LOCUS       NM_026984               7229 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus lysine (K)-specific methyltransferase 2E (Kmt2e),
            mRNA.
ACCESSION   NM_026984
VERSION     NM_026984.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7229)
  AUTHORS   Li,Y.J., Li,C.Y., Li,C.Y., Hu,D.X., Xv,Z.B., Zhang,S.H., Li,Q.,
            Zhang,P., Tian,B., Lan,X.L. and Chen,X.Q.
  TITLE     KMT2E Haploinsufficiency Manifests Autism-Like Behaviors and
            Amygdala Neuronal Development Dysfunction in Mice
  JOURNAL   Mol Neurobiol 60 (3), 1609-1625 (2023)
   PUBMED   36534336
  REMARK    GeneRIF: KMT2E Haploinsufficiency Manifests Autism-Like Behaviors
            and Amygdala Neuronal Development Dysfunction in Mice.
REFERENCE   2  (bases 1 to 7229)
  AUTHORS   Zhang,X., Zhang,B.W., Xiang,L., Wu,H., Alexander,S.A.S., Zhou,P.,
            Dai,M.Z., Wang,X., Xiong,W., Zhang,Y., Jin,Z.B. and Deng,L.W.
  TITLE     MLL5 is involved in retinal photoreceptor maturation through
            facilitating CRX-mediated photoreceptor gene transactivation
  JOURNAL   iScience 25 (4), 104058 (2022)
   PUBMED   35359806
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7229)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7229)
  AUTHORS   Zhou,P., Ding,X., Wan,X., Liu,L., Yuan,X., Zhang,W., Hui,X.,
            Meng,G., Xiao,H., Li,B., Zhong,J., Hou,F., Deng,L. and Zhang,Y.
  TITLE     MLL5 suppresses antiviral innate immune response by facilitating
            STUB1-mediated RIG-I degradation
  JOURNAL   Nat Commun 9 (1), 1243 (2018)
   PUBMED   29593341
  REMARK    GeneRIF: MLL5 has a role in suppressing antiviral innate immune
            response by facilitating STUB1-mediated RIG-I degradation
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7229)
  AUTHORS   Tasdogan,A., Kumar,S., Allies,G., Bausinger,J., Beckel,F.,
            Hofemeister,H., Mulaw,M., Madan,V., Scharffetter-Kochanek,K.,
            Feuring-Buske,M., Doehner,K., Speit,G., Stewart,A.F. and
            Fehling,H.J.
  TITLE     DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation
            Downstream of IFN-1 Signaling and Bid Mobilization
  JOURNAL   Cell Stem Cell 19 (6), 752-767 (2016)
   PUBMED   27641306
  REMARK    GeneRIF: toxic reactive oxygen species levels in Mll5(-/-) mice are
            critically dependent on type 1 interferon (IFN-1) signaling, which
            triggers mitochondrial accumulation of full-length Bid.[IFN-1]
            Erratum:[Cell Stem Cell. 2017 Mar 2;20(3):415. doi:
            10.1016/j.stem.2017.02.002.. PMID: 28257711]
REFERENCE   6  (bases 1 to 7229)
  AUTHORS   Sebastian,S., Sreenivas,P., Sambasivan,R., Cheedipudi,S.,
            Kandalla,P., Pavlath,G.K. and Dhawan,J.
  TITLE     MLL5, a trithorax homolog, indirectly regulates H3K4 methylation,
            represses cyclin A2 expression, and promotes myogenic
            differentiation
  JOURNAL   Proc Natl Acad Sci U S A 106 (12), 4719-4724 (2009)
   PUBMED   19264965
  REMARK    GeneRIF: MLL5 plays an integral role in novel chromatin regulatory
            mechanisms that suppress inappropriate expression of
            S-phase-promoting genes and maintain expression of determination
            genes in quiescent cells.
