LOCUS       NM_001099918            1108 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily B member 1
            (Klrb1), mRNA.
ACCESSION   NM_001099918 XM_001481108
VERSION     NM_001099918.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1108)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1108)
  AUTHORS   Ono,M., Toyoda,N., Kagami,K., Hosono,T., Matsumoto,T., Horike,S.I.,
            Yamazaki,R., Nakamura,M., Mizumoto,Y., Fujiwara,T., Ando,H.,
            Fujiwara,H. and Daikoku,T.
  TITLE     Uterine Deletion of Bmal1 Impairs Placental Vascularization and
            Induces Intrauterine Fetal Death in Mice
  JOURNAL   Int J Mol Sci 23 (14), 7637 (2022)
   PUBMED   35886985
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1108)
  AUTHORS   Friede,M.E., Leibelt,S., Dudziak,D. and Steinle,A.
  TITLE     Select Clr-g Expression on Activated Dendritic Cells Facilitates
            Cognate Interaction with a Minor Subset of Splenic NK Cells
            Expressing the Inhibitory Nkrp1g Receptor
  JOURNAL   J Immunol 200 (3), 983-996 (2018)
   PUBMED   29263211
  REMARK    GeneRIF: in the spleen, Nkrp1g is selectively expressed by a subset
            of Natural Killer Cells, thereby potentially allowing for an
            inhibitory engagement with Clr-g-expressing activated Dendritic
            Cells during immune responses.
REFERENCE   4  (bases 1 to 1108)
  AUTHORS   Aguilar,O.A., Berry,R., Rahim,M.M.A., Reichel,J.J., Popovic,B.,
            Tanaka,M., Fu,Z., Balaji,G.R., Lau,T.N.H., Tu,M.M., Kirkham,C.L.,
            Mahmoud,A.B., Mesci,A., Krmpotic,A., Allan,D.S.J.,
            Makrigiannis,A.P., Jonjic,S., Rossjohn,J. and Carlyle,J.R.
  TITLE     A Viral Immunoevasin Controls Innate Immunity by Targeting the
            Prototypical Natural Killer Cell Receptor Family
  JOURNAL   Cell 169 (1), 58-71 (2017)
   PUBMED   28340350
REFERENCE   5  (bases 1 to 1108)
  AUTHORS   Skalova,T., Kotynkova,K., Duskova,J., Hasek,J., Koval,T.,
            Kolenko,P., Novak,P., Man,P., Hanc,P., Vanek,O., Bezouska,K. and
            Dohnalek,J.
  TITLE     Mouse Clr-g, a ligand for NK cell activation receptor NKR-P1F:
            crystal structure and biophysical properties
  JOURNAL   J Immunol 189 (10), 4881-4889 (2012)
   PUBMED   23071282
REFERENCE   6  (bases 1 to 1108)
  AUTHORS   Griff,I.C. and Reed,R.R.
  TITLE     The genetic basis for specific anosmia to isovaleric acid in the
            mouse
  JOURNAL   Cell 83 (3), 407-414 (1995)
   PUBMED   8521470
REFERENCE   7  (bases 1 to 1108)
  AUTHORS   Stoneman,E.R., Bennett,M., An,J., Chesnut,K.A., Wakeland,E.K.,
            Scheerer,J.B., Siciliano,M.J., Kumar,V. and Mathew,P.A.
  TITLE     Cloning and characterization of 5E6(Ly-49C), a receptor molecule
            expressed on a subset of murine natural killer cells
  JOURNAL   J Exp Med 182 (2), 305-313 (1995)
   PUBMED   7629496
  REMARK    Erratum:[J Exp Med. 1996 Jun 1;183(6):2705. doi:
            10.1084/jem.183.6.2705. PMID: 8676094]
REFERENCE   8  (bases 1 to 1108)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Wallace,C.R., Gibbons,A.E.,
            Smart,Y.C., Burton,R.C. and Shellam,G.R.
  TITLE     The effect of the Cmv-1 resistance gene, which is linked to the
            natural killer cell gene complex, is mediated by natural killer
            cells
  JOURNAL   J Immunol 149 (2), 581-589 (1992)
   PUBMED   1378069
REFERENCE   9  (bases 1 to 1108)
  AUTHORS   Yokoyama,W.M., Ryan,J.C., Hunter,J.J., Smith,H.R., Stark,M. and
            Seaman,W.E.
  TITLE     cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49.
            Identification of a natural killer cell gene complex on mouse
            chromosome 6
  JOURNAL   J Immunol 147 (9), 3229-3236 (1991)
   PUBMED   1680927
REFERENCE   10 (bases 1 to 1108)
  AUTHORS   Giorda,R. and Trucco,M.
