LOCUS       NM_001159904            2542 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily B member 1C
            (Klrb1c), transcript variant 1, mRNA.
ACCESSION   NM_001159904 XM_003946192 XM_006544079
VERSION     NM_001159904.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2542)
  AUTHORS   He,X., Xu,R., Pan,L., Bhattarai,U., Liu,X., Zeng,H., Chen,J.X.,
            Hall,M.E. and Chen,Y.
  TITLE     Inhibition of NK1.1 signaling attenuates pressure overload-induced
            heart failure, and consequent pulmonary inflammation and remodeling
  JOURNAL   Front Immunol 14, 1215855 (2023)
   PUBMED   37554327
  REMARK    GeneRIF: Inhibition of NK1.1 signaling attenuates pressure
            overload-induced heart failure, and consequent pulmonary
            inflammation and remodeling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2542)
  AUTHORS   Rebejac,J., Eme-Scolan,E., Arnaud Paroutaud,L., Kharbouche,S.,
            Teleman,M., Spinelli,L., Gallo,E., Roussel-Queval,A., Zarubica,A.,
            Sansoni,A., Bardin,Q., Hoest,P., Michallet,M.C., Brousse,C.,
            Crozat,K., Manglani,M., Liu,Z., Ginhoux,F., McGavern,D.B.,
            Dalod,M., Malissen,B., Lawrence,T. and Rua,R.
  TITLE     Meningeal macrophages protect against viral neuroinfection
  JOURNAL   Immunity 55 (11), 2103-2117 (2022)
   PUBMED   36323311
REFERENCE   3  (bases 1 to 2542)
  AUTHORS   Berriel,E., Freire,T., Chiale,C., Rodriguez,E., Moron,G.,
            Fernandez-Grana,G., Crispo,M., Berois,N. and Osinaga,E.
  TITLE     Human hydatid cyst fluid-induced therapeutic anti-cancer immune
            responses via NK1.1+ cell activation in mice
  JOURNAL   Cancer Immunol Immunother 70 (12), 3617-3627 (2021)
   PUBMED   33944981
  REMARK    GeneRIF: Human hydatid cyst fluid-induced therapeutic anti-cancer
            immune responses via NK1.1(+) cell activation in mice.
REFERENCE   4  (bases 1 to 2542)
  AUTHORS   Etzerodt,A., Moulin,M., Doktor,T.K., Delfini,M.,
            Mossadegh-Keller,N., Bajenoff,M., Sieweke,M.H., Moestrup,S.K.,
            Auphan-Anezin,N. and Lawrence,T.
  TITLE     Tissue-resident macrophages in omentum promote metastatic spread of
            ovarian cancer
  JOURNAL   J Exp Med 217 (4) (2020)
   PUBMED   31951251
REFERENCE   5  (bases 1 to 2542)
  AUTHORS   Etzerodt,A., Tsalkitzi,K., Maniecki,M., Damsky,W., Delfini,M.,
            Baudoin,E., Moulin,M., Bosenberg,M., Graversen,J.H.,
            Auphan-Anezin,N., Moestrup,S.K. and Lawrence,T.
  TITLE     Specific targeting of CD163+ TAMs mobilizes inflammatory monocytes
            and promotes T cell-mediated tumor regression
  JOURNAL   J Exp Med 216 (10), 2394-2411 (2019)
   PUBMED   31375534
REFERENCE   6  (bases 1 to 2542)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 2542)
  AUTHORS   Ryan,J.C., Turck,J., Niemi,E.C., Yokoyama,W.M. and Seaman,W.E.
  TITLE     Molecular cloning of the NK1.1 antigen, a member of the NKR-P1
            family of natural killer cell activation molecules
  JOURNAL   J Immunol 149 (5), 1631-1635 (1992)
   PUBMED   1506685
REFERENCE   8  (bases 1 to 2542)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Wallace,C.R., Gibbons,A.E.,
            Smart,Y.C., Burton,R.C. and Shellam,G.R.
  TITLE     The effect of the Cmv-1 resistance gene, which is linked to the
            natural killer cell gene complex, is mediated by natural killer
            cells
  JOURNAL   J Immunol 149 (2), 581-589 (1992)
   PUBMED   1378069
REFERENCE   9  (bases 1 to 2542)
  AUTHORS   Asjo,B., Kiessling,R., Klein,G. and Povey,S.
