LOCUS       NM_008455               5226 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kallikrein B, plasma 1 (Klkb1), mRNA.
ACCESSION   NM_008455
VERSION     NM_008455.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5226)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5226)
  AUTHORS   Wang,J.K., Li,Y., Zhao,X.L., Liu,Y.B., Tan,J., Xing,Y.Y., Adi,D.,
            Wang,Y.T., Fu,Z.Y., Ma,Y.T., Liu,S.M., Liu,Y., Wang,Y., Shi,X.J.,
            Lu,X.Y., Song,B.L. and Luo,J.
  TITLE     Ablation of Plasma Prekallikrein Decreases Low-Density Lipoprotein
            Cholesterol by Stabilizing Low-Density Lipoprotein Receptor and
            Protects Against Atherosclerosis
  JOURNAL   Circulation 145 (9), 675-687 (2022)
   PUBMED   35189703
  REMARK    GeneRIF: Ablation of Plasma Prekallikrein Decreases Low-Density
            Lipoprotein Cholesterol by Stabilizing Low-Density Lipoprotein
            Receptor and Protects Against Atherosclerosis.
REFERENCE   3  (bases 1 to 5226)
  AUTHORS   Ding,C., Scicluna,B.P., Stroo,I., Yang,J., Roelofs,J.J., de
            Boer,O.J., de Vos,A.F., Nurnberg,P., Revenko,A.S., Crosby,J., Van't
            Veer,C. and van der Poll,T.
  TITLE     Prekallikrein inhibits innate immune signaling in the lung and
            impairs host defense during pneumosepsis in mice
  JOURNAL   J Pathol 250 (1), 95-106 (2020)
   PUBMED   31595971
  REMARK    GeneRIF: Circulating PKK confines pro-inflammatory signaling in the
            lung by a mechanism that does not involve contact system
            activation, which in the case of respiratory tract infection may
            impede early protective innate immunity.
REFERENCE   4  (bases 1 to 5226)
  AUTHORS   Wang,B., Yan,X., Chen,F., Yang,A., Lu,Y. and Wu,Y.
  TITLE     Plasma kallikrein contributes to ambient particulate matter-induced
            lung injury
  JOURNAL   Biochem Biophys Res Commun 518 (3), 409-415 (2019)
   PUBMED   31451224
  REMARK    GeneRIF: In ambient particulate matter-induced lung injury model,
            Klkb1(-/-) mice exhibited a decrease in total protein, cells
            numbers in bronchoalveolar lavage fluid (BALF) and histologic lung
            injury score. The TNF-alpha and IL-6 levels in BALF were
            significantly decreased in ambient particulate matter-treated
            Klkb1(-/-) mice.
REFERENCE   5  (bases 1 to 5226)
  AUTHORS   Suzuki,T., Kikuguchi,C., Nishijima,S., Nagashima,T., Takahashi,A.,
            Okada,M. and Yamamoto,T.
  TITLE     Postnatal liver functional maturation requires Cnot
            complex-mediated decay of mRNAs encoding cell cycle and immature
            liver genes
  JOURNAL   Development 146 (4) (2019)
   PUBMED   30733279
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5226)
  AUTHORS   Grewal,P.K., Bolland,D.J., Todd,L.C. and Hewitt,J.E.
  TITLE     High-resolution mapping of mouse chromosome 8 identifies an
            evolutionary chromosomal breakpoint
  JOURNAL   Mamm Genome 9 (8), 603-607 (1998)
   PUBMED   9680377
REFERENCE   7  (bases 1 to 5226)
  AUTHORS   Mills,K.A., Ellison,J.W. and Mathews,K.D.
  TITLE     The Ant1 gene maps near Klk3 on proximal mouse chromosome 8
  JOURNAL   Mamm Genome 7 (9), 707 (1996)
   PUBMED   8703133
REFERENCE   8  (bases 1 to 5226)
  AUTHORS   Mathews,K.D., Mills,K.A., Bailey,H.L., Schelper,R.L. and
            Murray,J.C.
  TITLE     Mouse myodystrophy (myd) mutation: refined mapping in an interval
            flanked by homology with distal human 4q
  JOURNAL   Muscle Nerve Suppl 2, S98-S102 (1995)
   PUBMED   7739634
REFERENCE   9  (bases 1 to 5226)
  AUTHORS   Beaubien,G., Rosinski-Chupin,I., Mattei,M.G., Mbikay,M.,
            Chretien,M. and Seidah,N.G.
  TITLE     Gene structure and chromosomal localization of plasma kallikrein
  JOURNAL   Biochemistry 30 (6), 1628-1635 (1991)
   PUBMED   1993180
REFERENCE   10 (bases 1 to 5226)
  AUTHORS   Seidah,N.G., Sawyer,N., Hamelin,J., Mion,P., Beaubien,G.,
            Brachpapa,L., Rochemont,J., Mbikay,M. and Chretien,M.
  TITLE     Mouse plasma kallikrein: cDNA structure, enzyme characterization,
            and comparison of protein and mRNA levels among species
  JOURNAL   DNA Cell Biol 9 (10), 737-748 (1990)
   PUBMED   2264928
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC120003.6.