REFERENCE   7  (bases 1 to 7229)
  AUTHORS   Madan,V., Madan,B., Brykczynska,U., Zilbermann,F., Hogeveen,K.,
            Dohner,K., Dohner,H., Weber,O., Blum,C., Rodewald,H.R.,
            Sassone-Corsi,P., Peters,A.H. and Fehling,H.J.
  TITLE     Impaired function of primitive hematopoietic cells in mice lacking
            the Mixed-Lineage-Leukemia homolog MLL5
  JOURNAL   Blood 113 (7), 1444-1454 (2009)
   PUBMED   18952892
  REMARK    GeneRIF: findings establish several nonredundant functions for
            Mll5, including an essential role in regulating proliferation and
            functional integrity of hematopoietic stem/progenitor cells
REFERENCE   8  (bases 1 to 7229)
  AUTHORS   Heuser,M., Yap,D.B., Leung,M., de Algara,T.R., Tafech,A.,
            McKinney,S., Dixon,J., Thresher,R., Colledge,B., Carlton,M.,
            Humphries,R.K. and Aparicio,S.A.
  TITLE     Loss of MLL5 results in pleiotropic hematopoietic defects, reduced
            neutrophil immune function, and extreme sensitivity to DNA
            demethylation
  JOURNAL   Blood 113 (7), 1432-1443 (2009)
   PUBMED   18854576
  REMARK    GeneRIF: MLL5 is a key regulator of normal hematopoiesis
REFERENCE   9  (bases 1 to 7229)
  AUTHORS   Zhang,Y., Wong,J., Klinger,M., Tran,M.T., Shannon,K.M. and
            Killeen,N.
  TITLE     MLL5 contributes to hematopoietic stem cell fitness and homeostasis
  JOURNAL   Blood 113 (7), 1455-1463 (2009)
   PUBMED   18818388
  REMARK    GeneRIF: inactivation of the Mll5 gene in mice results in a 30%
            reduction in the average representation of hematopoietic stem cells
            and in functional impairment of long-term hematopoietic
            repopulation potential under competitive conditions
REFERENCE   10 (bases 1 to 7229)
  AUTHORS   Allis,C.D., Berger,S.L., Cote,J., Dent,S., Jenuwien,T.,
            Kouzarides,T., Pillus,L., Reinberg,D., Shi,Y., Shiekhattar,R.,
            Shilatifard,A., Workman,J. and Zhang,Y.
  TITLE     New nomenclature for chromatin-modifying enzymes
  JOURNAL   Cell 131 (4), 633-636 (2007)
   PUBMED   18022353
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138671.16 and AC122022.4.
            
            On May 18, 2018 this sequence version replaced NM_026984.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164131,
                              SAMN01164132 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AC138671.16        12190-12509         c
            321-505             AC122022.4         29580-29764
            506-620             AC122022.4         42444-42558
            621-850             AC122022.4         44131-44360
            851-931             AC122022.4         46536-46616
            932-990             AC122022.4         51176-51234
            991-1163            AC122022.4         52909-53081
            1164-1202           AC122022.4         55914-55952
            1203-1433           AC122022.4         57942-58172
            1434-1564           AC122022.4         58281-58411
            1565-1682           AC122022.4         60637-60754
            1683-1792           AC122022.4         61830-61939
            1793-2057           AC122022.4         64775-65039
            2058-2156           AC122022.4         65730-65828
