LOCUS       NM_001101620            1178 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            8 (Klra8), transcript variant 1, mRNA.
ACCESSION   NM_001101620 XM_001471777
VERSION     NM_001101620.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1178)
  AUTHORS   Vetters,J., van Helden,M., De Nolf,C., Rennen,S., Cloots,E., Van De
            Velde,E., Fayazpour,F., Van Moorleghem,J., Vanheerswynghels,M.,
            Vergote,K., Boon,L., Vivier,E., Lambrecht,B.N. and Janssens,S.
  TITLE     Canonical IRE1 function needed to sustain vigorous natural killer
            cell proliferation during viral infection
  JOURNAL   iScience 26 (12), 108570 (2023)
   PUBMED   38162021
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1178)
  AUTHORS   Potempa,M., Aguilar,O.A., Gonzalez-Hinojosa,M.D.R., Tenvooren,I.,
            Marquez,D.M., Spitzer,M.H. and Lanier,L.L.
  TITLE     Influence of Self-MHC Class I Recognition on the Dynamics of NK
            Cell Responses to Cytomegalovirus Infection
  JOURNAL   J Immunol 208 (7), 1742-1754 (2022)
   PUBMED   35321880
REFERENCE   3  (bases 1 to 1178)
  AUTHORS   Riggan,L., Ma,F., Li,J.H., Fernandez,E., Nathanson,D.A.,
            Pellegrini,M. and O'Sullivan,T.E.
  TITLE     The transcription factor Fli1 restricts the formation of memory
            precursor NK cells during viral infection
  JOURNAL   Nat Immunol 23 (4), 556-567 (2022)
   PUBMED   35288713
REFERENCE   4  (bases 1 to 1178)
  AUTHORS   Flommersfeld,S., Bottcher,J.P., Ersching,J., Flossdorf,M.,
            Meiser,P., Pachmayr,L.O., Leube,J., Hensel,I., Jarosch,S.,
            Zhang,Q., Chaudhry,M.Z., Andrae,I., Schiemann,M., Busch,D.H.,
            Cicin-Sain,L., Sun,J.C., Gasteiger,G., Victora,G.D., Hofer,T.,
            Buchholz,V.R. and Grassmann,S.
  TITLE     Fate mapping of single NK cells identifies a type 1 innate
            lymphoid-like lineage that bridges innate and adaptive recognition
            of viral infection
  JOURNAL   Immunity 54 (10), 2288-2304 (2021)
   PUBMED   34437840
REFERENCE   5  (bases 1 to 1178)
  AUTHORS   Sheppard,S., Santosa,E.K., Lau,C.M., Violante,S., Giovanelli,P.,
            Kim,H., Cross,J.R., Li,M.O. and Sun,J.C.
  TITLE     Lactate dehydrogenase A-dependent aerobic glycolysis promotes
            natural killer cell anti-viral and anti-tumor function
  JOURNAL   Cell Rep 35 (9), 109210 (2021)
   PUBMED   34077737
REFERENCE   6  (bases 1 to 1178)
  AUTHORS   Scalzo,A.A., Lyons,P.A., Fitzgerald,N.A., Forbes,C.A.,
            Yokoyama,W.M. and Shellam,G.R.
  TITLE     Genetic mapping of Cmv1 in the region of mouse chromosome 6
            encoding the NK gene complex-associated loci Ly49 and musNKR-P1
  JOURNAL   Genomics 27 (3), 435-441 (1995)
   PUBMED   7558024
REFERENCE   7  (bases 1 to 1178)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   8  (bases 1 to 1178)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Wallace,C.R., Gibbons,A.E.,
            Smart,Y.C., Burton,R.C. and Shellam,G.R.
  TITLE     The effect of the Cmv-1 resistance gene, which is linked to the
            natural killer cell gene complex, is mediated by natural killer
            cells
  JOURNAL   J Immunol 149 (2), 581-589 (1992)
   PUBMED   1378069
REFERENCE   9  (bases 1 to 1178)
  AUTHORS   Yokoyama,W.M., Kehn,P.J., Cohen,D.I. and Shevach,E.M.
  TITLE     Chromosomal location of the Ly-49 (A1, YE1/48) multigene family.
            Genetic association with the NK 1.1 antigen
  JOURNAL   J Immunol 145 (7), 2353-2358 (1990)
   PUBMED   1975828
REFERENCE   10 (bases 1 to 1178)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Simmons,A., La Vista,A.B. and
            Shellam,G.R.
