LOCUS       NM_023197               5073 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus lysine rich nucleolar protein 1 (Knop1), transcript
            variant 1, mRNA.
ACCESSION   NM_023197
VERSION     NM_023197.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5073)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5073)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   3  (bases 1 to 5073)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 5073)
  AUTHORS   Valerius,M.T. and McMahon,A.P.
  TITLE     Transcriptional profiling of Wnt4 mutant mouse kidneys identifies
            genes expressed during nephron formation
  JOURNAL   Gene Expr Patterns 8 (5), 297-306 (2008)
   PUBMED   18346943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138717.2 and AC165086.4.
            
            On Jan 14, 2022 this sequence version replaced NM_023197.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.362292.1,
                                           SRR9219382.154556.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AC138717.2         105528-105589       c
            63-1000             AC138717.2         102308-103245       c
            1001-1069           AC138717.2         100526-100594       c
            1070-1195           AC138717.2         98354-98479         c
            1196-5073           AC165086.4         1524-5401
FEATURES             Location/Qualifiers
     source          1..5073
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 63.66 cM"
     gene            1..5073
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="lysine rich nucleolar protein 1"
                     /db_xref="GeneID:66356"
                     /db_xref="MGI:MGI:1913606"
     exon            1..62
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
     exon            63..1000
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1069
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1195
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..5073
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1503..1508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="hexamer: ATTAAA"
     polyA_site      1530
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="major polyA site"
     regulatory      1772..1777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="hexamer: AATAAA"
     polyA_site      1790
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
     regulatory      5048..5053
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="hexamer: AATAAA"
     polyA_site      5073
                     /gene="Knop1"
                     /gene_synonym="2310008H09Rik; Tsg118"
                     /note="major polyA site"
ORIGIN      
        1 gacttccgga tcgcggctgc gcggctgctc acgcggggac gcttggcctg ctagcgaacc
       61 agtaatggtc agcaagaccc agaaagcaga cctgggccca caactcccag agaagaagaa
      121 aaagaagaag aagaaaaaga gagtggttgc aaatgtctca gaaccagaga ctcaatactc
      181 agtcttaaac agtaatgatt attttataga cgcttctcct ccgagggcca cgtccccttc
      241 taacaatgtg gatgaggtgc agatccccga gatatcactg agcaagagaa agaagaaaaa
      301 aaagtcctgt agcactcact tggaggagtg cctgggggct gagcctacac gggcaaggca
      361 gaaaaagtca cctagcccta gaaggcaggc ccttgagcag tcagcagaag gcctcatcag
      421 agagaagaaa aagaagaggc ggaagtcctt atcaaaggct gcctcccaag gctcagggct
      481 gaagacctcc ccagacccca agcatgccaa ggaggtaagc aaagctggta ggaagtccaa
      541 aaaacaaagg aaggaaaaaa aggttcctga cacggaagcc cttcctcccc aggacgcttg
      601 gctctacgag gctggggatt ccctgcactc atgcttagag ggggcagagg cagaggaaca
      661 ggcagccttg gggcagaaaa ggaagcaggg gagccccaga gatcacaaca tgaagaaaaa
      721 gaagaagaag acccaccagg agggagacat cctcctggtc aactccaggg tctctgtgga
      781 gaacagcctg aagaaaggga gtaagaagtc agtcaaaagt gaagctttgg agttcgttcc
      841 aatagacagc ccgaaggccc ctgggaagaa gaaagtcaaa tccaagaaaa aggtggaaca
      901 gccagttggt gaagggctgg ctgtgaaaag gaagaagaag aagaagaaga agaggaaaga
      961 gaacggagta aaggaagacc cctggcagga ggaaaaggag gagtcagaca cagacttaga
     1021 ggtggtactg gagaaaaaag gcaacatgga tgagacctgc atagaccagg tgagacggaa
     1081 ggccttgcaa gaagagattg atcgtgagtc gggcaagaca gaggcttcag aacccaaaaa
     1141 gtggacagtg ggtttgtcgg tcaagacaga ggcttcagaa cccaaaaagt ggacgggaac
     1201 ccagtttggc cagtgggata ctgccggctt tgaaaatgaa gaacagaagc taaaattcct
     1261 gaagcttatg ggtggcttta agcatctgtc cccgtcattc agccgccctc ccagcatgac
     1321 tatcaggtcc aacatggccc tggacaaaaa gtcttcagaa atgctccagc agagtctgca
     1381 gcaggactat gaccgggcca tgagctggaa gtacagccac ggggctggcc tgggctttaa