            2157-2321           AC122022.4         71696-71860
            2322-2630           AC122022.4         72627-72935
            2631-2885           AC122022.4         75414-75668
            2886-3030           AC122022.4         75832-75976
            3031-3281           AC122022.4         76400-76650
            3282-3338           AC122022.4         76967-77023
            3339-3905           AC122022.4         77156-77722
            3906-4216           AC122022.4         78710-79020
            4217-4305           AC122022.4         79684-79772
            4306-4431           AC122022.4         79879-80004
            4432-4517           AC122022.4         80155-80240
            4518-7229           AC122022.4         80952-83663
FEATURES             Location/Qualifiers
     source          1..7229
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 10.33 cM"
     gene            1..7229
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /note="lysine (K)-specific methyltransferase 2E"
                     /db_xref="GeneID:69188"
                     /db_xref="MGI:MGI:1924825"
     exon            1..320
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            321..505
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     CDS             435..6041
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /EC_number="2.1.1.354"
                     /note="histone-lysine N-methyltransferase MLL5;
                     myeloid/lymphoid or mixed-lineage leukemia protein 5
                     homolog"
                     /codon_start=1
                     /product="inactive histone-lysine N-methyltransferase 2E"
                     /protein_id="NP_081260.1"
                     /db_xref="CCDS:CCDS51430.1"
                     /db_xref="GeneID:69188"
                     /db_xref="MGI:MGI:1924825"
                     /translation="MSIAIPLGVDTTETSYLEMAAGSEPESVEASPVVVEKSNSFPHQ
                     LYTSSSHHSHSYIGLPYADHNYGARPPPTPPASPPPSGLISKNEVGIFTTPNFDETSS
                     ATTISTSEDGSYGTDVTRCICGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPDTYLC
                     ERCQPRSLDKERAVLLQRRKRENMSDGDTSATESGDEVPVELYTAFQHTPTSITLTAS
                     RVPKVTDKRRKKSGEKEQNFSKCKKAFREGSRKSSRVKGSAPEIDPSSDSSNFVWETK
                     IKAWMDRYEEANNNQYSEGVQREAQRLAQRLGSGNDSKDMNKSELSTNNSLFRPPVES
                     HIQKNKKILKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLE
                     MCVDARTFGNEARFIRRSCTPNAEVRHEIEEGTIHLYIYSIQSIPKGTEITIAFDFDY
                     GNCKYKVDCACLKENPECPVLKRSSESTENINSGYETRRKKGKKEKDTSKEKDIQNQN
                     MTLDCEGTNNKIRSPETKQRKLSPLRLSVSNNQEPDFIDDMEEKTPISNEVEMESEEQ
                     IAERKRKMTREERKMEAILQAFARLEKREKRREQALERISTAKTEVKPECKESQVIAD
                     AEVVQEQVKEETAIKPAAAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIPPSSP
                     DIEVLSQQNEIENTVLAIEPETETAVAEIIPEAEVPALNKCPTKYPKTKKHLVNEWLS
                     EKNEKTGKPSDSLSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFL
                     SEKKRRKETTENISGSCKKRWLKQALEEENSTILHRYHSPCQERSRSPTVNGENKSPL
                     LLSDSCSLPDLTTPLKKRRLYQLLDTAYSESSTPTPSPYATPTHTDITPTDPAFATPP
