LOCUS       NM_001379678            5891 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Mus musculus lysine methyltransferase 5B (Kmt5b), transcript
            variant 8, mRNA.
ACCESSION   NM_001379678 XM_011248623
VERSION     NM_001379678.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5891)
  AUTHORS   Martinez-Mayer,J., Brinkmeier,M.L., O'Connell,S.P., Ukagwu,A.,
            Marti,M.A., Miras,M., Forclaz,M.V., Benzrihen,M.G., Cheung,L.Y.M.,
            Camper,S.A., Ellsworth,B.S., Raetzman,L.T., Perez-Millan,M.I. and
            Davis,S.W.
  TITLE     Knockout mice with pituitary malformations help identify human
            cases of hypopituitarism
  JOURNAL   Genome Med 16 (1), 75 (2024)
   PUBMED   38822427
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5891)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5891)
  AUTHORS   Angerilli,A., Tait,J., Berges,J., Shcherbakova,I., Pokrovsky,D.,
            Schauer,T., Smialowski,P., Hsam,O., Mentele,E., Nicetto,D. and
            Rupp,R.A.
  TITLE     The histone H4K20 methyltransferase SUV4-20H1/KMT5B is required for
            multiciliated cell differentiation in Xenopus
  JOURNAL   Life Sci Alliance 6 (7), e202302023 (2023)
   PUBMED   37116939
  REMARK    GeneRIF: The histone H4K20 methyltransferase SUV4-20H1/KMT5B is
            required for multiciliated cell differentiation in Xenopus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5891)
  AUTHORS   Sheppard,S.E., Bryant,L., Wickramasekara,R.N., Vaccaro,C.,
            Robertson,B., Hallgren,J., Hulen,J., Watson,C.J., Faundes,V.,
            Duffourd,Y., Lee,P., Simon,M.C., de la Cruz,X., Padilla,N.,
            Flores-Mendez,M., Akizu,N., Smiler,J., Pellegrino Da Silva,R.,
            Li,D., March,M., Diaz-Rosado,A., Peixoto de Barcelos,I., Choa,Z.X.,
            Lim,C.Y., Dubourg,C., Journel,H., Demurger,F., Mulhern,M.,
            Akman,C., Lippa,N., Andrews,M., Baldridge,D., Constantino,J., van
            Haeringen,A., Snoeck-Streef,I., Chow,P., Hing,A., Graham,J.M. Jr.,
            Au,M., Faivre,L., Shen,W., Mao,R., Palumbos,J., Viskochil,D.,
            Gahl,W., Tifft,C., Macnamara,E., Hauser,N., Miller,R., Maffeo,J.,
            Afenjar,A., Doummar,D., Keren,B., Arn,P., Macklin-Mantia,S.,
            Meerschaut,I., Callewaert,B., Reis,A., Zweier,C., Brewer,C.,
            Saggar,A., Smeland,M.F., Kumar,A., Elmslie,F., Deshpande,C.,
            Nizon,M., Cogne,B., van Ierland,Y., Wilke,M., van Slegtenhorst,M.,
            Koudijs,S., Chen,J.Y., Dredge,D., Pier,D., Wortmann,S.,
            Kamsteeg,E.J., Koch,J., Haynes,D., Pollack,L., Titheradge,H.,
            Ranguin,K., Denomme-Pichon,A.S., Weber,S., Perez de la Fuente,R.,
            Sanchez Del Pozo,J., Lezana Rosales,J.M., Joset,P., Steindl,K.,
            Rauch,A., Mei,D., Mari,F., Guerrini,R., Lespinasse,J., Tran
            Mau-Them,F., Philippe,C., Dauriat,B., Raymond,L., Moutton,S.,
            Cueto-Gonzalez,A.M., Tan,T.Y., Mignot,C., Grotto,S., Renaldo,F.,
            Drivas,T.G., Hennessy,L., Raper,A., Parenti,I., Kaiser,F.J.,
            Kuechler,A., Busk,O.L., Islam,L., Siedlik,J.A., Henderson,L.B.,
            Juusola,J., Person,R., Schnur,R.E., Vitobello,A., Banka,S.,
            Bhoj,E.J. and Stessman,H.A.F.
  TITLE     Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans
            and mice
  JOURNAL   Sci Adv 9 (10), eade1463 (2023)
   PUBMED   36897941
  REMARK    GeneRIF: Mechanism of KMT5B haploinsufficiency in neurodevelopment
            in humans and mice.
