LOCUS       NM_001102409            1612 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus kininogen 2 (Kng2), transcript variant 2, mRNA.
ACCESSION   NM_001102409
VERSION     NM_001102409.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1612)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1612)
  AUTHORS   Ohnaka,Y., Tsukamoto,S., Iwai,Y., Hamada-Kanazawa,M., Kariya,R. and
            Takano,M.
  TITLE     Bradykinin deficiency causes high blood pressure in mice
  JOURNAL   Biochem Biophys Res Commun 681, 73-79 (2023)
   PUBMED   37757669
REFERENCE   3  (bases 1 to 1612)
  AUTHORS   Kohler,J., Maletzki,C., Koczan,D., Frank,M., Springer,A.,
            Steffen,C., Revenko,A.S., MacLeod,A.R., Mikkat,S., Kreikemeyer,B.
            and Oehmcke-Hecht,S.
  TITLE     Kininogen supports inflammation and bacterial spreading during
            Streptococccus Pyogenes Sepsis
  JOURNAL   EBioMedicine 58, 102908 (2020)
   PUBMED   32707450
  REMARK    GeneRIF: Kininogen supports inflammation and bacterial spreading
            during Streptococccus Pyogenes Sepsis.
REFERENCE   4  (bases 1 to 1612)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1612)
  AUTHORS   Naba,A., Clauser,K.R., Mani,D.R., Carr,S.A. and Hynes,R.O.
  TITLE     Quantitative proteomic profiling of the extracellular matrix of
            pancreatic islets during the angiogenic switch and insulinoma
            progression
  JOURNAL   Sci Rep 7, 40495 (2017)
   PUBMED   28071719
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1612)
  AUTHORS   Ryder,E., Gleeson,D., Sethi,D., Vyas,S., Miklejewska,E., Dalvi,P.,
            Habib,B., Cook,R., Hardy,M., Jhaveri,K., Bottomley,J.,
            Wardle-Jones,H., Bussell,J.N., Houghton,R., Salisbury,J.,
            Skarnes,W.C. and Ramirez-Solis,R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Molecular characterization of mutant mouse strains generated from
            the EUCOMM/KOMP-CSD ES cell resource
  JOURNAL   Mamm Genome 24 (7-8), 286-294 (2013)
   PUBMED   23912999
REFERENCE   7  (bases 1 to 1612)
  AUTHORS   Shesely,E.G., Hu,C.B., Alhenc-Gelas,F., Meneton,P. and
            Carretero,O.A.
  TITLE     A second expressed kininogen gene in mice
  JOURNAL   Physiol Genomics 26 (2), 152-157 (2006)
   PUBMED   16837654
  REMARK    GeneRIF: in the kidney K2 is strongly expressed as both HMWK and
            LMWK, whereas K1 is not expressed as HMWK and expressed only very
            weakly as LMWK
REFERENCE   8  (bases 1 to 1612)
  AUTHORS   Cardoso,C.C., Garrett,T., Cayla,C., Meneton,P., Pesquero,J.B. and
            Bader,M.
  TITLE     Structure and expression of two kininogen genes in mice
  JOURNAL   Biol Chem 385 (3-4), 295-301 (2004)
   PUBMED   15134344
  REMARK    GeneRIF: Two genes, kininogen-I and kininogen-II, are located in
            close proximity on chromosome 16 in a head-to-head arrangement. In
            liver and kidney, both genes are expressed and for each gene three
            alternative splice variants are synthesized.
REFERENCE   9  (bases 1 to 1612)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY773346.1, BC139720.1, AA086752.1 and CT027991.8.
            
            Transcript Variant: This variant (2) uses an alternate splice
            pattern in the 3' coding region, compared to variant 1. The
            resulting isoform (2), also known as LMW kininogen-II, has a
            shorter and distinct C-terminus, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108335.1, AY462059.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                BY773346.1         2-93
            93-1332             BC139720.1         1-1240
            1333-1586           AA086752.1         147-400
            1587-1612           CT027991.8         30157-30182
FEATURES             Location/Qualifiers
     source          1..1612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.82 cM"
     gene            1..1612
                     /gene="Kng2"
                     /note="kininogen 2"
                     /db_xref="GeneID:385643"
                     /db_xref="MGI:MGI:3027157"
     exon            1..387
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            388..498
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..580
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            581..753
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..861
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            862..946
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1119
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1227
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1314
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1395
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1612
                     /gene="Kng2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1585..1590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kng2"
                     /note="hexamer: AATAAA"
     polyA_site      1610
                     /gene="Kng2"
                     /note="major polyA site"
ORIGIN      
        1 agagtcctgt ttgttctctg ggaagagggc acacaagagg tgacttcaag aatctaaata
       61 ggggcctaag tggtgaggca gagagagctg aggcaggaga gatcagagcc cggaggctgc
      121 caaaatcagc ttctgagttg gtttcccatt cttggcaaaa cagtccctca gttctagagg
      181 gacccttaaa tcatgaagct cattactaca ctgctcctct gctccggact cctgctgact
      241 ttaacacagg gagaagaagc gcaggaaatt gactgcaatg atgaggctgt atttcaggct
      301 gtggatgcct ctctgaagaa gcttaatgct aggttacaaa gcggcaacca gtttgtgttg
      361 taccgagtga ccaagcgcgc taaaatggat ggctctgcaa ccttttattc cttcaattat
      421 caaatcaagg agggcaactg ctctgctcag agaggcctgg cgtggcagga ctgtgacttc
      481 aaggactctg aggaagccgc cactggagaa tgcacagcaa ctatggggaa gaaagaaaat
      541 aagtttttca tagtcaccca gacctgcaag attactccag gtaagggccc catagtgaca
      601 gaggagtacc actgtgcgag ttgtgtgcat cccatatcgg cagataatcc agacctggag
      661 cctgttttga aacacgccat cgaatatttc aacaacaaca caggtcacag ccacctcttt
      721 gctctcagag aagtaaaaag tgcccaagga caggtggtgg gtggcctgaa ttttgacatt
      781 atctacacaa ttgtgcaaac aaattgttca aaggagcgtt ttccttccct ccgtggagac
      841 tgtgtggcac ttcccaatgg tgatggtggt gagtgtagag gtaatgcttt cctggatact
      901 gataacaaaa ttgaggactt cacgcagagc tgtgaccttc atccaggaga tgatttggta
      961 gaagcgcttc ccaagccttg ccctggctgc cccagggaca tacctgtaga cagcccagag
     1021 ctgaaggagg tgcttggtca ttccattgca cagctaaata cagagaatga ccatcctttc
     1081 tatttcaaga ttgacaccgt gaaaaaagca acatcacagg tggtagcagg aactaattat
     1141 gttattgagt tcatagccag agaaaccaaa tgttccaagg aaagtaacac agagctgaca
     1201 gaagattgtg agatcaagca ccttggacaa agtctcgact gcaatgctaa cgtgtacatg
     1261 agaccttggg agaacaaagt catcccgact gtgaaatgcc aagcattaga taagactatt
     1321 cctatccgaa ggaggcctcc aggcttttct cctttccggt cagccaaagt acaagaaaca
     1381 aaagcaggaa caactaggct cctacgcgcg tgcgagtaca agggcagact ctcaaaggca
     1441 ggggcagagc cagcgcctga gcgtcaggca gaatcttcac aagtgaagca gtagtcccag
     1501 caatgaccca gagggaagga gcagaagaat cctgagatgt gtggagcgcg ggaccatcgt
     1561 cttcatcacc ctgatcctag tggaaataaa attcagagtt gatgatttta ca
//