  TITLE     Genetic variation in antibody response and natural killer cell
            activity against a Moloney virus-induced lymphoma (YAC)
  JOURNAL   Eur J Immunol 7 (8), 554-558 (1977)
   PUBMED   902682
REFERENCE   10 (bases 1 to 2542)
  AUTHORS   Glimcher,L., Shen,F.W. and Cantor,H.
  TITLE     Identification of a cell-surface antigen selectively expressed on
            the natural killer cell
  JOURNAL   J Exp Med 145 (1), 1-9 (1977)
   PUBMED   187714
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102693.9.
            
            On Dec 21, 2021 this sequence version replaced NM_001159904.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK079743.1, BC061168.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AC102693.9         112571-112725
            156-254             AC102693.9         115099-115197
            255-329             AC102693.9         116311-116385
            330-484             AC102693.9         116863-117017
            485-600             AC102693.9         117343-117458
            601-2542            AC102693.9         120696-122637
FEATURES             Location/Qualifiers
     source          1..2542
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.09 cM"
     gene            1..2542
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /note="killer cell lectin-like receptor subfamily B member
                     1C"
                     /db_xref="GeneID:17059"
                     /db_xref="MGI:MGI:107538"
     exon            1..155
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..742
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lymphocyte antigen 55 complex, locus C; killer cell
                     lectin-like receptor subfamily A member 1C; natural killer
                     cell receptor protein NKR-P1C; natural killer cell
                     receptor-P1; NKR-P1 40; lymphocyte antigen 55c; CD161
                     antigen-like family member C; natural killer cell surface
                     protein P1-40; lymphocyte antigen 59; natural killer
                     cell-associated antigen 1; NKR-P1B"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1C isoform 1"
                     /protein_id="NP_001153376.2"
                     /db_xref="CCDS:CCDS51919.1"
                     /db_xref="GeneID:17059"
                     /db_xref="MGI:MGI:107538"
                     /translation="MDTASIYLGLKPPRTLGAWHESPPSLPPDACRCPRSHRLALKLS
                     CAGLILLVLTLIGMSVLVRVLVQKPSREKCCVFIQENLNKTTDCSVNLECPQDWLLHR
                     DKCFHVSQVSNTWEEGQADCGRKGATLLLIQDQEELRFLLDSIKEKYNSFWIGLRFTL
                     PDMNWKWINGTTFNSDVLKITGVTENGSCASILGDKVTPESCASDNRWICQKELNHET
                     PSNDS"
     exon            156..254
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /inference="alignment:Splign:2.1.0"
     exon            255..329
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /inference="alignment:Splign:2.1.0"
     exon            330..484
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /inference="alignment:Splign:2.1.0"
     exon            485..600
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /inference="alignment:Splign:2.1.0"
     exon            601..2542
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1547..1552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /note="hexamer: ACTAAA"
     polyA_site      1571
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /note="major polyA site"
     regulatory      2520..2525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
