LOCUS       NM_010651               1194 bp    mRNA    linear   ROD 17-MAR-2022
DEFINITION  Mus musculus killer cell lectin-like receptor subfamily A, member 9
            (Klra9), mRNA.
ACCESSION   NM_010651 XM_003688733 XM_918529
VERSION     NM_010651.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1194)
  AUTHORS   Parikh BA, Bern MD, Piersma SJ, Yang L, Beckman DL,
            Poursine-Laurent J, Plougastel-Douglas B and Yokoyama WM.
  TITLE     Control of Viral Infection by Natural Killer Cell Inhibitory
            Receptors
  JOURNAL   Cell Rep 32 (4), 107969 (2020)
   PUBMED   32726632
REFERENCE   2  (bases 1 to 1194)
  AUTHORS   Shi L, Li K, Guo Y, Banerjee A, Wang Q, Lorenz UM, Parlak M,
            Sullivan LC, Onyema OO, Arefanian S, Stelow EB, Brautigan DL,
            Bullock TNJ, Brown MG and Krupnick AS.
  TITLE     Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer
            cell-mediated control of lung cancer
  JOURNAL   Proc Natl Acad Sci U S A 115 (46), 11808-11813 (2018)
   PUBMED   30381460
  REMARK    GeneRIF: Clearance of lung cancer is facilitated by up-regulation
            of NKG2D, NKp46, and other activating receptors upon exposure to
            environmental MHCI. Surface expression of the inhibitory receptor
            Ly49C/I, on the other hand, is down-regulated upon exposure to
            tumor-bearing tissue.
REFERENCE   3  (bases 1 to 1194)
  AUTHORS   McCullen MV, Li H, Cam M, Sen SK, McVicar DW and Anderson SK.
  TITLE     Analysis of Ly49 gene transcripts in mature NK cells supports a
            role for the Pro1 element in gene activation, not gene expression
  JOURNAL   Genes Immun 17 (6), 349-357 (2016)
   PUBMED   27467282
REFERENCE   4  (bases 1 to 1194)
  AUTHORS   Schenkel AR, Kingry LC and Slayden RA.
  TITLE     The ly49 gene family. A brief guide to the nomenclature, genetics,
            and role in intracellular infection
  JOURNAL   Front Immunol 4, 90 (2013)
   PUBMED   23596445
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1194)
  AUTHORS   Gays F, Koh AS, Mickiewicz KM, Aust JG and Brooks CG.
  TITLE     Comprehensive analysis of transcript start sites in ly49 genes
            reveals an unexpected relationship with gene function and a lack of
            upstream promoters
  JOURNAL   PLoS One 6 (3), e18475 (2011)
   PUBMED   21483805
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1194)
  AUTHORS   Brennan J, Lemieux S, Freeman JD, Mager DL and Takei F.
  TITLE     Heterogeneity among Ly-49C natural killer (NK) cells:
            characterization of highly related receptors with differing
            functions and expression patterns
  JOURNAL   J Exp Med 184 (6), 2085-2090 (1996)
   PUBMED   8976165
REFERENCE   7  (bases 1 to 1194)
  AUTHORS   Sundback J, Karre K and Sentman CL.
  TITLE     Cloning of minimally divergent allelic forms of the natural killer
            (NK) receptor Ly-49C, differentially controlled by host genes in
            the MHC and NK gene complexes
  JOURNAL   J Immunol 157 (9), 3936-3942 (1996)
   PUBMED   8892625
REFERENCE   8  (bases 1 to 1194)
  AUTHORS   Stoneman ER, Bennett M, An J, Chesnut KA, Wakeland EK, Scheerer JB,
            Siciliano MJ, Kumar V and Mathew PA.
  TITLE     Cloning and characterization of 5E6(Ly-49C), a receptor molecule
            expressed on a subset of murine natural killer cells
  JOURNAL   J Exp Med 182 (2), 305-313 (1995)
   PUBMED   7629496
  REMARK    Erratum:[J Exp Med. 1996 Jun 1;183(6):2705. PMID: 8676094]
REFERENCE   9  (bases 1 to 1194)
  AUTHORS   Held W, Roland J and Raulet DH.
  TITLE     Allelic exclusion of Ly49-family genes encoding class I
            MHC-specific receptors on NK cells
  JOURNAL   Nature 376 (6538), 355-358 (1995)
   PUBMED   7630404
REFERENCE   10 (bases 1 to 1194)
  AUTHORS   Wong S, Freeman JD, Kelleher C, Mager D and Takei F.