                     RIKSDDETYRNGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRCTYNQEGYDR
                     PSNMLTLGPFRNSNLTELGLQEIKTIGYTSPRSRTEVNRPCPGEKESVSDLQLGLDAV
                     EPAALQKSMETPAHDRTEPSNQLDSTHSGRGTMYSSWVKSPDRTGVNFSVNSNLRDLT
                     PSHQLETGGGFRVSESKCLIQQDDTRGMFLGAAVFCTSEDGLASGFGRTVNDNLIDGS
                     CTPQNPPQKKKVSLLEYRKRQREARKSGSKPENFALISVSPHPSGSLSSSGDGCVHSS
                     ENGEQAENQASLPLPPPAAAAAATAAAAYSASSEEGSSNCPVKDANSSEKKDPEVQWT
                     ASTSVEQVRERSYQRALLLSDHRKDKDSGGESPCVSCSPSHVQSPPSSHSNHIPQVHA
                     QSLAPSLSELMADPDAEGTEATSTSECPSPDTSQSPSKTSKPGSPGPINPAQSHGKIL
                     TKPDSHWEATATVSEADNSVHQNPEPQHRQLSSNTPALSQNHAPQAHALSANDQLPQK
                     LPSAPTKLHCPPSPHTENPPKSSTPHTPVQHGYLSPKPPSQHLGSPFRPHHSQSPQVG
                     TPQRETQRNFYAAAQNLQANPQQATSGALFTQTPSGQSSATYSQFNQQSLNSTAPPPP
                     PPPPPSSYYQNQQPSANFQNYNQLKGSLSQQTVFTSGPNQALPGSTSQQSVPGHHVTP
                     GHFLPSQNPTIHHQPAAAAVVPPPPPPPPAPGPHLIQQPSSHQQHSVAHGVGPVHAVT
                     PGSHIHSQTAGHHLPPPPPPPGPAPHHHPPPHPTTGLQSLQAQHQHVVNSAPPPPPPP
                     PPPPPASVLVSGHHSASGQALHHPPHQGPPLFPASAHPAVPPYPSQATHHTTLGPGPQ
                     HQPSGTGPHCPLPVAGPHLQPQGPNSIPTPTASGFCPHPHPGSVALPHGVQGPQQASP
                     VPAQIPIHRAQVPPTFQNNYHGSGWH"
     exon            506..620
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            621..850
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            851..931
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            932..990
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1163
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1202
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1433
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1564
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1682
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1792
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..2057
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2156
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            2157..2321
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2630
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2885
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3030
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            3031..3281
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3338
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            3339..3905
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            3906..4216
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            4217..4305
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            4306..4431
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            4432..4517
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     exon            4518..7229
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6787..6792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /note="hexamer: AATAAA"
     regulatory      6812..6817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /note="hexamer: ACTAAA"
     polyA_site      6817
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /note="major polyA site"
