LOCUS       NM_029274               8457 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus lysine (K)-specific methyltransferase 2B (Kmt2b),
            transcript variant 2, mRNA.
ACCESSION   NM_029274 XM_194342
VERSION     NM_029274.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8457)
  AUTHORS   Niizuma,H., Searleman,A.C., Takeda,S., Armstrong,S.A., Park,C.Y.,
            Cheng,E.H. and Hsieh,J.J.
  TITLE     Taspase1 orchestrates fetal liver hematopoietic stem cell and
            vertebrae fates by cleaving TFIIA
  JOURNAL   JCI Insight 6 (15), e149382 (2021)
   PUBMED   34156981
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8457)
  AUTHORS   Zhang,F., Zhao,X., Jiang,R., Wang,Y., Wang,X., Gu,Y., Xu,L., Ye,J.,
            Chen,C.D., Guo,S., Zhang,D. and Zhao,D.
  TITLE     Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox
            Gene Temporal Collinear Activation for Body Axial Patterning in
            Mice
  JOURNAL   Front Cell Dev Biol 9, 642931 (2021)
   PUBMED   34368113
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8457)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8457)
  AUTHORS   Kobayashi,Y., Tomizawa,S.I., Ono,M., Kuroha,K., Minamizawa,K.,
            Natsume,K., Dizdarevic,S., Dockal,I., Tanaka,H., Kawagoe,T.,
            Seki,M., Suzuki,Y., Ogonuki,N., Inoue,K., Matoba,S.,
            Anastassiadis,K., Mizuki,N., Ogura,A. and Ohbo,K.
  TITLE     Tsga8 is required for spermatid morphogenesis and male fertility in
            mice
  JOURNAL   Development 148 (8) (2021)
   PUBMED   33766931
REFERENCE   5  (bases 1 to 8457)
  AUTHORS   Xiang,Y., Zhang,Y., Xu,Q., Zhou,C., Liu,B., Du,Z., Zhang,K.,
            Zhang,B., Wang,X., Gayen,S., Liu,L., Wang,Y., Li,Y., Wang,Q.,
            Kalantry,S., Li,L. and Xie,W.
  TITLE     Epigenomic analysis of gastrulation identifies a unique chromatin
            state for primed pluripotency
  JOURNAL   Nat Genet 52 (1), 95-105 (2020)
   PUBMED   31844322
REFERENCE   6  (bases 1 to 8457)
  AUTHORS   Glaser,S., Schaft,J., Lubitz,S., Vintersten,K., van der Hoeven,F.,
            Tufteland,K.R., Aasland,R., Anastassiadis,K., Ang,S.L. and
            Stewart,A.F.
  TITLE     Multiple epigenetic maintenance factors implicated by the loss of
            Mll2 in mouse development
  JOURNAL   Development 133 (8), 1423-1432 (2006)
   PUBMED   16540515
REFERENCE   7  (bases 1 to 8457)
  AUTHORS   Hough,T.A., Nolan,P.M., Tsipouri,V., Toye,A.A., Gray,I.C.,
            Goldsworthy,M., Moir,L., Cox,R.D., Clements,S., Glenister,P.H.,
            Wood,J., Selley,R.L., Strivens,M.A., Vizor,L., McCormack,S.L.,
            Peters,J., Fisher,E.M., Spurr,N., Rastan,S., Martin,J.E.,
            Brown,S.D. and Hunter,A.J.
  TITLE     Novel phenotypes identified by plasma biochemical screening in the
            mouse
  JOURNAL   Mamm Genome 13 (10), 595-602 (2002)
   PUBMED   12420138
REFERENCE   8  (bases 1 to 8457)
  AUTHORS   Wylin,T., Baes,M., Brees,C., Mannaerts,G.P., Fransen,M. and Van
            Veldhoven,P.P.
