LOCUS       NM_001411846            1266 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            4 (Klra4), transcript variant 3, mRNA.
ACCESSION   NM_001411846 XM_006505646
VERSION     NM_001411846.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1266)
  AUTHORS   Nabekura,T. and Lanier,L.L.
  TITLE     Activating Receptors for Self-MHC Class I Enhance Effector
            Functions and Memory Differentiation of NK Cells during Mouse
            Cytomegalovirus Infection
  JOURNAL   Immunity 45 (1), 74-82 (2016)
   PUBMED   27438766
  REMARK    GeneRIF: this study shows that after mouse cytomegalovirus
            infection, Ly49D augmented IFN-gamma production by virus-specific
            Ly49H(+) NK cells and preferentially promoted the generation of
            memory Ly49H(+) NK cells
REFERENCE   2  (bases 1 to 1266)
  AUTHORS   Liu,J., Liu,S., Xia,M., Xu,S., Wang,C., Bao,Y., Jiang,M., Wu,Y.,
            Xu,T. and Cao,X.
  TITLE     Rhomboid domain-containing protein 3 is a negative regulator of
            TLR3-triggered natural killer cell activation
  JOURNAL   Proc Natl Acad Sci U S A 110 (19), 7814-7819 (2013)
   PUBMED   23610400
REFERENCE   3  (bases 1 to 1266)
  AUTHORS   Schenkel,A.R., Kingry,L.C. and Slayden,R.A.
  TITLE     The ly49 gene family. A brief guide to the nomenclature, genetics,
            and role in intracellular infection
  JOURNAL   Front Immunol 4, 90 (2013)
   PUBMED   23596445
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1266)
  AUTHORS   Tassi,I., Le Friec,G., Gilfillan,S., Takai,T., Yokoyama,W.M. and
            Colonna,M.
  TITLE     DAP10 associates with Ly49 receptors but contributes minimally to
            their expression and function in vivo
  JOURNAL   Eur J Immunol 39 (4), 1129-1135 (2009)
   PUBMED   19247984
  REMARK    GeneRIF: these data demonstrate that DAP10 does associate with
            Ly49H and Ly49D in primary NK cells.
REFERENCE   5  (bases 1 to 1266)
  AUTHORS   Merck,E., Voyle,R.B. and MacDonald,H.R.
  TITLE     Ly49D engagement on T lymphocytes induces TCR-independent
            activation and CD8 effector functions that control tumor growth
  JOURNAL   J Immunol 182 (1), 183-192 (2009)
   PUBMED   19109149
  REMARK    GeneRIF: Ly49D stimulation triggers cellular activation of CD4 and
            CD8 populations; Ly49D recognizes the classical hamster class I
            molecule Hm1-C4 on CHO cells, as demonstrated by the killing of
            Hm1-C4-transfected thymoma cells by Ly49D cytotoxic T cells.
REFERENCE   6  (bases 1 to 1266)
  AUTHORS   Yokoyama,W.M.
  TITLE     Hybrid resistance and the Ly-49 family of natural killer cell
            receptors
  JOURNAL   J Exp Med 182 (2), 273-277 (1995)
   PUBMED   7629493
  REMARK    Review article
REFERENCE   7  (bases 1 to 1266)
  AUTHORS   Smith,H.R., Karlhofer,F.M. and Yokoyama,W.M.
  TITLE     Ly-49 multigene family expressed by IL-2-activated NK cells
  JOURNAL   J Immunol 153 (3), 1068-1079 (1994)
   PUBMED   8027540
REFERENCE   8  (bases 1 to 1266)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   9  (bases 1 to 1266)
  AUTHORS   Wong,S., Freeman,J.D., Kelleher,C., Mager,D. and Takei,F.
  TITLE     Ly-49 multigene family. New members of a superfamily of type II
            membrane proteins with lectin-like domains
  JOURNAL   J Immunol 147 (4), 1417-1423 (1991)
   PUBMED   1869832
REFERENCE   10 (bases 1 to 1266)
  AUTHORS   Yokoyama,W.M., Kehn,P.J., Cohen,D.I. and Shevach,E.M.
  TITLE     Chromosomal location of the Ly-49 (A1, YE1/48) multigene family.
            Genetic association with the NK 1.1 antigen
  JOURNAL   J Immunol 145 (7), 2353-2358 (1990)
   PUBMED   1975828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090127.11 and AC090563.17.
