LOCUS       NM_016659               1667 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Mus musculus killer cell lectin-like receptor, subfamily A, member
            1 (Klra1), mRNA.
ACCESSION   NM_016659 XM_001471680 XM_001471779
VERSION     NM_016659.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Parikh,B.A., Bern,M.D., Piersma,S.J., Yang,L., Beckman,D.L.,
            Poursine-Laurent,J., Plougastel-Douglas,B. and Yokoyama,W.M.
  TITLE     Control of Viral Infection by Natural Killer Cell Inhibitory
            Receptors
  JOURNAL   Cell Rep 32 (4), 107969 (2020)
   PUBMED   32726632
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Staaf,E., Hedde,P.N., Bagawath Singh,S., Piguet,J., Gratton,E. and
            Johansson,S.
  TITLE     Educated natural killer cells show dynamic movement of the
            activating receptor NKp46 and confinement of the inhibitory
            receptor Ly49A
  JOURNAL   Sci Signal 11 (517) (2018)
   PUBMED   29440510
  REMARK    GeneRIF: Most of the natural killer cell p46-related protein
            (NKp46) and NK cell Lectin-like receptor subfamily A (Ly49A)
            molecules were restricted to microdomains; however, individual
            NKp46 molecules resided in these domains for shorter periods and
            diffused faster on the surface of educated, compared to
            hyporesponsive, NK cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Bern,M.D., Beckman,D.L., Ebihara,T., Taffner,S.M.,
            Poursine-Laurent,J., White,J.M. and Yokoyama,W.M.
  TITLE     Immunoreceptor tyrosine-based inhibitory motif-dependent functions
            of an MHC class I-specific NK cell receptor
  JOURNAL   Proc Natl Acad Sci U S A 114 (40), E8440-E8447 (2017)
   PUBMED   28923946
REFERENCE   4  (bases 1 to 1667)
  AUTHORS   Ebihara,T., Jonsson,A.H. and Yokoyama,W.M.
  TITLE     Natural killer cell licensing in mice with inducible expression of
            MHC class I
  JOURNAL   Proc Natl Acad Sci U S A 110 (45), E4232-E4237 (2013)
   PUBMED   24145414
REFERENCE   5  (bases 1 to 1667)
  AUTHORS   Liu,J., Liu,S., Xia,M., Xu,S., Wang,C., Bao,Y., Jiang,M., Wu,Y.,
            Xu,T. and Cao,X.
  TITLE     Rhomboid domain-containing protein 3 is a negative regulator of
            TLR3-triggered natural killer cell activation
  JOURNAL   Proc Natl Acad Sci U S A 110 (19), 7814-7819 (2013)
   PUBMED   23610400
REFERENCE   6  (bases 1 to 1667)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 1667)
  AUTHORS   Scalzo,A.A., Fitzgerald,N.A., Wallace,C.R., Gibbons,A.E.,
            Smart,Y.C., Burton,R.C. and Shellam,G.R.
  TITLE     The effect of the Cmv-1 resistance gene, which is linked to the
            natural killer cell gene complex, is mediated by natural killer
            cells
  JOURNAL   J Immunol 149 (2), 581-589 (1992)
   PUBMED   1378069
REFERENCE   8  (bases 1 to 1667)
  AUTHORS   Yokoyama,W.M., Ryan,J.C., Hunter,J.J., Smith,H.R., Stark,M. and
            Seaman,W.E.
  TITLE     cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49.
            Identification of a natural killer cell gene complex on mouse
            chromosome 6
  JOURNAL   J Immunol 147 (9), 3229-3236 (1991)
   PUBMED   1680927
REFERENCE   9  (bases 1 to 1667)
  AUTHORS   Wong,S., Freeman,J.D., Kelleher,C., Mager,D. and Takei,F.
  TITLE     Ly-49 multigene family. New members of a superfamily of type II
            membrane proteins with lectin-like domains
  JOURNAL   J Immunol 147 (4), 1417-1423 (1991)
   PUBMED   1869832
REFERENCE   10 (bases 1 to 1667)
  AUTHORS   Yokoyama,W.M., Kehn,P.J., Cohen,D.I. and Shevach,E.M.
  TITLE     Chromosomal location of the Ly-49 (A1, YE1/48) multigene family.
            Genetic association with the NK 1.1 antigen
  JOURNAL   J Immunol 145 (7), 2353-2358 (1990)
   PUBMED   1975828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087336.5 and AK080158.1.