  TITLE     Identification and characterization of human PMP34, a protein
            closely related to the peroxisomal integral membrane protein PMP47
            of Candida boidinii
  JOURNAL   Eur J Biochem 258 (2), 332-338 (1998)
   PUBMED   9874197
REFERENCE   9  (bases 1 to 8457)
  AUTHORS   Bedford,M.T., Chan,D.C. and Leder,P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
REFERENCE   10 (bases 1 to 8457)
  AUTHORS   Chan,D.C., Bedford,M.T. and Leder,P.
  TITLE     Formin binding proteins bear WWP/WW domains that bind proline-rich
            peptides and functionally resemble SH3 domains
  JOURNAL   EMBO J 15 (5), 1045-1054 (1996)
   PUBMED   8605874
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ121348.1, AB182318.1, U92455.1 and CJ240818.1.
            
            On Oct 3, 2006 this sequence version replaced NM_029274.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction at the 5' end of an exon compared to variant 1. The
            resulting isoform (2) has the same N- and C-termini but is shorter
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB182318.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-265               CJ121348.1         1-265
            266-1283            AB182318.1         257-1274
            1284-1982           U92455.1           150-848
            1983-8453           AB182318.1         1974-8444
            8454-8457           CJ240818.1         347-350
FEATURES             Location/Qualifiers
     source          1..8457
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 18.63 cM"
     gene            1..8457
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /note="lysine (K)-specific methyltransferase 2B"
                     /db_xref="GeneID:75410"
                     /db_xref="MGI:MGI:109565"
     exon            1..372
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..8151
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /EC_number="2.1.1.364"
                     /note="isoform 2 is encoded by transcript variant 2;
                     histone-lysine N-methyltransferase MLL4; mixed lineage
                     leukemia 2; WBP-7; lysine N-methyltransferase 2B; WW
                     domain binding protein 7; histone-lysine
                     N-methyltransferase 2B; trithorax homolog 2;
                     myeloid/lymphoid or mixed-lineage leukemia protein 4
                     homolog"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase 2B isoform 2"
                     /protein_id="NP_083550.2"
                     /db_xref="CCDS:CCDS21101.1"
                     /db_xref="GeneID:75410"
                     /db_xref="MGI:MGI:109565"
                     /translation="MAAAAGGGSCPGPGSARGRFPGRPRGSGGGGGRGGRGNGAERVR
                     VALRRGGGAAGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGARVQRGRGRGRGRGWG
                     PNRGCMPEEESSDGESEEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTP
                     LPPRLADVTPVPPKAPTRKRGEEGTERMVQALTELLRRSQAPQPPRSRARAREPSTPR
                     RSRGRPPGRPAGPCRKKQQAVVLAEAAVTIPKPEPPPPVVPVKNKAGSWKCKEGPGPG
                     PGTPKRGGQPGRGGRGGRGRGRGGLPLMIKFVSKAKKVKMGQLSQELESGQGHGQRGE
                     SWQDAPQRKDGDEPERGSCRKKQEQKLEEEEEEEEKEGEEKEEKDDNEDNNKQEEEEE
                     TERAVAEEEAMLAKEKEEAKLPSPPLTPPVPSPPPPLPPPSTSPPPPASPLPPPVSPP
