LOCUS       NM_008464               1119 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            6 (Klra6), mRNA.
ACCESSION   NM_008464 XM_001471782
VERSION     NM_008464.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1119)
  AUTHORS   Schenkel,A.R., Kingry,L.C. and Slayden,R.A.
  TITLE     The ly49 gene family. A brief guide to the nomenclature, genetics,
            and role in intracellular infection
  JOURNAL   Front Immunol 4, 90 (2013)
   PUBMED   23596445
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1119)
  AUTHORS   Gays,F., Koh,A.S., Mickiewicz,K.M., Aust,J.G. and Brooks,C.G.
  TITLE     Comprehensive analysis of transcript start sites in ly49 genes
            reveals an unexpected relationship with gene function and a lack of
            upstream promoters
  JOURNAL   PLoS One 6 (3), e18475 (2011)
   PUBMED   21483805
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1119)
  AUTHORS   Gays,F., Martin,K., Kenefeck,R., Aust,J.G. and Brooks,C.G.
  TITLE     Multiple cytokines regulate the NK gene complex-encoded receptor
            repertoire of mature NK cells and T cells
  JOURNAL   J Immunol 175 (5), 2938-2947 (2005)
   PUBMED   16116180
  REMARK    Erratum:[J Immunol. 2005 Dec 15;175(12):8441]
REFERENCE   4  (bases 1 to 1119)
  AUTHORS   Makrigiannis,A.P., Pau,A.T., Saleh,A., Winkler-Pickett,R.,
            Ortaldo,J.R. and Anderson,S.K.
  TITLE     Class I MHC-binding characteristics of the 129/J Ly49 repertoire
  JOURNAL   J Immunol 166 (8), 5034-5043 (2001)
   PUBMED   11290784
REFERENCE   5  (bases 1 to 1119)
  AUTHORS   Depatie,C., Lee,S.H., Stafford,A., Avner,P., Belouchi,A., Gros,P.
            and Vidal,S.M.
  TITLE     Sequence-ready BAC contig, physical, and transcriptional map of a
            2-Mb region overlapping the mouse chromosome 6 host-resistance
            locus Cmv1
  JOURNAL   Genomics 66 (2), 161-174 (2000)
   PUBMED   10860661
REFERENCE   6  (bases 1 to 1119)
  AUTHORS   Corral,L., Takizawa,H., Hanke,T., Jamieson,A.M. and Raulet,D.H.
  TITLE     A new monoclonal antibody reactive with several Ly49 NK cell
            receptors mediates redirected lysis of target cells
  JOURNAL   Hybridoma 18 (4), 359-366 (1999)
   PUBMED   10571266
REFERENCE   7  (bases 1 to 1119)
  AUTHORS   Yokoyama,W.M.
  TITLE     Hybrid resistance and the Ly-49 family of natural killer cell
            receptors
  JOURNAL   J Exp Med 182 (2), 273-277 (1995)
   PUBMED   7629493
  REMARK    Review article
REFERENCE   8  (bases 1 to 1119)
  AUTHORS   Smith,H.R., Karlhofer,F.M. and Yokoyama,W.M.
  TITLE     Ly-49 multigene family expressed by IL-2-activated NK cells
  JOURNAL   J Immunol 153 (3), 1068-1079 (1994)
   PUBMED   8027540
REFERENCE   9  (bases 1 to 1119)
  AUTHORS   Wong,S., Freeman,J.D., Kelleher,C., Mager,D. and Takei,F.
  TITLE     Ly-49 multigene family. New members of a superfamily of type II
            membrane proteins with lectin-like domains
  JOURNAL   J Immunol 147 (4), 1417-1423 (1991)
   PUBMED   1869832
REFERENCE   10 (bases 1 to 1119)
  AUTHORS   Yokoyama,W.M., Kehn,P.J., Cohen,D.I. and Shevach,E.M.
  TITLE     Chromosomal location of the Ly-49 (A1, YE1/48) multigene family.
            Genetic association with the NK 1.1 antigen
  JOURNAL   J Immunol 145 (7), 2353-2358 (1990)
   PUBMED   1975828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090563.17.
            
            On Jul 27, 2022 this sequence version replaced NM_008464.2.
            
            Summary: This gene belongs to the highly polymorphic family of
            C-type lectin-like Ly49 genes that are expressed in natural killer
            (NK) cells. The encoded protein is a homodimeric type II
            transmembrane receptor located at the cell surface and inhibits NK
            cell activation upon ligand binding. This gene is located in a
            cluster of several Klra paralogs on chromosome 6. Different strains
            of mice show variation in the number of paralogs, including strain
            specific duplications, deletions and pseudogene sequences.