     polyA_site      6837
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
     regulatory      6881..6886
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /note="hexamer: AATATA"
     regulatory      6894..6899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
                     /note="hexamer: AGTAAA"
     polyA_site      6899
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
     polyA_site      6921
                     /gene="Kmt2e"
                     /gene_synonym="1810033J14Rik; 9530077A04Rik;
                     D230038D11Rik; Mll5; NKp44L"
ORIGIN      
        1 agagcgagaa gcagtgacac tgagcgggcg cagggggccg agtcggagat cgagcctgcg
       61 ttcgggagcg gcagcagagg gggcatagac actcggagca gcctcagcgt ctcctcgtca
      121 ttcctgccgt ggcccgcagt gcccgactct tgggttccca ctgaagacgc tgcgcgctgc
      181 tgcttgggga gggggtgtgg agtcggttct gcgaccgcag tggctgtcgt cgggggtcga
      241 ccgagcgctg aggtgtggag aacctcgccc ggggtcgagc cgataacagg gttcgggtgt
      301 ctggtgtgtg accatcacag ggtttgtgga tgcacttaga tgtttgcaat gagcactgtg
      361 gctggcatgc cccagtattt tggataccaa tgcataggac tccatagtaa tcgaatttac
      421 cagaggcgaa cgtcatgagc atagcgatcc cattgggggt tgatacaaca gaaacatcct
      481 acttggaaat ggctgcaggc tcagaaccgg aatccgtaga agctagccct gtggtagttg
      541 agaaatccaa cagttttccc caccagttat acaccagcag ctcccaccac tcacacagct
      601 acatcggtct gccctatgcg gaccataatt atggtgctcg tcctcctcca acacctccag
      661 catcccctcc tccatcaggt ctcattagca aaaacgaagt aggcatattt accactccta
      721 attttgatga aacttccagt gctactacaa tcagcacatc tgaagatgga agttacggta
      781 ctgatgtaac caggtgcata tgtggtttta cacatgatga cggatacatg atctgttgtg
      841 acaaatgcag tgtttggcaa catattgact gcatggggat tgacaggcag catattcctg
      901 atacatacct atgtgaacgt tgtcagccca ggagtttgga taaagagagg gcagtgctac
      961 tgcaacgccg gaaaagagaa aatatgtcag atggtgatac cagtgcaact gaaagtggtg
     1021 atgaagttcc tgtggaatta tatactgcat ttcagcatac tccaacttca atcactttaa
     1081 ctgcttccag agttcccaag gttactgata aaagaaggaa aaaaagtggg gagaaagaac
     1141 aaaacttttc aaaatgtaaa aaagcctttc gtgaaggatc taggaaatca tcaagggtta
     1201 agggttcagc accagaaatt gatccttcat ctgatagttc aaattttgtt tgggaaacaa
     1261 aaatcaaagc atggatggat cgttacgaag aagcaaataa taaccaatat agtgaaggtg
     1321 ttcagagaga ggcacaaaga ctagctcaaa gactcggtag tgggaatgac agcaaagaca
     1381 tgaataaatc agaattgagt accaacaact cactcttcag acctcctgta gagagccata
     1441 tacagaagaa taaaaaaatt ctgaaatctg ccaaagactt gcctcctgat gcacttatca
     1501 ttgaatatag agggaagttt atgctgagag aacagtttga agcaaatgga tatttcttta
     1561 aaaggccata cccttttgtt ttattctact ctaagttcca tgggcttgaa atgtgtgttg
     1621 atgcgaggac ttttgggaat gaggctcgat tcatcaggcg ttcttgtaca ccgaatgcag
     1681 aggtgaggca tgaaattgaa gaggggacca tacatctcta catttattct atacagagta
     1741 ttccaaaagg gactgaaatt accattgcct ttgattttga ctacgggaat tgcaaataca
     1801 aggtggactg tgcatgcctc aaggaaaatc cagagtgccc tgttctcaag cgaagctcgg
     1861 aatccacaga aaacatcaat agtggttatg agaccagaag gaaaaaagga aaaaaagaga
     1921 aagatacttc aaaagaaaaa gacatacaaa atcagaatat gactttggac tgtgaaggaa
     1981 caaacaacaa aataaggagt ccagaaacaa aacagagaaa gctttctcca ttgaggctgt
     2041 cggtgtcaaa caaccaggaa ccagatttta ttgatgatat ggaagaaaaa actcctatta
