LOCUS       NM_001381962            1190 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            17 (Klra17), transcript variant 1, mRNA.
ACCESSION   NM_001381962 XM_006505664
VERSION     NM_001381962.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1190)
  AUTHORS   Sasawatari S, Karyu H, Nguyen Tien D, Furuyama-Tanaka K and
            Toyama-Sorimachi N.
  TITLE     The inhibitory NK receptor Ly49Q protects plasmacytoid dendritic
            cells from pyroptotic cell death
  JOURNAL   Mol Immunol 135, 217-225 (2021)
   PUBMED   33932686
  REMARK    GeneRIF: The inhibitory NK receptor Ly49Q protects plasmacytoid
            dendritic cells from pyroptotic cell death.
REFERENCE   2  (bases 1 to 1190)
  AUTHORS   Wight A, Mahmoud AB, Scur M, Tu MM, Rahim MMA, Sad S and
            Makrigiannis AP.
  TITLE     Critical role for the Ly49 family of class I MHC receptors in
            adaptive natural killer cell responses
  JOURNAL   Proc Natl Acad Sci U S A 115 (45), 11579-11584 (2018)
   PUBMED   30249666
REFERENCE   3  (bases 1 to 1190)
  AUTHORS   Margraf A, Volmering S, Skupski J, Van Marck V, Makrigiannis AP,
            Block H and Zarbock A.
  TITLE     The ITIM Domain-Containing NK Receptor Ly49Q Impacts Pulmonary
            Infection by Mediating Neutrophil Functions
  JOURNAL   J Immunol 200 (12), 4085-4093 (2018)
   PUBMED   29712775
  REMARK    GeneRIF: Ly49Q regulates integrin activation and neutrophil
            recruitment and is required for an adequate immune response in
            pulmonary infection.
REFERENCE   4  (bases 1 to 1190)
  AUTHORS   Mahmoud AB, Tu MM, Wight A, Zein HS, Rahim MM, Lee SH, Sekhon HS,
            Brown EG and Makrigiannis AP.
  TITLE     Influenza Virus Targets Class I MHC-Educated NK Cells for
            Immunoevasion
  JOURNAL   PLoS Pathog 12 (2), e1005446 (2016)
   PUBMED   26928844
  REMARK    Erratum:[PLoS Pathog. 2016 Nov 4;12 (11):e1006021. PMID: 27814389]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1190)
  AUTHORS   Rahim MM and Makrigiannis AP.
  TITLE     Ly49 receptors: evolution, genetic diversity, and impact on
            immunity
  JOURNAL   Immunol Rev 267 (1), 137-147 (2015)
   PUBMED   26284475
  REMARK    Review article
REFERENCE   6  (bases 1 to 1190)
  AUTHORS   Toyama-Sorimachi N, Omatsu Y, Onoda A, Tsujimura Y, Iyoda T,
            Kikuchi-Maki A, Sorimachi H, Dohi T, Taki S, Inaba K and Karasuyama
            H.
  TITLE     Inhibitory NK receptor Ly49Q is expressed on subsets of dendritic
            cells in a cellular maturation- and cytokine stimulation-dependent
            manner
  JOURNAL   J Immunol 174 (8), 4621-4629 (2005)
   PUBMED   15814685
  REMARK    GeneRIF: Ly49Q serves a role for the biological functions of
            certain dendritic cell subsets through recognition of MHC class I
            or related molecules.
REFERENCE   7  (bases 1 to 1190)
  AUTHORS   Makrigiannis AP, Patel D, Goulet ML, Dewar K and Anderson SK.
  TITLE     Direct sequence comparison of two divergent class I MHC natural
            killer cell receptor haplotypes
  JOURNAL   Genes Immun 6 (2), 71-83 (2005)
   PUBMED   15674375
REFERENCE   8  (bases 1 to 1190)
  AUTHORS   Proteau MF, Rousselle E and Makrigiannis AP.
  TITLE     Mapping of the BALB/c Ly49 cluster defines a minimal natural killer
            cell receptor gene repertoire
  JOURNAL   Genomics 84 (4), 669-677 (2004)
   PUBMED   15475244
REFERENCE   9  (bases 1 to 1190)
  AUTHORS   Toyama-Sorimachi N, Tsujimura Y, Maruya M, Onoda A, Kubota T,
            Koyasu S, Inaba K and Karasuyama H.
