LOCUS       NM_001039124             869 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus kinocilin (Kncn), transcript variant 2, mRNA.
ACCESSION   NM_001039124
VERSION     NM_001039124.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 869)
  AUTHORS   Hu,Q., Guo,L., Li,J., Song,C., Yu,L., He,D.Z.Z. and Xiong,W.
  TITLE     Deletion of Kncn Does Not Affect Kinocilium and Stereocilia Bundle
            Morphogenesis and Mechanotransduction in Cochlear Hair Cells
  JOURNAL   Front Mol Neurosci 11, 326 (2018)
   PUBMED   30254566
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 869)
  AUTHORS   Kitajiri,S., Sakamoto,T., Belyantseva,I.A., Goodyear,R.J.,
            Stepanyan,R., Fujiwara,I., Bird,J.E., Riazuddin,S., Riazuddin,S.,
            Ahmed,Z.M., Hinshaw,J.E., Sellers,J., Bartles,J.R., Hammer,J.A.
            3rd, Richardson,G.P., Griffith,A.J., Frolenkov,G.I. and
            Friedman,T.B.
  TITLE     Actin-bundling protein TRIOBP forms resilient rootlets of hair cell
            stereocilia essential for hearing
  JOURNAL   Cell 141 (5), 786-798 (2010)
   PUBMED   20510926
REFERENCE   3  (bases 1 to 869)
  AUTHORS   Leibovici,M., Verpy,E., Goodyear,R.J., Zwaenepoel,I., Blanchard,S.,
            Laine,S., Richardson,G.P. and Petit,C.
  TITLE     Initial characterization of kinocilin, a protein of the hair cell
            kinocilium
  JOURNAL   Hear Res 203 (1-2), 144-153 (2005)
   PUBMED   15855039
  REMARK    GeneRIF: We propose that kinocilin has a role in stabilizing dense
            microtubular networks or in vesicular trafficking. (Kinocilin)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627085.13 and BC132036.1.
            
            On Feb 27, 2016 this sequence version replaced NM_001039124.3.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the central coding region compared to variant 1. The
            encoded isoform (2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ235452.1, BC132036.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL627085.13        50435-50487
            54-869              BC132036.1         1-816
FEATURES             Location/Qualifiers
     source          1..869
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.06 cM"
     gene            1..869
                     /gene="Kncn"
                     /gene_synonym="Kino; L5"
                     /note="kinocilin"
                     /db_xref="GeneID:654462"
                     /db_xref="MGI:MGI:3614952"
     exon            1..489
                     /gene="Kncn"
                     /gene_synonym="Kino; L5"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..713
                     /gene="Kncn"
                     /gene_synonym="Kino; L5"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="kinocilin isoform 2"
                     /protein_id="NP_001034213.1"
                     /db_xref="CCDS:CCDS18499.1"
                     /db_xref="GeneID:654462"
                     /db_xref="MGI:MGI:3614952"
                     /translation="MDIPISTRDFRCLQLACVALGLVAGSIIIGVSVSKAAAAVGGIF
                     LGAAGLGLLIFAYPFLKARFNLDHILPAIGNLRIHPNSGPDHGEGRSSNNSNKEGARS
                     GLSTVTRTLEKLKPGGRGTEEG"
     exon            490..558
                     /gene="Kncn"
                     /gene_synonym="Kino; L5"
                     /inference="alignment:Splign:2.1.0"
     exon            559..633
                     /gene="Kncn"
                     /gene_synonym="Kino; L5"
                     /inference="alignment:Splign:2.1.0"
     exon            634..869
                     /gene="Kncn"
                     /gene_synonym="Kino; L5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacagctg acagaggagg accccatgag gcagacccac gtcactagaa ccctggccaa
       61 agtggaaatg tggccaggca ggaaccccca aagtggtttc tggccgcaga gcccttcaca
      121 aaaggaagag taaactgggg tgttgaggtc aagctaggcc tccgggcccc tggaaaactg
      181 tgggataagg ttgcagataa atcccaggcc cagaccggcc taaagactta cagcccaaaa
      241 gtttccaccc tgggtgtggc gtcccaacaa ggaagcatcc atccaagaag tccaagactc
      301 ccaggaggcc tggaagcagc gccccagggt agacctgcat ggacatcccc atcagcacca
      361 gagacttccg ctgcctgcag ctggcctgtg tggccctcgg cctggtggcc ggcagcatca
      421 tcatcggtgt ctccgtgtcc aaggctgctg ctgctgtggg tggtatcttc cttggtgctg
      481 ctgggcttgg gctcctcatc ttcgcctacc ccttcctgaa ggctcggttc aacctggacc
      541 acatcctacc tgccatagga aacctgagaa tccatcctaa ctcaggacca gaccatgggg
      601 agggaagatc tagcaacaac agcaataaag aaggagcccg cagcggcctg tccacagtga
      661 ccagaaccct ggagaagctg aagcctggag gccggggaac tgaggagggc taagcaccct
      721 tcccactccc cacactccag tctcggggtc ctccttcaag ctggacgatg tggaaatgag
      781 ccctgggaat gctgggccta ccttctcttc cagtgatgct ctccctaacg gattccttca
      841 ctcccagaat cgtggaaaga cccacagga
//
