LOCUS       NM_010737               1284 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily B member 1A
            (Klrb1a), transcript variant 1, mRNA.
ACCESSION   NM_010737
VERSION     NM_010737.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1284)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1284)
  AUTHORS   Adamkova,L., Kvicalova,Z., Rozbesky,D., Kukacka,Z., Adamek,D.,
            Cebecauer,M. and Novak,P.
  TITLE     Oligomeric Architecture of Mouse Activating Nkrp1 Receptors on
            Living Cells
  JOURNAL   Int J Mol Sci 20 (8), 1884 (2019)
   PUBMED   30995786
  REMARK    GeneRIF: Nkrp1 isoforms c1, c2 and f were expressed prevalently as
            homodimers, whereas the Nkrp1a displays larger proportion of
            monomers on the cell surface.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1284)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1284)
  AUTHORS   Aguilar,O.A., Berry,R., Rahim,M.M.A., Reichel,J.J., Popovic,B.,
            Tanaka,M., Fu,Z., Balaji,G.R., Lau,T.N.H., Tu,M.M., Kirkham,C.L.,
            Mahmoud,A.B., Mesci,A., Krmpotic,A., Allan,D.S.J.,
            Makrigiannis,A.P., Jonjic,S., Rossjohn,J. and Carlyle,J.R.
  TITLE     A Viral Immunoevasin Controls Innate Immunity by Targeting the
            Prototypical Natural Killer Cell Receptor Family
  JOURNAL   Cell 169 (1), 58-71 (2017)
   PUBMED   28340350
REFERENCE   5  (bases 1 to 1284)
  AUTHORS   Rozbesky,D., Adamek,D., Pospisilova,E., Novak,P. and Chmelik,J.
  TITLE     Solution structure of the lymphocyte receptor Nkrp1a reveals a
            distinct conformation of the long loop region as compared to in the
            crystal structure
  JOURNAL   Proteins 84 (9), 1304-1311 (2016)
   PUBMED   27238500
  REMARK    GeneRIF: Solution structure of the lymphocyte receptor Nkrp1a
            reveals a distinct conformation of the long loop region as compared
            to in the crystal structure.
REFERENCE   6  (bases 1 to 1284)
  AUTHORS   Forbes,C.A., Brown,M.G., Cho,R., Shellam,G.R., Yokoyama,W.M. and
            Scalzo,A.A.
  TITLE     The Cmv1 host resistance locus is closely linked to the Ly49
            multigene family within the natural killer cell gene complex on
            mouse chromosome 6
  JOURNAL   Genomics 41 (3), 406-413 (1997)
   PUBMED   9169139
REFERENCE   7  (bases 1 to 1284)
  AUTHORS   Giorda,R., Weisberg,E.P., Ip,T.K. and Trucco,M.
  TITLE     Genomic structure and strain-specific expression of the natural
            killer cell receptor NKR-P1
  JOURNAL   J Immunol 149 (6), 1957-1963 (1992)
   PUBMED   1517565
REFERENCE   8  (bases 1 to 1284)
  AUTHORS   Ryan,J.C., Turck,J., Niemi,E.C., Yokoyama,W.M. and Seaman,W.E.
  TITLE     Molecular cloning of the NK1.1 antigen, a member of the NKR-P1
            family of natural killer cell activation molecules
  JOURNAL   J Immunol 149 (5), 1631-1635 (1992)
   PUBMED   1506685
REFERENCE   9  (bases 1 to 1284)
  AUTHORS   Yokoyama,W.M., Ryan,J.C., Hunter,J.J., Smith,H.R., Stark,M. and
            Seaman,W.E.
  TITLE     cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49.
            Identification of a natural killer cell gene complex on mouse
            chromosome 6
  JOURNAL   J Immunol 147 (9), 3229-3236 (1991)
   PUBMED   1680927
REFERENCE   10 (bases 1 to 1284)
  AUTHORS   Giorda,R. and Trucco,M.
  TITLE     Mouse NKR-P1. A family of genes selectively coexpressed in adherent
            lymphokine-activated killer cells
  JOURNAL   J Immunol 147 (5), 1701-1708 (1991)
   PUBMED   1880421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            M77676.1, BC120707.1, M77753.1 and AC132352.3.