     2101 gcaatgaagt ggaaatggaa tctgaggaac agattgcaga aaggaaaagg aagatgacaa
     2161 gagaagaaag aaaaatggaa gcaattttgc aggcttttgc cagacttgag aagagagaga
     2221 aaagacgaga acaagctttg gaaaggatca gcacagctaa gacagaagtt aagcctgaat
     2281 gcaaagagtc gcaggtcatc gccgatgccg aagtggtgca ggaacaagta aaagaagaaa
     2341 ctgctatcaa gccagccgct gccaaagtga acagaactaa gcagagaaag agcttttctc
     2401 gtagtaggac tcacattgga cagcagcgtc ggagacacag aactgtcagc atgtgttcag
     2461 acataccgcc atcttctcct gacatcgaag ttctgtcaca acagaacgag attgaaaata
     2521 ctgtacttgc tatagaacca gaaactgaaa ctgcagtagc agaaataatt cctgaagcgg
     2581 aagttccagc acttaataag tgtcccacaa agtaccccaa aacaaagaag cacttggtca
     2641 atgaatggtt aagtgagaag aatgagaaga caggaaaacc ttcagacagc ctttcagaaa
     2701 ggcctctgcg cataactaca gatccagagg tgttagctac acagctcaat tctttgccag
     2761 gtctcactta cagcccccat gtatactcta ctcctaagca ttatattaga tttacatcac
     2821 cattcctttc ggaaaaaaag agaagaaaag aaactactga aaacatttct ggctcatgca
     2881 aaaagcggtg gctgaagcaa gccctggagg aagaaaattc aacaatttta catagatatc
     2941 attcaccttg tcaggaaaga tccaggagtc ctacagttaa tggtgaaaac aaaagtccac
     3001 ttctgctaag cgacagctgc tccctcccag atttaaccac accactaaaa aagcgaagac
     3061 tttaccaatt gttagatact gcttactcag aaagctccac tcctacccct tcaccatatg
     3121 ctacaccaac tcacacagac atcactccta cggacccagc atttgccact cccccacgga
     3181 tcaaatcaga tgatgaaact tacagaaatg gttataaacc catatattca ccagtgaccc
     3241 ctgtaacccc tggcacacca ggaaacacca tgcactttga gaatatttct tccccagaaa
     3301 gttctccaga aataaagaga tgcacttaca atcaagaggg atatgaccga ccttcaaaca
     3361 tgctaacgtt ggggcctttt agaaattcca atttaactga gctgggcctg caagaaataa
     3421 agactattgg ttataccagc cctaggagca ggactgaggt taacaggcct tgcccagggg
     3481 agaaggagtc tgtgtcagac cttcaactgg gactcgatgc agtcgagcca gctgccttac
     3541 agaaatccat ggaaacacca gcccatgaca ggactgagcc cagcaaccaa ctggattcga
     3601 cccactctgg acggggcaca atgtattcat cctgggtaaa gagtcctgac agaacaggag
     3661 ttaacttctc agtaaactcc aacttgaggg acttaacacc ctctcatcag ttggagactg
     3721 gaggcggctt ccgagtaagt gagtccaagt gcctgattca gcaggatgac actagaggca
     3781 tgtttctggg agcggctgtc ttttgtactt ctgaagacgg gcttgcctct ggttttggac
     3841 ggactgttaa tgacaatttg atcgacggga gttgcacgcc ccagaatcca ccacaaaaga
     3901 aaaaggtttc tctattagaa taccgtaaga gacaacgtga agctaggaag agtgggtcta
     3961 agccagagaa ctttgctttg attagtgtgt cacctcaccc gagtgggagc ctgagcagca
     4021 gtggcgacgg gtgtgtccac agcagtgaaa acggggagca ggcagaaaac caggctagct
     4081 tgcctttacc accgcctgct gccgccgccg ccgccaccgc cgccgccgct tacagtgcct
     4141 cttctgaaga aggcagcagt aactgtcctg ttaaagacgc caattccagt gagaagaaag
     4201 acccagaagt tcagtggact gcctccactt cagtggagca agtgagagag agaagttacc
     4261 agagagcctt actgctcagt gaccaccgca aagacaaaga cagtggggga gagtcaccat
     4321 gtgtctcatg ctcaccgagt catgttcagt ctccaccttc atctcattca aatcacattc
     4381 cccaggtgca cgctcagagc ctagctcctt ctttgagtga actcatggca gaccctgatg
     4441 cggaaggtac agaagccaca agtacaagtg aatgtccatc ccctgacact tctcagagcc
     4501 cttctaaaac aagcaagcct ggttcaccag ggccaatcaa tcctgctcag tcacatggga
     4561 aaatactcac aaaaccagat agccactggg aggcaactgc cactgtatca gaagctgaca
     4621 acagtgttca ccaaaaccca gagcctcagc acagacagct gtcaagtaac accccagcac
