LOCUS       NM_153094               1708 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily B member 1F
            (Klrb1f), transcript variant 1, mRNA.
ACCESSION   NM_153094 NM_181064
VERSION     NM_153094.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1708)
  AUTHORS   Adamkova,L., Kvicalova,Z., Rozbesky,D., Kukacka,Z., Adamek,D.,
            Cebecauer,M. and Novak,P.
  TITLE     Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on
            Living Cells
  JOURNAL   Int J Mol Sci 20 (8), 1884 (2019)
   PUBMED   30995786
  REMARK    GeneRIF: Nkrp1 isoforms c1, c2 and f were expressed prevalently as
            homodimers, whereas the Nkrp1a displays larger proportion of
            monomers on the cell surface.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1708)
  AUTHORS   Aguilar,O.A., Berry,R., Rahim,M.M.A., Reichel,J.J., Popovic,B.,
            Tanaka,M., Fu,Z., Balaji,G.R., Lau,T.N.H., Tu,M.M., Kirkham,C.L.,
            Mahmoud,A.B., Mesci,A., Krmpotic,A., Allan,D.S.J.,
            Makrigiannis,A.P., Jonjic,S., Rossjohn,J. and Carlyle,J.R.
  TITLE     A Viral Immunoevasin Controls Innate Immunity by Targeting the
            Prototypical Natural Killer Cell Receptor Family
  JOURNAL   Cell 169 (1), 58-71 (2017)
   PUBMED   28340350
REFERENCE   3  (bases 1 to 1708)
  AUTHORS   Skalova,T., Kotynkova,K., Duskova,J., Hasek,J., Koval,T.,
            Kolenko,P., Novak,P., Man,P., Hanc,P., Vanek,O., Bezouska,K. and
            Dohnalek,J.
  TITLE     Mouse Clr-g, a ligand for NK cell activation receptor NKR-P1F:
            crystal structure and biophysical properties
  JOURNAL   J Immunol 189 (10), 4881-4889 (2012)
   PUBMED   23071282
  REMARK    GeneRIF: The electrostatic profile of NKR-P1F is complementary to
            that of Clr-g, which suggests a plausible interaction mechanism
            based on contacts between surface sites of opposite potential.
REFERENCE   4  (bases 1 to 1708)
  AUTHORS   Chen,P., Belanger,S., Aguilar,O.A., Zhang,Q., St-Laurent,A.,
            Rahim,M.M., Makrigiannis,A.P. and Carlyle,J.R.
  TITLE     Analysis of the mouse 129-strain Nkrp1-Clr gene cluster reveals
            conservation of genomic organization and functional receptor-ligand
            interactions despite significant allelic polymorphism
  JOURNAL   Immunogenetics 63 (10), 627-640 (2011)
   PUBMED   21667046
REFERENCE   5  (bases 1 to 1708)
  AUTHORS   Kveberg,L., Dai,K.Z., Inngjerdingen,M., Brooks,C.G., Fossum,S. and
            Vaage,J.T.
  TITLE     Phylogenetic and functional conservation of the NKR-P1F and NKR-P1G
            receptors in rat and mouse
  JOURNAL   Immunogenetics 63 (7), 429-436 (2011)
   PUBMED   21409442
REFERENCE   6  (bases 1 to 1708)
  AUTHORS   Carlyle,J.R., Mesci,A., Ljutic,B., Belanger,S., Tai,L.H.,
            Rousselle,E., Troke,A.D., Proteau,M.F. and Makrigiannis,A.P.
  TITLE     Molecular and genetic basis for strain-dependent NK1.1
            alloreactivity of mouse NK cells
  JOURNAL   J Immunol 176 (12), 7511-7524 (2006)
   PUBMED   16751398
REFERENCE   7  (bases 1 to 1708)
  AUTHORS   Tian,W., Feng,B. and Liou,H.C.
