                     EDWAVAAEHYLKGSGENGGWEQPAPGVQPSHPATMASAKTVCDAQPHSMPSCGLPADT
                     QTRATSKLPVKSKEADLLRHLHPGGPEPDVTKVTKSRRENGQVKAAETASRRNLRNSY
                     KPFNKQKPEEELKDKNELLEAVNKQLHQKLTETQGELKDLTQKVELLEKFQDNCLALL
                     ESKGLNPGQETLASKQEPTTDHTDSMLLLETLKDELKVFNETAKKQMEELQALKVKLK
                     LKEEESVQFLEQQTLCKDEASDFTIILEEMEQLLEM"
     exon            308..399
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..526
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            527..574
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            575..680
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..774
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..830
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..905
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     exon            906..3118
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="hexamer: AATAAA"
     polyA_site      1513
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="major polyA site"
     regulatory      1530..1535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="hexamer: AATAAA"
     polyA_site      1553
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
                     /note="major polyA site"
     polyA_site      3075
                     /gene="Knstrn"
                     /gene_synonym="1700025D04Rik; C15orf23; D2Ertd750e; SKAP;
                     Traf4af1"
ORIGIN      
        1 agcttggctc aatagctcca ttcaagccag cccagtgagt ccctggccca gcctcgacca
       61 gcaggctgga gcaactctgc tcgaaccttc cgtacagcat ggcggctccc gaggccgagg
      121 cacaagagac agccttccgt acaacagggc cgcctacaga ctcggagccg cgccccttcc
      181 ctcccagctc ccggaagttt ccttttgaaa gcgcggcggc agactctaac gaggactggg
      241 cagttgctgc ggagcattat ttgaaaggga gcggagagaa cggcggatgg gagcagccgg
      301 caccgggggt ccagccaagc cacccggcta cgatggccag tgctaagacg gtgtgcgatg
      361 cgcagcctca ctcgatgccg agctgcggct tgcccgcaga tacacaaact cgagctactt
      421 ctaaactacc tgttaaatcc aaagaagcgg atttgcttag acatcttcat ccaggagggc
      481 cagagcctga tgttacaaaa gtcaccaaat cgagacgaga gaatgggcag gtgaaagcgg
      541 cagagactgc cagcaggagg aacctcagaa acagctacaa accgtttaat aagcaaaaac
      601 cggaggagga actaaaggat aaaaatgagc tgctggaggc tgtcaacaag cagttacacc
      661 agaagctgac agagactcag ggagagctga aggacctgac acagaaagtg gagctactgg
      721 agaagtttca ggataactgc ttagcacttt tggagagcaa aggtctcaac ccaggccaag
      781 agaccctggc atcaaagcag gaacccacca cagatcacac ggactccatg ctgctgctcg
      841 aaactttgaa agacgaactg aaggttttca atgaaaccgc caagaagcag atggaggagc
      901 tacaggcctt gaaggtgaag ttgaagctga aagaagagga gagtgtccag ttcctggaac
      961 agcagacctt atgtaaggac gaagccagtg acttcacaat aatcctagag gaaatggagc
     1021 agctcttaga aatgtagctc aaggcaggtg gccggacggc ttcttcctgg ataaaccctc
     1081 ggcagaggct acttaggata tcttcaagga ctcaccatcc cttaggtaaa gaccttctgc
     1141 agcagttgat ccgataaggc cagttgatgc tggggttcct cctttaagca gattgcccca
     1201 ccttcagatg gctcagctct cctgcaagag aggaacctgg gagtttgact ccatttcctg
     1261 tgcagcagag agagcagcag cccttagaac taggatacta aaccagctgc cttggagact
     1321 ctagagactc ggaaacatgg gaagaaggcc cacaccacaa cagcacgagt gctgtgcgag
     1381 agatgtgact gtgagccatg ctgtcccctt gtctctctgg ttgagttaag ttttatgaac
     1441 ttgaaattct tgaagttttt ttggcttaat aaatgggggt ggaggtatac aaagtagcac
     1501 ctacctaaaa ctacaactag agctttggaa ataaatgttt ctatgaatat taatattctg
     1561 actaacacta gggaatgaaa gtagcctctt taacccagtg tggtggctca tatctataac
     1621 aatcatagga cttgggaggc tgaggcagga gaattgtctt gagttagagg atagcctagg
     1681 ctgcagaaat actgtctcag aaaagcaagg aagatgttgg ggattaggaa attgccacac
     1741 aaaccatatg tacaccaatc tcagttaagc aagaatagtt tagtgaacgc acatcataat
     1801 atggaagtcc gggtccacga gaaggaaaag ctcaactgtg gcaccagtct gctctcggag
     1861 taggctttct ataggaaaaa ccaggtttaa aggtcaagga gaggagcagc tggcttacta
     1921 ggtaaagtat tgttagccaa cctttaagcc aattggtcct gagtgaggta agaaagatgg
     1981 tggtcaggcg gtgaacaagg gaatttcaga acactgagat aactaggaac aagtgattta
     2041 atcacgttgt ttttgcttgt tagtagcatt tttcagtgtc agttacacta atcactatga
     2101 ccttaatttc accttgtgac taacattgag cctgaataca aatggctaca gttgtgttaa
     2161 aaggaacagg cctcaacatg aggaggagga ggaggtagga ttaagcggtg tttggtctgg
     2221 atctgtgagt tgagcatact ggcataagtc caaggtactg tgactgcctt tccctccatc
     2281 cgctccgtgc ctgtgacaag gcctcctgcc ttccaggatt gtcagttctt ccacattcgt
     2341 agctgtgtgt gccatgctct attcaccgtg ttggtggcca gatgcctgtg ttctgtctgt
     2401 atgtctgcag cttgtctgtc agagccaacc tagagcctgg tgcaacaggc cctccccatt
     2461 gggatcacca aaatgcagcc atgttctccc ccttagctga aacacagcag cctttgcttt
     2521 ggccattccc attgcttttg agctttctgt tttctttacc aaacttgcct aatgtctcct
     2581 tcaaaatcac taagactgac cagagtcccg atccccaacg aagctgagta atgtcccata
     2641 cttaactttt tctttctttc tttacttttt caaatgtata aaatggttta taaggtttat
     2701 aaggtacaac taaagaccat cgcacagcag gtgaagcata cctactttat ataggttcac
     2761 catacacaga atgggactcc aggaagagtc ctatagaaca ctgcattctg gcttcctgtg
     2821 tgatccacat ctgctccttt gacgtgtgat tcttcgaaga tgaagtccta gcagaagtca
     2881 tatgagggag ttcacagtct catggagtgc actgcgctgc tgctgtccat gcacgcagtg
     2941 gactgaagga cactagctat aggatccaca cgggagcagg tgtcccacca tcatggagct
     3001 gtcttatgtg tcatagtcca ttcttatata tctatcaaaa cgtatactga acaatgactt
     3061 ctgggttgca aaagatttta acctgccttc catgcctttg tatacacaca cacacaca
//