REFERENCE   5  (bases 1 to 5891)
  AUTHORS   Zhang,T., Kunne,C., Ding,D., Gunther,S., Guo,X., Zhou,Y., Yuan,X.
            and Braun,T.
  TITLE     Replication collisions induced by de-repressed S-phase
            transcription are connected with malignant transformation of adult
            stem cells
  JOURNAL   Nat Commun 13 (1), 6907 (2022)
   PUBMED   36376321
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5891)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
REFERENCE   7  (bases 1 to 5891)
  AUTHORS   Benetti,R., Gonzalo,S., Jaco,I., Schotta,G., Klatt,P., Jenuwein,T.
            and Blasco,M.A.
  TITLE     Suv4-20h deficiency results in telomere elongation and derepression
            of telomere recombination
  JOURNAL   J Cell Biol 178 (6), 925-936 (2007)
   PUBMED   17846168
  REMARK    GeneRIF: There is a novel role for histone lysine methylation in
            controlling telomere recombination.
REFERENCE   8  (bases 1 to 5891)
  AUTHORS   Isaac,C.E., Francis,S.M., Martens,A.L., Julian,L.M., Seifried,L.A.,
            Erdmann,N., Binne,U.K., Harrington,L., Sicinski,P., Berube,N.G.,
            Dyson,N.J. and Dick,F.A.
  TITLE     The retinoblastoma protein regulates pericentric heterochromatin
  JOURNAL   Mol Cell Biol 26 (9), 3659-3671 (2006)
   PUBMED   16612004
REFERENCE   9  (bases 1 to 5891)
  AUTHORS   Gonzalo,S., Garcia-Cao,M., Fraga,M.F., Schotta,G., Peters,A.H.,
            Cotter,S.E., Eguia,R., Dean,D.C., Esteller,M., Jenuwein,T. and
            Blasco,M.A.
  TITLE     Role of the RB1 family in stabilizing histone methylation at
            constitutive heterochromatin
  JOURNAL   Nat Cell Biol 7 (4), 420-428 (2005)
   PUBMED   15750587
REFERENCE   10 (bases 1 to 5891)
  AUTHORS   Schotta,G., Lachner,M., Sarma,K., Ebert,A., Sengupta,R., Reuter,G.,
            Reinberg,D. and Jenuwein,T.
  TITLE     A silencing pathway to induce H3-K9 and H4-K20 trimethylation at
            constitutive heterochromatin
  JOURNAL   Genes Dev 18 (11), 1251-1262 (2004)
   PUBMED   15145825
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132452.3.
            
            On Apr 13, 2020 this sequence version replaced XM_011248623.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY555192.1, SRR9219379.23363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-452               AC132452.3         51922-52373         c
            453-691             AC132452.3         33635-33873         c
            692-839             AC132452.3         27047-27194         c
            840-908             AC132452.3         23554-23622         c
            909-1074            AC132452.3         18022-18187         c
            1075-1184           AC132452.3         17365-17474         c
            1185-1351           AC132452.3         15701-15867         c
            1352-1371           AC132452.3         15429-15448         c
            1372-1508           AC132452.3         15209-15345         c
            1509-1705           AC132452.3         12841-13037         c
            1706-5891           AC132452.3         1962-6147           c
FEATURES             Location/Qualifiers
     source          1..5891
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.5 cM"
     gene            1..5891
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /note="lysine methyltransferase 5B"
                     /db_xref="GeneID:225888"
                     /db_xref="MGI:MGI:2444557"
     exon            1..452
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..691