  TITLE     Silencing OCILRP2 leads to intrinsic defects in T cells in response
            to antigenic stimulation
  JOURNAL   Cell Immunol 235 (1), 72-84 (2005)
   PUBMED   16143319
REFERENCE   8  (bases 1 to 1708)
  AUTHORS   Tian,W., Nunez,R., Cheng,S., Ding,Y., Tumang,J., Lyddane,C.,
            Roman,C. and Liou,H.C.
  TITLE     C-type lectin OCILRP2/Clr-g and its ligand NKRP1f costimulate T
            cell proliferation and IL-2 production
  JOURNAL   Cell Immunol 234 (1), 39-53 (2005)
   PUBMED   15963483
  REMARK    GeneRIF: studies reveal a unique functional interaction between two
            C-type lectins, OCILRP2/Clr-g and NKRP1f, during APC-mediated T
            cell costimulation and suggest a role for C-type lectins in
            maintaining T cell response or memory in vivo
REFERENCE   9  (bases 1 to 1708)
  AUTHORS   Iizuka,K., Naidenko,O.V., Plougastel,B.F., Fremont,D.H. and
            Yokoyama,W.M.
  TITLE     Genetically linked C-type lectin-related ligands for the NKRP1
            family of natural killer cell receptors
  JOURNAL   Nat Immunol 4 (8), 801-807 (2003)
   PUBMED   12858173
REFERENCE   10 (bases 1 to 1708)
  AUTHORS   Plougastel,B., Matsumoto,K., Dubbelde,C. and Yokoyama,W.M.
  TITLE     Analysis of a 1-Mb BAC contig overlapping the mouse Nkrp1 cluster
            of genes: cloning of three new Nkrp1 members, Nkrp1d, Nkrp1e, and
            Nkrp1f
  JOURNAL   Immunogenetics 53 (7), 592-598 (2001)
   PUBMED   11685472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041601.1, BC127142.1 and AK042352.1.
            
            On or before Oct 28, 2008 this sequence version replaced
            NM_181064.3, NM_153094.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and is protein-coding.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154278.1, AK041601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               AK041601.1         2-249
            249-946             BC127142.1         226-923
            947-1708            AK042352.1         14-775
FEATURES             Location/Qualifiers
     source          1..1708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.12 cM"
     gene            1..1708
                     /gene="Klrb1f"
                     /gene_synonym="A630024B12Rik; Nkr-p1f; Nkrp1-f; Nkrp1f"
                     /note="killer cell lectin-like receptor subfamily B member
                     1F"
                     /db_xref="GeneID:232408"
                     /db_xref="MGI:MGI:2442965"
     exon            1..132
                     /gene="Klrb1f"
                     /gene_synonym="A630024B12Rik; Nkr-p1f; Nkrp1-f; Nkrp1f"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..701
                     /gene="Klrb1f"
                     /gene_synonym="A630024B12Rik; Nkr-p1f; Nkrp1-f; Nkrp1f"
                     /note="CD161 antigen-like family member F; natural killer
                     cell surface protein NKR-P1F"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1F"
                     /protein_id="NP_694734.1"
                     /db_xref="CCDS:CCDS20579.1"
                     /db_xref="GeneID:232408"
                     /db_xref="MGI:MGI:2442965"
                     /translation="MDTSKVHGNVKPFRCPGYKQASSPSFSPDACRCPHWHHLALKSG
                     CAGLILLLLSLIGLSVLVRFLVQKPPIEKCSVAAQENRTELTGRSAILECPRYWHPHW
