LOCUS       NM_010654                867 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily D, member
            1 (Klrd1), mRNA.
ACCESSION   NM_010654
VERSION     NM_010654.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 867)
  AUTHORS   Ferez,M., Knudson,C.J., Lev,A., Wong,E.B., Alves-Peixoto,P.,
            Tang,L., Stotesbury,C. and Sigal,L.J.
  TITLE     Viral infection modulates Qa-1b in infected and bystander cells to
            properly direct NK cell killing
  JOURNAL   J Exp Med 218 (5) (2021)
   PUBMED   33765134
REFERENCE   2  (bases 1 to 867)
  AUTHORS   Dupont,M.S.J., Guillemot,V., Campagne,P., Serafini,N., Marie,S.,
            Montagutelli,X., Di Santo,J.P. and Vosshenrich,C.A.J.
  TITLE     Host genetic control of natural killer cell diversity revealed in
            the Collaborative Cross
  JOURNAL   Proc Natl Acad Sci U S A 118 (10) (2021)
   PUBMED   33649222
REFERENCE   3  (bases 1 to 867)
  AUTHORS   Knutsen,L.E., Dissen,E., Saether,P.C., Bjornsen,E.G., Pialek,J.,
            Storset,A.K. and Boysen,P.
  TITLE     Evidence of functional Cd94 polymorphism in a free-living house
            mouse population
  JOURNAL   Immunogenetics 71 (4), 321-333 (2019)
   PUBMED   30535636
  REMARK    GeneRIF: Data suggest that the Cd94(LocA)/NKG2A receptor (NKG2A)
            heterodimeric receptor is widely expressed among M. musculus
            subspecies musculus.
REFERENCE   4  (bases 1 to 867)
  AUTHORS   Shin,D.L., Pandey,A.K., Ziebarth,J.D., Mulligan,M.K.,
            Williams,R.W., Geffers,R., Hatesuer,B., Schughart,K. and Wilk,E.
  TITLE     Segregation of a spontaneous Klrd1 (CD94) mutation in DBA/2 mouse
            substrains
  JOURNAL   G3 (Bethesda) 5 (2), 235-239 (2014)
   PUBMED   25520036
  REMARK    GeneRIF: Segregation of a spontaneous Klrd1 mutation in DBA/2 mouse
            substrains
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 867)
  AUTHORS   Zeng,L., Sullivan,L.C., Vivian,J.P., Walpole,N.G., Harpur,C.M.,
            Rossjohn,J., Clements,C.S. and Brooks,A.G.
  TITLE     A structural basis for antigen presentation by the MHC class Ib
            molecule, Qa-1b
  JOURNAL   J Immunol 188 (1), 302-310 (2012)
   PUBMED   22131332
REFERENCE   6  (bases 1 to 867)
  AUTHORS   Idris,A.H., Scalzo,A.A. and Yokoyama,W.M.
  TITLE     Close genetic linkage of Chok with the NKC-linked loci Cd94, Ly49,
            and Cmv1 on mouse chromosome 6
  JOURNAL   Immunogenetics 49 (10), 906-908 (1999)
   PUBMED   10436186
REFERENCE   7  (bases 1 to 867)
  AUTHORS   Brown,M.G., Zhang,J., Du,Y., Stoll,J., Yokoyama,W.M. and
            Scalzo,A.A.
  TITLE     Localization on a physical map of the NKC-linked Cmv1 locus between
            Ly49b and the Prp gene cluster on mouse chromosome 6
  JOURNAL   J Immunol 163 (4), 1991-1999 (1999)
   PUBMED   10438936
REFERENCE   8  (bases 1 to 867)
  AUTHORS   Scalzo,A.A., Brown,M.G., Chu,D.T., Heusel,J.W., Yokoyama,W.M. and
            Forbes,C.A.
  TITLE     Development of intra-natural killer complex (NKC) recombinant and
            congenic mouse strains for mapping and functional analysis of NK
            cell regulatory loci
  JOURNAL   Immunogenetics 49 (3), 238-241 (1999)
   PUBMED   9914339
REFERENCE   9  (bases 1 to 867)
  AUTHORS   Ho,E.L., Heusel,J.W., Brown,M.G., Matsumoto,K., Scalzo,A.A. and
            Yokoyama,W.M.
