LOCUS       NM_010648               1303 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            3 (Klra3), transcript variant 1, mRNA.
ACCESSION   NM_010648 XM_918261 XM_925604
VERSION     NM_010648.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1303)
  AUTHORS   Ma,J., Ayres,C.M., Hellman,L.M., Devlin,J.R. and Baker,B.M.
  TITLE     Dynamic allostery controls the peptide sensitivity of the Ly49C
            natural killer receptor
  JOURNAL   J Biol Chem 296, 100686 (2021)
   PUBMED   33891944
  REMARK    GeneRIF: Dynamic allostery controls the peptide sensitivity of the
            Ly49C natural killer receptor.
REFERENCE   2  (bases 1 to 1303)
  AUTHORS   Parikh,B.A., Bern,M.D., Piersma,S.J., Yang,L., Beckman,D.L.,
            Poursine-Laurent,J., Plougastel-Douglas,B. and Yokoyama,W.M.
  TITLE     Control of Viral Infection by Natural Killer Cell Inhibitory
            Receptors
  JOURNAL   Cell Rep 32 (4), 107969 (2020)
   PUBMED   32726632
REFERENCE   3  (bases 1 to 1303)
  AUTHORS   Shi,L., Li,K., Guo,Y., Banerjee,A., Wang,Q., Lorenz,U.M.,
            Parlak,M., Sullivan,L.C., Onyema,O.O., Arefanian,S., Stelow,E.B.,
            Brautigan,D.L., Bullock,T.N.J., Brown,M.G. and Krupnick,A.S.
  TITLE     Modulation of NKG2D, NKp46, and Ly49C/I facilitates natural killer
            cell-mediated control of lung cancer
  JOURNAL   Proc Natl Acad Sci U S A 115 (46), 11808-11813 (2018)
   PUBMED   30381460
  REMARK    GeneRIF: Clearance of lung cancer is facilitated by up-regulation
            of NKG2D, NKp46, and other activating receptors upon exposure to
            environmental MHCI. Surface expression of the inhibitory receptor
            Ly49C/I, on the other hand, is down-regulated upon exposure to
            tumor-bearing tissue.
REFERENCE   4  (bases 1 to 1303)
  AUTHORS   Wight,A., Mahmoud,A.B., Scur,M., Tu,M.M., Rahim,M.M.A., Sad,S. and
            Makrigiannis,A.P.
  TITLE     Critical role for the Ly49 family of class I MHC receptors in
            adaptive natural killer cell responses
  JOURNAL   Proc Natl Acad Sci U S A 115 (45), 11579-11584 (2018)
   PUBMED   30249666
  REMARK    GeneRIF: The Ly49 family of class I MHC receptors have critical
            role for adaptive natural killer cell responses.
REFERENCE   5  (bases 1 to 1303)
  AUTHORS   Sullivan,L.C., Berry,R., Sosnin,N., Widjaja,J.M., Deuss,F.A.,
            Balaji,G.R., LaGruta,N.L., Mirams,M., Trapani,J.A., Rossjohn,J.,
            Brooks,A.G. and Andrews,D.M.
  TITLE     Recognition of the Major Histocompatibility Complex (MHC) Class Ib
            Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C
  JOURNAL   J Biol Chem 291 (36), 18740-18752 (2016)
   PUBMED   27385590
  REMARK    GeneRIF: This docking mode was conserved with that previously
            observed for Ly49C.H-2K(b) Indeed, structure-guided mutation of
            Ly49C indicated that Ly49C.H2-Q10 and Ly49C.H-2K(b) possess similar
            energetic footprints focused around residues located within the
            Ly49C beta4-stand and L5 loop, which contact the underside of the
            peptide-binding platform floor.
REFERENCE   6  (bases 1 to 1303)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 1303)
  AUTHORS   Wong,S., Freeman,J.D., Kelleher,C., Mager,D. and Takei,F.
  TITLE     Ly-49 multigene family. New members of a superfamily of type II
            membrane proteins with lectin-like domains
  JOURNAL   J Immunol 147 (4), 1417-1423 (1991)
   PUBMED   1869832
REFERENCE   8  (bases 1 to 1303)
  AUTHORS   Yokoyama,W.M., Kehn,P.J., Cohen,D.I. and Shevach,E.M.
  TITLE     Chromosomal location of the Ly-49 (A1, YE1/48) multigene family.
            Genetic association with the NK 1.1 antigen
  JOURNAL   J Immunol 145 (7), 2353-2358 (1990)
   PUBMED   1975828
REFERENCE   9  (bases 1 to 1303)
  AUTHORS   Pollack,S.B. and Emmons,S.L.
  TITLE     NK-2.1: an NK-associated antigen detected with NZB anti-BALB/c
            serum
  JOURNAL   J Immunol 129 (5), 2277-2281 (1982)
   PUBMED   6749989
REFERENCE   10 (bases 1 to 1303)
  AUTHORS   Burton,R.C. and Winn,H.J.
  TITLE     Studies on natural killer (NK) cells. I. NK cell specific
            antibodies in CE anti-CBA serum
  JOURNAL   J Immunol 126 (5), 1985-1989 (1981)
   PUBMED   7217676
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087336.5, AK159595.1, U56404.1 and BX515458.1.
