LOCUS       NM_008463               1155 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            5 (Klra5), mRNA.
ACCESSION   NM_008463
VERSION     NM_008463.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1155)
  AUTHORS   Van Acker,A., Louagie,E., Filtjens,J., Taveirne,S., Van Ammel,E.,
            Kerre,T., Elewaut,D., Taghon,T., Vandekerckhove,B., Plum,J. and
            Leclercq,G.
  TITLE     The role of Ly49E receptor expression on murine intraepithelial
            lymphocytes in intestinal cancer development and progression
  JOURNAL   Cancer Immunol Immunother 65 (11), 1365-1375 (2016)
   PUBMED   27585789
  REMARK    GeneRIF: this study shows that Ly49E expression on intraepithelial
            lymphocytes does not influence the development or progression of
            intestinal cancer
REFERENCE   2  (bases 1 to 1155)
  AUTHORS   Filtjens,J., Keirsse,J., Van Ammel,E., Taveirne,S., Van Acker,A.,
            Kerre,T., Taghon,T., Vandekerckhove,B., Plum,J., Van
            Ginderachter,J.A. and Leclercq,G.
  TITLE     Expression of the inhibitory Ly49E receptor is not critically
            involved in the immune response against cutaneous, pulmonary or
            liver tumours
  JOURNAL   Sci Rep 6, 30564 (2016)
   PUBMED   27469529
  REMARK    GeneRIF: Ly49E is highly expressed on epidermal gammadelta T cells
            and liver NK cells, this receptor does not play a major role in the
            control of skin tumour formation or in lung and liver tumour
            development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1155)
  AUTHORS   Van Acker,A., Filtjens,J., Van Welden,S., Taveirne,S., Van
            Ammel,E., Vanhees,M., Devisscher,L., Kerre,T., Taghon,T.,
            Vandekerckhove,B., Plum,J. and Leclercq,G.
  TITLE     Ly49E expression on CD8alphaalpha-expressing intestinal
            intraepithelial lymphocytes plays no detectable role in the
            development and progression of experimentally induced inflammatory
            bowel diseases
  JOURNAL   PLoS One 9 (10), e110015 (2014)
   PUBMED   25310588
  REMARK    GeneRIF: Ly49E is expressed on a high proportion of
            CD8alphaalpha-positive intestinal intraepithelial lymphocytes.
            Erratum:[PLoS One. 2015 Apr 09;10(4):e0124464. doi:
            10.1371/journal.pone.0124464.. PMID: 25856310]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1155)
  AUTHORS   Filtjens,J., Foquet,L., Taveirne,S., Van Ammel,E., Vanhees,M., Van
            Acker,A., Kerre,T., Taghon,T., Vandekerckhove,B., Plum,J., Van den
            Steen,P.E. and Leclercq,G.
  TITLE     Contribution of the Ly49E natural killer receptor in the immune
            response to Plasmodium berghei infection and control of hepatic
            parasite development
  JOURNAL   PLoS One 9 (1), e87463 (2014)
   PUBMED   24498110
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1155)
  AUTHORS   Schenkel,A.R., Kingry,L.C. and Slayden,R.A.
  TITLE     The ly49 gene family. A brief guide to the nomenclature, genetics,
            and role in intracellular infection
  JOURNAL   Front Immunol 4, 90 (2013)
   PUBMED   23596445
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1155)
  AUTHORS   Yokoyama,W.M.
  TITLE     Hybrid resistance and the Ly-49 family of natural killer cell
            receptors
  JOURNAL   J Exp Med 182 (2), 273-277 (1995)
   PUBMED   7629493
  REMARK    Review article
REFERENCE   7  (bases 1 to 1155)
  AUTHORS   Smith,H.R., Karlhofer,F.M. and Yokoyama,W.M.
  TITLE     Ly-49 multigene family expressed by IL-2-activated NK cells
  JOURNAL   J Immunol 153 (3), 1068-1079 (1994)
   PUBMED   8027540
REFERENCE   8  (bases 1 to 1155)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (bases 1 to 1155)
  AUTHORS   Wong,S., Freeman,J.D., Kelleher,C., Mager,D. and Takei,F.
  TITLE     Ly-49 multigene family. New members of a superfamily of type II
            membrane proteins with lectin-like domains
  JOURNAL   J Immunol 147 (4), 1417-1423 (1991)
   PUBMED   1869832
REFERENCE   10 (bases 1 to 1155)
  AUTHORS   Yokoyama,W.M., Kehn,P.J., Cohen,D.I. and Shevach,E.M.