            [provided by RefSeq, Apr 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10092.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849383
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC090563.17        173669-173723       c
            56-192              AC090563.17        171877-172013       c
            193-282             AC090563.17        170407-170496       c
            283-501             AC090563.17        169352-169570       c
            502-641             AC090563.17        165602-165741       c
            642-745             AC090563.17        163411-163514       c
            746-900             AC090563.17        160096-160250       c
            901-1119            AC090563.17        159799-160017       c
FEATURES             Location/Qualifiers
     source          1..1119
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1119
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 6"
                     /db_xref="GeneID:16637"
                     /db_xref="MGI:MGI:101902"
     exon            1..55
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /inference="alignment:Splign:2.1.0"
     exon            56..192
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..881
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /note="lymphocyte antigen 49f; T-cell surface glycoprotein
                     Ly-49F"
                     /codon_start=1
                     /product="killer cell lectin-like receptor 6"
                     /protein_id="NP_032490.1"
                     /db_xref="CCDS:CCDS20597.1"
                     /db_xref="GeneID:16637"
                     /db_xref="MGI:MGI:101902"
                     /translation="MSEPEVTYSTVRLHKSSRLQKLVRHEETQGPREAGYRKCSVCWQ
                     LIVKALGILCFLLLITVAVLAVKIFQYGQHNQEIHETLNYHHNCSNMQSDFNLKEEML
                     TNRSIDSRPGNELLESLNREQNRGYSETKTDLDSSQDTGTGVKYWFCYRTKCYYFIMN
                     KNTWSGCKQNCQHYSLPLVKIDDENELKFLQFQVIPDSYWIGLSYDKEKKEWAWIDNG
                     QSKLDMKIRKMNFKPGGCVFLSKRRLEDTNCKNSHYCICGKKLDKFPH"
     exon            193..282
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /inference="alignment:Splign:2.1.0"
     exon            283..501
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /inference="alignment:Splign:2.1.0"
     exon            502..641
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /inference="alignment:Splign:2.1.0"
     exon            642..745
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /inference="alignment:Splign:2.1.0"
     exon            746..900
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1119
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1092..1097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /note="hexamer: AATAAA"
     polyA_site      1119
                     /gene="Klra6"
                     /gene_synonym="ly-49f; Ly49f"
                     /note="major polyA site"
ORIGIN      
        1 caccaactct acagacaaat tttccctcac cagaatcact ccggtagaga cacagagaac
       61 agacttcttg tactcccaca atgagtgagc cggaggtcac ttactcaact gtgagacttc
      121 ataagtcttc aaggttgcag aaacttgtaa ggcatgagga gactcaaggg cccagagaag
      181 ctggctacag aaagtgttca gtatgctggc agctcattgt gaaagctctt ggaatcctct
      241 gtttccttct tcttataaca gttgcagtgt tggcagtaaa gatttttcag tatggtcaac
      301 acaaccaaga aatccatgaa actctaaact accaccataa ctgcagcaac atgcaaagtg
      361 atttcaactt aaaggaagaa atgttgacaa ataggtctat agactctagg ccaggcaatg
      421 aacttctgga atccctcaac agagaacaga acagagggta cagtgaaact aagacagatt
      481 tagattcctc acaggacaca gggacaggtg ttaaatactg gttctgctac cgtactaaat
      541 gttattattt catcatgaac aaaaatacat ggagtggatg taaacagaac tgccagcatt
      601 acagcttacc ccttgtgaag atagacgatg aaaatgaact gaaattcctt caattccagg
      661 ttattccaga cagttactgg attggattgt catatgataa ggaaaaaaag gagtgggcat
      721 ggattgacaa tggccaatct aaacttgaca tgaaaataag gaaaatgaac tttaagcctg
      781 gaggatgtgt atttttatct aaaagaagac tagaagatac taactgtaaa aattcccact
      841 actgtatttg tgggaagaaa ctggataaat ttcctcatta actttccacc aaagttaaag
      901 aacatagact gctgtgaata gagacaaagc tgcaagagca ttgggactgt tctctggtat
      961 ctaacttgca gaacagaggc catcttcctt cctgttggag acaggacaca tctactctgg
     1021 tgaaggggac cctttgccct aaagccttca gaattgtgtt ctttctgatt ttttaaactc
     1081 ctataaaact aaataaagaa ccctcccctc cccccaaaa
//