            
            On Jan 24, 2014 this sequence version replaced NM_010648.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U10305.1, AK159595.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849375,
                                           SAMN00849381 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC087336.5         93427-93478         c
            53-658              AK159595.1         2-607
            659-1032            U56404.1           534-907
            1033-1074           AC087336.5         79357-79398         c
            1075-1303           BX515458.1         1-229
FEATURES             Location/Qualifiers
     source          1..1303
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1303
                     /gene="Klra3"
                     /gene_synonym="5E6; Ly49c; Nk-2; NK-2.1; Nk2; Nk2.1"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 3"
                     /db_xref="GeneID:16634"
                     /db_xref="MGI:MGI:101905"
     exon            1..156
                     /gene="Klra3"
                     /gene_synonym="5E6; Ly49c; Nk-2; NK-2.1; Nk2; Nk2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            157..286
                     /gene="Klra3"
                     /gene_synonym="5E6; Ly49c; Nk-2; NK-2.1; Nk2; Nk2.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..975
                     /gene="Klra3"
                     /gene_synonym="5E6; Ly49c; Nk-2; NK-2.1; Nk2; Nk2.1"
                     /note="natural killer cell-associated antigen 2;
                     lymphocyte antigen 49c; T-cell surface glycoprotein
                     Ly-49C"
                     /codon_start=1
                     /product="killer cell lectin-like receptor 3"
                     /protein_id="NP_034778.2"
                     /db_xref="CCDS:CCDS20601.1"
                     /db_xref="GeneID:16634"
                     /db_xref="MGI:MGI:101905"
                     /translation="MSEPEVTYSTVRLHKSSGLQKLVRHEETQGPREVGNRKCSAPWQ
                     LIVKALGILCFLLLVTVAVLAVKIFQYNQHKQEINETLNHHHNCSNMQRAFNLKEEML
                     TNKSIDCRPSNETLEYIKREQDRWDSKTKTVLDSSRDTGRGVKYWFCYSTKCYYFIMN
                     KTTWSGCKANCQHYSVPILKIEDEDELKFLQRHVIPENYWIGLSYDKKKKEWAWIDNG
                     PSKLDMKIRKMNFKSRGCVFLSKARIEDIDCNIPYYCICGKKLDKFPD"
     exon            287..376
                     /gene="Klra3"
                     /gene_synonym="5E6; Ly49c; Nk-2; NK-2.1; Nk2; Nk2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..595
                     /gene="Klra3"
                     /gene_synonym="5E6; Ly49c; Nk-2; NK-2.1; Nk2; Nk2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            596..735
                     /gene="Klra3"
                     /gene_synonym="5E6; Ly49c; Nk-2; NK-2.1; Nk2; Nk2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            736..839
                     /gene="Klra3"
                     /gene_synonym="5E6; Ly49c; Nk-2; NK-2.1; Nk2; Nk2.1"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1290
                     /gene="Klra3"
                     /gene_synonym="5E6; Ly49c; Nk-2; NK-2.1; Nk2; Nk2.1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgacgaggag gggcagaaaa tcatgaggtt gagtatcacc cggtggaaat ttagttccga
       61 ctttcaattt tgaaactcgt aggagatcta aaccagaaaa cgccaacgtt tcagacaaat
      121 tttccctcca ccagcatcac tccggtagag acacagactt cttgtactcc cacgatgagt
      181 gagccagagg tcacttactc aactgtgaga cttcataagt cttcagggtt gcagaaacta
      241 gtaaggcatg aggagactca agggcccaga gaagttggca acagaaagtg ttcagcaccc
      301 tggcaactca ttgtgaaagc tcttggaatc ctctgtttcc ttcttcttgt aacagttgca
      361 gtgttggcag taaagatttt tcagtataat caacacaaac aagaaatcaa tgaaactcta
      421 aaccaccacc ataactgcag caacatgcaa agggctttca acttaaagga agaaatgttg
      481 acaaataagt ctatagattg taggccaagc aatgaaactc tggaatatat caaaagagaa
      541 caggacagat gggacagtaa aacaaagact gttttagatt cctcacggga cacaggcaga
      601 ggtgttaaat actggttctg ctatagtact aaatgttatt atttcatcat gaacaaaacg
      661 acatggagtg gatgtaaagc gaactgccag cattatagcg ttcccattct gaagatagaa
      721 gatgaagatg aactgaaatt ccttcaacgc catgttattc cagagaatta ctggattgga
      781 ttgtcttatg ataagaaaaa aaaggaatgg gcatggattg acaatggccc atctaaactt
      841 gacatgaaaa taaggaaaat gaactttaag tctagaggat gtgtattttt atctaaagca
      901 agaatagaag atattgactg taatattccc tactactgta tttgtgggaa gaaactggat
      961 aaattccctg attaattttc caactagagt taaaggtaaa aatggaatga gttgatcctt
     1021 attcgtttct tgtaataatt catgactcca acaaacaagt attttgatta cagaacatag
     1081 tctcctgtga agagaaacaa agctgcaaga acattgggac tgtactctcc tatctatctt
     1141 gacagaacag aggtcatttt ttatcctgtt ggagagagga cgcatctact cgggtgaatg
     1201 ggcacgcttt gccctaaagc cttcagaatt gtgttctttc tgatttctta aactcccata
     1261 aaactgaata aagagtcctc cctaaaataa aaaaaaaaaa aaa
//
