LOCUS       NM_023125               1950 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus kininogen 1 (Kng1), transcript variant 2, mRNA.
ACCESSION   NM_023125 XM_358832
VERSION     NM_023125.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1950)
  AUTHORS   Ohnaka,Y., Tsukamoto,S., Iwai,Y., Hamada-Kanazawa,M., Kariya,R. and
            Takano,M.
  TITLE     Bradykinin deficiency causes high blood pressure in mice
  JOURNAL   Biochem Biophys Res Commun 681, 73-79 (2023)
   PUBMED   37757669
REFERENCE   2  (bases 1 to 1950)
  AUTHORS   Henderson,M.W., Sparkenbaugh,E.M., Wang,S., Ilich,A.,
            Noubouossie,D.F., Mailer,R., Renne,T., Flick,M.J., Luyendyk,J.P.,
            Chen,Z.L., Strickland,S., Stravitz,R.T., McCrae,K.R., Key,N.S. and
            Pawlinski,R.
  TITLE     Plasmin-mediated cleavage of high-molecular-weight kininogen
            contributes to acetaminophen-induced acute liver failure
  JOURNAL   Blood 138 (3), 259-272 (2021)
   PUBMED   33827130
  REMARK    GeneRIF: Plasmin-mediated cleavage of high-molecular-weight
            kininogen contributes to acetaminophen-induced acute liver failure.
REFERENCE   3  (bases 1 to 1950)
  AUTHORS   Cheng,X., Liu,D., Song,H., Tian,X., Yan,C. and Han,Y.
  TITLE     Overexpression of Kininogen-1 aggravates oxidative stress and
            mitochondrial dysfunction in DOX-induced cardiotoxicity
  JOURNAL   Biochem Biophys Res Commun 550, 142-150 (2021)
   PUBMED   33706097
  REMARK    GeneRIF: Overexpression of Kininogen-1 aggravates oxidative stress
            and mitochondrial dysfunction in DOX-induced cardiotoxicity.
REFERENCE   4  (bases 1 to 1950)
  AUTHORS   Kohler,J., Maletzki,C., Koczan,D., Frank,M., Springer,A.,
            Steffen,C., Revenko,A.S., MacLeod,A.R., Mikkat,S., Kreikemeyer,B.
            and Oehmcke-Hecht,S.
  TITLE     Kininogen supports inflammation and bacterial spreading during
            Streptococccus Pyogenes Sepsis
  JOURNAL   EBioMedicine 58, 102908 (2020)
   PUBMED   32707450
  REMARK    GeneRIF: Kininogen supports inflammation and bacterial spreading
            during Streptococccus Pyogenes Sepsis.
REFERENCE   5  (bases 1 to 1950)
  AUTHORS   Yang,J., van 't Veer,C., Roelofs,J.J.T.H., van Heijst,J.W.J., de
            Vos,A.F., McCrae,K.R., Revenko,A.S., Crosby,J. and van der Poll,T.
  TITLE     Kininogen deficiency or depletion reduces enhanced pause
            independent of pulmonary inflammation in a house dust mite-induced
            murine asthma model
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 316 (1), L187-L196 (2019)
   PUBMED   30358441
REFERENCE   6  (bases 1 to 1950)
  AUTHORS   Kawasaki,M., Maeda,T., Hanasawa,K., Ohkubo,I. and Tani,T.
  TITLE     Effect of His-Gly-Lys motif derived from domain 5 of high molecular
            weight kininogen on suppression of cancer metastasis both in vitro
            and in vivo
  JOURNAL   J Biol Chem 278 (49), 49301-49307 (2003)
   PUBMED   14506238
  REMARK    GeneRIF: His-Gly-Lys motif and lysine residue (Lys487) play
            essential roles in inhibition of cell adhesion and invasion in
            vitro and in prevention of metastasis of cancer cells in vivo
REFERENCE   7  (bases 1 to 1950)
  AUTHORS   Chavakis,T., Kanse,S.M., May,A.E. and Preissner,K.T.
