LOCUS       NM_001170851            1885 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            2 (Klra2), transcript variant 1, mRNA.
ACCESSION   NM_001170851
VERSION     NM_001170851.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1885)
  AUTHORS   Mickiewicz,K.M., Gays,F., Lewis,R.J. and Brooks,C.G.
  TITLE     Mutagenesis of Ly49B reveals key structural elements required for
            promiscuous binding to MHC class I molecules and new insights into
            the molecular evolution of Ly49s
  JOURNAL   J Immunol 192 (4), 1558-1569 (2014)
   PUBMED   24403531
  REMARK    GeneRIF: BALB/c, but not the C57, isoform of Ly49B displays
            promiscuous MHC class I binding.
REFERENCE   2  (bases 1 to 1885)
  AUTHORS   Schenkel,A.R., Kingry,L.C. and Slayden,R.A.
  TITLE     The ly49 gene family. A brief guide to the nomenclature, genetics,
            and role in intracellular infection
  JOURNAL   Front Immunol 4, 90 (2013)
   PUBMED   23596445
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1885)
  AUTHORS   Scarpellino,L., Oeschger,F., Guillaume,P., Coudert,J.D., Levy,F.,
            Leclercq,G. and Held,W.
  TITLE     Interactions of Ly49 family receptors with MHC class I ligands in
            trans and cis
  JOURNAL   J Immunol 178 (3), 1277-1284 (2007)
   PUBMED   17237373
REFERENCE   4  (bases 1 to 1885)
  AUTHORS   Gays,F., Aust,J.G., Reid,D.M., Falconer,J., Toyama-Sorimachi,N.,
            Taylor,P.R. and Brooks,C.G.
  TITLE     Ly49B is expressed on multiple subpopulations of myeloid cells
  JOURNAL   J Immunol 177 (9), 5840-5851 (2006)
   PUBMED   17056508
  REMARK    GeneRIF: Ly49B is expressed at low levels on approximately 1.5% of
            spleen cells, none which are NK cells or T cells but which instead
            belong to several distinct subpopulations of myeloid cells.
REFERENCE   5  (bases 1 to 1885)
  AUTHORS   Lian,R.H., Maeda,M., Lohwasser,S., Delcommenne,M., Nakano,T.,
            Vance,R.E., Raulet,D.H. and Takei,F.
  TITLE     Orderly and nonstochastic acquisition of CD94/NKG2 receptors by
            developing NK cells derived from embryonic stem cells in vitro
  JOURNAL   J Immunol 168 (10), 4980-4987 (2002)
   PUBMED   11994449
REFERENCE   6  (bases 1 to 1885)
  AUTHORS   Wilhelm,B.T., McQueen,K.L., Freeman,J.D., Takei,F. and Mager,D.L.
  TITLE     Comparative analysis of the promoter regions and transcriptional
            start sites of mouse Ly49 genes
  JOURNAL   Immunogenetics 53 (3), 215-224 (2001)
   PUBMED   11398966
REFERENCE   7  (bases 1 to 1885)
  AUTHORS   Yokoyama,W.M.
  TITLE     Hybrid resistance and the Ly-49 family of natural killer cell
            receptors
  JOURNAL   J Exp Med 182 (2), 273-277 (1995)
   PUBMED   7629493
  REMARK    Review article
REFERENCE   8  (bases 1 to 1885)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Wallace,C.R., Gibbons,A.E.,
            Smart,Y.C., Burton,R.C. and Shellam,G.R.
  TITLE     The effect of the Cmv-1 resistance gene, which is linked to the
            natural killer cell gene complex, is mediated by natural killer
            cells
  JOURNAL   J Immunol 149 (2), 581-589 (1992)
   PUBMED   1378069
REFERENCE   9  (bases 1 to 1885)
  AUTHORS   Wong,S., Freeman,J.D., Kelleher,C., Mager,D. and Takei,F.
  TITLE     Ly-49 multigene family. New members of a superfamily of type II
            membrane proteins with lectin-like domains
  JOURNAL   J Immunol 147 (4), 1417-1423 (1991)
   PUBMED   1869832
REFERENCE   10 (bases 1 to 1885)
  AUTHORS   Yokoyama,W.M., Kehn,P.J., Cohen,D.I. and Shevach,E.M.
  TITLE     Chromosomal location of the Ly-49 (A1, YE1/48) multigene family.
            Genetic association with the NK 1.1 antigen
  JOURNAL   J Immunol 145 (7), 2353-2358 (1990)
   PUBMED   1975828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC148326.2 and AC163356.2.
            
            On Jul 27, 2022 this sequence version replaced NM_001170851.1.
            
            Summary: The gene is a member of the large lectin-like type 2
            transmembrane receptor family of the natural killer gene complex.
