LOCUS       NM_133809               2512 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus kynurenine 3-monooxygenase (Kmo), mRNA.
ACCESSION   NM_133809
VERSION     NM_133809.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2512)
  AUTHORS   Hasegawa,M., Niijima,M., Kunisawa,K., Teshigawara,T., Kubota,H.,
            Fujigaki,S., Fujigaki,H., Yamamoto,Y., Kim,H.C., Saito,K.,
            Nabeshima,T. and Mouri,A.
  TITLE     Maternal immune activation induces neurodevelopmental impairments
            of adult offspring through alterations in tryptophane-kynurenine
            pathway in the placenta
  JOURNAL   Biochem Biophys Res Commun 737, 150922 (2024)
   PUBMED   39486137
REFERENCE   2  (bases 1 to 2512)
  AUTHORS   Zhai,Y., Chavez,J.A., D'Aquino,K.E., Meng,R., Nawrocki,A.R.,
            Pocai,A., Wang,L. and Ma,L.J.
  TITLE     Kynurenine 3-monooxygenase limits de novo NAD+ synthesis through
            dietary tryptophan in renal proximal tubule epithelial cell models
  JOURNAL   Am J Physiol Cell Physiol 326 (5), C1423-C1436 (2024)
   PUBMED   38497113
  REMARK    GeneRIF: Kynurenine 3-monooxygenase limits de novo NAD[+] synthesis
            through dietary tryptophan in renal proximal tubule epithelial cell
            models.
REFERENCE   3  (bases 1 to 2512)
  AUTHORS   Hayes,A.J., Zheng,X., O'Kelly,J., Neyton,L.P.A., Bochkina,N.A.,
            Uings,I., Liddle,J., Baillie,J.K., Just,G., Binnie,M.,
            Homer,N.Z.M., Murray,T.B.J., Baily,J., McGuire,K., Skouras,C.,
            Garden,O.J., Webster,S.P., Iredale,J.P., Howie,S.E.M. and Mole,D.J.
  TITLE     Kynurenine monooxygenase regulates inflammation during critical
            illness and recovery in experimental acute pancreatitis
  JOURNAL   Cell Rep 42 (8), 112763 (2023)
   PUBMED   37478012
REFERENCE   4  (bases 1 to 2512)
  AUTHORS   Kubota,H., Kunisawa,K., Niijima,M., Hirakawa,M., Mori,Y.,
            Hasegawa,M., Fujigaki,S., Fujigaki,H., Yamamoto,Y., Saito,K.,
            Nabeshima,T. and Mouri,A.
  TITLE     Deficiency of kynurenine 3-monooxygenase exacerbates impairment of
            prepulse inhibition induced by phencyclidine
  JOURNAL   Biochem Biophys Res Commun 629, 142-151 (2022)
   PUBMED   36116377
REFERENCE   5  (bases 1 to 2512)
  AUTHORS   Zhao,J., Chen,J., Wang,C., Liu,Y., Li,M., Li,Y., Li,R., Han,Z.,
            Wang,J., Chen,L., Shu,Y., Cheng,G. and Sun,C.
  TITLE     Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections
            via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-beta
            production
  JOURNAL   PLoS Pathog 18 (3), e1010366 (2022)
   PUBMED   35235615
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2512)
  AUTHORS   Stephens,G.L., Wang,Q., Swerdlow,B., Bhat,G., Kolbeck,R. and
            Fung,M.
  TITLE     Kynurenine 3-monooxygenase mediates inhibition of Th17
            differentiation via catabolism of endogenous aryl hydrocarbon
            receptor ligands
  JOURNAL   Eur J Immunol 43 (7), 1727-1734 (2013)
   PUBMED   23568529
  REMARK    GeneRIF: expression of KMO by Th17 cells serves to limit their
            continuous exposure to physiological levels of endogenous aryl
            hydrocarbon receptor ligands in vivo.
REFERENCE   7  (bases 1 to 2512)
  AUTHORS   Miu,J., Ball,H.J., Mellor,A.L. and Hunt,N.H.