  TITLE     Haemostatic factors occupy new territory: the role of the urokinase
            receptor system and kininogen in inflammation
  JOURNAL   Biochem Soc Trans 30 (2), 168-173 (2002)
   PUBMED   12023845
  REMARK    GeneRIF: Domain 5 of kininogen was identified as an anti-adhesive
            component with a potent anti-inflammatory action in a peritonitis
            mouse model.
            Review article
REFERENCE   8  (bases 1 to 1950)
  AUTHORS   Ylonen,A., Rinne,A., Herttuainen,J., Bogwald,J., Jarvinen,M. and
            Kalkkinen,N.
  TITLE     Atlantic salmon (Salmo salar L.) skin contains a novel kininogen
            and another cysteine proteinase inhibitor
  JOURNAL   Eur J Biochem 266 (3), 1066-1072 (1999)
   PUBMED   10583403
REFERENCE   9  (bases 1 to 1950)
  AUTHORS   Takano,M., Kondo,J., Yayama,K., Otani,M., Sano,K. and Okamoto,H.
  TITLE     Molecular cloning of cDNAs for mouse low-molecular-weight and
            high-molecular-weight prekininogens
  JOURNAL   Biochim Biophys Acta 1352 (2), 222-230 (1997)
   PUBMED   9199253
REFERENCE   10 (bases 1 to 1950)
  AUTHORS   Caubin,J., Iglesias,T., Bernal,J., Munoz,A., Marquez,G.,
            Barbero,J.L. and Zaballos,A.
  TITLE     Isolation of genomic DNA fragments corresponding to genes modulated
            in vivo by a transcription factor
  JOURNAL   Nucleic Acids Res 22 (20), 4132-4138 (1994)
   PUBMED   7937138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154540.2, AK005547.1 and BY463622.1.
            
            On Aug 23, 2007 this sequence version replaced NM_023125.2.
            
            Transcript Variant: This variant (2) uses an alternate splice
            pattern in the 3' coding region, compared to variant 1. The
            resulting isoform (2), also known as LMW kininogen-I, has a shorter
            and distinct C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005547.1, BC018158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC154540.2         110516-110557
            43-1935             AK005547.1         8-1900
            1936-1950           BY463622.1         444-458
FEATURES             Location/Qualifiers
     source          1..1950
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 13.88 cM"
     gene            1..1950
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /note="kininogen 1"
                     /db_xref="GeneID:16644"
                     /db_xref="MGI:MGI:1097705"
     exon            1..339
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1443
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; H-kininigen; L-kininogen"
                     /codon_start=1
                     /product="kininogen-1 isoform 2 precursor"
                     /protein_id="NP_075614.1"
                     /db_xref="CCDS:CCDS28073.1"
                     /db_xref="GeneID:16644"
                     /db_xref="MGI:MGI:1097705"
                     /translation="MKLITTLLLCSGLLLTLTQGEEAQEIDCNDEAVFQAVDFSLKQF
                     NPGVKSGNQYMLHRVIEGTKTDGSPTFYSFKYLIKEGNCSAQSGLAWQDCDFKDAEEA
                     ATGECTATVGKRENEFFIVTQTCKIAPSKAPILKAYFPCIGCVHAISTDSPDLEPVLK
                     HSIEHFNNNTDHSHLFTLRKVKSAHRQVVAGLNFDITYTIVQTNCSKERFPSLHGDCV
                     ALPNGDDGECRGNLFMDINNKIANFSQSCTLYSGDDLVEALPKPCPGCPRDIPVDSPE
                     LKEVLGHSIAQLNAENDHPFYYKIDTVKKATSQVVAGTKYVIEFIARETKCSKESNTE
                     LAEDCEIKHLGQSLDCNANVYMRPWENKVVPTVKCQALDMTEMARRPPGFSPFRSVTV
                     QETKEGRTRLLRACEYKGRLSKAGAEPAPERQAESSQVKQ"
     exon            340..450