     1441 ctctgaggcc cgaaaggtct tctacattga ccggaatgcc tccaagtcta tcaagttgca
     1501 agattaaata ttattgtctt gttcttcaaa ctgcatttct tgatcagttg catccgtcaa
     1561 gttggcttga aatagtcacc tgcagttatt gaggaccaat aggaattgct aaagcctcct
     1621 attttctatg ttaaacattc cacctccggg tgacagtatt ttaatagtag ctagcagttg
     1681 ttggcacgtg gagggtcctg actattttcc ttgcattgtt acactaatta tggaatgggt
     1741 gctgttctca tctctatcaa gttcagggat aaataaagta attaaacggc ctagggtcac
     1801 cttccgttaa gtgccatcaa gagtacatca cccagagtca ctcaattatc agtgcagaaa
     1861 gcaagtgata tgccatgact tgcaagtttg ttttccttct cccttatcag gaggcaggtg
     1921 tggtgcagca ggcagacgtg gccagtacct ctgagctggc ttctttccag ccgtcctcct
     1981 tccatctgac tgctgtgctt ggatttgatg ctgctgtatt ggctggatct caaggcattt
     2041 tggacagtag gtaatcctgc gtatggaccc atgacagatt ctcagcagca tgttttgtgt
     2101 ttgtgttcac tagacagaag accttggaca cttgtgtgat gaaatcaaac atataagggg
     2161 tggagaaaaa gatactttgc tgcaggcacc ataccctccc acccctccct cccaaatcac
     2221 agcaatcttc atggagctcc tgatacagag acccatgtga catgattttc tctcccacca
     2281 gctattggca gtctggtatc aaggttcaga gaaggttact ttcctgtttt ggcctgattt
     2341 ctcacaggca gaaacactgg gtggggatgg aggtgtttga tgctgcactc agccaggaca
     2401 ttcattcatc cttccagcac cgtcatcagt gttgatgcct tcatgctgct aagaagatga
     2461 gagacaattc ccagcattcc agagatggga gaaaaccctc tctacaacta aagaaacttc
     2521 cggcagtccc tcagggaacc tgtgatggcg tcattcagct ttgtagtttt tcctgtatca
     2581 gcccccttgg taaggagatg cccctcaggc cagccaggga gagggtgagg tgtgcagtac
     2641 tgccaaatgg gcagcagagg tgttgctgtg ccccctacct tgttcctgtc ctgtgggcat
     2701 aggccatatg tatggcaaag acctgtttac accactttcc tggaatgaac ttggcttctc
     2761 atcaattcag cctcaagatt cagaaaagac cacttccagt cacgtcaatg gcagaattct
     2821 gcatttgagt caacttccag acaaatctcc ctcggccttg gtgaactctg ggaaccatct
     2881 gcataactcc aatagcttgt gttccccaca agtcacattc cagcctaagt gtctcagctc
     2941 atcaaaaact tgcacatggc aatcttacgg gtggtagatg gttttctatc ttatgtcaca
     3001 tatgccttgg aagctgtcat caaagtgtga gagccagatc tttttcttag ctgttacaca
     3061 tacctcagtg ctgaaagact tgattttgta gcttggtacc tcagcgttga cttaggtgct
     3121 ccactagccc acctttctct aagaattgaa gtctgtagtc tatctccaag gcactggagg
     3181 tagggtcagt gatctaacac aaccttgaac ttgactgatt ctctcaggca tttcttacca
     3241 gcttggtggc acttaagcaa tatccttgtc caacagtcac caaaatctca tgattcttaa
     3301 cacttgtgct tgagctgatt tctgtgctat atctgcttgg gcccatgagg ccctgccctg
     3361 aggctacatg tacaaccaga ctaacctgtg aaaaggctct ctcagacaca ggtgtccctg
     3421 ctcttagtac tacttgggtt atggtaggca ggacacacac atacccagca gaagggaaat
     3481 taaagtcact aatcacatgc tgctattatt attgttgttg ttgttttttt gagacagggt
     3541 ttctttgtgt agccctgaag accataccat gctagcctta aaagtcacag cgattcacct
     3601 gtctgcctcc tggagtgcta ggattaaagg tatacatcac tgctgcctgg cttccagcca
     3661 ccactggcta tcagatagat ttgaaatcag atccttgata acctgagcag gttcttttct
     3721 tcacagttcc ctaactgata cgtagcagaa gatttagtgt ggaagacact tgggaaggaa
     3781 aaggccacaa gccaagatca caggcaacgt acagaagcca tgcagcatct ctttccacca
     3841 gagtacccac aaaagaactt agacatgggg ataccttgac ctagcccaga gaaaccagtg
     3901 agttctgacc aacagcagtc aagacagtaa aaccacagga agtcactgtg cttgtaattt
     3961 cttaaaggaa taagaaccag gaatcactca cagatggaca tgaggcatcc tgtttttcat
     4021 ttcctaaaag tctctttaca tgtccttctc aggggaagta gatgctgttt gtggaggcgg
     4081 gcttcaaaga ctggactgtc agtaacactt ctgcccaggt cagcagactg ttgcaggagc
     4141 cccgtggtat gtgtacccag tgtgaggata agccgaggtt aacacaagca gtgggaattc
     4201 cccaggccag tgtaagctgc ttatgctgtt atcctgggca gccttgaggc aggagagtaa
     4261 cgtacaaagg attatttatg aatttgccag ttatttttga aagaattagc atcacagtga
     4321 aagtgacata aaataatttt agtagaaaca gtttggtgaa ataaaggcca tttgggagta
     4381 tttgaacagc accatagtgc attctgggtt ctggcatgtt cacagcagga ggaaaggcat
     4441 tttttagcat ctggtttttg tttttgagac tggggctcat atatcccaga ccagcttcaa
     4501 acatgtaact ggggaccttg atcagatctt gatcctcctg tctctacctc ctaactactg
     4561 ccgttctagg tctgcacctt ggcactctgt cttatgtggg gtcttgtgtc tgccaggcaa
     4621 gcattccact gactgagcca tatccttcgc ctcatctgct catttttggt ttggtttttg
     4681 ttttaagaaa ttgtatcaat tccttgggct ggagggtatt ctcatcagat tggccccaaa
     4741 tgtatataca acagtaaccc tgctctttgt tgttgttgtt ttgttttgtt tgttttttcg
     4801 agacagggtt tctctgtgta gccctgactg tcctggaact cactctgtag accaacctga
     4861 ccttgaactc agaaatccac ctgcctctgc ctctgcctcc caagtgctgg gattaaaggc
     4921 gtgcaccgcc accacctggc tgtaactctg ctcttaaact agtaaagaca caagctgtgt
     4981 gtgtatgtgt gtgtgagact taataacttc tactttctga ggttagtcat gtatagtatt
     5041 tcagataaat aaaatccatg cctaaagcac aaa
//