  TITLE     Mouse NKR-P1. A family of genes selectively coexpressed in adherent
            lymphokine-activated killer cells
  JOURNAL   J Immunol 147 (5), 1701-1708 (1991)
   PUBMED   1880421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132352.3.
            
            On Jun 25, 2019 this sequence version replaced NM_001099918.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JF429832.1, KX443626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               AC132352.3         6597-6732
            137-226             AC132352.3         16022-16111
            227-301             AC132352.3         17363-17437
            302-456             AC132352.3         19015-19169
            457-572             AC132352.3         19532-19647
            573-1108            AC132352.3         23063-23598
FEATURES             Location/Qualifiers
     source          1..1108
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.08 cM"
     gene            1..1108
                     /gene="Klrb1"
                     /gene_synonym="100043861; 4930431A04Rik; Gm4696; Klrb1g;
                     Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g"
                     /note="killer cell lectin-like receptor subfamily B member
                     1"
                     /db_xref="GeneID:100043861"
                     /db_xref="MGI:MGI:96877"
     exon            1..136
                     /gene="Klrb1"
                     /gene_synonym="100043861; 4930431A04Rik; Gm4696; Klrb1g;
                     Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g"
                     /inference="alignment:Splign:2.1.0"
     exon            137..226
                     /gene="Klrb1"
                     /gene_synonym="100043861; 4930431A04Rik; Gm4696; Klrb1g;
                     Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g"
                     /inference="alignment:Splign:2.1.0"
     exon            227..301
                     /gene="Klrb1"
                     /gene_synonym="100043861; 4930431A04Rik; Gm4696; Klrb1g;
                     Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g"
                     /inference="alignment:Splign:2.1.0"
     exon            302..456
                     /gene="Klrb1"
                     /gene_synonym="100043861; 4930431A04Rik; Gm4696; Klrb1g;
                     Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g"
                     /inference="alignment:Splign:2.1.0"
     exon            457..572
                     /gene="Klrb1"
                     /gene_synonym="100043861; 4930431A04Rik; Gm4696; Klrb1g;
                     Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g"
                     /inference="alignment:Splign:2.1.0"
     exon            573..1108
                     /gene="Klrb1"
                     /gene_synonym="100043861; 4930431A04Rik; Gm4696; Klrb1g;
                     Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1084..1089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klrb1"
                     /gene_synonym="100043861; 4930431A04Rik; Gm4696; Klrb1g;
                     Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g"
                     /note="hexamer: AATAAA"
     polyA_site      1108
                     /gene="Klrb1"
                     /gene_synonym="100043861; 4930431A04Rik; Gm4696; Klrb1g;
                     Klrb6; Ly-55; Ly55; NKR-P1G; Nkrp-1e; Nkrp1g"
                     /note="major polyA site"
ORIGIN      
        1 aatgctgagt ttgttctcac tcaaaggtca gtgttacatc tcccatctct aatggatgca
       61 ccagtgctct atgctgaatt aaatttagcc gagaccagag ggctcaggtg tacatcagct
      121 ccatctctcc cccaagatgc ctgtcaggga ccaggctggc atcgggtggc tctgaaactc
      181 ggctgtgctg ggctgatctt tcttctgatg gtactcagtg tcttagtggg attcttggtg
      241 caaaaacctc taatagaaaa atgcagtgtg gctgttcaag aaaacaggac tgaaccaaca
      301 gggagatcag ccacactaga gtgcccgaga gactggcatc cacactgtga taaatgctta
      361 tttacttctc aaacttccag accttgggct gacggtctgg ttgactgtaa tttgaaagga
      421 gccactttgc tgctcattca agatgaagaa gaattgagat tattgcagaa cttctcaaag
      481 ggaaaaggac aacaatttta tattggacta aaatatgaag aagtggacaa ggtttggaag
      541 tggatgaatg gttctatttt aaatactaat ctattacaaa tcactggcaa ggatgaagaa
      601 aacagctgtg ccctcatctc acaaacagaa gtgttttctg attcctgttc ttcagacaac
      661 cattggatct gccaaaagac actgaaacac gtctgaaacc ctgtgtcctg actcctgatt
      721 atgaatctca tctctgttac ttcactattc acgccagatc tgtgaattga acagtctttg
      781 ctgttggcca gtccagtgca ccgttagtgg cacaaagcat gaattccaaa accacagtga
      841 ctcttacaga tgctcatgtc cagtttcttt attgtgtaaa tgcaaatgta caccgacaca
      901 gatgtgccat tctaagagag gagttctaca gagggtcatc agggggcact ggagtctggg
      961 aaggttttgc tgatctctgt gcctgaggtc atctgcagac agctgcagaa aagatgttgt
     1021 aaagtctaga tctctactct accccttcct caaaccatct aacatctgaa ctgtagaact
     1081 ttgaataaag tattgttctt gactgaca
//