  TITLE     Effect of indoleamine dioxygenase-1 deficiency and kynurenine
            pathway inhibition on murine cerebral malaria
  JOURNAL   Int J Parasitol 39 (3), 363-370 (2009)
   PUBMED   19000912
  REMARK    GeneRIF: partial protection against cerebral malaria was observed
            in C57BL/6 mice treated with Ro 61-8048, an inhibitor of
            kynurenine-3-hydroxylase. Protection was associated with suppressed
            levels of picolinic acid within the brain.
REFERENCE   8  (bases 1 to 2512)
  AUTHORS   Giorgini,F., Moller,T., Kwan,W., Zwilling,D., Wacker,J.L., Hong,S.,
            Tsai,L.C., Cheah,C.S., Schwarcz,R., Guidetti,P. and Muchowski,P.J.
  TITLE     Histone deacetylase inhibition modulates kynurenine pathway
            activation in yeast, microglia, and mice expressing a mutant
            huntingtin fragment
  JOURNAL   J Biol Chem 283 (12), 7390-7400 (2008)
   PUBMED   18079112
REFERENCE   9  (bases 1 to 2512)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 2512)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC014683.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014683.1, AK171812.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2512
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 81.6 cM"
     gene            1..2512
                     /gene="Kmo"
                     /note="kynurenine 3-monooxygenase"
                     /db_xref="GeneID:98256"
                     /db_xref="MGI:MGI:2138151"
     exon            1..81
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1467
                     /gene="Kmo"
                     /EC_number="1.14.13.9"
                     /note="kynurenine 3-hydroxylase"
                     /codon_start=1
                     /product="kynurenine 3-monooxygenase"
                     /protein_id="NP_598570.1"
                     /db_xref="CCDS:CCDS15548.1"
                     /db_xref="GeneID:98256"
                     /db_xref="MGI:MGI:2138151"
                     /translation="MASSDTQGKRVAVIGGGLVGALNACFLAKRNFQVDVYEAREDIR
                     VAKSARGRSINLALSYRGRQALKAIGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNK
                     SQYILSISRENLNKDLLTAVESYANAKVHFGHKLSKCIPEEGVLTVLGPDKVPRDVTC
                     DLVVGCDGAYSTVRAHLMKKPRFDYTQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPR
                     NAYMMIALPNMDKSFTCTLFMPFEEFERLPTRSDVLDFFQKNFPDAIPLMGEQALMRD
                     FFLLPAQPMISVKCSPFHLKSHCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKF
                     NNNLSMCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQKLLDKFLHAIMPS
                     TFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLIAIGGTYLLVHHLSLRPL
                     EFLRRPAWMGTTGYWTRSTDISLQVPWSY"
     exon            82..151
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            152..249
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            250..339
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            340..388
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            389..476
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            477..642
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            643..714
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            715..836
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            837..984
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1042
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1125
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1227