  TITLE     Cmv-1, a genetic locus that controls murine cytomegalovirus
            replication in the spleen
  JOURNAL   J Exp Med 171 (5), 1469-1483 (1990)
   PUBMED   2159050
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090127.11.
            
            On Sep 4, 2008 this sequence version replaced XM_001471777.1.
            
            Transcript Variant: represents the longer transcript and encodes
            the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U12889.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC090127.11        96472-96576
            106-257             AC090127.11        98170-98321
            258-347             AC090127.11        100058-100147
            348-566             AC090127.11        101102-101320
            567-706             AC090127.11        104193-104332
            707-810             AC090127.11        107304-107407
            811-966             AC090127.11        110699-110854
            967-1178            AC090127.11        110933-111144
FEATURES             Location/Qualifiers
     source          1..1178
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1178
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 8"
                     /db_xref="GeneID:16639"
                     /db_xref="MGI:MGI:102968"
     exon            1..105
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            106..257
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..946
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /note="isoform 1 is encoded by transcript variant 1;
                     killer cell lectin-like receptor 8; ly-49h; lymphocyte
                     antigen 49h; T-cell surface glycoprotein Ly-49H;
                     cytomegalovirus resistance 1"
                     /codon_start=1
                     /product="killer cell lectin-like receptor 8 isoform 1"
                     /protein_id="NP_001095090.1"
                     /db_xref="CCDS:CCDS51927.1"
                     /db_xref="GeneID:16639"
                     /db_xref="MGI:MGI:102968"
                     /translation="MSEQEVTFPTMRFHKSSGLNSQVRLEGTQRSRKAGLRVCSVPWQ
                     LIVIALGILCSLRLVIVAVFVTKFFQYSQHKQEINETLNHRHNCSNMQRDFNLKEEML
                     TNKSIDCRPSYELLEYIKREQERWDSETKSVSDSSRDTGRGVKYWFCYGTKCYYFIMN
                     KTTWSGCKANCQHYSVPIVKIEDEDELKFLQRHVILESYWIGLSYDKKKKEWAWIHNG
                     QSKLDMKIKKMNFTSRGCVFLSKARIEDTDCNTPYYCICGKKLDKFPD"
     exon            258..347
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            348..566
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            567..706
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            707..810
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            811..966
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1178
                     /gene="Klra8"
                     /gene_synonym="Cmv-1; Cmv1; Ly49h; Ly49u<129>"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttcttcttg gagcctctta ggggatacag accagtaaag gcccacatta ccccaattga
       61 ggcatccatt ctttctaccg gcatcacttc agggtggaga cacaggacat attttttaaa
      121 agaacatact ctacgtattc ccaagatgag tgagcaggag gtcactttcc caactatgag
      181 attccacaag tcttcagggt tgaacagcca ggtgagactt gaggggactc agagatctag
      241 aaaagctggc ctaagagtgt gttcagtccc ttggcagctc attgtgatag ctcttggaat
      301 cctctgttcc cttcggctgg taattgttgc agtgtttgtg acaaagtttt ttcagtatag
      361 tcaacacaaa caagaaatca atgaaactct caaccaccgc cataactgca gcaacatgca
      421 aagggatttc aacttaaagg aagaaatgtt gacaaataag tctatagatt gtaggccaag
      481 ctatgaactt ctggaataca tcaaaagaga acaggagaga tgggacagtg aaaccaagag
      541 tgtttcagat tcttcacgag acacaggcag aggtgttaaa tactggttct gctatggtac
      601 taaatgttat tatttcatca tgaataaaac tacatggagt ggatgtaaag cgaactgcca
      661 gcattacagc gttcccattg tgaagataga agatgaagat gaactgaaat tccttcaacg
      721 ccatgttatt ctagagagtt actggattgg attgtcatat gataagaaaa aaaaggaatg
      781 ggcatggatt cacaatggcc aatctaaact tgacatgaaa ataaagaaaa tgaactttac
      841 gtctagagga tgtgtatttt tatctaaagc aagaatagaa gatactgact gtaatactcc
      901 ctactactgt atttgtggga agaaactgga taaattccct gattaacttt ccaaccagag
      961 ttaaagaaca tagtctgctg tgaagagaaa caaagctgca agaacattgg gactgtcctc
     1021 tcctatctat cttgacagaa cagaggtcat ttttctatcc tgttggagag aggacaaatc
     1081 tactcaggtg aatgggcatg ctttgcccta aagccttcag aattgtgttc tttctgattt
     1141 cttaaactcc cataaaactg aataaagagt ccccccta
//