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     CDS             529..3180
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /EC_number="2.1.1.361"
                     /EC_number="2.1.1.362"
                     /note="isoform a is encoded by transcript variant 8;
                     histone-lysine N-methyltransferase SUV420H1; [histone
                     H4]-lysine20 N-methyltransferase KMT5B; [histone
                     H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B;
                     su(var)4-20 homolog 1; lysine-specific methyltransferase
                     5B; suppressor of variegation 4-20 homolog 1;
                     histone-lysine N-methyltransferase KMT5B"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase KMT5B isoform
                     a"
                     /protein_id="NP_001366607.1"
                     /db_xref="GeneID:225888"
                     /db_xref="MGI:MGI:2444557"
                     /translation="MKWLGDSKNMVVNGRRNGGKLSNDHQQNQSKLQQHSGKDTLKTG
                     RNAVERRSSRCHGNSGFEGQSRYVPSSGMSAKELCENDDLATSLVLDPYLGFQTHKMN
                     TSAFPSRSSRHISKADSFSHNNPVRFRPIKGRQEELKEVIERFKKDEHLEKAFKCLTS
                     GEWARHYFLNKNKMQEKLFKEHVFIYLRMFATDSGFEILPCNRYSSEQNGAKIVATKE
                     WKRNDKIELLVGCIAELSEIEENMLLRHGENDFSVMYSTRKNCAQLWLGPAAFINHDC
                     RPNCKFVSTGRDTACVKALRDIEPGEEISCYYGDGFFGENNEFCECYTCERRGTGAFK
                     SRVGLPAPAPVINSKYGLRETDKRLNRLKKLGDSSKNSDSQSVSSNTDADTTQEKDNA
                     TSNRKSSVGVKKSSKSRALTRPSMPRVPAASNSTSPKLVHTNNPRVPKKLRKPAKPLL
                     SKIRLRNHCKRLDQKSASRKLEMGSLVLKEPKVVLYKNLPIKKEREPEGPAHAAVGSG
                     CLTRHAAREHRQNHGRGAHSQGDSLPCTYTTRRSLRTRTGLKETTDIKLEPSPLDGYK
                     NGILEPCPDSGQQPTPEVLEELAPETAHREEASQECPKNDSCLSRKKFRQVKPVKHLA
                     KTEDCSPEHSFPGKDGLPDLPGSHPDQGEPSGTVRVPVSHTDSAPSPVGCSVVAPDSF
                     TKDSFRTAQSKKKRRVTRYDAQLILENSSGIPKLTLRRRHDSSSKTNDHESDGVNSSK
                     ISIKLSKDHDSDSNLYVAKLSNGVSAGPGSSSTKLKIQLKRDEESRGPCAEGLHENGV
                     CCSDPLSLLESQMEVDDYSQYEEDSTDESSSSEGEEEEEDCEDDFDDDFIPLPPAKRL
                     RLIVGKDSIDIDISSRRREDQSLRLNA"
     exon            692..839
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..908
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1074
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1075..1184
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1351
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1371
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1508
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1509..1705
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..5891
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5872..5877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /note="hexamer: AATAAA"
     polyA_site      5891
                     /gene="Kmt5b"
                     /gene_synonym="C630029K18Rik; Suv4-20h1; Suv420h1"
                     /note="major polyA site"
ORIGIN      
        1 gatccctccg cctcgaggct cagcgacggc aacgacgtgg tttctttggt ggtggtggtg
       61 ggggggattt actcttgtgc ctccgctgtc gggtgccgcg gcagggaact tcattctctc
      121 tggtgtctct cagcctcttc ccgcagaatt ccgtcgaagc catcgcggcc actagcgcgg
      181 agcaaaggtg cgcgcacgct cggtgtcggc gtggtgtccc tccgccgtca gtcgtggact
      241 ccttttcgtg tccttccacc gagcccgggc ggtgtccggg tggctcaccg ggggcggcga
      301 cgcgtctgcg gcgcggcagc gaggctcggg ggctatgagg tgaggacgcc cggggaccgg