                     PPLSPPPYPAPEKQEESPPLVPATCSRKRGRPPLTPSQRAEREAARSGPEGTLSPTPN
                     PSTTTGSPLEDSPTVVPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPK
                     VEASIVRPPVATSPPAPQEPVPVSSPPRVPTPPSTPVPLPEKRRSILREPTFRWTSLT
                     RELPPPPPAPPPAPSPPPAPATPSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGALE
                     TPEPELPPADDSPAEPEPRAVGRTNHLSLPRFVPVVTSPVKVEVPPHGAPALSEGQQL
                     QLQQPPQALQTQLLPQALPPQQPQAQPPPSPQHTPPLEKARVASLGSLPLSGVEEKMF
                     SLLKRAKVQLFKIDQQQQQKVAASMPLSPAVQTEEAVGTVKQTPDRGCVRSEDESMEA
                     KRDRASGPESPLQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDT
                     SSASETESVPSRSQREKVESAGPGGDSEPTGSTGALAHTPRRSLPSHHGKKMRMARCG
                     HCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVK
                     TLLPWDSDESPEASPGPPGPRRGAGAGGSREEVGATPGPEEQDSLLLQRKSARRCVKQ
                     RPSYDVFEDSDDSEPGGPPAPRRRTPREHELPVLEPEEQSRPRKPTLQPVLQLKARRR
                     LDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWLMGGLSVLTSVPG
                     GPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPSPQHRDTWCCRRCKFCHVCG
                     RKGRGSKHLLECERCRHAYHPACLGPSYPTRATRRRRHWICSACVRCKSCGATPGKNW
                     DVEWSGDYSLCPRCTELYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLS
                     DEDYEILSGLPDSVLYTCGPCAGATQPRWREALSGALQGGLRQVLQGLLSSKVAGPLL
                     LCTQCGQDGKQLHPGPCDLQAVGKRFEEGLYKSVHSFMEDVVAILMRHSEEGETPERR
                     AGSQMKGLLLKLLESAFCWFDAHDPKYWRRSTRLPNGVLPNAVLPPSLDHVYAQWRQQ
                     ESETPESGQPPGDPSAAFQSKDPAAFSHLDDPRQCALCLKYGDADSKEAGRLLYIGQN
                     EWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNF
                     HFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVTPDGFDVLRRVYVDFEGINFKRKFL
                     TGLEPDVINVLIGSIRINSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRC
                     RILEYRPWGPREEPVHLEAAEENQTIVHSPTPSSDTDSLIPGDPVHHSPIQNLDPPLR
                     TDSSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDS
                     DFPAPPRRSRRPSPLATRPPPSRRTSSPLRTSPQLRVPLSTSVTALTPTSGELAPPDL
                     APSPLPPSEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAVGSSQGGP
                     GDSSEEEASPTTHYVHFPVTVVSGPALAPSSLAGAPRIEQLDGVDDGTDSEAEAVQQP
                     RGQGTPPSGPGVGRGGVLGAAGDRAQPPEDLPSEIVDFVLKNLGGPGEGAAGPREDSL
                     PSAPPLANGSQPPQSLSTSPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILV
                     NKLGQVFVKMAGEGEPVAPPVKQPPLPPIIPPTAPTSWTLPPGPLLSVLPVVGVGVVR
                     PAPPPPPPPLTLVFSSGPPSPPRQAIRVKRVSTFSGRSPPVPPPNKTPRLDEDGESLE
                     DAHHVPGISGSGFSRVRMKTPTVRGVLDLNNPGEQPEEESPGRPQDRCPLLPLAEAPS
                     QALDGSSDLLFESQWHHYSAGEASSSEEEPPSPEDKENQVPKRVGPHLRFEISSDDGF
                     SVEAESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGA
                     QRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRKCTFDMFNFLASQHRVLPEGATC
                     DEEEDEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAG
                     EMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCE
                     PNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFL
                     N"
     exon            373..445