            
            On Sep 7, 2022 this sequence version replaced XM_006505646.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422591.92740.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC090127.11        159091-159203
            114-277             AC090127.11        161016-161179
            278-367             AC090127.11        163175-163264
            368-574             AC090127.11        164145-164351
            575-717             AC090127.11        166705-166847
            718-821             AC090563.17        199734-199837       c
            822-1266            AC090563.17        190499-190943       c
FEATURES             Location/Qualifiers
     source          1..1266
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1266
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 4"
                     /db_xref="GeneID:16635"
                     /db_xref="MGI:MGI:101904"
     exon            1..113
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            114..277
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..957
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /note="isoform 2 is encoded by transcript variant 3;
                     killer cell lectin-like receptor 4; killer cell
                     lectin-like receptor subfamily A member 32; lymphocyte
                     antigen 49d; T-cell surface glycoprotein Ly-49D; killer
                     cell lectin-like receptor subfamily A member 33"
                     /codon_start=1
                     /product="killer cell lectin-like receptor 4 isoform 2"
                     /protein_id="NP_001398775.1"
                     /db_xref="GeneID:16635"
                     /db_xref="MGI:MGI:101904"
                     /translation="MTEQEDTFSAVRFHKSSGLQNEMRLKETRKPEKARLRVCSVPWQ
                     LIVIALGILISLRLVTVAVLMTNIFQYGQQKHELKEFLKHHNNCSIMQSDINLKDELL
                     KNKSIECNLLESLNRDQNILCDKTRTVLDYLQHTGRGVKVYWFCYGMKCYYFVMDRKP
                     WSRCKQSCQNSSLTLLKIDDEDELKFLQLVVPSDSCWIGLSYDNKKKDWAWIDNRPSK
                     LALNTTKYNIRDGGCMFLSKTRLDNNYCDQSFICICGKRLDKFPH"
     exon            278..367
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            368..574
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            575..717
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            718..821
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /inference="alignment:Splign:2.1.0"
     exon            822..1266
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1246..1251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /note="hexamer: AATAAA"
     polyA_site      1266
                     /gene="Klra4"
                     /gene_synonym="Chok; Klra32; Klra33; Ly-49d; Ly49d;
                     ly49r<129>"
                     /note="major polyA site"
ORIGIN      
        1 agttctgcct ttcttcttgg agcctctaag gggatacaca ccagaaaagg cccacattac
       61 cccaacaggg acatccattc cttctaccca cctcacttca ggtagagtca cagaaatcac
      121 tcaaggacat attttaaaag agaacatact ctacatactc ccaagatgac tgaacaggaa
      181 gacactttct cagctgtgag attccataag tcttcagggt tgcagaacga gatgaggctc
      241 aaggagacac ggaagcctga aaaagctcgc ctcagagtgt gttcagttcc ctggcagctc
      301 attgtgatag ctctcgggat cctcatttcc cttcgactgg taactgttgc agtgcttatg
      361 acaaacattt ttcagtatgg tcaacaaaaa catgaactga aggaatttct aaaacaccac
      421 aataactgca gcatcatgca aagtgacatc aacttgaagg atgaactgct gaaaaataag
      481 tctatagagt gtaatcttct ggaatccctc aacagggatc aaaacatact gtgtgataaa
      541 accaggactg ttttagatta cttacagcac acaggcagag gtgttaaagt atactggttc
      601 tgttatggta tgaaatgtta ttatttcgtc atggacagaa aaccatggag tagatgtaaa
      661 cagagctgcc agaattccag cttaaccctt ctgaagatag atgatgagga tgaactgaag
      721 ttccttcagc tcgtggttcc ttcagacagt tgctggattg gattgtcata tgataataag
      781 aaaaaagatt gggcatggat tgacaatcgc ccatctaaac ttgccttgaa cacaacgaaa
      841 tacaatataa gagatggagg atgtatgttc ttatctaaaa ctagactaga caataattac
      901 tgtgatcaat cattcatctg tatttgtggg aagagattgg acaaattccc tcattgactc
      961 tccagtgagt gttaaaagta aaaaaaaaaa aaaatgaaaa tttctgactc tcatttgttt
     1021 cctgtaataa ttcatgactc cttagaaaca agtgcttgac cattggacat agtctgcagt
     1081 gcaaagagag agacaatctg gaagattttg ggaatgttct ctgaaacatg acatgaaaga
     1141 gcagaggata tcttccttcc ctgtggagac tggacagatc ttctctggtc ccgcaaaact
     1201 tgaatgaatc tgatttattt gtttgcataa actccaatag aattaaataa aggatcttaa
     1261 taacca
//
