LOCUS       NM_030599               2212 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily B member 1B
            (Klrb1b), transcript variant 1, mRNA.
ACCESSION   NM_030599 NM_008526
VERSION     NM_030599.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2212)
  AUTHORS   Al Olabi,R., Hendy,A.E.A., Alkassab,M.B., Alnajm,K., Elias,M.,
            Ibrahim,M., Carlyle,J.R., Makrigiannis,A.P. and Rahim,M.M.A.
  TITLE     The inhibitory NKR-P1B receptor regulates NK cell-mediated mammary
            tumor immunosurveillance in mice
  JOURNAL   Oncoimmunology 12 (1), 2168233 (2023)
   PUBMED   36704449
  REMARK    GeneRIF: The inhibitory NKR-P1B receptor regulates NK cell-mediated
            mammary tumor immunosurveillance in mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2212)
  AUTHORS   Aguilar,O.A., Sampaio,I.S., Rahim,M.M.A., Samaniego,J.D.,
            Tilahun,M.E., Krishnamoorthy,M., Popovic,B., Babic,M., Krmpotic,A.,
            Treanor,B., Margulies,D.H., Allan,D.S.J., Makrigiannis,A.P.,
            Jonjic,S. and Carlyle,J.R.
  TITLE     Mouse Cytomegalovirus m153 Protein Stabilizes Expression of the
            Inhibitory NKR-P1B Ligand Clr-b
  JOURNAL   J Virol 94 (1), e01220-19 (2019)
   PUBMED   31597762
  REMARK    GeneRIF: Mouse cytomegalovirus m153 protein stabilizes expression
            of the inhibitory NKR-P1B ligand Clr-b.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2212)
  AUTHORS   Abou-Samra,E., Hickey,Z., Aguilar,O.A., Scur,M., Mahmoud,A.B.,
            Pyatibrat,S., Tu,M.M., Francispillai,J., Mortha,A., Carlyle,J.R.,
            Rahim,M.M.A. and Makrigiannis,A.P.
  TITLE     NKR-P1B expression in gut-associated innate lymphoid cells is
            required for the control of gastrointestinal tract infections
  JOURNAL   Cell Mol Immunol 16 (11), 868-877 (2019)
   PUBMED   30275537
  REMARK    GeneRIF: NKR-P1B expression in gut-associated innate lymphoid cells
            is required for the control of gastrointestinal tract infections.
REFERENCE   4  (bases 1 to 2212)
  AUTHORS   Aguilar,O.A., Berry,R., Rahim,M.M.A., Reichel,J.J., Popovic,B.,
            Tanaka,M., Fu,Z., Balaji,G.R., Lau,T.N.H., Tu,M.M., Kirkham,C.L.,
            Mahmoud,A.B., Mesci,A., Krmpotic,A., Allan,D.S.J.,
            Makrigiannis,A.P., Jonjic,S., Rossjohn,J. and Carlyle,J.R.
  TITLE     A Viral Immunoevasin Controls Innate Immunity by Targeting the
            Prototypical Natural Killer Cell Receptor Family
  JOURNAL   Cell 169 (1), 58-71 (2017)
   PUBMED   28340350
REFERENCE   5  (bases 1 to 2212)
  AUTHORS   Rahim,M.M., Wight,A., Mahmoud,A.B., Aguilar,O.A., Lee,S.H.,
            Vidal,S.M., Carlyle,J.R. and Makrigiannis,A.P.
  TITLE     Expansion and Protection by a Virus-Specific NK Cell Subset Lacking
            Expression of the Inhibitory NKR-P1B Receptor during Murine
            Cytomegalovirus Infection
  JOURNAL   J Immunol 197 (6), 2325-2337 (2016)
   PUBMED   27511735
  REMARK    GeneRIF: findings show that NKR-P1B negatively regulates the NK
            cell-mediated immune response during murine cytomegalovirus
            Infection
REFERENCE   6  (bases 1 to 2212)
  AUTHORS   Kung,S.K., Su,R.C., Shannon,J. and Miller,R.G.
  TITLE     The NKR-P1B gene product is an inhibitory receptor on SJL/J NK
            cells
  JOURNAL   J Immunol 162 (10), 5876-5887 (1999)
   PUBMED   10229823
REFERENCE   7  (bases 1 to 2212)
  AUTHORS   Ho,E.L., Heusel,J.W., Brown,M.G., Matsumoto,K., Scalzo,A.A. and
            Yokoyama,W.M.