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     exon            451..532
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     exon            533..705
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     exon            706..813
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     exon            814..898
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1071
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1179
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1266
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1344
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1945
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1534..1539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /note="hexamer: AATAAA"
     polyA_site      1559
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /note="major polyA site"
     regulatory      1924..1929
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kng1"
                     /gene_synonym="Kng"
                     /note="hexamer: ATTAAA"
     polyA_site      1942
                     /gene="Kng1"
                     /gene_synonym="Kng"
ORIGIN      
        1 ggaatctaaa taggggccta agtggtgagg cagagagagc tgaggcagga gagatcagag
       61 cccagaggct gccaaaatca gcttctgagt tggtttccca ttcttggcaa aacagtccct
      121 cagttctaga gggaccctta aatcatgaag ctcattacta cactgctcct ctgctccgga
      181 ctcctgctga ctttaacaca gggagaagaa gcgcaggaaa ttgactgcaa tgatgaggct
      241 gtatttcagg ctgtggattt ctctctgaag cagtttaacc ctggggtaaa aagtggcaac
      301 cagtatatgt tgcaccgagt gatcgagggc actaaaacgg atggctctcc aaccttttac
      361 tccttcaagt atctaatcaa ggagggcaac tgctctgctc agagtggcct cgcatggcag
      421 gactgtgact tcaaggacgc tgaggaagcc gccactggag aatgcacagc aactgtgggg
      481 aaaagagaaa atgaattctt catagtcacc cagacctgca agattgctcc aagtaaggcc
      541 cccatactga aagcctattt cccctgtatt ggttgtgtgc atgccatatc gacagatagt
      601 ccagacctgg agcctgttct gaaacactcc atcgaacatt tcaacaacaa cacagatcac
      661 agccacctct ttactctcag aaaagtaaaa agtgcccaca gacaggtggt ggctggcctg
      721 aattttgaca ttacctacac aattgtgcaa acaaattgtt caaaggagcg ttttccttcc
      781 ctccatggag actgcgtggc ccttcccaat ggtgatgatg gtgaatgtag aggaaatctc
      841 ttcatggata ttaataacaa aattgccaac ttctcacaga gctgtaccct ttattcagga
      901 gatgatttgg tagaagcgct tcccaagcct tgccctggct gccccaggga catacctgta
      961 gacagcccag agctgaagga ggtgcttggt cattccattg cacagctaaa tgcagagaat
     1021 gaccatcctt tctattacaa gattgacacc gtgaaaaaag caacatcaca ggtggtagca
     1081 ggaactaaat atgttattga gttcatagcc agagaaacca aatgctccaa ggaaagtaac
     1141 acagagctgg cagaagattg tgagatcaag caccttggac aaagtctcga ctgcaatgct
     1201 aacgtgtaca tgagaccttg ggagaacaaa gtcgtcccga ctgtgaaatg ccaagcatta
     1261 gatatgactg aaatggcaag aaggcctcca ggtttttctc ctttccggag tgtcacagta
     1321 caagaaacaa aagaaggaag aactaggctc ctacgcgcgt gcgagtacaa gggcagactc
     1381 tcaaaggcag gggcagagcc agcgcctgag cgtcaggcag aatcttcaca agtgaagcag
     1441 tagtcccagc aatgacccag agggaaggac cagaagaatc ctgggatgtg tggagcgcgg
     1501 gaccatcgtc ttcatcaccc tgatcctagt ggaaataaaa ttcagacttg atgattttac
     1561 agtggtctcc tttcagccat ccctgacatg aggcgaattg gagctgtctc taaagcttga
     1621 gtttggccac agacgcttat agtctctctc tggaacatcc tctctaaggt agacaggaat
     1681 ccttagatgg agcttccttg ccacagaggc acgggtgcca cagggatgat tagagggtct
     1741 cacttctgtg agaacttgct ctttttgccc ccctctcctg ctcaccaagc caatgctagg
     1801 aatagttaga attgcttacc aatgtttcta aatttgtgtc attacccaac tagaaaaata
     1861 atctatgtca atatgatgcc taccagcatc ttatcagaaa gtgcccagtg acctgggcac
     1921 ttcattaaaa tcatgaacaa gagaaaaaaa
//