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            446..2481
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2595
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2746
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            2747..3026
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3027..3082
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3083..3361
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3456
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3457..3555
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3556..3669
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3816
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3817..3912
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            3913..4030
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4031..4144
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4145..4329
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4330..4419
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4420..4524
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4525..4598
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4599..4714
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4715..4806
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4807..4944
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            4945..5103
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            5104..5224
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            5225..5303
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            5304..5464
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            5465..5662
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            5663..6962
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            6963..7052
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            7053..7159
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            7160..7300
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            7301..7375
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            7376..7553
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            7554..7661
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            7662..7745
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            7746..7875
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     exon            7876..8457
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8432..8437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /note="hexamer: AATAAA"
     polyA_site      8454
                     /gene="Kmt2b"
                     /gene_synonym="2610014H22Rik; mKIAA0304; Mll2; Wbp7"
                     /note="major polyA site"
ORIGIN      
        1 ggtgccaaga tggcggcggc ggcgggcggc ggcagttgcc ccgggcctgg ctccgcacgg
       61 ggccgcttcc cgggccggcc gcggggttcc ggcgggggcg ggggccgcgg cggccgaggc
      121 aacggagccg aaagagtgcg ggtagccctg cggcgcggtg gcggcgcggc ggggccggga
      181 ggagccgagc ccggggagga cacggccctg ctccgtttgc tgggtcttcg ccggggcctg
      241 cgccggctcc gccgcctgtg ggctggtgcg cgagttcagc gaggccgagg ccgcggccgg
      301 ggacggggct ggggcccgaa ccgaggctgc atgccggagg aagagagcag tgacggggaa
      361 tccgaggagg aggagtttca gggttttcat tcagatgaag atgtggcccc cagttccctg
      421 cgctctgcgc ttcggtccca gcgaggtcga gcccctcggg gtcggggccg caagcataag