  TITLE     Murine Nkg2d and Cd94 are clustered within the natural killer
            complex and are expressed independently in natural killer cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (11), 6320-6325 (1998)
   PUBMED   9600963
REFERENCE   8  (bases 1 to 2212)
  AUTHORS   Brown,M.G., Fulmek,S., Matsumoto,K., Cho,R., Lyons,P.A., Levy,E.R.,
            Scalzo,A.A. and Yokoyama,W.M.
  TITLE     A 2-Mb YAC contig and physical map of the natural killer gene
            complex on mouse chromosome 6
  JOURNAL   Genomics 42 (1), 16-25 (1997)
   PUBMED   9177771
REFERENCE   9  (bases 1 to 2212)
  AUTHORS   Giorda,R., Weisberg,E.P., Ip,T.K. and Trucco,M.
  TITLE     Genomic structure and strain-specific expression of the natural
            killer cell receptor NKR-P1
  JOURNAL   J Immunol 149 (6), 1957-1963 (1992)
   PUBMED   1517565
REFERENCE   10 (bases 1 to 2212)
  AUTHORS   Giorda,R. and Trucco,M.
  TITLE     Mouse NKR-P1. A family of genes selectively coexpressed in adherent
            lymphokine-activated killer cells
  JOURNAL   J Immunol 147 (5), 1701-1708 (1991)
   PUBMED   1880421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041228.1, AK030702.1 and AC102693.9.
            
            [WARNING] On Jan 30, 2025 this sequence was replaced by
            NM_030599.5.
            
            On or before Jan 29, 2009 this sequence version replaced
            NM_008526.1, NM_030599.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030702.1, BC055379.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-500               AK041228.1         2-501
            501-1389            AK030702.1         450-1338
            1390-1390           AC102693.9         86594-86594
            1391-2212           AK030702.1         1340-2161
FEATURES             Location/Qualifiers
     source          1..2212
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.09 cM"
     gene            1..2212
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /note="killer cell lectin-like receptor subfamily B member
                     1B"
                     /db_xref="GeneID:80782"
                     /db_xref="MGI:MGI:107539"
     exon            1..157
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..741
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lymphocyte antigen 55 complex, locus B; lymphocyte antigen
                     55 complex, locus D; killer cell lectin-like receptor
                     subfamily B member 1D; NKR-P1 34; natural killer cell
                     receptor-P1; natural killer cell receptor protein NKR-P1B;
                     lymphocyte antigen 55b; lymphocyte antigen 55d; inhibitory
                     receptor NKR-P1B; CD161 antigen-like family member B;
                     natural killer cell surface protein NKR-P1B"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1B allele B isoform 1"
                     /protein_id="NP_085102.4"
                     /db_xref="CCDS:CCDS39655.1"
                     /db_xref="GeneID:80782"
                     /db_xref="MGI:MGI:107539"
                     /translation="MDSTTLVYADLNLARIQEPKHDSPPSLSPDTCRCPRWHRLALKF
                     GCAGLILLVLVVIGLCVLVLSVQKSSVQKICADVQENRTHTTGCSAKLECPQDWLSHR
                     DKCFHVSQVSNTWKECRIDCDKKGATLLLIQDQEELRFLLDSIKEKYNSFWIGLSYTL
                     TDMNWKWINGTAFNSDVLKITGVTENGSCAAISGEKVTSEGCSSDNRWICQKELNHET
                     PCNDS"
     exon            158..256
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /inference="alignment:Splign:2.1.0"
     exon            257..328
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /inference="alignment:Splign:2.1.0"
     exon            329..483
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /inference="alignment:Splign:2.1.0"
     exon            484..599