  TITLE     Ly-49 multigene family. New members of a superfamily of type II
            membrane proteins with lectin-like domains
  JOURNAL   J Immunol 147 (4), 1417-1423 (1991)
   PUBMED   1869832
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090127.11 and U49865.1.
            
            On or before Dec 1, 2013 this sequence version replaced
            XM_003688733.1, NM_010651.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U49865.1, AF237686.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-138               AC090127.11        33258-33395
            139-984             U49865.1           139-984
            985-1194            AC090127.11        47479-47688
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1194
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /note="killer cell lectin-like receptor subfamily A,
                     member 9"
                     /db_xref="GeneID:16640"
                     /db_xref="MGI:MGI:1321153"
     exon            1..138
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..275
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..964
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /note="Ly49I receptor"
                     /codon_start=1
                     /product="killer cell lectin-like receptor subfamily A,
                     member 9"
                     /protein_id="NP_034781.2"
                     /db_xref="CCDS:CCDS39667.1"
                     /db_xref="GeneID:16640"
                     /db_xref="MGI:MGI:1321153"
                     /translation="MNEPEVTYSTVRLHKSSGLQKLVRHEETQGPREAGNRKCSVSWQ
                     LIVKALGILCFLLLVIVAVLTIKIFQYSQHKQEINETLNHYHNCSNMQSDFNLKEEML
                     TNKSIDCRPSNELLDYIKREQDRWNSETKTVLDSSRDTGRGVKHWFCYGTKCYYFIMN
                     KTTWSGCKANCQHYSVPIVKIEDEDELKFLQRHVIPESYWIGLSYDKKKKEWAWIDNG
                     QSKLDMKTRKMNFKSRGCVFLSKARIEDTDCNIPYYCICGKKLDKFPD"
     exon            276..365
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /inference="alignment:Splign:2.1.0"
     exon            366..584
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..724
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..828
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /inference="alignment:Splign:2.1.0"
     exon            829..984
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1194
                     /gene="Klra9"
                     /gene_synonym="Ly49I; LY49I1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcacgaggt tgagtatcac tcggtggaaa tttagctctg tctttcaatt ttgaaactca
       61 taggagatat agaccagaaa aacgccaact tttcagacaa attttccctc caccagaatc
      121 actccggtag agacacagag aacagacttc ttgtactccc acgatgaatg agccggaggt
      181 cacttactca actgtgagac ttcataagtc ttcagggttg cagaaattag taaggcatga
      241 ggagactcaa gggcccagag aagctggcaa cagaaagtgt tcagtatcct ggcaactcat
      301 tgtgaaagct cttggaatcc tctgtttcct tcttctggta atagttgcag tgttgacgat
      361 aaagattttt cagtatagtc aacacaaaca agaaatcaat gaaactctca accactacca
      421 taactgcagc aacatgcaaa gtgatttcaa cttaaaggaa gaaatgttga caaataagtc
      481 tatagattgt aggccaagca atgaacttct ggattacatc aaaagagaac aggacagatg
      541 gaacagtgaa accaagacgg ttttagattc ctcacgggac acaggcagag gtgttaaaca
      601 ctggttctgc tatggtacta aatgttatta tttcatcatg aacaaaacta catggagtgg
      661 atgtaaagcg aactgccagc attacagcgt tcccattgtg aagatagaag atgaagatga
      721 actgaaattc cttcaacgcc atgttattcc agagagttac tggattggat tgtcttatga
      781 taagaaaaaa aaggaatggg catggattga caatggccaa tctaaacttg acatgaaaac
      841 aaggaaaatg aactttaagt ctagaggatg tgtattttta tctaaagcaa gaatagaaga
      901 tactgactgt aatattccct actactgtat ttgtgggaag aaactggata aattccctga
      961 ttaactttcc aaccagagtt aaagaacaaa gtctgctgtg aagagaaaca aagctgcaag
     1021 aacattggga ctgtactctc ctatctatct tgacagaaca gaggtcattt tctatcctgt
     1081 tggagagagg acgcatctac tcgggtgaat gggctcgctt tgccctaaag ccttcagaat
     1141 tgtgttcttt ctgatttctt aaactcccat aaaactgaat aaagagtcct ccct
//
