LOCUS       NM_033078               3272 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily K, member 1
            (Klrk1), transcript variant 1, mRNA.
ACCESSION   NM_033078 XM_001004553 XM_001004557 XM_001004559
VERSION     NM_033078.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3272)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3272)
  AUTHORS   Liu,L., Yang,Y., Wu,T., Du,J. and Long,F.
  TITLE     NKG2D knockdown improves hypoxic-ischemic brain damage by
            inhibiting neuroinflammation in neonatal mice
  JOURNAL   Sci Rep 14 (1), 2326 (2024)
   PUBMED   38282118
  REMARK    GeneRIF: NKG2D knockdown improves hypoxic-ischemic brain damage by
            inhibiting neuroinflammation in neonatal mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3272)
  AUTHORS   Jin,W.J., Jagodinsky,J.C., Vera,J.M., Clark,P.A., Zuleger,C.L.,
            Erbe,A.K., Ong,I.M., Le,T., Tetreault,K., Berg,T.,
            Rakhmilevich,A.L., Kim,K., Newton,M.A., Albertini,M.R., Sondel,P.M.
            and Morris,Z.S.
  TITLE     NK cells propagate T cell immunity following in situ tumor
            vaccination
  JOURNAL   Cell Rep 42 (12), 113556 (2023)
   PUBMED   38096050
REFERENCE   4  (bases 1 to 3272)
  AUTHORS   Marinovic,S., Lenartic,M., Mladenic,K., Sestan,M., Kavazovic,I.,
            Benic,A., Krapic,M., Rindlisbacher,L., Cokaric Brdovcak,M.,
            Sparano,C., Litscher,G., Turk Wensveen,T., Mikolasevic,I., Fuckar
            Cupic,D., Bilic-Zulle,L., Steinle,A., Waisman,A., Hayday,A.,
            Tugues,S., Becher,B., Polic,B. and Wensveen,F.M.
  TITLE     NKG2D-mediated detection of metabolically stressed hepatocytes by
            innate-like T cells is essential for initiation of NASH and
            fibrosis
  JOURNAL   Sci Immunol 8 (87), eadd1599 (2023)
   PUBMED   37774007
  REMARK    GeneRIF: NKG2D-mediated detection of metabolically stressed
            hepatocytes by innate-like T cells is essential for initiation of
            NASH and fibrosis.
REFERENCE   5  (bases 1 to 3272)
  AUTHORS   Cui,T.X., Brady,A.E., Zhang,Y.J., Anderson,C. and Popova,A.P.
  TITLE     IL-17a-producing gammadeltaT cells and NKG2D signaling mediate
            bacterial endotoxin-induced neonatal lung injury: implications for
            bronchopulmonary dysplasia
  JOURNAL   Front Immunol 14, 1156842 (2023)
   PUBMED   37744375
  REMARK    GeneRIF: IL-17a-producing gammadeltaT cells and NKG2D signaling
            mediate bacterial endotoxin-induced neonatal lung injury:
            implications for bronchopulmonary dysplasia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3272)
  AUTHORS   Vance,R.E., Jamieson,A.M. and Raulet,D.H.
  TITLE     Recognition of the class Ib molecule Qa-1(b) by putative activating
            receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells
  JOURNAL   J Exp Med 190 (12), 1801-1812 (1999)
   PUBMED   10601355
REFERENCE   7  (bases 1 to 3272)
  AUTHORS   Depatie,C., Chalifour,A., Pare,C., Lee,S.H., Vidal,S.M. and
            Lemieux,S.
  TITLE     Assessment of Cmv1 candidates by genetic mapping and in vivo
            antibody depletion of NK cell subsets
  JOURNAL   Int Immunol 11 (9), 1541-1551 (1999)
   PUBMED   10464175
REFERENCE   8  (bases 1 to 3272)
  AUTHORS   Brown,M.G., Zhang,J., Du,Y., Stoll,J., Yokoyama,W.M. and
            Scalzo,A.A.
  TITLE     Localization on a physical map of the NKC-linked Cmv1 locus between
            Ly49b and the Prp gene cluster on mouse chromosome 6
  JOURNAL   J Immunol 163 (4), 1991-1999 (1999)
   PUBMED   10438936
REFERENCE   9  (bases 1 to 3272)
  AUTHORS   Ho,E.L., Heusel,J.W., Brown,M.G., Matsumoto,K., Scalzo,A.A. and
            Yokoyama,W.M.