                     NKCLFVSQISRPWAEGRDACSMEDAILLLIENKEELRFVQNLIKGKEQLFFIGLKYVQ
                     KEKIWKWIDGSILNPNLLRITGKDKENSCAIISHTEVFSDSCSSDNHWICQKTLIHV"
     exon            133..231
                     /gene="Klrb1f"
                     /gene_synonym="A630024B12Rik; Nkr-p1f; Nkrp1-f; Nkrp1f"
                     /inference="alignment:Splign:2.1.0"
     exon            232..306
                     /gene="Klrb1f"
                     /gene_synonym="A630024B12Rik; Nkr-p1f; Nkrp1-f; Nkrp1f"
                     /inference="alignment:Splign:2.1.0"
     exon            307..461
                     /gene="Klrb1f"
                     /gene_synonym="A630024B12Rik; Nkr-p1f; Nkrp1-f; Nkrp1f"
                     /inference="alignment:Splign:2.1.0"
     exon            462..577
                     /gene="Klrb1f"
                     /gene_synonym="A630024B12Rik; Nkr-p1f; Nkrp1-f; Nkrp1f"
                     /inference="alignment:Splign:2.1.0"
     exon            578..1708
                     /gene="Klrb1f"
                     /gene_synonym="A630024B12Rik; Nkr-p1f; Nkrp1-f; Nkrp1f"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaacttaga atttgtcact gttcacagtt cccatctcct gtctacaatg gacacatcaa
       61 aggtccatgg caatgtaaag ccatttaggt gtccagggta taagcaagca tcttctccat
      121 ctttctcccc agatgcttgt cggtgcccac actggcatca tttggctctg aaatctggct
      181 gtgctgggct gatccttctt ctcttgagcc tgattggact cagtgtctta gtgagattcc
      241 tagtgcaaaa accaccaata gaaaaatgca gtgtggctgc tcaagagaac aggactgaac
      301 taacaggaag atcagccata ctagagtgcc cgagatattg gcatccacac tggaacaaat
      361 gtttatttgt ttctcaaatt tccagacctt gggcagaagg tcgagatgcc tgctctatgg
      421 aagacgccat tttgttgctc attgaaaata aagaagaact gagatttgtg cagaacttga
      481 taaagggaaa agaacagtta ttttttattg gactaaaata tgtacagaag gagaagatct
      541 ggaagtggat agatggctct attttaaatc ctaacctatt acgaatcact ggcaaggaca
      601 aagaaaacag ctgtgccatc atctcacaca cggaagtgtt ttcagattct tgttcttcag
      661 acaaccactg gatctgccaa aagaccctga tacatgtctg aaagcctgtg tcctgattcc
      721 tgattgtgag tctcatctgg attacttcac tgtccacatc ggatctctgt actgaacatt
      781 ctgttggccc acccagtgag tagctagtgg cacaaaacaa ggactccaaa atcactgtga
      841 cttttacaga tgctcatgtc tagtttatta tgtaaacata aatgtacaca gacacagatg
      901 tgccattcta ggagaggagt tctatagaag gaagcccaga ccagcaagag gcagtgaagg
      961 ccttgtgatg cccttgctga tctttttgtc taaggtcatc tgcagagagc tacagaaaac
     1021 tgtttgtaaa gtctagattt tgaccctatc cccacttcaa gctacttcac atttgggctg
     1081 tagaaccttg attaaagtcg tgctgtcatt tatttgactg acagcagagg ctcagagtta
     1141 aggagcttga gatgaaaagg gtttgtattg attgacactc gccaactagt tgactaataa
     1201 tggactaatg ctgtgttcga cattgagtgt gactttatgt aaacagaact ctactcatat
     1261 gatacctact actttgtggt gatgtaccag cagactctgg gcagattctg ggccattgga
     1321 gtggggcttc tcagtctcct gagttgcatg aaagtgggat gtcctcttct ccagtgacct
     1381 gttagtacag ctataacaat accaccacca ccactaccaa taacaaaaac aaaaagacta
     1441 agacagggac ttgtctcttc ccactgccca caggcatcct attttaattt tcccatcact
     1501 tctttcttcc acatttctct ataatttata gcttatgtac aaattgtagg acatatgtag
     1561 ctaaatattg gataattgta gtaggaaata aatgacagct ttttaatatt taagttagag
     1621 aaattttcaa aaataagtat tctgataaat ctttcagatg tcctcttctc aaaaaaacaa
     1681 aacaaaataa acaaacaaac cacaaacc
//