            The gene is located distantly telomeric to its family's gene
            cluster on chromosome 6. The gene differs from the other genes in
            its cluster as its promoter region contains long and short
            interspersed repetitive elements suggesting a possible
            rearrangement or gene conversion. It is unknown whether this gene's
            encoded protein is involved with natural killer cell
            differentiation as are its other family members. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: EF025059.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               AC148326.2         52933-53037
            106-269             AC148326.2         54908-55071
            270-359             AC148326.2         56301-56390
            360-581             AC148326.2         57272-57493
            582-724             AC163356.2         200771-200913       c
            725-828             AC163356.2         198899-199002       c
            829-927             AC163356.2         192500-192598       c
            928-1083            AC163356.2         190802-190957       c
            1084-1885           AC163356.2         189920-190721       c
FEATURES             Location/Qualifiers
     source          1..1885
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1885
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 2"
                     /db_xref="GeneID:16633"
                     /db_xref="MGI:MGI:101906"
     exon            1..105
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /inference="alignment:Splign:2.1.0"
     exon            106..269
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..1123
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /note="isoform 1 is encoded by transcript variant 1; NK
                     cell inhibitory receptor Klra2; membrane protein Ly49b;
                     lymphocyte antigen 49b; T-cell surface glycoprotein Ly49b;
                     killer cell lectin-like receptor 2; killer cell
                     lectin-like receptor subfamily A member 30; ly-49b; T-cell
                     surface glycoprotein Ly-49B"
                     /codon_start=1
                     /product="killer cell lectin-like receptor 2 isoform 1"
                     /protein_id="NP_001164322.1"
                     /db_xref="CCDS:CCDS51929.1"
                     /db_xref="GeneID:16633"
                     /db_xref="MGI:MGI:101906"
                     /translation="MSEQEVTYTTLRFHKSSGLQNPVRPEETQRPRDVGHRECSVPWK
                     FIVIVLGILCFLLLVTVAVLVIHIFRDGQEKHEQEKTLNNLRQEYQVMKNDSSLMEEM
                     LRNKSSECKALNDSLHYLNREQNRCLRKTKIVLDCSQNKGKQVEGYWFCCGMKCYYFI
                     MDDKKLKGCKQICQAYNLTLLKTNDEDELKFLKSQLQRNTYWIALTHHESKEESQQIG
                     DRPSKPAQEEQSFIEDLSLCHLIPVDFFPWFIFSDTDCHVSAARNSVPNREKCAYLNS
                     FSTEEDDRARNHGCICEKRLNKFPIPGSCAKGRTQSALQRDEDES"
     exon            270..359
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /inference="alignment:Splign:2.1.0"
     exon            360..581
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /inference="alignment:Splign:2.1.0"
     exon            582..724
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /inference="alignment:Splign:2.1.0"
     exon            725..828
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /inference="alignment:Splign:2.1.0"
     exon            829..927
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1083
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1885
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1450..1455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /note="hexamer: AATATA"
     polyA_site      1469
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /note="major polyA site"
     regulatory      1864..1869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /note="hexamer: CATAAA"
     polyA_site      1885
                     /gene="Klra2"
                     /gene_synonym="Klra30; Ly49b"
                     /note="major polyA site"
ORIGIN      
        1 attcttcttg aagctctgag tgtatacaga ccaggaatgg ccaacttgtc cctcagttag
       61 tggattaatt cccttcacca gaattacttc ctggtagaga cacagaaatc acttgaggcc
      121 acattttaat acaaatcgta ctttacatac ttccaagatg agtgagcagg aggtcactta
      181 cacaactctg agatttcata agtcttcagg gttgcagaac ccagtgaggc ctgaggagac
      241 tcaaaggccc agagatgtgg gccacagaga gtgttcagtc ccctggaagt tcattgtgat
      301 agttcttgga atcctctgtt tccttctgct ggtaactgtg gcagtgttgg tgatacacat
      361 tttccgggat ggacaagaga aacatgaaca ggagaaaact ctaaataacc tccgtcaaga
      421 gtaccaggtc atgaaaaatg acagctcctt aatggaagaa atgttaagaa ataagtcttc
      481 agagtgtaag gccctcaatg atagcctgca ctacctcaac agagaacaga acagatgcct
      541 caggaaaacc aagattgttt tagattgctc acagaacaaa ggcaagcaag tggaaggata
      601 ctggttctgc tgtggcatga aatgttatta tttcatcatg gatgataaaa aattgaaagg
      661 atgtaaacag atctgccagg cttacaactt aactcttttg aagacaaatg atgaggatga
      721 attgaagttc cttaaatccc aacttcaaag aaacacatac tggattgcac tgacacatca
      781 cgaaagcaaa gaggaatcgc aacagattgg tgatagacca tctaaaccgg ctcaagaaga
      841 gcaaagtttc attgaagatt tatccctctg ccatctcatc cctgtggatt tctttccctg
      901 gttcatcttc tctgacacag attgtcatgt ttcagcagca aggaattcag tacctaatag
      961 agaaaagtgt gcatatctaa attcattttc tacagaagag gatgaccgtg ctagaaatca
     1021 tggttgtatt tgtgaaaaga gattgaataa attccctatt ccagggagct gtgccaaggg
     1081 aagaactcaa tctgctctgc agagggatga agatgaaagt taagaaatgt tttgacaaca
     1141 gacttaacag agcaggagcc atcttccttc ctggtaaaca gagaagcttg tgtctgaaga
     1201 atggacactc tttgccctaa gctttgaaga atcactctgt ttcctgaatt atacacagaa
     1261 caatatacaa tactcagaca atcactcaca ttcttaatca tcactaggat aatccatttc
     1321 tataacctgt tgctctgaaa tcacttaaga accaggatgc agttgctgtt tgttagttgg
     1381 ttggtaactt tttattttta ttttttggag gtaggagaat taacctgaaa atttttttat
     1441 ttgctggaaa atataatttt ataacttgat gatagttgcc aagctatttt agtgaaccca
     1501 tacaaccttt catatttcat gtgttcttat tctctctctc tccctccctc cctccctctg
     1561 tgtgtatgtg tgtgtttgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgta tgtgtttgtc
     1621 tttctgtctc tgtttccctg atcaatataa tgcatttggt gataaatgga aaccccatag
     1681 ttgcagtaat atttattgac gccagctaga tgcaatggct cagaggtata atttataggt
     1741 acgtgagttt gaaggcagtc taggctacat agtatgtttg tggccattgt gggccttagt
     1801 gtgagactct gttatgaaat ataattatga tgatgatgat gatgataata acattaaact
     1861 gtccataaat attttctaaa aacaa
//