  TITLE     Murine Nkg2d and Cd94 are clustered within the natural killer
            complex and are expressed independently in natural killer cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6320-6325 (1998)
   PUBMED   9600963
REFERENCE   10 (bases 1 to 3272)
  AUTHORS   Vance,R.E., Tanamachi,D.M., Hanke,T. and Raulet,D.H.
  TITLE     Cloning of a mouse homolog of CD94 extends the family of C-type
            lectins on murine natural killer cells
  JOURNAL   Eur J Immunol 27 (12), 3236-3241 (1997)
   PUBMED   9464811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA174479.1, AK040436.1 and AC171002.2.
            
            On Oct 26, 2013 this sequence version replaced NM_033078.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by mRNA and EST alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK040436.1, AF039026.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AA174479.1         17-28
            13-1177             AK040436.1         2-1166
            1178-3272           AC171002.2         32923-35017         c
FEATURES             Location/Qualifiers
     source          1..3272
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..3272
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /note="killer cell lectin-like receptor subfamily K,
                     member 1"
                     /db_xref="GeneID:27007"
                     /db_xref="MGI:MGI:1196250"
     exon            1..147
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..809
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /note="isoform a is encoded by transcript variant 1;
                     natural killer cell group 2D; NKG2-D type II integral
                     membrane protein; NK cell receptor D; NKG2-D-activating NK
                     receptor"
                     /codon_start=1
                     /product="NKG2-D type II integral membrane protein isoform
                     a"
                     /protein_id="NP_149069.1"
                     /db_xref="CCDS:CCDS39660.1"
                     /db_xref="GeneID:27007"
                     /db_xref="MGI:MGI:1196250"
                     /translation="MALIRDRKSHHSEMSKCHNYDLKPAKWDTSQEQQKQRLALTTSQ
                     PGENGIIRGRYPIEKLKISPMFVVRVLAIALAIRFTLNTLMWLAIFKETFQPVLCNKE
                     VPVSSREGYCGPCPNNWICHRNNCYQFFNEEKTWNQSQASCLSQNSSLLKIYSKEEQD
                     FLKLVKSYHWMGLVQIPANGSWQWEDGSSLSYNQLTLVEIPKGSCAVYGSSFKAYTED
                     CANLNTYICMKRAV"
     exon            148..255
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            256..294
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            295..399
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            400..435
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            436..587
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            588..691
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /inference="alignment:Splign:2.1.0"
     exon            692..3272
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1159..1164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /note="hexamer: ATTAAA"
     polyA_site      1178
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /note="major polyA site"
     regulatory      2096..2101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /note="hexamer: AATAAA"
     polyA_site      2122
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
     regulatory      2468..2473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /note="hexamer: AATAAA"
     polyA_site      2485
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
     regulatory      2771..2776
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
                     /note="hexamer: AATAAA"
     polyA_site      2796
                     /gene="Klrk1"
                     /gene_synonym="D6H12S2489E; NKG2-D; Nkg2d"
ORIGIN      
        1 gtagccatgg ctgcagagag atacactgtc ttaaaaaatg ttagttaata aataacaaaa
       61 actacaacct ggatcagttt ctgaagtaaa tctctcataa ttctcacata atggcattga
