LOCUS       NM_001358044            2814 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus lysine methyltransferase 5C (Kmt5c), transcript
            variant 3, mRNA.
ACCESSION   NM_001358044 XM_006539774
VERSION     NM_001358044.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2814)
  AUTHORS   Zhang F, Zhao X, Jiang R, Wang Y, Wang X, Gu Y, Xu L, Ye J, Chen
            CD, Guo S, Zhang D and Zhao D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2814)
  AUTHORS   Kurup JT, Han Z, Jin W and Kidder BL.
  TITLE     H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape
            of pluripotent embryonic stem cells
  JOURNAL   Development 147 (23) (2020)
   PUBMED   33144397
  REMARK    GeneRIF: H4K20me3 methyltransferase SUV420H2 shapes the chromatin
            landscape of pluripotent embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2814)
  AUTHORS   Zhao Q, Zhang Z, Rong W, Jin W, Yan L, Jin W, Xu Y, Cui X, Tang QQ
            and Pan D.
  TITLE     KMT5c modulates adipocyte thermogenesis by regulating Trp53
            expression
  JOURNAL   Proc Natl Acad Sci U S A 117 (36), 22413-22422 (2020)
   PUBMED   32839323
  REMARK    GeneRIF: KMT5c modulates adipocyte thermogenesis by regulating
            Trp53 expression.
REFERENCE   4  (bases 1 to 2814)
  AUTHORS   Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de
            Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I,
            Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E and Gabellini
            D.
  TITLE     The Suv420h histone methyltransferases regulate PPAR-gamma and
            energy expenditure in response to environmental stimuli
  JOURNAL   Sci Adv 5 (4), eaav1472 (2019)
   PUBMED   31001581
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2814)
  AUTHORS   Bromberg KD, Mitchell TR, Upadhyay AK, Jakob CG, Jhala MA, Comess
            KM, Lasko LM, Li C, Tuzon CT, Dai Y, Li F, Eram MS, Nuber A, Soni
            NB, Manaves V, Algire MA, Sweis RF, Torrent M, Schotta G, Sun C,
            Michaelides MR, Shoemaker AR, Arrowsmith CH, Brown PJ, Santhakumar
            V, Martin A, Rice JC, Chiang GG, Vedadi M, Barsyte-Lovejoy D and
            Pappano WN.
  TITLE     The SUV4-20 inhibitor A-196 verifies a role for epigenetics in
            genomic integrity
  JOURNAL   Nat Chem Biol 13 (3), 317-324 (2017)
   PUBMED   28114273
REFERENCE   6  (bases 1 to 2814)
  AUTHORS   Benetti R, Gonzalo S, Jaco I, Schotta G, Klatt P, Jenuwein T and
            Blasco MA.
  TITLE     Suv4-20h deficiency results in telomere elongation and derepression
            of telomere recombination
  JOURNAL   J Cell Biol 178 (6), 925-936 (2007)
   PUBMED   17846168
  REMARK    GeneRIF: There is a novel role for histone lysine methylation in
            controlling telomere recombination.
REFERENCE   7  (bases 1 to 2814)
  AUTHORS   Isaac CE, Francis SM, Martens AL, Julian LM, Seifried LA, Erdmann
            N, Binne UK, Harrington L, Sicinski P, Berube NG, Dyson NJ and Dick
            FA.
  TITLE     The retinoblastoma protein regulates pericentric heterochromatin
  JOURNAL   Mol Cell Biol 26 (9), 3659-3671 (2006)
   PUBMED   16612004
REFERENCE   8  (bases 1 to 2814)
  AUTHORS   Gonzalo S, Garcia-Cao M, Fraga MF, Schotta G, Peters AH, Cotter SE,
            Eguia R, Dean DC, Esteller M, Jenuwein T and Blasco MA.
  TITLE     Role of the RB1 family in stabilizing histone methylation at
            constitutive heterochromatin
  JOURNAL   Nat Cell Biol 7 (4), 420-428 (2005)
   PUBMED   15750587
REFERENCE   9  (bases 1 to 2814)
  AUTHORS   Schotta G, Lachner M, Sarma K, Ebert A, Sengupta R, Reuter G,
            Reinberg D and Jenuwein T.
  TITLE     A silencing pathway to induce H3-K9 and H4-K20 trimethylation at
            constitutive heterochromatin
  JOURNAL   Genes Dev 18 (11), 1251-1262 (2004)
   PUBMED   15145825
REFERENCE   10 (bases 1 to 2814)
  AUTHORS   Garcia-Frigola C, Burgaya F, Calbet M, Lopez-Domenech G, de Lecea L
            and Soriano E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161197.9.
            
            [WARNING] On May 3, 2023 this sequence was replaced by
            NM_001358044.2.