            
            On May 7, 2009 this sequence version replaced NM_010737.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            CCDS Note: An upstream translation start codon is selected for this
            CCDS based on better conservation with mouse paralogs. The use of
            an alternative upstream start codon, which appears to be
            mouse-specific, would result in a protein that is 6 aa longer at
            the N-terminal.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC120707.1, DQ237927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                M77676.1           1-62
            63-745              BC120707.1         1-683
            746-1157            M77753.1           645-1056
            1158-1158           AC132352.3         120351-120351
            1159-1284           M77753.1           1057-1182
FEATURES             Location/Qualifiers
     source          1..1284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.06 cM"
     gene            1..1284
                     /gene="Klrb1a"
                     /gene_synonym="ly-55A; Ly55a; NKR-P1.7; NKR-P1A; Nkrp1-a;
                     NKRP12; Nkrp1a"
                     /note="killer cell lectin-like receptor subfamily B member
                     1A"
                     /db_xref="GeneID:17057"
                     /db_xref="MGI:MGI:107540"
     exon            1..204
                     /gene="Klrb1a"
                     /gene_synonym="ly-55A; Ly55a; NKR-P1.7; NKR-P1A; Nkrp1-a;
                     NKRP12; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..803
                     /gene="Klrb1a"
                     /gene_synonym="ly-55A; Ly55a; NKR-P1.7; NKR-P1A; Nkrp1-a;
                     NKRP12; Nkrp1a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     lymphocyte antigen 55 complex, locus A; natural killer
                     cell receptor protein NKR-P1A; natural killer cell
                     receptor-P1; NKR-P1 2; lymphocyte antigen 55A; CD161
                     antigen-like family member A; natural killer cell surface
                     protein P1-2"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily B
                     member 1A isoform 1"
                     /protein_id="NP_034867.3"
                     /db_xref="CCDS:CCDS20574.2"
                     /db_xref="GeneID:17057"
                     /db_xref="MGI:MGI:107540"
                     /translation="MHLLCTMDTARVYFGLKPPRTPGAWHESPPSLPPDACRCPRSHR
                     LALKLSCAGLILLVVTLIGMSVLVRVLIQKPSIEKCYVLIQENLNKTTDCSAKLECPQ
                     DWLSHRDKCFHVSQVSNTWEEGLVDCDGKGATLMLIQDQEELRFLLDSIKEKYNSFWI
                     GLRYTLPDMNWKWINGSTLNSDVLKITGDTENDSCAAISGDKVTFESCNSDNRWICQK
                     ELYHETLSNYVGYGH"
     exon            205..303
                     /gene="Klrb1a"
                     /gene_synonym="ly-55A; Ly55a; NKR-P1.7; NKR-P1A; Nkrp1-a;
                     NKRP12; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            304..378
                     /gene="Klrb1a"
                     /gene_synonym="ly-55A; Ly55a; NKR-P1.7; NKR-P1A; Nkrp1-a;
                     NKRP12; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            379..533
                     /gene="Klrb1a"
                     /gene_synonym="ly-55A; Ly55a; NKR-P1.7; NKR-P1A; Nkrp1-a;
                     NKRP12; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            534..649
                     /gene="Klrb1a"
                     /gene_synonym="ly-55A; Ly55a; NKR-P1.7; NKR-P1A; Nkrp1-a;
                     NKRP12; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
     exon            650..1274
                     /gene="Klrb1a"
                     /gene_synonym="ly-55A; Ly55a; NKR-P1.7; NKR-P1A; Nkrp1-a;
                     NKRP12; Nkrp1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagtgggt gtaggcacag agcagagcat tcacagagga cttccttttg ctcacttcac
       61 cccaaaggcc ttggagtttg cccctgctca ccagttcagt gatgcatctc ctatgcacaa
      121 tggacacagc aagggtctac tttggtttaa agccacccag gactccaggg gcttggcatg
      181 agtcaccccc atctcttccc ccagatgcct gtcggtgccc acgttcacac aggttggctc
      241 tgaagctcag ctgtgctggg ctcatcctcc ttgtcgtgac cctgattggg atgagtgttt
      301 tagtgcgagt cctaatacaa aaaccatcaa tagaaaaatg ctatgtgctt attcaagaga
      361 acctgaataa aacaacagat tgttcagcta agctagagtg cccacaagac tggctttcac
      421 accgagataa gtgctttcac gtttctcaag tttccaacac ttgggaggaa ggtctagttg
      481 attgtgatgg aaaaggagcc actttgatgc tcattcaaga ccaagaagaa ctgagattcc
      541 tactggactc aataaaggaa aaatacaatt cattttggat tggactaagg tacacattgc
      601 cagacatgaa ctggaagtgg ataaatggat cgactttaaa ttctgatgta ttaaaaatca
      661 ctggtgacac tgaaaatgac agctgtgctg ctatctcagg agacaaagtg acttttgaga
      721 gctgtaattc agacaaccgt tggatctgcc aaaaggaact ataccatgaa accctgagca
      781 actatgtggg ttatggacac tgaactcaga tcctgtccaa gagcagccag tgctctcaat
      841 cactgagcca tgtctacagc ttgaccctgt atattaaaca aaactgaagt gctacaacat
      901 gaagcttttc acatgatgtg ttagagtgtg aatcccatct caattacttt accatccaca
      961 ccagatctct gcacctaacc tgtctctgct gtctgcctct cagtacagtt agtggcacag
     1021 cacatggact ctgaaaacac tgggactctt acagatgccc atgtgtagtt tctctattct
     1081 gtaaaggaga tagagatgtt gatgtgccat tctacgtgag gggttctaca aaaagaagcc
     1141 ctggcacctg aggtgccctg gattctaatc ctggagtctg tgaccccccc cacccacagt
     1201 ctgtgtctga gctcatctac aaaacagtca taagaaaacc atttaccaaa atcattaaaa
     1261 ttctcttaat acagaaaaaa aaaa
//
