LOCUS       NM_001310723            2762 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus lysine methyltransferase 5A (Kmt5a), transcript
            variant 2, mRNA.
ACCESSION   NM_001310723 XM_011248237
VERSION     NM_001310723.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2762)
  AUTHORS   Galanopoulou,O., Tachmatzidi,E.C., Deligianni,E., Botskaris,D.,
            Nikolaou,K.C., Gargani,S., Dalezios,Y., Chalepakis,G. and
            Talianidis,I.
  TITLE     Endonucleosis mediates internalization of cytoplasm into the
            nucleus
  JOURNAL   Nat Commun 15 (1), 5843 (2024)
   PUBMED   38992049
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2762)
  AUTHORS   Zhou,X., Xu,Y., Ren,S., Yang,N., Sun,Y., Yang,Q., Zhang,Y., Cai,H.,
            Deng,W., Chen,J., Chen,D., Cao,B., Qi,H., Wang,H. and Lu,J.
  TITLE     Trophoblast PR-SET7 dysfunction induces viral mimicry response and
            necroptosis associated with recurrent miscarriage
  JOURNAL   Proc Natl Acad Sci U S A 120 (25), e2216206120 (2023)
   PUBMED   37307441
  REMARK    GeneRIF: Trophoblast PR-SET7 dysfunction induces viral mimicry
            response and necroptosis associated with recurrent miscarriage.
REFERENCE   3  (bases 1 to 2762)
  AUTHORS   Modzelewski,A.J., Shao,W., Chen,J., Lee,A., Qi,X., Noon,M.,
            Tjokro,K., Sales,G., Biton,A., Anand,A., Speed,T.P., Xuan,Z.,
            Wang,T., Risso,D. and He,L.
  TITLE     A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform
            essential for development
  JOURNAL   Cell 184 (22), 5541-5558 (2021)
   PUBMED   34644528
REFERENCE   4  (bases 1 to 2762)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2762)
  AUTHORS   Myers,J.A., Couch,T., Murphy,Z., Malik,J., Getman,M. and
            Steiner,L.A.
  TITLE     The histone methyltransferase Setd8 alters the chromatin landscape
            and regulates the expression of key transcription factors during
            erythroid differentiation
  JOURNAL   Epigenetics Chromatin 13 (1), 16 (2020)
   PUBMED   32178723
  REMARK    GeneRIF: The histone methyltransferase Setd8 alters the chromatin
            landscape and regulates the expression of key transcription factors
            during erythroid differentiation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2762)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   7  (bases 1 to 2762)
  AUTHORS   Xiao,B., Wilson,J.R. and Gamblin,S.J.
  TITLE     SET domains and histone methylation
  JOURNAL   Curr Opin Struct Biol 13 (6), 699-705 (2003)
   PUBMED   14675547
  REMARK    Review article
REFERENCE   8  (bases 1 to 2762)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2762)
  AUTHORS   Fang,J., Feng,Q., Ketel,C.S., Wang,H., Cao,R., Xia,L.,
            Erdjument-Bromage,H., Tempst,P., Simon,J.A. and Zhang,Y.
  TITLE     Purification and functional characterization of SET8, a nucleosomal
            histone H4-lysine 20-specific methyltransferase
  JOURNAL   Curr Biol 12 (13), 1086-1099 (2002)
   PUBMED   12121615
REFERENCE   10 (bases 1 to 2762)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127339.3.
            
            On Apr 22, 2022 this sequence version replaced NM_001310723.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010835.1, SRR7345562.3799548.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AC127339.3         187961-188190
            231-387             AC127339.3         189676-189832
            388-607             AC127339.3         193123-193342
            608-695             AC127339.3         193748-193835
            696-755             AC127339.3         199521-199580
            756-946             AC127339.3         202237-202427
            947-2762            AC127339.3         202950-204765
FEATURES             Location/Qualifiers
     source          1..2762
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.59 cM"
     gene            1..2762
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /note="lysine methyltransferase 5A"
                     /db_xref="GeneID:67956"
                     /db_xref="MGI:MGI:1915206"
     exon            1..230
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1157
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /EC_number="2.1.1.361"
                     /note="isoform 2 is encoded by transcript variant 2;
                     histone-lysine N-methyltransferase SETD8; N-lysine
                     methyltransferase SETD8; H4-K20-HMTase SETD8; SET
                     domain-containing protein 8; PR/SET domain-containing
                     protein 07; H4-K20-HMTase KMT5A; lysine-specific methylase
                     5A; histone-lysine N-methyltransferase KMT5A; N-lysine
                     methyltransferase KMT5A; SET domain containing (lysine
                     methyltransferase) 8"
                     /codon_start=1
                     /product="N-lysine methyltransferase KMT5A isoform 2"
                     /protein_id="NP_001297652.1"
                     /db_xref="CCDS:CCDS80410.1"
                     /db_xref="GeneID:67956"