                     /note="hexamer: AATAAA"
     polyA_site      2542
                     /gene="Klrb1c"
                     /gene_synonym="CD161; Klrb1b; ly-55c; Ly-59; Ly55c; Ly59;
                     Nk-1; Nk-1.2; NK-RP1; Nk1; NK1.1; Nk1.2; NKR-P1.9; NKRP1;
                     NKRP140; Nkrp1b; Nkrp1c"
ORIGIN      
        1 cttatttcac ctcaaaggcc ttggagtttg tcccttctca ccaccagtta agtgttgcat
       61 ctcctgtgaa atggacacag caagtatcta cctcggttta aagccaccca ggacactggg
      121 ggcttggcat gagtcacccc catctcttcc cccagatgcc tgtcggtgcc cacgttcaca
      181 caggttggct ctgaagctca gctgtgctgg gctcatcctc cttgtcctga ccctgattgg
      241 gatgagtgtc ttagtgcgag tcttagtaca aaaaccatca agagaaaaat gctgtgtgtt
      301 tattcaagag aacctgaata aaacaacaga ttgttcagtt aatttagagt gcccacaaga
      361 ctggctttta caccgagata agtgctttca cgtttctcaa gtttccaaca cttgggagga
      421 aggtcaagct gactgtggta gaaaaggagc cactttgctg ctcattcaag accaagaaga
      481 actgagattc ctactggact caataaagga aaaatataat tcattttgga ttggactaag
      541 gttcacattg ccagacatga actggaagtg gataaatggc acaactttca attctgatgt
      601 actaaaaatc actggtgtca ctgaaaatgg cagctgtgcc tccatcttag gagataaagt
      661 gactcctgag agctgtgctt cagacaaccg ttggatctgc caaaaggaac taaaccatga
      721 aaccccgagt aatgactcct gactgcgaat cccatcctga ttattttacc atccgcacca
      781 gatctctgca cctaacctgt ctctgctgtc tgcctcccag tgcagttagt ggcacagcac
      841 atggactctg aaagcactgg gcctcttaca gattcttgat tgtgtaaagt gtgtaaatgt
      901 cagtgtacac agacacagtt gtgccattct aagagaagag ttctatgcaa agaagccctg
      961 gtagctgagg gcactggatt ctaatccttg tgtctgtgtg acatttgctg gtctctgtgc
     1021 ctgagctcct ctgccaacag ccatggaaga ctggatctaa tttcttagaa agataggtca
     1081 caggctgctt tcatggctcc caaagtttga gtcaggaccc ctttggctat tcctttccat
     1141 tcgttgactc atcgacctac aagtgaaatg gttttgtgat gtctggtagc cccaaagtgg
     1201 gagctgacag tagggcctgc tttattttat caaaggcctt ttgatgatct tgagtctaag
     1261 caaagtcttt gccctctctg gtggccttat ataaaggttt gactatttca gtgaaacctg
     1321 gagtccataa tctgcaaaag cctgtggacc ccaagaattc tcttacctgt cttgtgctta
     1381 tgaagctggt atgctgaaga cagtctcttt tcttgctgtg gaacgctact gctgcccctc
     1441 agtcttgtag agctgtgcct ttttggcaga cactcaatat cccaggtctc ccagaacatg
     1501 taggagattc tggataccct tgcattcttc tttggtttct gctgcaacta aaagatcatc
     1561 tacatactga acaagagtta tatctggatt attaactgtg tactcaccca ggtcttcatg
     1621 caaagcttca tcaaaaatag taggtgaatt cttgtaatct tgaggcaggc aggtccaggt
     1681 gagttgtcca ttaatgccac tttcagaatc atgccactca aatgcaaagt atttctggct
     1741 tttggaagcc aaaggtaagc tgaagaaagc attctttaga tccaaaacag aataccattt
     1801 ccgatctgaa ggtagagagc tcaacagggt ataagggtta ggcacttttg ggtgtatgta
     1861 catcaccccg cagttaactt ccagtagatc ctagacaggg tggttgtcat tggactttgg
     1921 ctttttcaca gacaataatg gggtgtttca gactgactga catgccctaa ggactcccaa
     1981 ggccaacagt ttcttgatat ggggagtgat ccccttccat gtttcctggg gcatgaccca
     2041 tactgggtct gctcttggct tgagctctac aaatacagga ggttgatgtt ttaccagcct
     2101 catatctcca gtctctgccc atgcctgggg aaactctgcc agccaggcat ccaggtcttg
     2161 ttcggggctg gctggtgact cgtatagtct ctactcagtc tcagaggcca ggtcaagtgt
     2221 cagcacctgg attggattgc tgtttccgtc tgtcagctgg actttcccag ggtcaaaatg
     2281 aatctgagct cccattttgg ctagtaaatc tctccccaac aaggggtatg ggcattcaag
     2341 gaggtaggaa tatgactttt tccggtgtac tgtcctgtag gataggatag agaagcttta
     2401 aaggcttgga gtcttcccat ttttgttctt ttgacatcag agcaggcatg gtttctgggg
     2461 ggcaaagtag cgttaatcag ggataataaa aaggatttca cccaaggtgg tgggttgaca
     2521 ataaaatctt tccagactac aa
//