            
            On May 3, 2016 this sequence version replaced NM_008455.2.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic
            processing to generate a disulfide-linked heterodimeric enzyme
            comprised of heavy and light chains. A complete deletion of the
            encoded protein prevents occlusive thrombus formation in mice with
            a minimal role in provoked bleeding. [provided by RefSeq, May
            2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026555.1, SRR5189682.158533.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                AC120003.6         105890-105983       c
            95-153              AC120003.6         105222-105280       c
            154-316             AC120003.6         100168-100330       c
            317-423             AC120003.6         98074-98180         c
            424-583             AC120003.6         94359-94518         c
            584-693             AC120003.6         93875-93984         c
            694-853             AC120003.6         89116-89275         c
            854-963             AC120003.6         88123-88232         c
            964-1126            AC120003.6         87398-87560         c
            1127-1239           AC120003.6         87190-87302         c
            1240-1408           AC120003.6         86556-86724         c
            1409-1584           AC120003.6         84624-84799         c
            1585-1680           AC120003.6         83464-83559         c
            1681-1820           AC120003.6         81800-81939         c
            1821-5226           AC120003.6         77836-81241         c
FEATURES             Location/Qualifiers
     source          1..5226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 25.17 cM"
     gene            1..5226
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /note="kallikrein B, plasma 1"
                     /db_xref="GeneID:16621"
                     /db_xref="MGI:MGI:102849"
     exon            1..94
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            95..153
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..2012
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /EC_number="3.4.21.34"
                     /note="kallikrein 3, plasma; plasma kallikrein;
                     kininogenin; fletcher factor; plasma prekallikrein;
                     antigen, prostate specific"
                     /codon_start=1
                     /product="plasma kallikrein preproprotein"
                     /protein_id="NP_032481.2"
                     /db_xref="CCDS:CCDS22275.1"
                     /db_xref="GeneID:16621"
                     /db_xref="MGI:MGI:102849"
                     /translation="MILFNRVGYFVSLFATVSCGCMTQLYKNTFFRGGDLAAIYTPDA
                     QYCQKMCTFHPRCLLFSFLAVTPPKETNKRFGCFMKESITGTLPRIHRTGAISGHSLK
                     QCGHQISACHRDIYKGLDMRGSNFNISKTDNIEECQKLCTNNFHCQFFTYATSAFYRP
                     EYRKKCLLKHSASGTPTSIKSADNLVSGFSLKSCALSEIGCPMDIFQHSAFADLNVSQ
                     VITPDAFVCRTICTFHPNCLFFTFYTNEWETESQRNVCFLKTSKSGRPSPPIPQENAI
                     SGYSLLTCRKTRPEPCHSKIYSGVDFEGEELNVTFVQGADVCQETCTKTIRCQFFIYS
                     LLPQDCKEEGCKCSLRLSTDGSPTRITYGMQGSSGYSLRLCKLVDSPDCTTKINARIV
                     GGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTAAHCFDGIPYPDVWRIYGG
                     ILSLSEITKETPSSRIKELIIHQEYKVSEGNYDIALIKLQTPLNYTEFQKPICLPSKA
                     DTNTIYTNCWVTGWGYTKEQGETQNILQKATIPLVPNEECQKKYRDYVINKQMICAGY
                     KEGGTDACKGDSGGPLVCKHSGRWQLVGITSWGEGCARKDQPGVYTKVSEYMDWILEK
                     TQSSDVRALETSSA"
     exon            154..316
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            317..423
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            424..583
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            584..693
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            694..853
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            854..963
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1126
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1239
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1408
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1584
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1680
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1820
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     exon            1821..5226
