LOCUS       NM_153590                927 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus killer cell lectin-like receptor family E member 1
            (Klre1), transcript variant 1, mRNA.
ACCESSION   NM_153590
VERSION     NM_153590.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 927)
  AUTHORS   Saether,P.C., Westgaard,I.H., Hoelsbrekken,S.E., Benjamin,J.,
            Lanier,L.L., Fossum,S. and Dissen,E.
  TITLE     KLRE/I1 and KLRE/I2: a novel pair of heterodimeric receptors that
            inversely regulate NK cell cytotoxicity
  JOURNAL   J Immunol 181 (5), 3177-3182 (2008)
   PUBMED   18713988
REFERENCE   2  (bases 1 to 927)
  AUTHORS   Shimizu,E., Koike,J., Wakao,H., Seino,K., Koseki,H., Kakiuchi,T.,
            Nakayama,T. and Taniguchi,M.
  TITLE     Role of a NK receptor, KLRE-1, in bone marrow allograft rejection:
            analysis with KLRE-1-deficient mice
  JOURNAL   Blood 104 (3), 781-783 (2004)
   PUBMED   15069013
  REMARK    GeneRIF: mediates recognition and rejection of allogeneic target
            cells in the host immune system
REFERENCE   3  (bases 1 to 927)
  AUTHORS   Koike,J., Wakao,H., Ishizuka,Y., Sato,T.A., Hamaoki,M., Seino,K.,
            Koseki,H., Nakayama,T. and Taniguchi,M.
  TITLE     Bone marrow allograft rejection mediated by a novel murine NK
            receptor, NKG2I
  JOURNAL   J Exp Med 199 (1), 137-144 (2004)
   PUBMED   14707119
  REMARK    Erratum:[J Exp Med. 2004 Feb 2;199(3):following 434]
REFERENCE   4  (bases 1 to 927)
  AUTHORS   Westgaard,I.H., Dissen,E., Torgersen,K.M., Lazetic,S., Lanier,L.L.,
            Phillips,J.H. and Fossum,S.
  TITLE     The lectin-like receptor KLRE1 inhibits natural killer cell
            cytotoxicity
  JOURNAL   J Exp Med 197 (11), 1551-1561 (2003)
   PUBMED   12782717
  REMARK    GeneRIF: cloning and functional characterization of a novel natural
            killer (NK) cell receptor termed KLRE1
REFERENCE   5  (bases 1 to 927)
  AUTHORS   Wilhelm,B.T. and Mager,D.L.
  TITLE     Identification of a new murine lectin-like gene in close proximity
            to CD94
  JOURNAL   Immunogenetics 55 (1), 53-56 (2003)
   PUBMED   12715246
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF306663.1, BG145575.1 and BX518942.1.
            
            On May 3, 2007 this sequence version replaced NM_153590.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY100458.1, AF306663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AF306663.1         1-218
            219-371             BG145575.1         197-349
            372-897             AF306663.1         372-897
            898-927             BX518942.1         476-505
FEATURES             Location/Qualifiers
     source          1..927
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.41 cM"
     gene            1..927
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /note="killer cell lectin-like receptor family E member 1"
                     /db_xref="GeneID:243655"
                     /db_xref="MGI:MGI:2662547"
     exon            1..80
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /inference="alignment:Splign:2.1.0"
     exon            81..280
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..780
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /note="isoform 1 is encoded by transcript variant 1;
                     killer cell lectin-like receptor subfamily E member 1"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily E
                     member 1 isoform 1"
                     /protein_id="NP_705818.3"
                     /db_xref="CCDS:CCDS20589.1"
                     /db_xref="GeneID:243655"
                     /db_xref="MGI:MGI:2662547"
                     /translation="MDEAPVTRSTLNVNSQQKSKAKNKIKNTLNSNELSSIEQRKKYQ
                     KHLKKHKNTAEDISGKGNCSPPWRLLSSVLGAMCLLLMAVAMVMTTFTTKSSSERSSS
                     TIQQEGLHHPCPENWVWFRCSCYFFSKEELIWRDSQRACLSLNSSLIRMNKEEMNFFS
                     LKSFFWVGVYYNETRRQWLWEDHSVLPSGLFSKLEANMKNFCASYKSKEAYMEENCAN
                     KLTYICKK"
     exon            281..382
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /inference="alignment:Splign:2.1.0"
     exon            383..421
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /inference="alignment:Splign:2.1.0"
     exon            422..567
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /inference="alignment:Splign:2.1.0"
     exon            568..668
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /inference="alignment:Splign:2.1.0"
     exon            669..913
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      892..897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /note="hexamer: AATAAA"
     polyA_site      913
                     /gene="Klre1"
                     /gene_synonym="Klre-1; NKG2I"
                     /note="major polyA site"
ORIGIN      
        1 acatatcctg ctccagaccc tgctgattag cacatattaa agttttaaca tctgtgcctg
       61 gaattccctc tttgcttcag catttttgtc tttataaaga tggatgaagc acctgtaacc
      121 cgttctaccc taaatgtgaa ttcccagcag aagagtaaag caaagaacaa gattaagaat
      181 acacttaatt caaatgaatt gtcatccatt gagcagagga aaaaatacca gaaacatctt
      241 aagaagcaca aaaacacagc agaagacatc agtggtaaag ggaattgctc acctccatgg
      301 aggcttctct cgagtgtgct cggtgccatg tgccttctcc tgatggctgt agccatggtg
      361 atgaccactt ttaccacaaa gtcatcttct gaaagatcat cttctactat tcagcaagaa
      421 gggctccatc atccctgtcc agagaactgg gtctggttca ggtgcagctg ttatttcttc
      481 tccaaggaag agctaatttg gagagacagt cagcgtgcct gcttgtctct taactccagt
      541 ctcataagga tgaacaaaga ggaaatgaat ttcttctctt tgaagtcttt cttttgggtt
      601 ggagtttact ataatgaaac tcgcagacag tggctgtggg aagaccattc ggttctaccc
      661 tctgggctgt tttctaaact tgaagctaat atgaaaaact tctgtgcatc ttataaatca
      721 aaagaagctt atatggaaga aaactgtgcg aacaaactga catatatttg caagaagtag
      781 catatttaat tctatgagtt catgaaatat atgaaaatta atctttttta acattttttc
      841 ctggagtgct tattttatga agaaaatgtg acaaatattt gcctttgctt aaataaaact
      901 gtattcaaat ataaaaaaaa aaaaaaa
//
