LOCUS       NM_010653                717 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily C, member 2
            (Klrc2), transcript variant 1, mRNA.
ACCESSION   NM_010653
VERSION     NM_010653.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 717)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 717)
  AUTHORS   Ferez,M., Knudson,C.J., Lev,A., Wong,E.B., Alves-Peixoto,P.,
            Tang,L., Stotesbury,C. and Sigal,L.J.
  TITLE     Viral infection modulates Qa-1b in infected and bystander cells to
            properly direct NK cell killing
  JOURNAL   J Exp Med 218 (5) (2021)
   PUBMED   33765134
REFERENCE   3  (bases 1 to 717)
  AUTHORS   Saether,P.C., Hoelsbrekken,S.E., Fossum,S. and Dissen,E.
  TITLE     Rat and mouse CD94 associate directly with the activating
            transmembrane adaptor proteins DAP12 and DAP10 and activate NK cell
            cytotoxicity
  JOURNAL   J Immunol 187 (12), 6365-6373 (2011)
   PUBMED   22084441
  REMARK    GeneRIF: Rat and mouse CD94/NKG2C heterodimers bind efficiently to
            both adadptor proteins DAP12 and DAP10; this binding activity is
            critically dependent on the transmembrane lysine residue of CD94.
REFERENCE   4  (bases 1 to 717)
  AUTHORS   Kaiser,B.K., Pizarro,J.C., Kerns,J. and Strong,R.K.
  TITLE     Structural basis for NKG2A/CD94 recognition of HLA-E
  JOURNAL   Proc Natl Acad Sci U S A 105 (18), 6696-6701 (2008)
   PUBMED   18448674
REFERENCE   5  (bases 1 to 717)
  AUTHORS   Vance,R.E., Jamieson,A.M. and Raulet,D.H.
  TITLE     Recognition of the class Ib molecule Qa-1(b) by putative activating
            receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells
  JOURNAL   J Exp Med 190 (12), 1801-1812 (1999)
   PUBMED   10601355
REFERENCE   6  (bases 1 to 717)
  AUTHORS   Silver,E.T., Lau,J.C. and Kane,K.P.
  TITLE     Molecular cloning of mouse NKG2A and C
  JOURNAL   Immunogenetics 49 (7-8), 727-730 (1999)
   PUBMED   10369936
REFERENCE   7  (bases 1 to 717)
  AUTHORS   Lohwasser,S., Hande,P., Mager,D.L. and Takei,F.
  TITLE     Cloning of murine NKG2A, B and C: second family of C-type lectin
            receptors on murine NK cells
  JOURNAL   Eur J Immunol 29 (3), 755-761 (1999)
   PUBMED   10092077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF109785.1.
            
            On Jun 16, 2007 this sequence version replaced NM_010653.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform (1,
            also known as NKG2C1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF109785.1, AF106010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..717
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..717
                     /gene="Klrc2"
                     /gene_synonym="NKG2C"
                     /note="killer cell lectin-like receptor subfamily C,
                     member 2"
                     /db_xref="GeneID:16642"
                     /db_xref="MGI:MGI:1336162"
     CDS             1..717
                     /gene="Klrc2"
                     /gene_synonym="NKG2C"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily C,
                     member 2 isoform 1"
                     /protein_id="NP_034783.3"
                     /db_xref="CCDS:CCDS51925.1"
                     /db_xref="GeneID:16642"
                     /db_xref="MGI:MGI:1336162"
                     /translation="MSHLLGTEQASEPRKATKKTQAQFRFSNAAGDRLLEFSLQHASQ
                     KHLKASRHGYCKNFASPPEKLIAGILGTIWFTLLIALVISTRIVSPYAELKKQIHPFL
                     VRTQKGSHALLSKAQPCPHCPKEWISYSHNCYFIGMERKSWNDSLGSCLSKNCSLLHI
                     DSEEEQDFLQSLSLVSWTGILRKGRGQAWDWKKDSIFKPKIAEISHDECNCAMMSASG
                     LTADNCTTLHPYLCKCKFPI"
     exon            1..169
                     /gene="Klrc2"
                     /gene_synonym="NKG2C"
                     /inference="alignment:Splign:2.1.0"
     exon            170..271
                     /gene="Klrc2"
                     /gene_synonym="NKG2C"
                     /inference="alignment:Splign:2.1.0"
     exon            272..346
                     /gene="Klrc2"
                     /gene_synonym="NKG2C"
                     /inference="alignment:Splign:2.1.0"
     exon            347..498
                     /gene="Klrc2"
                     /gene_synonym="NKG2C"
                     /inference="alignment:Splign:2.1.0"
     exon            499..599
                     /gene="Klrc2"
                     /gene_synonym="NKG2C"
                     /inference="alignment:Splign:2.1.0"
     exon            600..717
                     /gene="Klrc2"
                     /gene_synonym="NKG2C"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagtcacc tgcttggaac tgaacaggcc tcagaaccca ggaaagccac aaagaaaacc
       61 caggcgcagt tccgtttcag taatgcagca ggagatcgcc tgctggagtt tagccttcaa
      121 catgcttccc agaagcatct gaaggccagc aggcatggct actgcaaaaa ttttgcatca
      181 cctccagaga agctcatcgc tggaatcctg ggcaccatct ggtttacctt attgattgct
      241 ctagtaatct caaccagaat tgtttctcca tatgctgaac tgaagaagca gatccacccc
      301 ttcttggtta gaacccagaa aggctcacac gccttgctct ccaaagcaca gccttgtcct
      361 cattgtccaa aggagtggat atcatattct cacaattgtt atttcattgg tatggagaga
      421 aaatcttgga atgacagttt ggggtcctgc ctttccaaaa actgtagtct gcttcacata
      481 gatagtgaag aggagcagga ttttctgcaa tctctttcac tggtctcatg gactggaatc
      541 cttcggaagg gcagaggtca ggcctgggac tggaaaaaag actcaatttt caaaccaaag
      601 atagcagaga tttcccatga tgaatgtaac tgtgccatga tgtcagcttc tggtctcaca
      661 gcagacaact gtacaacttt acatccatat ctttgtaagt gtaaattccc catctga
//