            
            On or before Nov 15, 2007 this sequence version replaced
            XM_001471779.1, XM_001471680.1, NM_016659.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY078436.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849375,
                                           SAMN00849380 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                AC087336.5         142679-142726       c
            49-243              AC087336.5         139348-139542       c
            244-521             AC087336.5         138256-138533       c
            522-1667            AK080158.1         104-1249
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 63.44 cM"
     gene            1..1667
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /note="killer cell lectin-like receptor, subfamily A,
                     member 1"
                     /db_xref="GeneID:16627"
                     /db_xref="MGI:MGI:101907"
     exon            1..48
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /inference="alignment:Splign:2.1.0"
     exon            49..243
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /inference="alignment:Splign:2.1.0"
     exon            244..521
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /inference="alignment:Splign:2.1.0"
     exon            522..688
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /inference="alignment:Splign:2.1.0"
     CDS             577..1365
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /note="natural killer cell receptor Ly49A; class I MHC
                     receptor KLRA22; ly-49a; lymphocyte antigen 49a; t
                     lymphocyte antigen A1; novel killer cell lectin-like
                     receptor subfamily A protein"
                     /codon_start=1
                     /product="T-cell surface glycoprotein YE1/48"
                     /protein_id="NP_057868.2"
                     /db_xref="CCDS:CCDS20602.1"
                     /db_xref="GeneID:16627"
                     /db_xref="MGI:MGI:101907"
                     /translation="MSEQEVTYSMVRFHKSAGLQKQVRPEETKGPREAGYRRCSFHWK
                     FIVIALGIFCFLLLVAVSVLAIKIFQYDQQKKLQEFLNHHNNCSNMQSDINLKDEMLK
                     NKSIECDLLESLNRDQNRLYNKTKTVLDSLQHTGRGDKVYWFCYGMKCYYFVMDRKTW
                     SGCKQTCQSSSLSLLKIDDEDELKFLQLVVPSDSCWVGLSYDNKKKDWAWIDNRPSKL
                     ALNTRKYNIRDGGCMLLSKTRLDNGNCDQVFICICGKRLDKFPH"
     exon            689..778
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /inference="alignment:Splign:2.1.0"
     exon            779..982
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1125
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1229
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1667
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1649..1654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klra1"
                     /gene_synonym="A1; CH29-493D4.3; Klra22; Ly49a;
                     Ly49o<129>; Ly49v"
                     /note="putative"
ORIGIN      
        1 ttgcaactgt gcaatgatag tactacagtc caagggtgtg actggaaggt tacttagagg
       61 gtcctagcct ctggtaacat aattattccc gagacccaca acactacaaa gtcctcactt
      121 ctctctgtgt taaatccttc attgctgaaa cagcttcttt cccaggaatt ctcatcacaa
      181 acacatgtac aaaactcata gaagaaaaaa aaatcatatc atctcatctc taaaaaaata
      241 actgagtttt catcttctcc ttcttaaaaa tatcagttat ggacatttgt tttgcagcat
      301 ctggcacaat acgttacttc tctcctttgt tctgagggtc aggtttcatt aagcagtttc
      361 ctctttttgc tttgatgacg aggaggagca taaaatcatg aggttgagta tctctcagtg
      421 gaaatttagt tctaccgttt attttggaga cacttagggg atatcaacca gaaaaagcca
      481 actttttcct ccaccagaac cacttcttgc tagcgacaca gaaaccactc gaggcaccat
      541 ttgaactgag aacatacttt atatatcaat cccaagatga gtgagcagga ggtcacttat
      601 tcaatggtga gatttcataa atctgcagga ttgcagaaac aagtgagacc tgaggagact
      661 aaagggccca gagaagctgg ctacagaagg tgttcattcc actggaagtt cattgtgata
      721 gctcttggca tcttctgttt ccttcttctg gtagctgttt cagtgttggc aataaaaatt
      781 tttcagtatg atcaacaaaa aaaactgcag gaatttctaa accaccacaa taactgcagc
      841 aacatgcaaa gtgacatcaa cttgaaggat gaaatgctga aaaataagtc tatagagtgt
      901 gatcttctgg aatccctcaa cagggatcag aacagattgt ataataaaac caagactgtt
      961 ttagattcct tacagcacac aggcagaggt gataaagtat actggttctg ctatggtatg
     1021 aaatgttatt atttcgtcat ggacagaaaa acatggagtg gatgtaaaca gacctgccag
     1081 agttccagtt tatcccttct gaagatagat gatgaggatg aactgaagtt ccttcagctc
     1141 gtggttcctt cagacagttg ctgggttgga ttgtcatatg ataataagaa aaaagattgg
     1201 gcatggattg acaatcgccc atctaaactt gccttgaaca caaggaaata caatataaga
     1261 gatgggggat gtatgttgtt atctaaaaca agactagaca atggtaactg tgatcaagta
     1321 ttcatctgta tttgtgggaa gagactggat aaattccctc attgactctc caatgagtgt
     1381 taaaggaaaa agtgaaattt tcttactctc atttgtttcc tgtattaatt aatgacacct
     1441 tgcaaacaag tgttttgacc attggactta gtctgcagtg caaagagaga gagagaaaat
     1501 ctggaagatt ttgggaatat tctctgaaac atgacatgac agagcagatg acatcttcct
     1561 tccctgttga gactggacag atcttctctg ataccccaaa gcttggacga atctgtttta
     1621 tttgtttgca taaactctaa aagaagtaaa taaagaacct tgatgac
//
