LOCUS       NM_016970               1374 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily G, member 1
            (Klrg1), mRNA.
ACCESSION   NM_016970
VERSION     NM_016970.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1374)
  AUTHORS   Burton,O.T., Bricard,O., Tareen,S., Gergelits,V., Andrews,S.,
            Biggins,L., Roca,C.P., Whyte,C., Junius,S., Brajic,A., Pasciuto,E.,
            Ali,M., Lemaitre,P., Schlenner,S.M., Ishigame,H., Brown,B.D.,
            Dooley,J. and Liston,A.
  TITLE     The tissue-resident regulatory T cell pool is shaped by transient
            multi-tissue migration and a conserved residency program
  JOURNAL   Immunity 57 (7), 1586-1602 (2024)
   PUBMED   38897202
REFERENCE   2  (bases 1 to 1374)
  AUTHORS   Gurram,R.K., Wei,D., Yu,Q., Butcher,M.J., Chen,X., Cui,K., Hu,G.,
            Zheng,M., Zhu,X., Oh,J., Sun,B., Urban,J.F. Jr., Zhao,K.,
            Leonard,W.J. and Zhu,J.
  TITLE     Crosstalk between ILC2s and Th2 cells varies among mouse models
  JOURNAL   Cell Rep 42 (2), 112073 (2023)
   PUBMED   36735533
REFERENCE   3  (bases 1 to 1374)
  AUTHORS   Yu,M., Su,Z., Huang,X. and Wang,X.
  TITLE     Single-Cell Sequencing Reveals the Novel Role of Ezh2 in NK Cell
            Maturation and Function
  JOURNAL   Front Immunol 12, 724276 (2021)
   PUBMED   34764950
  REMARK    GeneRIF: Single-Cell Sequencing Reveals the Novel Role of Ezh2 in
            NK Cell Maturation and Function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1374)
  AUTHORS   Tata,A., Dodard,G., Fugere,C., Leget,C., Ors,M., Rossi,B.,
            Vivier,E. and Brossay,L.
  TITLE     Combination blockade of KLRG1 and PD-1 promotes immune control of
            local and disseminated cancers
  JOURNAL   Oncoimmunology 10 (1), 1933808 (2021)
   PUBMED   34188973
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1374)
  AUTHORS   Hochheiser,K., Wiede,F., Wagner,T., Freestone,D., Enders,M.H.,
            Olshansky,M., Russ,B., Nussing,S., Bawden,E., Braun,A., Bachem,A.,
            Gressier,E., McConville,R., Park,S.L., Jones,C.M., Davey,G.M.,
            Gyorki,D.E., Tscharke,D., Parish,I.A., Turner,S., Herold,M.J.,
            Tiganis,T., Bedoui,S. and Gebhardt,T.
  TITLE     Ptpn2 and KLRG1 regulate the generation and function of
            tissue-resident memory CD8+ T cells in skin
  JOURNAL   J Exp Med 218 (6) (2021)
   PUBMED   33914023
  REMARK    GeneRIF: Ptpn2 and KLRG1 regulate the generation and function of
            tissue-resident memory CD8+ T cells in skin.
REFERENCE   6  (bases 1 to 1374)
  AUTHORS   Robbins,S.H., Nguyen,K.B., Takahashi,N., Mikayama,T., Biron,C.A.
            and Brossay,L.
  TITLE     Cutting edge: inhibitory functions of the killer cell lectin-like
            receptor G1 molecule during the activation of mouse NK cells
  JOURNAL   J Immunol 168 (6), 2585-2589 (2002)
   PUBMED   11884419
  REMARK    GeneRIF: Both pathogenic and nonpathogenic in vivo activation of NK
            cells induces cell surface expression of KLRG1, while in vitro
            studies show that engagement of the receptor on a transfected NK
            cell line inhibits cytokine production and cell-mediated
            cytoxicity.
REFERENCE   7  (bases 1 to 1374)
  AUTHORS   Voehringer,D., Kaufmann,M. and Pircher,H.
  TITLE     Genomic structure, alternative splicing, and physical mapping of
            the killer cell lectin-like receptor G1 gene (KLRG1), the mouse
            homologue of MAFA
  JOURNAL   Immunogenetics 52 (3-4), 206-211 (2001)
   PUBMED   11220622
REFERENCE   8  (bases 1 to 1374)
  AUTHORS   Corral,L., Hanke,T., Vance,R.E., Cado,D. and Raulet,D.H.
  TITLE     NK cell expression of the killer cell lectin-like receptor G1
            (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I
            molecules
  JOURNAL   Eur J Immunol 30 (3), 920-930 (2000)
   PUBMED   10741410
REFERENCE   9  (bases 1 to 1374)
  AUTHORS   Blaser,C., Kaufmann,M. and Pircher,H.
  TITLE     Virus-activated CD8 T cells and lymphokine-activated NK cells
            express the mast cell function-associated antigen, an inhibitory
            C-type lectin
  JOURNAL   J Immunol 161 (12), 6451-6454 (1998)
   PUBMED   9862665
REFERENCE   10 (bases 1 to 1374)
  AUTHORS   Hanke,T., Corral,L., Vance,R.E. and Raulet,D.H.
