LOCUS       NM_021378                666 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily C, member 3
            (Klrc3), mRNA.
ACCESSION   NM_021378
VERSION     NM_021378.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 666)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 666)
  AUTHORS   Ferez,M., Knudson,C.J., Lev,A., Wong,E.B., Alves-Peixoto,P.,
            Tang,L., Stotesbury,C. and Sigal,L.J.
  TITLE     Viral infection modulates Qa-1b in infected and bystander cells to
            properly direct NK cell killing
  JOURNAL   J Exp Med 218 (5) (2021)
   PUBMED   33765134
REFERENCE   3  (bases 1 to 666)
  AUTHORS   Orr,M.T., Wu,J., Fang,M., Sigal,L.J., Spee,P., Egebjerg,T.,
            Dissen,E., Fossum,S., Phillips,J.H. and Lanier,L.L.
  TITLE     Development and function of CD94-deficient natural killer cells
  JOURNAL   PLoS One 5 (12), e15184 (2010)
   PUBMED   21151939
  REMARK    GeneRIF: expression of CD94 and its associated NKG2A, NKG2C, and
            NKG2E subunits is dispensable for NK cell development, education,
            and many NK cell functions
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 666)
  AUTHORS   Kaiser,B.K., Pizarro,J.C., Kerns,J. and Strong,R.K.
  TITLE     Structural basis for NKG2A/CD94 recognition of HLA-E
  JOURNAL   Proc Natl Acad Sci U S A 105 (18), 6696-6701 (2008)
   PUBMED   18448674
REFERENCE   5  (bases 1 to 666)
  AUTHORS   Koike,J., Wakao,H., Ishizuka,Y., Sato,T.A., Hamaoki,M., Seino,K.,
            Koseki,H., Nakayama,T. and Taniguchi,M.
  TITLE     Bone marrow allograft rejection mediated by a novel murine NK
            receptor, NKG2I
  JOURNAL   J Exp Med 199 (1), 137-144 (2004)
   PUBMED   14707119
  REMARK    Erratum:[J Exp Med. 2004 Feb 2;199(3):following 434]
REFERENCE   6  (bases 1 to 666)
  AUTHORS   Vance,R.E., Jamieson,A.M. and Raulet,D.H.
  TITLE     Recognition of the class Ib molecule Qa-1(b) by putative activating
            receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells
  JOURNAL   J Exp Med 190 (12), 1801-1812 (1999)
   PUBMED   10601355
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF195779.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF195779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..666
                     /gene="Klrc3"
                     /gene_synonym="Klrc2; Nkg2e"
                     /note="killer cell lectin-like receptor subfamily C,
                     member 3"
                     /db_xref="GeneID:58179"
                     /db_xref="MGI:MGI:1929720"
     CDS             1..666
                     /gene="Klrc3"
                     /gene_synonym="Klrc2; Nkg2e"
                     /note="forms CD94/NKG2E heterodimer which is a receptor
                     for the nonclassical major histocompatibility complex
                     class Ib molecule Qa-1(b); natural killer cell group 2E
                     cell receptor; killer cell lectin-like receptor subfamily
                     C, member 2"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily C,
                     member 3"
                     /protein_id="NP_067353.1"
                     /db_xref="CCDS:CCDS20591.1"
                     /db_xref="GeneID:58179"
                     /db_xref="MGI:MGI:1929720"
                     /translation="MSHLLGTEQASEPRKATKKTQAQLRFSNAAGDRLLEFSLQHASQ
                     KHLKASRHGYCKNFASPPEKLIAGILGTIWFTLLIALVISTRIVSPYINHSLSSAQTY
                     ALCPKEWILYSHNCYYIGMERKSWNDSLVSCISKNCSLLYIDSEEEQDFLQSLSLVSW
                     TGILRKGRGQPWVWKKDSTFKPKIAEILHDECNCAMMSASGLTADSCTTLHPYLCKCK
                     FPI"
     exon            1..169
                     /gene="Klrc3"
                     /gene_synonym="Klrc2; Nkg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            170..271
                     /gene="Klrc3"
                     /gene_synonym="Klrc2; Nkg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            272..447
                     /gene="Klrc3"
                     /gene_synonym="Klrc2; Nkg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            448..548
                     /gene="Klrc3"
                     /gene_synonym="Klrc2; Nkg2e"
                     /inference="alignment:Splign:2.1.0"
     exon            549..666
                     /gene="Klrc3"
                     /gene_synonym="Klrc2; Nkg2e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtcacc tgcttggaac tgaacaggcc tcagaaccca ggaaagccac aaagaaaacc
       61 caggcgcagc tccgtttcag taatgcagca ggagatcgcc tgctggagtt tagccttcaa
      121 catgcttccc agaagcatct gaaggccagc aggcatggct actgcaaaaa ttttgcatca
      181 cctccagaga agctcatcgc tggaatcctg ggcaccatct ggtttacctt attgattgct
      241 ctagtaatct caaccagaat tgtttctcca tatataaacc acagtctatc ttcagcacaa
      301 acttatgctc tttgtccaaa ggaatggatc ttatattctc acaattgtta ttacattggc
      361 atggaaagaa aatcttggaa tgacagtttg gtgtcctgca tttccaaaaa ctgtagtctg
      421 ctttatatag acagtgaaga ggagcaggac tttctgcaat ccctttcact ggtctcatgg
      481 actggaatcc ttcggaaggg cagaggtcag ccctgggtct ggaaaaaaga ctcaactttc
      541 aaaccaaaga tagcagagat tctccatgat gaatgtaact gtgccatgat gtcagcttct
      601 ggtctcacag cagacagctg tacaacttta catccatatc tttgtaagtg taaattcccc
      661 atctga
//