  TITLE     Ly49Q, a member of the Ly49 family that is selectively expressed on
            myeloid lineage cells and involved in regulation of cytoskeletal
            architecture
  JOURNAL   Proc Natl Acad Sci U S A 101 (4), 1016-1021 (2004)
   PUBMED   14732700
  REMARK    GeneRIF: has unique features different from other known Ly49 family
            members and appears to be involved in regulation of cytoskeletal
            architecture of macrophages through ITIM-mediated signaling
REFERENCE   10 (bases 1 to 1190)
  AUTHORS   Makrigiannis AP, Pau AT, Schwartzberg PL, McVicar DW, Beck TW and
            Anderson SK.
  TITLE     A BAC contig map of the Ly49 gene cluster in 129 mice reveals
            extensive differences in gene content relative to C57BL/6 mice
  JOURNAL   Genomics 79 (3), 437-444 (2002)
   PUBMED   11863373
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090563.17 and AB033769.1.
            
            On Apr 21, 2020 this sequence version replaced XM_006505664.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033769.1, BC132236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC090563.17        23440-23441         c
            3-43                AB033769.1         1-41
            44-45               AC090563.17        23397-23398         c
            46-1190             AB033769.1         44-1188
FEATURES             Location/Qualifiers
     source          1..1190
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1190
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 17"
                     /db_xref="GeneID:170733"
                     /db_xref="MGI:MGI:2180674"
     exon            1..116
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /inference="alignment:Splign:2.1.0"
     exon            117..268
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..978
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /note="isoform 1 is encoded by transcript variant 1; NK
                     receptor Ly-49Q"
                     /codon_start=1
                     /product="killer cell lectin-like receptor, subfamily A,
                     member 17 isoform 1"
                     /protein_id="NP_001368891.1"
                     /db_xref="GeneID:170733"
                     /db_xref="MGI:MGI:2180674"
                     /translation="MMSEQEVTYSTVRFHKSSGLQNQVRPEDNQGSREAGHKECSIPW
                     HLIVIAFGILCVLLLVIVAVLVTNILQYKQEKHELQETLNCHHNCSTMQNDINAKEEM
                     LRNMPLECSTGDDLLKSLNREQKRWYSETKSVLNSSKHPGGSLEIHWFCYGIKCYYFI
                     MNKKGWRKCKQICEHYSLSLLKIDAEDELKFLQLQVTPDSYWIGFSFDKKSEKWTWIE
                     NGTSKYALNMSTYNVKSGECVFLSKTRLENNKCEHVYPCICEKRLDKFPDSLPNNS"
     exon            269..358
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..577
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /inference="alignment:Splign:2.1.0"
     exon            578..720
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..824
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..980
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1190
                     /gene="Klra17"
                     /gene_synonym="Ly49q; Ly49q1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttctgcct ttcttcttgg agcctcttac aggatagaga ccaggaaaga caacttttcc
       61 cccataactg caggatctat tatcttcacc agaatctctt cagggtagag acacaggcac
      121 cattttaaca gagaacacac tctacataca cccatgatga gtgagcagga ggtcacttat
      181 tcaactgtga gatttcataa atcttcagga ttgcagaacc aagtgaggcc tgaggacaat
      241 caagggtcaa gagaagctgg ccacaaagag tgctctatcc cctggcatct cattgtgata
      301 gcttttggaa tcctctgtgt ccttcttctg gtaattgttg cagtgttggt gacaaacatt
      361 ttgcagtata agcaagaaaa acatgaactg caggaaactc taaactgcca ccataactgt
      421 agcaccatgc aaaatgacat caacgcaaag gaagaaatgc tgagaaatat gcctctagag
      481 tgtagtacag gagatgatct tctgaaatcc ctcaacagag aacagaagag atggtacagt
      541 gaaaccaaga gtgttttaaa ttcctcaaag cacccaggtg gaagcctgga aatacactgg
      601 ttctgctatg gtataaagtg ttattatttc atcatgaata aaaaaggatg gcgtaaatgt
      661 aaacagatat gtgagcatta cagcttatcc cttctgaaga tagatgctga ggatgaactg
      721 aaattccttc agttacaggt tactccagac agttactgga ttggcttctc atttgataag
      781 aaaagtgaaa aatggacatg gattgaaaat ggcacatcta aatatgcctt gaacatgtcc
      841 acatacaatg taaagagtgg agaatgtgtg ttcttatcta aaacaagact agaaaataat
      901 aaatgtgaac atgtctaccc atgtatttgt gagaagagac tggataagtt ccctgattcg
      961 ctccccaaca acagttaaag gacttagtct gctgtgtaaa cagaaggaag agctggaaga
     1021 ggtcaggaat gttccctgga atctgatgtg gcagaggctt cttcctacct ggtggaaaca
     1081 ggacacacct cctctggttt ttggatacac tttgccccca aacctccaga actctgctct
     1141 ttctgctttc ttaaactcat atagagctaa ataaagaacc ccaataaaca
//
