LOCUS       NM_001136068            1993 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily C, member 1
            (Klrc1), transcript variant 1, mRNA.
ACCESSION   NM_001136068
VERSION     NM_001136068.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   Middelburg,J., Ghaffari,S., Schoufour,T.A.W., Sluijter,M.,
            Schaap,G., Goynuk,B., Sala,B.M., Al-Tamimi,L., Scheeren,F.,
            Franken,K.L.M.C., Akkermans,J.J.L.L., Cabukusta,B., Joosten,S.A.,
            Derksen,I., Neefjes,J., van der Burg,S.H., Achour,A.,
            Wijdeven,R.H.M., Weidanz,J. and van Hall,T.
  TITLE     The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by
            inflammatory signals, whereas LILRB1/2 receptors are peptide
            indifferent
  JOURNAL   Cell Rep 42 (12), 113516 (2023)
   PUBMED   38048225
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Mac Donald,A., Guipouy,D., Lemieux,W., Harvey,M., Bordeleau,L.J.,
            Guay,D., Romero,H., Li,Y., Dion,R., Beland,K. and Haddad,E.
  TITLE     KLRC1 knockout overcomes HLA-E-mediated inhibition and improves NK
            cell antitumor activity against solid tumors
  JOURNAL   Front Immunol 14, 1231916 (2023)
   PUBMED   37675109
  REMARK    GeneRIF: KLRC1 knockout overcomes HLA-E-mediated inhibition and
            improves NK cell antitumor activity against solid tumors.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Battaglia,N.G., Murphy,J.D., Uccello,T.P., Hughson,A., Gavras,N.W.,
            Caldon,J.J., Gerber,S.A. and Lord,E.M.
  TITLE     Combination of NKG2A and PD-1 Blockade Improves Radiotherapy
            Response in Radioresistant Tumors
  JOURNAL   J Immunol 209 (3), 629-640 (2022)
   PUBMED   35840162
  REMARK    GeneRIF: Combination of NKG2A and PD-1 Blockade Improves
            Radiotherapy Response in Radioresistant Tumors.
REFERENCE   5  (bases 1 to 1993)
  AUTHORS   Shreeve,N., Depierreux,D., Hawkes,D., Traherne,J.A., Sovio,U.,
            Huhn,O., Jayaraman,J., Horowitz,A., Ghadially,H., Perry,J.R.B.,
            Moffett,A., Sled,J.G., Sharkey,A.M. and Colucci,F.
  TITLE     The CD94/NKG2A inhibitory receptor educates uterine NK cells to
            optimize pregnancy outcomes in humans and mice
  JOURNAL   Immunity 54 (6), 1231-1244 (2021)
   PUBMED   33887202
REFERENCE   6  (bases 1 to 1993)
  AUTHORS   Roda-Navarro,P., Arce,I., Renedo,M., Montgomery,K., Kucherlapati,R.
            and Fernandez-Ruiz,E.
  TITLE     Human KLRF1, a novel member of the killer cell lectin-like receptor
            gene family: molecular characterization, genomic structure,
            physical mapping to the NK gene complex and expression analysis
  JOURNAL   Eur J Immunol 30 (2), 568-576 (2000)
   PUBMED   10671213
REFERENCE   7  (bases 1 to 1993)
  AUTHORS   Vance,R.E., Jamieson,A.M. and Raulet,D.H.
  TITLE     Recognition of the class Ib molecule Qa-1(b) by putative activating
            receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells
  JOURNAL   J Exp Med 190 (12), 1801-1812 (1999)
   PUBMED   10601355
REFERENCE   8  (bases 1 to 1993)
  AUTHORS   Silver,E.T., Lau,J.C. and Kane,K.P.
  TITLE     Molecular cloning of mouse NKG2A and C
  JOURNAL   Immunogenetics 49 (7-8), 727-730 (1999)
   PUBMED   10369936
REFERENCE   9  (bases 1 to 1993)
  AUTHORS   Lohwasser,S., Hande,P., Mager,D.L. and Takei,F.
  TITLE     Cloning of murine NKG2A, B and C: second family of C-type lectin
            receptors on murine NK cells
  JOURNAL   Eur J Immunol 29 (3), 755-761 (1999)
   PUBMED   10092077
REFERENCE   10 (bases 1 to 1993)
  AUTHORS   Vance,R.E., Kraft,J.R., Altman,J.D., Jensen,P.E. and Raulet,D.H.
  TITLE     Mouse CD94/NKG2A is a natural killer cell receptor for the
            nonclassical major histocompatibility complex (MHC) class I
            molecule Qa-1(b)
  JOURNAL   J Exp Med 188 (10), 1841-1848 (1998)
   PUBMED   9815261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC171002.2 and AF106008.1.