      361 aggcggcacc cggcgctgcg cgagaacgca ggacgcgaag ccccgaagtc ggcggatgcc
      421 tctcagatcc cgcgactgcg cgcgaggtgg aggagagaac attgaaatta ttctctaagc
      481 tatctgaaga gagtgactaa atgctcctgg gtcaggctgt ctgtgggtat gaagtggttg
      541 ggagactcca agaacatggt ggtgaatggc aggagaaatg gaggcaagtt gtctaatgac
      601 catcagcaga atcaatcaaa attacagcag cactcgggca aggacaccct gaagaccggc
      661 agaaacgccg ttgagaggcg gtccagcaga tgtcatggta actcgggatt tgaagggcag
      721 agccgctatg tgccgtcctc tggaatgtcc gccaaggagc tctgtgagaa cgatgactta
      781 gcaaccagtt tggttcttga tccctactta ggttttcaga cacacaaaat gaacactagc
      841 gcctttcctt cgaggagctc gaggcatatt tcaaaagctg acagtttttc tcacaacaat
      901 cctgtgagat ttcggcctat aaaaggaagg caagaagagc taaaggaagt aattgaacgc
      961 tttaagaaag atgaacactt agagaaagct ttcaaatgtt tgacttctgg ggaatgggca
     1021 cggcattatt ttctcaacaa aaacaaaatg caggagaaat tattcaagga acatgtcttt
     1081 atttacttgc ggatgtttgc aactgacagt ggatttgaaa tactgccttg taatagatat
     1141 tcttcagaac aaaatggagc caagatagtt gcaacaaaag agtggaaacg aaatgacaaa
     1201 atagaattac tggtgggttg tattgccgaa ctttcagaaa ttgaggagaa catgctactt
     1261 agacacggag aaaacgactt cagtgtcatg tattccacaa ggaaaaattg tgctcaactc
     1321 tggctcggtc ctgctgcatt tataaatcat gattgcagac ctaactgtaa gtttgtgtca
     1381 actggtcgag atacagcatg cgttaaggct ctgagagata ttgaacctgg agaagaaatt
     1441 tcttgttact atggagatgg cttttttgga gaaaataatg agttctgcga atgttatact
     1501 tgtgaaagac ggggaactgg tgcttttaaa tcacgagtag gactgcctgc gcctgctcct
     1561 gttatcaata gcaaatacgg acttagagaa acagataaac gcttaaatag gcttaaaaag
     1621 ttaggtgaca gcagcaaaaa ctcagacagt cagtctgtca gctctaacac agatgcagac
     1681 accactcagg aaaaagacaa tgcaacttct aatcgaaaat cttcagttgg tgtgaaaaag
     1741 agcagcaaga gtcgagctct gacaaggccg tccatgccga gagtcccggc tgcttccaac
     1801 tctacctcac ccaagctagt gcacaccaac aatccccggg taccaaagaa actgagaaag
     1861 ccggcaaagc ctttactctc caagatcaga ctgcggaatc actgcaagcg gctggaccag
     1921 aagagcgcat cccgcaagct cgagatgggg agcttagtgc ttaaggagcc caaagtcgtg
     1981 ctatataaaa atttgccaat taagaaagaa agggagccag agggaccagc ccatgctgca
     2041 gtggggagtg ggtgcttgac tagacatgct gcgagagaac acaggcagaa tcatgggaga
     2101 ggtgctcatt cgcagggcga cagtttgccc tgcacctaca caacccggcg ctctttgagg
     2161 acaaggacag gtctgaagga gaccactgac atcaagcttg aaccaagtcc cttggatggc
     2221 tataaaaatg gtatactgga accttgccca gacagtggcc agcagccaac cccagaggtg
     2281 ctggaagaac tggctcctga gactgcacac agggaggaag catcccagga gtgtcccaag
     2341 aacgactcct gcctgtcacg aaagaaattt cgacaagtga aacctgtgaa acacttagca
     2401 aagaccgagg actgcagtcc agagcacagc ttccctggga aagacgggct gccagatttg
     2461 ccagggtctc atcctgatca aggtgagccc agtggcacag tcagggtgcc cgtgagccac
     2521 acggactctg ctccctcacc ggttggctgc tctgttgtcg cacccgacag cttcacaaaa
     2581 gacagcttca gaactgcaca aagtaaaaag aagcggcggg tcaccaggta cgatgcacag
     2641 ctgatcctgg agaacagctc tggaatcccc aagctgacgc ttcgcaggcg gcacgacagc
     2701 agcagcaaga caaacgacca tgagagtgac ggcgtgaact cctccaagat cagcatcaaa
     2761 ctcagcaagg accacgacag tgacagcaac ctctatgttg ccaagctcag taacggggtc
     2821 agcgcagggc cgggcagcag ctccaccaag ctcaagatcc agctcaagcg ggatgaggag
     2881 agcagggggc catgtgcaga gggcctgcac gagaacgggg tgtgctgcag cgaccccctc
     2941 tccctgctcg agtcccagat ggaggtggac gactacagtc aatatgagga ggacagcaca
     3001 gatgaatcct catcttctga gggggaggag gaggaggagg actgcgagga tgacttcgat
     3061 gatgacttca ttcctcttcc tccggcaaag cggctgaggc taattgttgg taaagactcc