  TITLE     Murine Nkg2d and Cd94 are clustered within the natural killer
            complex and are expressed independently in natural killer cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6320-6325 (1998)
   PUBMED   9600963
REFERENCE   10 (bases 1 to 867)
  AUTHORS   Vance,R.E., Tanamachi,D.M., Hanke,T. and Raulet,D.H.
  TITLE     Cloning of a mouse homolog of CD94 extends the family of C-type
            lectins on murine natural killer cells
  JOURNAL   Eur J Immunol 27 (12), 3236-3241 (1997)
   PUBMED   9464811
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK162976.1 and AK136548.1.
            
            On Feb 24, 2018 this sequence version replaced NM_010654.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136548.1, AF030312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AK162976.1         2-2
            2-867               AK136548.1         2-867
FEATURES             Location/Qualifiers
     source          1..867
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.42 cM"
     gene            1..867
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /note="killer cell lectin-like receptor, subfamily D,
                     member 1"
                     /db_xref="GeneID:16643"
                     /db_xref="MGI:MGI:1196275"
     exon            1..28
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..561
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /codon_start=1
                     /product="natural killer cells antigen CD94"
                     /protein_id="NP_034784.1"
                     /db_xref="CCDS:CCDS57456.1"
                     /db_xref="GeneID:16643"
                     /db_xref="MGI:MGI:1196275"
                     /translation="MAVSRITRWRLMSVIFGIKCLFLMVTLGVLLINSFTIQNIQSTP
                     SPTTTVEFQEVSECCVCLDKWVGHQCNCYFISKEEKSWKRSRDFCASQNSSLLQPQSR
                     NELSFMNFSQTFFWIGMHYSEKRNAWLWEDGTVPSKDLFPEFSVIRPEHCIVYSPSKS
                     VSAESCENKNRYICKKLPI"
     exon            29..121
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     exon            122..184
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     exon            185..336
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     exon            337..440
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     exon            441..867
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /inference="alignment:Splign:2.1.0"
     regulatory      843..848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /note="hexamer: AATAAA"
     polyA_site      864
                     /gene="Klrd1"
                     /gene_synonym="CD94"
                     /note="major polyA site"
ORIGIN      
        1 atccttggaa catcacttct catggcagtt tctaggatca ctcggtggag actgatgtct
       61 gtcatctttg gaataaaatg tcttttcttg atggttactt tgggagtttt gctgataaat
      121 tcatttacta tacagaacat tcaatcaaca ccttctccaa ccaccactgt agaattccag
      181 gaagtttctg aatgctgtgt ttgcctggac aagtgggttg ggcatcagtg caattgttac
      241 tttatttcca aagaagaaaa gtcttggaaa agaagcagag atttctgtgc ttcgcagaat
      301 tccagccttc ttcagcccca atccagaaat gaattgagtt ttatgaactt cagtcaaacc
      361 tttttctgga ttggaatgca ttatagtgaa aaaagaaatg cctggctatg ggaggatggc
      421 acagttccct caaaagattt atttccagaa ttctcagtta tcaggccaga gcactgcatt
      481 gtttacagtc caagcaaaag cgtttctgct gaatcctgtg aaaataaaaa ccgttacatc
      541 tgtaagaaac tgcctattta aatgtttctt aaggcaaagg gtatagacaa ggaaggtcca
      601 cggttactaa aaatagtaac agctctcaat attactacct ttccatcttg tgtctgtaga
      661 atgtttttgt ttggtagtat ataattctca tacatttgta cccaagtaat ttatacttga
      721 tggcttcttc acacgtgtgc ataaagttca gatgaagcaa aaatagagag gttttataaa
      781 tattttgact tatgaaatat aattttattc aatattcctg taaagttttc ttggaaacat
      841 taaataaaat ttattctaca ccaagtc
//