  TITLE     Chromosomal location of the Ly-49 (A1, YE1/48) multigene family.
            Genetic association with the NK 1.1 antigen
  JOURNAL   J Immunol 145 (7), 2353-2358 (1990)
   PUBMED   1975828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090563.17 and U10091.1.
            
            On Nov 17, 2006 this sequence version replaced NM_008463.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10091.1, AF247643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AC090563.17        59979-59993         c
            16-940              U10091.1           16-940
            941-1053            AC090563.17        45859-45971         c
            1054-1155           U10091.1           1053-1154
FEATURES             Location/Qualifiers
     source          1..1155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1155
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 5"
                     /db_xref="GeneID:16636"
                     /db_xref="MGI:MGI:101903"
     exon            1..85
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /inference="alignment:Splign:2.1.0"
     exon            86..220
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..909
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /note="Ly49E receptor; class I MHC receptor KLRA5; ly-49e;
                     lymphocyte antigen 49e; T-cell surface glycoprotein
                     Ly-49E"
                     /codon_start=1
                     /product="killer cell lectin-like receptor 5"
                     /protein_id="NP_032489.1"
                     /db_xref="CCDS:CCDS20596.1"
                     /db_xref="GeneID:16636"
                     /db_xref="MGI:MGI:101903"
                     /translation="MSEPEVTYSTVRLHKSSGLQRLVSHEEIQGPGEAGYRKCSVPWQ
                     LTVRSLGIFCFLLLVTVAVLAVKIFQYSQHKQEIHETLNHNHNCSNMQSDIKLKEEML
                     RNKSIDCSPGEELLESLNREQNRWYSETKTDLDSSQDTGTGVKHWFCYGTKCFYFIMS
                     KNTWSGCKQTCQHYSLPLVKIEDEDELKFLQFQVISDSYWIGLSYDKKKKQWAWIDNG
                     PSKLDMKTRKMNFKPGGCIFLSKTRLEDTNCNNSYFCICGKKLDHFPG"
     exon            221..310
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /inference="alignment:Splign:2.1.0"
     exon            311..529
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /inference="alignment:Splign:2.1.0"
     exon            530..669
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /inference="alignment:Splign:2.1.0"
     exon            670..773
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /inference="alignment:Splign:2.1.0"
     exon            774..929
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1155
                     /gene="Klra5"
                     /gene_synonym="Ly49e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaaactcgta ggggatatag accagaaaac gccaactttt cacccaactt ttccctccac
       61 cagaatcact ccggtagaga cacagaacat acttcatgca ctcccacgat gagtgaacca
      121 gaggtcactt actcaactgt gagacttcat aagtcttcag ggttgcagag actagtgagc
      181 catgaggaga ttcaagggcc cggagaagct ggctacagaa agtgttcagt accctggcag
      241 ctcactgtga gatcgcttgg aatcttctgt ttccttcttc tagtaacagt tgcagtgttg
      301 gcagtaaaga tttttcagta tagtcaacac aaacaagaaa tccacgaaac tctaaaccac
      361 aaccataact gcagcaacat gcaaagtgac atcaaattaa aggaagaaat gttgagaaat
      421 aagtctatag attgcagtcc aggtgaggaa cttctggaat ccctcaacag agaacagaac
      481 agatggtaca gtgaaaccaa gacagattta gattcctcac aagacacagg gacaggtgtt
      541 aaacactggt tctgctatgg tactaaatgt ttttatttca tcatgagcaa aaatacatgg
      601 agtggatgta aacagacctg ccagcattac agcttacccc ttgtgaagat agaagatgaa
      661 gatgaactga aattccttca gttccaggtt atttcagaca gttactggat tggattgtca
      721 tatgataaga aaaaaaagca atgggcatgg attgacaatg gcccatctaa acttgacatg
      781 aaaacaagga aaatgaactt taagcctgga ggttgtatat ttttatctaa aacaagacta
      841 gaagatacta actgtaataa ttcctacttc tgcatttgtg ggaagaaact ggatcatttc
      901 cctggttaac tttccaaaga gagttaaaga acatagtctg ctgtgaagag aaacaaagct
      961 gcaggagcat tgggactgtt ctctggtatc tattttgaca gaacagagtt catcttcctt
     1021 cctcttggag acagaacaca tctactctgg ggaatgggca ccctttgcat aaagccttca
     1081 gaattttgtt ctttctgatt tcttatactc ctataaaact gaataaagaa ccctatcccc
     1141 ccccccgaaa aaaaa
//