     3121 atagatattg acatttcttc aaggagaaga gaagatcagt ctctaagact gaacgcatga
     3181 gcgctcactc attgttctgg agaactaaaa agtaaaaatc ccgccacagc ttcttggcac
     3241 agcacttctg tggtctcttc acctgtaggc ataatactgt agaaagtgta cagcatcctg
     3301 actcttaagt ctgatttgtg caaattttta ttgtactttt taaatagcct tcttatgtgc
     3361 aattccgagg gaaagccctg ttgtaaaata tccagtgaca gcagctctcc acatagggcc
     3421 ttcagacact catgtggtta gaccatgttg tcacctataa gagcaaacgc cagccctcct
     3481 ctcctccata gatgactaaa ccgtagttag ggcggagcag agcagagcag ccttgtggga
     3541 agggtttcca gcatctgcgc ctatcaccag cattgacctc tggcttttgg tttatttgct
     3601 agatgtttcc cccttggagt tgtgtcggtt tcacactgtt tactggccca ggtgtcctgt
     3661 ccgtggcctt cgttaccata gcagaccatt ggctggaagt cagattgatt tctttgaaga
     3721 aaaaaaagtg aacttgaatc ttgtgcgtga cagctcgttc tcagtacatt ctctatcgag
     3781 gctggcggtg tgcagggtgg gttttcagag cggcttattt attgcttttt gtgtaaatta
     3841 aagaccgtgt atttaacact ttccaatcct tttagataaa attgttcttt gcaagaatga
     3901 ttggtgctta ttttttcaaa cctttgctgt gaacagcgtg gcgacagcga gcagcgtttg
     3961 tccaatgaac tccagctatc ttaatttggg tcttcaagtt tctgttgcac ttgtaaaatg
     4021 ctacaaggaa tattaaaaga aatctattca ctttaactta taatagttta tgaaataaga
     4081 acatgagtca cagcttttgt tctgtggtaa cctatacaaa catttgtctt tgggattcaa
     4141 tgtaaagagc tgaaaacgat gtatatgttg taaatatttg tgtgttgtga gaaatttttg
     4201 tcataagaaa ttaaaagaac ttaccaggaa ggtttttaag tttagaaata ttcatgccaa
     4261 taaaatagga gattataaat aatagtgtaa gcactgcatc agtggacgtc ttggcttatg
     4321 ttagtttatt atgaagatat cagattgttt tgattatatt atcagtcaaa caaaaagagg
     4381 agtcagattt aatttgtttt tgaagcactt tgagaagaga aattaatttt aagtaactta
     4441 atgagcaatt tttgattact gctttatgtt caataccagg cttgtttgtt tctctggatt
     4501 attttacaaa tcaaagaatt tgagaatatc agtctatagc aggtgtatga caccagtggg
     4561 tctgtttatt tactgggaaa tgtatagctg cccattcaga tagatagtgt tactaaatga
     4621 cacaagctaa tggactcagt gttccagtgt gtcagaaggg acctgcaggg agtgaaaggt
     4681 ccaccagaga gcatctccat gctttccttt tgctgatgac acctaccagt attcagcttg
     4741 gggatgcttt ggttctcaaa gctgttgctt gtaggtccca gtgcaagtta gcaagattta
     4801 tgaatgtttc taggccatga tgtctttgct cctgtgcatg gtaggattcc ctgctgtggt
     4861 cctatacagt cttgtctttg ccatgcagtc tcaccctgtt gggtatctat gtcatttgga
     4921 agcagaagga gagactgcag tgtgcctaca cacacacaca cacacacaca cacaaaccat
     4981 ttgctatagc cgtgaagaaa ggtagccctg tgtctcaaga cttcctgtct caaagcaccc
     5041 agagcacctc catgatgttc ccagtcttca tgggttccca agtgtaagtg tgagccatgt
     5101 gccacctcca ggaagctgac ggtgagctca ggagcctgca cagggtaact ggtcaccttc
     5161 attctcatgt tctcttgggc tgttgagact taaatcctcg aatttctttg aataccaaca
     5221 atagccattt caggaatttc aatcttaagg aaaaagtaac aaaataacaa tttcccattt
     5281 tctccatttt aagcttaatt ttagtaactt atttatgatg tttattttag ttttgttgtg
     5341 gcctcatctt tggaggccga ccttcccatg ggtctaagag cagtgacatt gtgaggagtt
     5401 gctgcctctc aggagttgta tgcacaagca ttcagcagtg ctgctgatgc cttctaggga
     5461 accttatttc cgtttctcaa ggcaggggcc tcggactgtt ctcgatctgc tgtagaactt
     5521 cactgtgggg gtgccagaac cccacactct tgaccagtct ggaagaggat acactcaata
     5581 aaactctcag cttgagctta tgcaatgatt ggtaaagttt ttggaaattg taagaattag
     5641 gaaatgatcc tagaaatata tgtaaagtat tcaattttca atcatttttc aaattactgt
     5701 tttaaattgt tttgctgagt tgtaatactt ttgagataca atgtattcct tgtactgaaa
     5761 gaatgaaaag gactttttca gcatttgagg taagttcttt aacgtttcat taaaaaacat
     5821 tttttacaaa tattttgtac atgcacttgc agtattgagg ttaatcattt taataaattc
     5881 ggaaattaaa a
//