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1287
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..2498
                     /gene="Kmo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2473..2478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Kmo"
                     /note="hexamer: AATAAA"
     polyA_site      2498
                     /gene="Kmo"
                     /note="major polyA site"
ORIGIN      
        1 gacctgaaca gaggtgttct ggaagctatg gcatcgtctg atactcaggg gaaaagagtg
       61 gctgttattg gcggtggttt ggttggagca ctgaatgcct gctttcttgc aaagaggaat
      121 tttcaagttg atgtgtacga agctagggaa gatattcgcg tggctaaatc tgcacgtgga
      181 aggagcatta acttggccct ttcttataga ggacggcagg ccttgaaagc cattggtctg
      241 gaagatcaga tcgtttccaa aggtgtgccc atgaaagcca gaatgatcca ctctctttcg
      301 ggaaagaagt ctgcaattcc ctatgggaac aagtcacagt atatcctttc aataagcaga
      361 gaaaacttaa acaaggacct gctgactgcc gtggagtcct atgccaatgc gaaggtgcac
      421 tttggccaca agctgtcgaa atgcattccg gaggaagggg tactcacagt gctcggacct
      481 gacaaggttc cccgagatgt cacatgtgac cttgttgtag ggtgtgatgg agcctattca
      541 actgtcagag cccacctcat gaagaagccc cgctttgatt acactcagca atatatccct
      601 catggataca tggagttgac aattccacct aagaatgggg agtacgccat ggaacctaac
      661 tgtcttcaca tttggcctag aaatgcctat atgatgatcg cccttccaaa catggacaaa
      721 tctttcacat gcaccttgtt catgcccttt gaggagtttg aaagacttcc aacgcgcagc
      781 gatgtgctgg acttcttcca gaagaacttt ccagatgcta tccctctgat gggagagcaa
      841 gccctcatga gagatttctt tctgttgcct gcccagccca tgatatcagt gaagtgctct
      901 cccttccacc tgaagtcaca ctgtgtgctg atgggagatg ccgctcatgc cattgtccca
      961 ttttttgggc aaggaatgaa tgcgggcttt gaagactgct tggtgtttga tgaattgatg
     1021 gacaaattca ataataatct tagtatgtgc cttcctgaat tctcaagatt taggatccca
     1081 gatgaccatg caatttcaga cctatctatg tacaattaca tagagatgcg agcgcatgtc
     1141 aactctaggt ggttcctgtt ccaaaagctc ctggataaat ttcttcacgc gatcatgccc
     1201 tctaccttta tccctctcta taccatggtc gccttcacca gaataagata ccacgaggca
     1261 gtgctgcgtt ggcattggca aaaaaaggtg ataaacagag gactctttgt ccttgggtcc
     1321 ctgatagcca ttggaggcac ctacctactt gtgcaccatc tgtccctgag acctctggag
     1381 ttcttgagaa gacctgcctg gatgggaacc actggctact ggactaggag tacagacatt
     1441 tctctgcaag ttccatggag ttactaggac aaattccccc gttcaccaac catagtgtca
     1501 aagttctggg tagcaaatgt ttgattcctc ttccatctca agggtgaaaa gcatgtctcc
     1561 attgccatat tcagttcact gctggaaact aattgtcagc ctagaattaa gcgtggtgag
     1621 gagtttgtgt atttgtcagc tgagcgaggg aagaatctgt cttgacaggg tctcatcggt
     1681 ttgcgtgctt gggctgggcc tcttccaatt taaaaatgca ataaccaaca tctctttcac
     1741 ttctcaaaag aacccatgtt ttttcctgta gaggacaata taggatcaac aacactgctt
     1801 gcctagtgct acttcctctt aatgcagtag atggggcttg caggctcata gccacttgct
     1861 atggtagagc tgagaatgag agacaaggtg ttctgaagag ttccaggata tatctgtttt
     1921 atttcccagt ctccagatct cagaattatt atgtttttaa aaagaaggaa agagctatca
     1981 atggcattct aagtgaagga tgagaaaggg ttgttagtag taataaattt atagcaggga
     2041 ggagaggaga taggagggtg ttttccagaa gcatggagac acagtttagt ccacttcaga
     2101 cgtacagaag tggttccttg actgtcccac ggacagacgc agaagttaac ttcatcatca
     2161 gagtgcagtg cacagatacc ctctccgctt ctgtcttctc caagctggct gactgggacc
     2221 cttagaagtt cttttcattg tcaattttga gagctaccat aatagttaac tagaaaatca
     2281 aaacccgagg aaataaagat aaaacaaatt ggcatttccc ataatgtcaa agacatcctt
     2341 gggtcttaac aatctatatt tgatgtgtag ggaaagaaaa atcattgttt tcctggtaag
     2401 ggatgtagca ctgtgggaga gcgcttatgt aacctgcata ggaccctggg ttagattcac
     2461 cagcactgca aaaataaaca gaaacattgt tccttttaaa aaaaaaaaaa aa
//