      481 acgacccccc ttcctcctcg cctagcagat gtgactcctg tccccccaaa ggcccctact
      541 cggaaacggg gtgaggaggg cacagaacgg atggtgcagg cactgactga acttctccgg
      601 cggtcccaag caccccaacc cccccggagc cgggcacggg cacgtgaacc ctctactccc
      661 cgacggtctc ggggaaggcc cccaggacgg ccagccggtc cctgccggaa aaagcagcaa
      721 gcagtagtgt tagcagaagc ggctgtgaca atccctaaac ccgagcctcc gccccctgtg
      781 gttccagtaa agaacaaagc tggcagttgg aaatgcaagg agggacctgg tccaggacct
      841 ggaaccccca aacgtggagg acagcctggg agaggaggcc gtggaggcag gggcagaggc
      901 cgaggcggac ttccccttat gatcaagttt gtttccaagg ccaagaaagt gaagatggga
      961 caattgtccc aggaactaga atcaggtcag ggtcatggtc aacgtgggga aagctggcag
     1021 gatgcccccc aaagaaaaga tggagatgaa ccagaaaggg gctcgtgtag aaagaaacag
     1081 gagcagaaac tggaggagga ggaggaggag gaggagaagg agggagaaga gaaggaagaa
     1141 aaagatgaca atgaggataa caacaagcaa gaggaagagg aggagactga gagagctgtg
     1201 gctgaggaag aagcgatgct agccaaggag aaggaagagg caaagcttcc gtcaccaccc
     1261 ttgactcctc cagtcccttc accacctcct cctctaccac ccccttcaac atctcctcca
     1321 cctccagcat cccctctacc acccccagtt tctcctcctc ccccactttc ccctccccca
     1381 tatccagccc cagagaagca ggaagagtct cctcctcttg tcccagctac atgctctagg
     1441 aagaggggca ggcctcccct gactcctagc cagcgggcag agagggaagc tgctcggtca
     1501 ggaccagagg gcaccctttc tcccactcca aaccctagca ccaccacagg aagccctttg
     1561 gaagacagtc ctactgtggt ccccaaaagt accacctttt taaagaatat acggcagttt
     1621 attatgcctg tagtgagtgc tcgctcctcc cgtgttatca agacaccccg gcgatttatg
     1681 gatgaagatc ctcccaaacc tccaaaggtg gaggcttcta ttgttcgacc tcctgttgca
     1741 acctccccac ctgctcccca ggaaccagta ccagtctcct ctccacctcg tgtcccaact
     1801 cccccatcta ccccagtccc actccctgag aagaggcggt ctatcctaag ggaacccaca
     1861 tttcgctgga cctcactaac ccgggagctg ccgccacctc cacctgctcc tccaccagcc
     1921 ccatctccac cacctgcccc tgccactccc tcccggaggc ccttgctcct tcgggcccct
     1981 cagtttaccc caagtgaagc ccacctgaag atctatgaat cggtgcttac ccctcctcct
     2041 cttggggctc ttgaaacccc tgagccagag ctgcctcctg ctgatgactc tccagcagag
     2101 cctgagccta gggcagtggg gcggaccaat cacctcagct tgcctcgctt tgtccctgtg
     2161 gtcaccagtc ctgttaaggt tgaggtgccc ccccatggag ctccagctct gagtgaaggc
     2221 cagcagcttc agctccagca gcccccgcag gccttgcaga cccagctcct accccaggca
     2281 ctaccaccac agcaaccaca agcgcagcca cctccatcac cacaacacac accaccactg
     2341 gaaaaggccc gtgttgcaag tctgggttcc ctgccactat ctggggtgga ggagaaaatg
     2401 tttagccttc ttaagagagc taaggtgcag ttattcaaga tcgatcaaca gcaacagcag
     2461 aaagtggcgg cttcaatgcc gctaagccct gcagtacaaa ccgaggaggc tgtggggact
     2521 gtcaaacaga ccccggacag aggctgtgtc aggtctgaag atgaatccat ggaagctaag
     2581 agagatcgag cctcgggccc tgagtcacct ttacaaggcc cccgaatcaa acatgtctgc
     2641 cgtcacgctg ctgtggcctt gggtcaggct cgggccatgg tgcctgaaga tgtaccccgc
     2701 ctcagtgccc tccctctccg ggatcggcag gacctcgcca ctgaggatac gtcatcagca
     2761 tcagagactg agagtgtccc ttcccgatcc cagcgggaaa aggtggaatc tgcagggcct
     2821 gggggagact cggagcctac agggtctaca ggggccctgg cccacacacc acggcggtca
     2881 ctgccatccc accatggcaa gaagatgaga atggctcgtt gtgggcactg tcggggttgc
     2941 ttgcgtgtgc aggactgtgg ctcttgtgtc aactgcttgg ataaacctaa atttgggggt
     3001 cccaacacta agaagcagtg ctgtgtatac cggaagtgtg acaagataga ggctcggaag
     3061 atggagcggc tggcaaaaaa aggccggacg atagtgaaga cgctgttgcc ctgggattcc