  TITLE     2F1 antigen, the mouse homolog of the rat 'mast cell
            function-associated antigen', is a lectin-like type II
            transmembrane receptor expressed by natural killer cells
  JOURNAL   Eur J Immunol 28 (12), 4409-4417 (1998)
   PUBMED   9862378
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF097357.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF097357.1, BC103546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C.B-17 SCID"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.52 cM"
     gene            1..1374
                     /gene="Klrg1"
                     /gene_synonym="2F1-Ag; MAFA; MAFA-L"
                     /note="killer cell lectin-like receptor subfamily G,
                     member 1"
                     /db_xref="GeneID:50928"
                     /db_xref="MGI:MGI:1355294"
     exon            1..104
                     /gene="Klrg1"
                     /gene_synonym="2F1-Ag; MAFA; MAFA-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..589
                     /gene="Klrg1"
                     /gene_synonym="2F1-Ag; MAFA; MAFA-L"
                     /note="mast cell function-associated antigen 2F1"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily G
                     member 1"
                     /protein_id="NP_058666.1"
                     /db_xref="CCDS:CCDS20492.1"
                     /db_xref="GeneID:50928"
                     /db_xref="MGI:MGI:1355294"
                     /translation="MADSSIYSTLELPEAPQVQDESRWKLKAVLHRPHLSRFAMVALG
                     LLTVILMSLLMYQRILCCGSKDSTCSHCPSCPILWTRNGSHCYYFSMEKKDWNSSLKF
                     CADKGSHLLTFPDNQGVKLFGEYLGQDFYWIGLRNIDGWRWEGGPALSLRILTNSLIQ
                     RCGAIHRNGLQASSCEVALQWICKKVLY"
     exon            105..209
                     /gene="Klrg1"
                     /gene_synonym="2F1-Ag; MAFA; MAFA-L"
                     /inference="alignment:Splign:2.1.0"
     exon            210..379
                     /gene="Klrg1"
                     /gene_synonym="2F1-Ag; MAFA; MAFA-L"
                     /inference="alignment:Splign:2.1.0"
     exon            380..477
                     /gene="Klrg1"
                     /gene_synonym="2F1-Ag; MAFA; MAFA-L"
                     /inference="alignment:Splign:2.1.0"
     exon            478..1365
                     /gene="Klrg1"
                     /gene_synonym="2F1-Ag; MAFA; MAFA-L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrg1"
                     /gene_synonym="2F1-Ag; MAFA; MAFA-L"
                     /note="hexamer: ATTAAA"
     polyA_site      1365
                     /gene="Klrg1"
                     /gene_synonym="2F1-Ag; MAFA; MAFA-L"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgaaagg gatttggtag agatggctga cagctctatc tattcaacac tagagctgcc
       61 ggaggcacct caagtccaag atgagtccag atggaagctc aaagctgtct tacaccggcc
      121 ccatctttcc cgctttgcaa tggtggcttt ggggcttttg actgtgattc tcatgagtct
      181 actgatgtat caacggatcc tgtgctgcgg ctccaaggac tctacatgtt cccactgccc
      241 cagctgcccc atcctctgga cgaggaatgg tagccactgt tactattttt caatggagaa
      301 aaaggactgg aattctagtc tgaaattctg tgcagacaaa ggctcacatc tccttacatt
      361 tccggacaac cagggagtga agctgtttgg agagtacctg ggtcaggact tttactggat
      421 cggcttgagg aacattgatg gctggaggtg ggaaggcggc ccagcgctca gcttgaggat
      481 tcttaccaac agcttgatac agaggtgcgg tgccattcac agaaatggcc tccaagcctc
      541 cagttgtgaa gttgctttgc agtggatctg taagaaggtc ctatactgat ggatgccact
      601 gtgtcctgag cctcggatct gccacatgtc tttaaaaaga gggaatgggt ctggggaatc
      661 tttgtctaca aatgtgtgtt taacaaatgc caaacctgtt atgatatgcc attagacaga
      721 ggattagcat acctttctgg gggttggcct tttcctgttg ggctttttcc gcgactgttt
      781 aagtattagg ctagccattt aaagcctaaa tctgggcaaa tgaaatggat aaagtttatt
      841 ttaatggata cccaccctgc agatagccac cctggctctc tcatcccttc ctctgccatc
      901 tctgtcaaag atatgtagaa aactattcat cctcagaaga atgaacccct gccgcattca
      961 gtaacacgtt ccatagacat caacaagaca gaaagacgca aacacctcat gtgctcactc
     1021 ctgcttggga gctgaccgag cttgtgcctg agctgtaggg agaagtgcag tggttaccgg
     1081 agtccagagt gatggggtgg gtggtagagc ttaggtaatg gtttggctgg tgtggggtga
     1141 caataacgat caataatagt tgtatggttg ccaatttatt gtgagcttcc aaatagctag
     1201 gcggaaggac tgtgggtgct tccgaatgcc tgaaggacag gtatgctgag cacgccgact
     1261 ggatcatttt ccacccacac tgaagtatca cactgtgcct cataaatgtg tacaatcact
     1321 atctctccat gaaaattaaa gaagtcacaa ttaaaacgaa aaaaaaaaaa aaaa
//