     4681 tttctcagaa ccatgctcct caggcccacg ctctgagtgc gaatgatcaa cttccgcaaa
     4741 agctgccttc tgcaccgacg aagttgcact gtcctccgtc acctcacaca gaaaaccctc
     4801 ccaagtcctc cacacctcac acccccgtgc agcatggtta cctctcgcca aagcctcctt
     4861 cacagcactt aggatctccc ttcaggcctc accattcaca atcacctcaa gttggaactc
     4921 ctcaacgaga gactcagaga aacttttatg cagcggcaca gaaccttcaa gctaatcctc
     4981 agcaggcaac ttctggagcg ttatttaccc agacaccctc aggacaatct tcagcaacct
     5041 acagtcagtt caaccaacag agtctcaaca gcacggcccc accccctccc cctcctcccc
     5101 ctccttcatc ctactatcaa aaccagcagc cctctgcaaa ctttcagaat tataatcagc
     5161 taaaaggtag tctttcccaa caaactgtgt ttacatctgg accaaatcaa gcacttcctg
     5221 gcagcaccag ccagcaatca gttcctggac atcacgttac tccagggcat tttctgccat
     5281 ctcaaaaccc caccattcac catcaacctg ctgctgctgc tgtggtcccg cccccgcccc
     5341 cacccccgcc cgctccagga ccacacctca tacagcagcc aagctcacat cagcagcact
     5401 ctgtagcaca tggagttggg ccagttcatg ctgttacccc tgggtcacac attcattctc
     5461 aaactgcagg acaccattta ccaccacccc ctccaccacc tggtcctgcc ccacatcacc
     5521 atcccccacc ccatcctacc acgggactgc aaagtctaca agcacaacac cagcatgtag
     5581 taaactcggc acccccgccc cctccccctc ccccgccccc tcccccagcc agtgttctgg
     5641 tttctgggca tcattcagca tcaggtcaag ccttacacca cccacctcat caaggacctc
     5701 cacttttccc tgcaagcgct catccagctg tcccgccgta cccctcacaa gccacacatc
     5761 ataccacttt gggaccggga ccccaacacc agccttccgg aacagggcca cattgtccat
     5821 taccagttgc aggtcctcat ctccagcccc aaggaccaaa cagtattcca acccctactg
     5881 cttcagggtt ctgtcctcat cctcatcctg gctctgtggc cctgccacat ggggtgcaag
     5941 gacctcagca ggcatcgcca gtgcctgcac agattccaat tcacagagca caggtgccgc
     6001 cgacatttca aaacaattac cacggttcag ggtggcatta aaatggactc caataacatt
     6061 ttttaaaatg ttctgtaaga taaactgtat atttcatatg tacctgttaa ggtacttttt
     6121 aaagcttgta catgaaactt tgtataaaaa aacaaaaaca aaacaaaaaa aaaaaaacaa
     6181 aagcaaacac cagtgctctt tcattgtatc tttcccattt ttgcttttta cacttcctta
     6241 tgaaatgtgc tcttaagcca gctgtaggta tctttatttt gtaagtgaac attccaactg
     6301 tttttctgac catagatctg atgatacatg acctttaaat ttcattgttg cagttaaatt
     6361 catttaatga atattttctg tattatttta tacatatgca ttaagtatac agttaaagaa
     6421 agcactaagg atttcctttt ttttttatgg tcagcagtta tttgagtgca tcttaggtct
     6481 gaaaatgcaa tacaggtttt tatgatttgg tgtggacatg gctcatattg ttttatcagt
     6541 tttttgcaag caaaatgtaa tttaatgtat agataatttt tagtgtctcc tgacagactg
     6601 taaatactga atttcctttg cgtatataat tgctcccgcc cttttcattt ggaatatagc
     6661 actgtacata tggcaagtct gctgcaaacg tgtgatctct gtgaaagtag tacagcacat
     6721 gacctttcct ttttatttca atacgctgtc acattgaagc actggttggg cattttaatt
     6781 catgttaata aaccacaatt atgtcagttt tactaaattg ttctgtacaa cttctgagat
     6841 tgaggtctgc ttaatgattt tacaaaagtt aagattttca aatataattt gtaagtaaag
     6901 aatcattcat tttcttcggt agctgctacc tcagctgcac tgcaggctac cagcagccga
     6961 tctgggtgag tctcacggtc ctctctactg cttgcctttc ctttagaagc acgggtcaga
     7021 ggaaattaaa tagccactct atgcgactta gctaacagtc taagaaccta acattctact
     7081 acaacattaa tccacattat tgatgcattc catactgtat agttgcacac tgcagtttaa
     7141 cgcagtttga aaaggagtaa tttacttaaa acagggagat ttaatttgta cagtataaaa
     7201 tatgactgaa atagctccac taatcaaaa
//
