LOCUS       NP_001012538             248 aa            linear   ROD 27-JUL-2024
DEFINITION  killer cell lectin-like receptor subfamily I member 1 [Mus
            musculus].
ACCESSION   NP_001012538 XP_620368
VERSION     NP_001012538.2
DBSOURCE    REFSEQ: accession NM_001012520.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 248)
  AUTHORS   Saether,P.C., Westgaard,I.H., Hoelsbrekken,S.E., Benjamin,J.,
            Lanier,L.L., Fossum,S. and Dissen,E.
  TITLE     KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that
            inversely regulate NK cell cytotoxicity
  JOURNAL   J Immunol 181 (5), 3177-3182 (2008)
   PUBMED   18713988
REFERENCE   2  (residues 1 to 248)
  AUTHORS   Saether,P.C., Westgaard,I.H., Flornes,L.M., Hoelsbrekken,S.E.,
            Ryan,J.C., Fossum,S. and Dissen,E.
  TITLE     Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like
            natural killer-cell receptors with opposing signalling motifs
  JOURNAL   Immunogenetics 56 (11), 833-839 (2005)
   PUBMED   15650876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171002.2.
            
            On Sep 7, 2007 this sequence version replaced NP_001012538.1.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY324874.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849388, SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..248
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     Protein         1..248
                     /product="killer cell lectin-like receptor subfamily I
                     member 1"
                     /calculated_mol_wt=28511
     Region          16..21
                     /region_name="ITIM motif 1.
                     /evidence=ECO:0000250|UniProtKB:P27812"
                     /note="propagated from UniProtKB/Swiss-Prot (B2KG20.1)"
     Region          47..52
                     /region_name="ITIM motif 2.
                     /evidence=ECO:0000250|UniProtKB:P27812"
                     /note="propagated from UniProtKB/Swiss-Prot (B2KG20.1)"
     Site            81..101
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (B2KG20.1)"
     Region          132..245
                     /region_name="CLECT_NK_receptors_like"
                     /note="C-type lectin-like domain (CTLD) of the type found
                     in natural killer cell receptors (NKRs); cd03593"
                     /db_xref="CDD:153063"
     Site            order(186,213,230,232..233)
                     /site_type="other"
                     /note="ligand binding surface [chemical binding]"
                     /db_xref="CDD:153063"
     Site            197
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (B2KG20.1)"
     Site            214
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (B2KG20.1)"
     Site            220
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU00498; propagated
                     from UniProtKB/Swiss-Prot (B2KG20.1)"
     CDS             1..248
                     /gene="Klri1"
                     /coded_by="NM_001012520.3:244..990"
                     /db_xref="CCDS:CCDS20593.1"
                     /db_xref="GeneID:503550"
                     /db_xref="MGI:MGI:3530275"
ORIGIN      
        1 mlhskrreyt annqdvtyte lktckspwkh riptvkqspv vlceeqlkyg eltfhrtpqp
       61 qprkqamgrk rqgpkstvwr vvtgmlgalc vvlmtttgil lpklfssqee qcrktslhpl
      121 rcpkddascd lcssdwiafg nnfycvfken tktwaesqsa ceelnshlvi idskaevenl
      181 llfemdgwil hkmdgtnssw lwrndikiqn tltndsekkn hschylrgnl fmpdecsakk
      241 syicefni
//