            
            On Dec 27, 2013 this sequence version replaced NM_001136068.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF106008.1, AK138801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AC171002.2         101537-101573       c
            38-957              AF106008.1         1-920
            958-1974            AC171002.2         88625-89641         c
            1975-1993           AF106008.1         1938-1956
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1993
                     /gene="Klrc1"
                     /gene_synonym="CD159a; NKG2A; NKG2B"
                     /note="killer cell lectin-like receptor subfamily C,
                     member 1"
                     /db_xref="GeneID:16641"
                     /db_xref="MGI:MGI:1336161"
     exon            1..250
                     /gene="Klrc1"
                     /gene_synonym="CD159a; NKG2A; NKG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            251..352
                     /gene="Klrc1"
                     /gene_synonym="CD159a; NKG2A; NKG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            353..403
                     /gene="Klrc1"
                     /gene_synonym="CD159a; NKG2A; NKG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            404..579
                     /gene="Klrc1"
                     /gene_synonym="CD159a; NKG2A; NKG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            580..680
                     /gene="Klrc1"
                     /gene_synonym="CD159a; NKG2A; NKG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            681..823
                     /gene="Klrc1"
                     /gene_synonym="CD159a; NKG2A; NKG2B"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1984
                     /gene="Klrc1"
                     /gene_synonym="CD159a; NKG2A; NKG2B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctcctcc tttggcctca tcagattgtg tacctttgcc tcagcacatc actagctgca
       61 gacatgagta atgaacgcgt cacctatgca gaactgaagg tggcaaagaa ctcaaggaac
      121 cagcacagga aaccaagggg tcctcgcagc tccatttcag tcatcgagca ggaaatcatc
      181 tattcggact tcagctttca aaatccttct caggagcatc cctggatctg caggaattgc
      241 ccctgcaaag gttttccatc tcctccagag aaactcattg ctggtaccct gggcctcatc
      301 tgttttgtct taattgtcgc tgtggttgta attactacag ttgccacacc atataccgaa
      361 gcaaaggcac agatcaattc ctcaatgact agaacccaca gagatataaa ctacactcta
      421 tcttcagcac agccttgtcc tcattgtcca aaggagtgga tatcatattc tcacaattgt
      481 tatttcattg gtatggagag aaaatcttgg aatgacagtt tggtgtcctg catttccaaa
      541 aactgtagtc tgctttacat agatagtgaa gaggagcagg attttctgca atctctttca
      601 ctgatctcat ggactggaat ccttcggaag ggcagaggtc agccctgggt ctggaaagaa
      661 gactcaattt tcaaaccaaa gatagcagag attctccatg atgaatgtaa ctgtgccatg
      721 atgtcagctt ctggtctcac agcagacaac tgtacaactt tacatccata tctttgtaag
      781 tgtaaattcc ccatctgaaa cacctgcact ggaagtctgc cagatctctg gctcccttta
      841 gatgaatttg caactagaat ccaaaggatc atcagctttc tctaactgtc ctgttcgacg
      901 gtaacaaaca cagttattgt tacctataag aatgcctttt gaaagattat ggggaatttt
      961 tcattcagaa ggatggaagt ctctgtacat tcttctctga acaaaatcat cagagaacac
     1021 atttaatata ttcctattta tgtaattttg ttaaaaatct ttccaatgtt tattcttaat
     1081 tttgtcaaaa gtacaataac aaaattattg caaagtggtt tttagtctat atgctgtgat
     1141 tttgtaactc aatgtcatgc tggaaatatt tcttaagatg ctaattagta tttataagtg
     1201 gttataataa ttattgtgaa atttggtctg ttttagttgt gagcctagcc tttaacagct
     1261 gagtcatcta tccagtccaa attttggtca gttttgaatc tttttccaca taaaatagtt
     1321 ttattaaata ctttaatatt ttaatataaa ataaatttca aactaagaaa ttaacatttg
     1381 attttcagga atattaattg tttaagatct cctttatctt tttctagcta ttttaactaa
     1441 ggagcagaac attaaaccct aataaacccc aaaaaggtac acaataattt tcaaagttcc
     1501 agtgtttgca caggtttaac tttgtcttga tctcagccta ggcaaaagtg attgtgactt
     1561 tcaaaggaaa tgaaccaaag aatcagtcaa tgaatcttca caaatatttt acaaaaacat
     1621 gtattcttgt acaatattca aagaacatgc ttaaggtcaa actgtccatt ggtatcaatc
     1681 acctcaaaat ttgctactgt tgttataaga caagatttaa atactttttc ctgtttcaca
     1741 gaatgacttc tgtgcagaga ctatttagaa catgtatagg atgagatttt gcttgttttc
     1801 ttcatatgca catagatttg gggatgagtg cctgactttt tctatgtata tatttattag
     1861 tgtgtgggct gttttatttg taacaggcta caagaatgca tgtctataat ttgtatgtgc
     1921 ctgattatac ctgtgcaaag atacgaagtc attattaaat accaatgctg cttctgagac
     1981 aaaaaaaaaa aaa
//