      121 ttcgtgatcg aaagtctcat cactcagaga tgagcaaatg ccataattac gacctcaagc
      181 cagcaaagtg ggatacttct caagaacaac agaaacaaag attagcacta actaccagtc
      241 aacctggaga aaatggtatc ataagaggaa gataccctat agaaaaactc aaaatatctc
      301 caatgttcgt tgttcgagtc cttgctatag ccttggcaat tcgattcacc cttaacacat
      361 tgatgtggct tgccattttc aaagagacgt ttcagccagt attgtgcaac aaggaagtcc
      421 cagtttcctc aagagagggc tactgtggcc catgccctaa caactggata tgtcacagaa
      481 acaactgtta ccaatttttt aatgaagaga aaacctggaa ccagagccaa gcttcctgtt
      541 tgtctcaaaa ttccagcctt ctgaagatat acagtaaaga agaacaggat ttcttaaagc
      601 tggttaagtc ctatcactgg atgggactgg tccagatccc agcaaatggc tcctggcagt
      661 gggaagatgg ctcctctctc tcatacaatc agttaactct ggtggaaata ccaaaaggat
      721 cctgtgctgt ctatggctca agctttaagg cttacacaga agactgtgca aatctaaaca
      781 cgtacatctg catgaaaagg gcggtgtaaa aactttcatt acccatctca gcaacaacca
      841 gaacaagaga attgtctcgg gagaaattgg gactaagaag aagagactgg gcataagaca
      901 aaagcaaaac agcaggtctg caccctccac caaatgatta gctaaacaca ttgtgttccc
      961 ataaaacaag ggaagcctgt ggggccaagg aaccatgaga caggggaaga gggaacagga
     1021 ggaccaagag tgtggttgaa gcctatccaa actagggaaa tatggtcctg ccctactgga
     1081 ggaggtggtg ttgcccagta gactctcagc accttgattt cctcccagat atcccctact
     1141 cactctctaa aggtttaaat taaatatgat attttattca agatgcctct agagagtcta
     1201 gactctattt ttgtagtggt caccgaggcc tgaggtcttt tcactcctgg cagttcttgc
     1261 ctcacttccc ctctcagggt ctgctattgt gatcattggt tgatcatgct gcttctagga
     1321 tatggggaag aagacgagga ggagcttcca tttcaagatg gaatcaaaac agaggaactg
     1381 tgagaactgg agaataaaac cctatagctc actgggagct taatctccag cactatggaa
     1441 aactgatggc tgggtatagc cacagcaggg accacaggga gtgctgtgcc tggcagtgtt
     1501 gccatctcag tgactcaaga aagcagcctg ctgtctggga gggacagcag agactctctg
     1561 agaaaggtca agcaggactg cttttggaac ttgacaatct catggaactc actttgttga
     1621 tttttgtgct ttcttgggat tctcccactc tttcatatgc tttccacttg agatgacagt
     1681 gtctgttgaa agcaaggcac tatatttgaa agtatatagc ttgtttcact ttacaagtca
     1741 gaaaggtggt gctggaagga gttgtcagct ctgtggttgt tagggtagaa tggatacagt
     1801 ttgcaagtga ggagatggac tcctggagcc atgggtataa gttatacacc aaatgatttt
     1861 gtattttgta cctccacgtt tcatatttaa aattcaaact ccaggtatta atatgaggag
     1921 acaggcactg gatcataatg ttttaaatca taaggataaa ggctttgtaa gtgggattac
     1981 aagaaatgga gttagttttg cctcttaaga atgcacccag gcagtcacct ttcttctctt
     2041 agctataaga gaacacagga taattctgat atacaacctg cacaatgacc tcatcaataa
     2101 acagtagatg tggttatcag tagccatcga ttcccagact tcataattgt gggaagtaga
     2161 tttctgttgc gtacagcttg atctgttgta ttttataata taatcccaaa taagctgaga
     2221 ccagagggga agatcgctag atattaggtc ttagtgaaaa atttgaaaac agggctggag
     2281 aggtggctca gaggttaaga acacaagtaa agaggttaag acttgggttc acttcacagc
     2341 acctgtatga caacccataa ccagctgtaa ccccacttcc agaggaccca acaccctctc
     2401 tggtttctac agtcacctgc atgcatatct tgtacataga tgagtgaaga caagcactca
     2461 aaataaaaat aaattttaga agaaatgttt tataatagtg ttgtatacta ttttacaaca
     2521 tagaaaatac taaaaaataa taggcaggtt taaaagtctg taggacatca tatataaata
     2581 acacagagaa tcacaacaga aagggagcca cagagcctta ctttcatctg agagactata
     2641 ataaaactgt gggagcctta ggtttctgtt ttgaaagttt ttgtgaagca atagaaacat
     2701 gcgatttagc tttgggatcc tctgaatgag ggattccccc aaaggctata agcttataca
     2761 aagaatggca aataaaaccc acactttaga aagtaacaac aagattcctt gctatctatg
     2821 cccatgagat gggggggggg ggggagaaaa cctccatgaa gactctgcat cgatggaaag
     2881 gcttccttta atctcacagc ccaaggtctg cctagcactc tttgcaggaa aacaaatctg
     2941 tatcttttca aggtaaataa cagtctacca tcaacacttt attttataag tctagtgtac
     3001 atccatttgg acaagagaga cacccaacaa cactttgggt tttttggttt gttgtttggt
     3061 tggtttgttt agtttttata gaacttcaac tcattcctta aagatttctc acacacaatc
     3121 taaagagtaa aacaaaaatt gaagaatagt gatagttagg ggtggcagtt agttagctca
     3181 tggcagtgtt acagtatcca ggggacctac ctgggtgagt ggtagtattg tgattcattg
     3241 aataattaaa gaaagtttag ccctacacta ac
//