     3121 gatgaatctc ctgaggcctc ccctggtcct ccaggcccac gccggggggc gggagctggg
     3181 gggtcccggg aggaggtggg ggccactccc gggcccgagg agcaggactc cctcctactg
     3241 cagcgcaagt cagcccgacg ctgcgtcaaa cagcggccct cctatgatgt cttcgaggac
     3301 tcagatgact cagagcccgg gggtcctcct gctccaagac gtcgcacccc cagagaacat
     3361 gagctgccag tactagaacc tgaggagcag agccggcccc gcaaacccac cctgcagcct
     3421 gtgttgcagc tcaaggcccg aaggcgcctg gacaaggatg ctttagcccc tggccccttt
     3481 gcctcttttc ccaatggctg gactggaaag cagaagtctc ctgacggtgt gcaccgggtc
     3541 cgagtagatt ttaaggagga ttgcgaccta gagaatgtgt ggcttatggg tggtctcagt
     3601 gtgctgactt ctgtgccagg ggggccaccg atggtgtgtc tgctgtgtgc tagcaaaggc
     3661 ctccatgagc tggttttttg ccaagtctgc tgcgatcctt tccacccctt ctgtctggag
     3721 gaggctgagc ggccctcacc tcagcatcgt gacacctggt gctgcaggcg ctgcaagttc
     3781 tgccatgttt gtgggcgcaa aggccgaggg tccaagcacc tcctggaatg tgaacgctgt
     3841 cgtcatgctt accacccagc ctgcctggga cccagctacc caacccgggc cacgcgtaga
     3901 cggcgccact ggatctgttc agcctgtgtg cgctgtaaga gctgtggggc aactccaggc
     3961 aagaactggg atgtcgagtg gtctggagat tacagcctct gccccaggtg caccgagctc
     4021 tatgaaaaag ggaactactg cccaatttgc acacgctgct atgaagacaa tgactatgag
     4081 agcaagatga tgcagtgtgc acagtgtgac cactgggtgc atgccaagtg tgagggactc
     4141 tcagatgaag actacgagat cctttctgga ctgccagact cagtgttgta cacgtgtggg
     4201 ccatgtgctg gggcgacaca gccccgctgg cgagaggccc tgagtggggc cctgcaggga
     4261 ggcctgcgtc aggtgctcca gggcctgtta agctcaaagg tggcaggccc attgctgctg
     4321 tgcacccagt gtgggcagga tgggaagcag ctccacccag gaccctgtga tttacaagct
     4381 gtgggaaagc gctttgagga aggtctctat aagtctgtgc acagcttcat ggaagacgta
     4441 gtggccatct tgatgaggca ttcagaagaa ggagagaccc cagagcgccg ggctggaagc
     4501 cagatgaaag gactcctact gaagctgcta gagtctgcgt tctgctggtt tgacgcccat
     4561 gatcctaagt actggcgacg gagtacacgg ctgccaaacg gagtgctccc caatgctgtg
     4621 ttgcctccat ccttggacca tgtctatgct cagtggagac aacaggaatc agagacccca
     4681 gaatcggggc agcctccagg ggatccttca gcagctttcc agagcaagga cccagctgct
     4741 ttctcacacc tggatgaccc tcgtcagtgt gcactctgtc tcaagtatgg ggatgctgac
     4801 tctaaggagg cggggcggct cctgtacatt gggcagaatg agtggacaca tgtcaattgt
     4861 gccatttggt cagctgaagt gtttgaggag aatgatggct ccctcaagaa cgtccatgct
     4921 gctgttgcac gtggaaggca gatgcgctgt gagctctgcc tcaagcctgg agccacagtt
     4981 ggctgctgcc tgtcctcatg tctcagcaac ttccacttca tgtgtgcccg ggccagctac
     5041 tgcatcttcc aggatgacaa gaaggttttc tgccagaaac acacagacct cctagatggc
     5101 aaggagatcg tgacccctga tggttttgat gttcttcggc gagtctatgt ggacttcgag
     5161 ggcatcaact tcaagcgaaa gttcttgact ggacttgaac cagatgtcat caatgtactc
     5221 attggctcca tcagaatcaa ctccctgggc accctatctg atctctcaga ctgtgagggt
     5281 cgactcttcc ccattggcta ccaatgctcc cgcctgtatt ggagcacagt ggatgctcgg
     5341 aggcgctgct ggtatcggtg ccgaattcta gagtatcgcc cttgggggcc aagggaggag
     5401 ccagtgcacc tagaagcagc agaggagaac cagaccattg tgcatagccc aaccccttcc
     5461 tcagatacag attctctgat ccctggagat cctgtacacc actcccccat tcagaatctg
     5521 gatcccccgc ttcggacaga ttcaagcaat ggccctcctc ccacccctcg ctccttctca
     5581 ggggctcgaa tcaaagtgcc caactactca ccgtctcgga ggcccttagg gggagtctct
     5641 tttggtcctc tgccctctcc aggaagtcca tcttccctga cccaccacat ccctactgtg
     5701 ggagactcgg actttccagc tcccccaagg cgatctcggc gtcctagccc cctggccacc
     5761 aggccaccac catcccggag gacctcctct cctctcagaa cttcccctca gctcagggtg