                     /db_xref="MGI:MGI:1915206"
                     /translation="MGEAGAVGRRRPFPGAPRRRWWRRQQQQQRRRQRWWPGRGEGEG
                     AGRAAMGLAGLQENVFAGQSKIYAYMSPNKCSAMRSPLQEENSVAHHEVKCPGKPLAG
                     IYRKREEKRNTGNVIRSAVKSDEQKSKDTRRGPLAPFPNQKSEAAEPPKTPPPSCDST
                     NVAVAKQALKKSLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKI
                     DELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYAQ
                     DPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIA
                     SRDIAAGEELLYDYGDRSKASIEAYPWLKH"
     exon            231..387
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            388..607
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            608..695
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            696..755
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            756..946
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /inference="alignment:Splign:2.1.0"
     exon            947..2762
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2725..2730
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /note="hexamer: AATAAA"
     regulatory      2739..2744
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /note="hexamer: ATTAAA"
     polyA_site      2759
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
     polyA_site      2762
                     /gene="Kmt5a"
                     /gene_synonym="2410195B05Rik; PR-SET7; PR/SET07; Setd8"
                     /note="major polyA site"
ORIGIN      
        1 gtccccggcc tcgctccggg ccccggctgc ggcgcgcgcg ggcgcccggc ctgctacggg
       61 ccatgggcga agcgggcgcc gtggggcgcc gccggccctt tcccggagcg ccgcggcggc
      121 gctggtggcg tcggcagcag cagcagcagc ggcggcggca gcgctggtgg cccggccgcg
      181 gcgagggcga gggtgccggc cgcgccgcca tgggcctagc cgggctgcag gagaacgtgt
      241 ttgctgggca gtcaaagatc tatgcctaca tgagtccgaa caagtgctct gcaatgcgct
      301 ctccacttca ggaagagaac tcggttgccc atcatgaggt caaatgcccg gggaaaccat
      361 tagctggaat ctacaggaag cgagaagaga aaaggaacac cgggaacgtt atacgaagcg
      421 ctgtgaagtc agatgaacag aagagcaaag acaccaggag aggtcccctg gcgccttttc
      481 caaaccaaaa atccgaagca gcagaacctc caaaaactcc acccccatca tgtgattcta
      541 ccaatgtagc agtcgctaag caagccctga aaaagtccct caagggcaaa caggcccctc
      601 ggaaaaagtc tcaagggaaa acccagcaga atagaaaact cacagatttc taccctgtgc
      661 ggaggagttc ccggaagagc aaagctgagc tgcagtctga agaaaggaag aaaatagatg
      721 agctgattga gagcgggaag gaagaaggca tgaagattga tctaattgat ggcaaaggca
      781 ggggtgtgat cgctaccaag cagttctcca ggggagactt tgtggtagaa taccatgggg
      841 acctcattga aatcactgat gccaagaagc gggaggctct gtacgcacag gacccctcca
      901 ctggctgcta catgtactat tttcagtatc tgagcaaaac ctactgcgtg gatgccactc
      961 aagaaacgaa ccgcctaggg agactcatca atcacagtaa gtgtgggaac tgccagacca
     1021 aactgcacga catcgacggc gtgcctcacc tcatcctcat cgcctcccga gacatcgcag
     1081 ctggggagga gctcctgtac gactatgggg accgaagcaa ggcctccatc gaagcctacc
     1141 cctggctgaa gcactaacca cgtggcctcc ctgcctccct gccaccctgc ctccttcaaa
     1201 ggacaaagtg ccctcaaagg gaaatgaatt tttttttaca cacacacacg cacacacaca
     1261 cacatacaca cacactcaca ctcactctta gctaattact tcaaatgttt ttaaaaagta
     1321 tattaaagat gccttttcat gtagtattta aatatctgtt acaggtttcc aaggtggact
     1381 tgaacagatg gccttatatt accaaaactt ttatattcta gttgtttttg tacctttttg
     1441 catacaagct gaacgtttgt gcttcccgcg cagtgtaaga ctcggcacag gttttagaga
     1501 atggagttga acatgaacta ggaagccggg ctctgcccaa gatgaaagcc aggactcccc
     1561 cacaccccac gtccaaggac aggccggtgt gagggcgctg cccccccacg cacagcctgg
     1621 acgggatgtc tccaagctct tgttctcctc agcatcctga caggcgtaca cactgtcgtg
     1681 tatgaatatt ttttagcaaa agtttcacag taagctagtc ttcccctctg ctttctccaa
     1741 agcttactga gcccggggct gggaggcccg gccaggaaca gacctcttcc acaggcttac
     1801 ggcttttcca ggcaccttga agcatcaggg tggacagtca gattagaggc gggccgggaa
     1861 aagcactgtt ctcctgctca agaagggcag gtctcctgaa actgcattaa ttctttatag
     1921 aaatgtgaac actgaattta ttttaaaaaa taataaaaac aaaacatttt aaaaaaatca
     1981 aaaaaagaaa aaatggaaaa aaaaacccac agaaaacaac ttaacgtgta tataggtttt
     2041 gaagggagtg aaatgaatgc ggttttcttt tcttctgggg tttatttttt ttctttttgg
     2101 cttggctggt tggtttgtgt agagaagatt tgagatggta ctctattcta atcaaaagtg
     2161 aggttttgta gtgggaccag aaattactaa gcccacaccc cctccctaac cccaattctg
     2221 ctgcatggga agttctccac ctgctgccaa ggcagagctc ctggtctccc atgaagatgc
     2281 tgtcagctgt cagtctagca ccccggagca tcaggcacca gacgtgcttg gcactagggt
     2341 acctggcagc cggcagagaa ccaggatgat gcttcggttt tgacctgtga gagcaagagt
     2401 aggtggcttc cttctccctc cctggggagg actcaccatt caccttcagt ccaggggcct
     2461 ggggttcagg agccaggtat aagaccctac cctcgtcccc tacaccccca tctcccaggc
     2521 tcatgatggt gctacctacg aaagtctccc ccgcaccctc tgctagccca gtcagtggtc
     2581 agacttggag gaggatccga caggagggtg taactgtgag ataaaaatgt cttggttgta
     2641 cctgtttgtg gcttagcttt gtatttaaat agcaaacaaa caaaaaaaaa ggaaataaac
     2701 ttgaaactta tttgtcatct taagaataaa gcaaaaaaat taaaatattt attgccaggc
     2761 aa
//