            
            On Nov 16, 2017 this sequence version replaced XM_006539774.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154848.1, SRR7652917.757693.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-692               AC161197.9         27032-27723         c
            693-894             AC161197.9         25869-26070         c
            895-1060            AC161197.9         25563-25728         c
            1061-1170           AC161197.9         25122-25231         c
            1171-1334           AC161197.9         24740-24903         c
            1335-1354           AC161197.9         24584-24603         c
            1355-1491           AC161197.9         21912-22048         c
            1492-1676           AC161197.9         21589-21773         c
            1677-2814           AC161197.9         20336-21473         c
FEATURES             Location/Qualifiers
     source          1..2814
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7"
     gene            1..2814
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /note="lysine methyltransferase 5C"
                     /db_xref="GeneID:232811"
                     /db_xref="MGI:MGI:2385262"
     exon            1..692
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            693..894
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1060
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1170
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1334
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1354
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1491
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1676
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..2814
                     /gene="Kmt5c"
                     /gene_synonym="Suv4-20h2; Suv420h2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacgccggcc gaggggaggc gcggcggctg tgtcggacga gagccggagg aggcggtggg
       61 tggaggtggc ggctgcaacg cgggttcctg aggagaagga ggaggagaag cgggtgaggg
      121 gcggcgcggg gcccgacctc tgagccccct cttggccccc gccccgcgcc gcccggcctc
      181 ccagtcaccc cctgaaccgg ctgtccccgg gcccttcctc gaaccttgcg gtccaagtct
      241 ccagccccgc ggatctacgc gctcctcact cgtacccttc cctgcaccct tggagcccat
      301 gcagactcct ctctcactct caggactttc cttgcacctt aggagtcgct ccttgcccca
      361 ccagggccca tccccaccac cttttcctgc atcgtaacct acctaccctg tcacactcag
      421 ggcacttcct gactcctgtc tcactatcct ggtctctgag gcccttcctc tgactctctg
      481 tttccccagc ccccttctgc aaccttccca ggctttagtt agctacttag cgccctcaat
      541 tccctcctcg aacccgtagg atctttcagg tttccatcac ttcaaatccc ccaggattcc
      601 ctcaaaccct gcttggaacc gctaagccct tcccttggac cccaggcata tctacccttt
      661 ggatttcgtg ggctcctccc ttgcaacctc agataagcag gctctggggc ccacagacac
      721 cccatgcagc gcctgagcgg cacatccatg ctctgtgcca gagcagcatg gtttttaaag
      781 caccatgggg cctgatcgag tgacagcccg agaactgtgc gagaatgatg acctggccac
      841 cagccttgtt cttgacccct acctcggctt ccgcacccat aagatgaatg tcagtcctgt
      901 gcccaccttg cgacgacaac accaccttcg ttcagcactg gaagctttcc taaggcaacg
      961 ggacctggag gctgcattcc gggccctgac gctaggaggc tggatggccc actacttcca
     1021 gagccgtgcc cctcggcagg aggctgctct caagacccac attttctgct acctccgcgc
     1081 cttcctgcct gagagtggct tcaccattct gccctgcacc cgctactcca tggagaccaa
     1141 tggggccaag attgtgtcta cccgtgcttg gaagaagaat gagaagctgg agctgctggt
     1201 gggctgcatt gcagagctgc gtgaagagga tgaagacctg cttagggccg gtgagaacga
     1261 cttcagcatc atgtactcca cccgaaaaag gagtgcccag ctgtggcttg gcccagctgc
     1321 cttcatcaac catgactgca aacccaactg caagtttgtg ccctcagatg ggaatactgc
     1381 ctgtgtgaag gtgctacggg acattgagcc aggggatgaa gtgacttgct tctatggtga
     1441 gggcttcttc ggcgagaaga atgagcactg tgaatgctat acctgtgaga ggaaaggcga
     1501 gggagctttc agacttcagc ccagggagcc tgagctgcga ccaaagcccc tagacaagta
     1561 tgagctccga gagacaaaga ggcgtctgca gcagggcttg gtcagcagcc agcagagcct
     1621 gatgagccgg tgggcctgct cccacctgtc cccactgcgc cctgacccat tctgtgctgc
     1681 ctgccagccc tcatgcctgc tgcctgccag cccccacatg gattacttgc ccctttggct
     1741 ccagcgggcg cctcaacccc agcccatagt acctcccagg aagcgccacc gccgccgccg
     1801 ccccaggatc cgccaggctt cattgcctcc tgtcctccgc actgcctgtg tccccctgca
     1861 ccgatgggga ggctgtggtc cccactgcca gctacgtgct gaggccatgg tgaccctaca
     1921 cctgcgcccc cagactcgct ggaccccaca acaggactgg tactgggccc ggcgctatgg
     1981 gctaccttct gtggggcgtg tggaacttac ccgcctagcc ccagccctgc cagctgctcc
     2041 tgcccctgct gggaacccag gtcctgtccc cactcctgat ttcatcccta agcaggccct
     2101 tgcctttgct ccgttctgcc cacctaagcg cctccggcta gtggtcagtc atggttctat
     2161 tgatctggac atcaatagtg gtgagccatg atgggctgct tacagggagc ggaatggagt
     2221 gcagagtcta tcttggagcc ctccagaagg gaaggagagc tgacccaggt ctgatcctgg
     2281 tagtgtgttg tttgggacat ccctagagag ctgatccttg ttctatgatt gctgacccct
     2341 gagccagccc caacccagca gggagccctg gccatttgct gtacccatcc ctgcccccac
     2401 ctcaggacta taggagtcaa cctcctccct cagcctctcc ctcccaggga gcaaagccat
     2461 aagggagggg ggcactccat ggcgactctc tagaaggcca ggcctcaggg ggtggaattg
     2521 acttgggggt ttgccttccc ctgagctgct cccacagtgg ggagtgagtt ggctctcagc
     2581 tctacagttg atggaggtag gggcggtcag atgaggtggg tggtacccag gggcacatcc
     2641 ttggctctgc cccacgggtc tcagggaggc caggtgtgac ctcatctttt tcacggtgct
     2701 atccctggtg ctactggggt gtcggggagg cttcctctcc ttcccacatc ggaatggggg
     2761 atgatggggg attggaagaa cttgaacttt ttattaaaat attgtaagtc ctta
//