     5821 cccctgtcta cctcagtcac agccctcaca cctacctcag gggagctggc tccccctgac
     5881 ctggccccat ctccccttcc accgtctgaa gacctgggcc cagactttga agacatggag
     5941 gtggtgtcag gactaagtgc tgctgacctg gactttgcag ccagcctgct ggggactgag
     6001 cctttccagg aagagattgt ggctgctggg gcagtgggga gcagccaggg aggtccaggg
     6061 gacagctcag aggaggaggc cagccctacc actcactatg tccacttccc tgtgaccgtg
     6121 gtgtctggcc ctgccctggc ccccagttcc cttgctggag ctccccgaat cgagcagctg
     6181 gacggagtgg atgatggcac agacagcgag gctgaggctg tccaacaacc ccggggacag
     6241 gggactcctc cttcaggacc aggagtgggc cgaggagggg tccttggagc agcaggcgac
     6301 agagcccaac ctcctgaaga cctgccttca gaaattgtgg atttcgtgtt gaagaaccta
     6361 gggggtcctg gggagggggc tgctggcccc agagaggact ctcttccttc agcacctccc
     6421 ttggctaatg gcagccaacc cccacaaagc ctgtccacta gcccagctga ccccacccga
     6481 acatttgctt ggctccctgg agctccaggg gtccgggtat tgagtctggg tcctgctcca
     6541 gaacccccca aacctgccac atccaagatc atccttgtca acaagctggg gcaagtattt
     6601 gtgaagatgg caggggaggg tgagcctgta gcacccccag taaagcagcc ccctctaccc
     6661 cccatcattc ccccaacagc tcccacctcc tggactctgc ccccaggacc cctgctcagt
     6721 gtgttaccag tggtaggggt aggagtggtc cggcctgccc cacccccacc tccaccccca
     6781 ctaacactgg tgtttagcag tgggcccccc agcccaccac gccaggccat tcgtgtcaag
     6841 agggtatcca ccttctctgg ccgatcccct ccagttcctc ccccaaacaa aactccccgg
     6901 ctggatgaag atggagagtc cttggaggat gcccatcatg tgccagggat cagtggcagt
     6961 gggttcagtc gtgttcgcat gaaaacgccc acagtccgtg gagttctgga cctgaacaat
     7021 cctggggagc agcctgagga ggaaagccct gggcgccccc aggaccggtg tcctttgctg
     7081 ccacttgcag aagctccttc ccaggccctc gatggttcct cagacctact gtttgagtcc
     7141 cagtggcatc actattcagc aggcgaggcc tcaagctctg aggaagagcc tccatctcca
     7201 gaggacaaag aaaaccaggt ccccaaacgg gttggtccac acctgcgctt tgagatcagc
     7261 agtgatgatg gcttcagtgt ggaggcagag agcttggagg tggcatggag aactctgatt
     7321 gagaaagtgc aagaagcacg agggcatgca cggctcaggc atctctcctt tagtggaatg
     7381 agtggagcgc ggctcctggg catccaccac gatgctgtca tcttcctggc agagcagctc
     7441 cctggggccc agcgctgcca gcattataag ttccgctacc accagcaggg agagggccag
     7501 gaagagccac ctctgaatcc ccatggggct gctcgtgctg aggtctatct ccggaagtgt
     7561 acctttgaca tgttcaactt cctggcctcc cagcaccgtg tgctccccga gggagccacc
     7621 tgtgatgaag aagaggatga ggtgcagctt cggtccacca gacgtgccac cagcctggag
     7681 cttcctatgg ccatgcgctt tcgtcatctc aaaaagacat ccaaagaggc tgtgggagtc
     7741 tacagatcag ctatccatgg acgaggtctg ttttgtaaac gcaacatcga tgcgggagag
     7801 atggtcattg agtactctgg cattgtcatt cgctctgtgc tgactgacaa gcgagagaag
     7861 ttctatgatg ggaagggtat tgggtgctac atgttccgca tggatgactt tgatgtggtg
     7921 gacgccacca tgcacggcaa tgctgcccga ttcatcaacc actcatgtga gcccaactgc
     7981 ttctctcgtg tcatccatgt ggaaggccag aaacacattg tcatctttgc cttgcgccgc
     8041 atcctgcgag gtgaggagct cacctatgac tacaagtttc ctatcgagga tgccagcaac
     8101 aagctgccct gcaactgtgg cgccaagcgc tgccgtcgct ttcttaactg aggccatggc
     8161 tgcccggatt cctcacgtgc ccgctgccat ctcaccctgg cctgtggctc cctagtctca
     8221 gtatctcact cctaccttcc tgtccatggt gaatgtgggc atgtagtggg gcaggagtct
     8281 gccttcaccc ctcctgccta cccagccatt gcctccttcc tccttccctg gggacccagg
     8341 atgtagatat tgtacaaagg tttctaaatc ccttcttttc tatgcacttt tttatttaag
     8401 agggcggggt cccaggtggg aatcccccca caataaagtc tgtcagcgtt tggagag
//