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /inference="alignment:Splign:2.1.0"
     exon            600..2212
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /inference="alignment:Splign:2.1.0"
     regulatory      882..887
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /note="hexamer: TATAAA"
     polyA_site      903
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /note="major polyA site"
     regulatory      1507..1512
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /note="hexamer: AATAAA"
     polyA_site      1539
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /note="major polyA site"
     regulatory      2190..2195
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /note="hexamer: AATAAA"
     polyA_site      2212
                     /gene="Klrb1b"
                     /gene_synonym="Klrb1d; ly-55b; ly-55d; Ly55b; Ly55d;
                     NKR-P1B; NKR-P1D; Nkrp1-b; Nkrp1b; Nkrp1d"
                     /note="major polyA site"
ORIGIN      
        1 tcatttcacc tcacaggact caaagtttgt ccctgttcac gaggccggtg tcaagtccct
       61 ccatctacaa tggattcaac aacactggtc tatgcagatt taaacctagc caggatccaa
      121 gaacctaagc atgattcacc tccatctctt tccccagaca cctgtcggtg ccctcgctgg
      181 catcggttgg ctctgaaatt tggctgtgct ggcctcatcc ttcttgtgct ggtcgtgatt
      241 ggactctgtg tcttggtgct atcagtacaa aaatcatcag tacaaaaaat ctgcgcggat
      301 gttcaagaga acagaacaca tacaacaggt tgttcagcta agctagagtg cccacaagac
      361 tggctttcac accgagataa gtgctttcac gtttctcaag tttccaacac ttggaaggaa
      421 tgtcgaattg attgtgataa aaaaggagcc actttgctgc tcattcaaga ccaagaagaa
      481 ctgagattcc tactggactc aataaaggaa aaatacaatt cattttggat tggactaagt
      541 tacacattaa cagacatgaa ctggaagtgg ataaatggca cagctttcaa ttctgatgta
      601 ctaaaaatca ctggtgtcac tgaaaatggc agctgtgccg ccatctcagg agaaaaagtg
      661 acttctgagg gctgttcttc agacaaccgt tggatctgcc aaaaggaact aaaccatgaa
      721 accccgtgta atgactcctg actgcgaatc ccatcctgat tactttacca tccgcaccag
      781 atctctgcac ctaacctgtc tctgctgtct gcctcccagt gcagttagtg gcacagcaca
      841 tggactctga aaacactggg attcttaaag gttcttcatt gtataaatgg aagtgtacac
      901 agacacagat gtgccgttct aagaggagtt ctgtggaaag aagccctggt agctgagggg
      961 cacctgattt taatccttga gtctgtgtga cctttgctgg tctctgtccc tgaggtcacc
     1021 tgcagacagc ctcggaagac tattggggaa atctccatct ctcctctgtc ccctactagc
     1081 caccacactg aggaatagaa tattgactaa tgcctttgct ctcaaatgac accagaagcc
     1141 cagggttagg ggatttgggg gagagactga caggtttaaa tagcacccac atatcctggg
     1201 taaactgagc tctgggcacg tgatgcctct accaggccat gatgtaccag cagaccctga
     1261 gccaaggctg gcaccttggg gctaggcttc tcagctccat tactggcaga gagggccttc
     1321 ttttctttga aaggttttgg tttatgtgac agaaaagcaa actaaggtaa cttacctctt
     1381 cctgccgtcc tttttgctct agtttgcttc acagttcttc tttccatgat tggggaaaat
     1441 taagctttaa aaagatacat cttttgaatg tccccttttc taaaaatttg ccaaactttc
     1501 catgaaaata aaaggagtat gaatattgaa tttactttat aaggagacct aaaatgtctt
     1561 taaaaaatgg gcttctacaa gttcttatca ttccatttca aattgaatta cttaaactga
     1621 agtacatgat atcatgattc caatgaattc tccacttcta tttgccagga acaaagagtt
     1681 ttaatatttg ataataatga ctttcaatac actgacactc aaagaattaa ttcattttgt
     1741 gaaaattcct agaaatcaat ttacctaagg aaaaacttca gagaaaagca gcgctagaaa
     1801 tcaatcctta acaacagtgg tgttttagga gcctataact gttaagtgca tggagcatgc
     1861 agctaagcag atatgagcag gagggatccc atgtaagaaa gtaagacacc agaggacttt
     1921 ctcagtggcc atatatgcta ccaatgaata tgctgatgag aagggaaggc acagctgtgg
     1981 ggacatcttg gtcctgaatc aatgtcagca gagtagataa atgaagctgt ctcccaaagg
     2041 caggaacttg acattgacat aggagagagg aacccaaaag acattttttt aaaatccacc
     2101 atctagatcc ccgagggctg ccacccacct ccagaccagc ctgctccagt attcttctgg
     2161 agtttgttat gaattctttt gctttgctaa ataaacatgg gctctatcag tg
//