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5208..5213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /note="hexamer: AATAAA"
     polyA_site      5226
                     /gene="Klkb1"
                     /gene_synonym="APS; Kal-3; Kal3; Klk3; PSA"
                     /note="major polyA site"
ORIGIN      
        1 agaccgccct cggtgccata ttcagagggc ttgaagacca tcttcatgtg aagactccct
       61 ctcctccaga accacaacgt gaccatcctt ccaggatgat tttattcaac cgagtgggtt
      121 attttgtttc cttgtttgct accgtctcct gtgggtgtat gactcaactg tataaaaata
      181 ccttcttcag aggtggggat ctagctgcca tctacacccc agatgcccag tactgtcaga
      241 agatgtgcac ttttcacccc aggtgcctgc tgttcagctt tctcgccgtg actccaccca
      301 aagagacaaa taaacggttt ggttgcttca tgaaagagag cattacaggg actttgccaa
      361 gaatacaccg gacaggggcc atttctggtc attctttaaa gcagtgtggc catcaaataa
      421 gtgcttgcca ccgagacata tacaaaggac ttgatatgag agggtccaac tttaatatct
      481 ctaagaccga caatattgaa gaatgccaga aactgtgcac aaataatttt cactgccaat
      541 ttttcacata tgctacaagt gcattttaca gaccagagta ccggaagaag tgcctgctga
      601 agcacagtgc aagcggaaca cccaccagca taaagtcagc ggacaacctg gtgtctggat
      661 tctcactgaa gtcctgtgcg ctttcggaga taggttgccc catggatatt ttccagcact
      721 ctgcctttgc agacctgaat gtaagccagg tcatcacccc cgatgccttt gtgtgtcgca
      781 ccatctgcac cttccatccc aactgccttt tcttcacgtt ctacacgaat gaatgggaga
      841 cagaatcaca gagaaatgtt tgttttctta agacgtctaa aagtggaaga ccaagtcccc
      901 ctattcctca agaaaacgct atatctggat atagtctcct cacctgcaga aaaactcgcc
      961 ctgaaccctg ccattccaaa atttactctg gagttgactt tgaaggggaa gaactgaatg
     1021 tgaccttcgt gcaaggagca gatgtctgcc aagagacttg tacaaagaca atccgctgcc
     1081 agttttttat ttactcctta ctcccccaag actgcaagga ggaggggtgt aaatgttcct
     1141 taaggttatc cacagatggc tccccaacta ggatcaccta tggcatgcag gggagctccg
     1201 gttattctct gagattgtgt aaacttgtgg acagccctga ctgtacaaca aaaataaatg
     1261 cacgtattgt gggaggaaca aacgcttctt taggggagtg gccatggcag gtcagcctgc
     1321 aagtgaagct ggtatctcag acccatttgt gtggagggtc catcattggt cgccaatggg
     1381 tactgacagc tgcccattgc tttgatggaa ttccctatcc agatgtgtgg cgtatatatg
     1441 gcggaattct tagtctgtcc gagattacga aagaaacgcc ttcctcgaga ataaaggagc
     1501 ttattattca tcaggaatac aaagtctcag aaggcaatta tgatattgcc ttaataaagc
     1561 ttcagacgcc cctgaattat actgaattcc aaaaaccaat atgcctgcct tccaaagctg
     1621 acacaaatac aatttatacc aactgttggg tgactggatg gggctacacg aaggaacaag
     1681 gtgaaacgca aaatattcta caaaaggcta ctattccttt ggtaccaaat gaagaatgcc
     1741 agaaaaaata cagagattat gttataaaca agcagatgat ctgtgctggc tacaaagaag
     1801 gcggaacaga cgcttgtaag ggagattccg gtggcccctt agtctgtaaa cacagtggac
     1861 ggtggcagtt ggtgggtatc accagctggg gtgaaggctg cgcccgcaag gaccaaccag
     1921 gagtctacac caaagtttct gagtacatgg actggatatt ggagaagaca cagagcagtg
     1981 atgtaagagc tctggagaca tcttcagcct gaggaggctg ggtaccaagg aggaagaacc
     2041 cagctggctt taccacctgc cctcaaggca aactagagct ccaggattct cggctgtaaa
     2101 atgttgataa tggtgtctac ctcacatccg tatcattgga ttgaaaattc aagtgtagat
     2161 atagttgctg aagacagcgt tttgctcaag tgtgtttcct gccttgagtc acaggagctc
     2221 caatgggagc attacaaaga tcaccaagct tgttaggaaa gagaatgatc aaagggtttt
     2281 attaggtaat gaaatgtcta gatgtgatgc aattgaaaaa aagaccccag attctagcac
     2341 agtccttggg accattctca tgtaactgtt gactctggac ctcagcagat ctcagagtta
     2401 cctgtccact tctgacattt gtttattaga gcctgatgct attctttcaa gtggagcaaa
     2461 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaactg agaaagaggt
     2521 agaaatcttt gtaacatttc atttagaata aaaagagtct ctacttgaac ctgatgggac
     2581 atctaaacca cctttctggc cattgctgca gagttctgca tggtcatgac tgcatgaggt
     2641 ttcctacccc tggagcagag ccatctgggc atgagggttg cttgtataaa cttcatgttc
     2701 ctccctcagg aaataacctc tctgcctagg ttattgagga atatcctctc tgccaggaca
     2761 gcccttaaga ctgtgggaaa gaactcttaa aacataagtt caagaatata taatttctca
     2821 gctatgtaaa atataaggat acaatatgaa ttgtataagg agattcgatt cgtggaccta
     2881 aaagaacaaa ggcagctgca ctatgagcca gcttgtcaga aagatactac tgaaggagat
     2941 aaagagataa agagatttag ggagtggtga taacagggca agatcccagc cagctaagtt
     3001 tattatttgt gcttacatag gcaggcagag tcctgagttc aagatcagcc tgggacagag
     3061 ctagtttaga cccagggttg gtgggaatcc cacccagcta gcttgttgtc tatgctaaga
     3121 aagacaggca gatctctgaa ttcatttggc atgttttttt tttttaaaaa aagtacctga
     3181 tgtcttttct taagaatcaa gaggctagag tcatggaatg ctgactcatg ggttaaacaa
     3241 aagggaatct agagtaagtg actgagttga tatgtaaata aaagactggg ctttagtctg
     3301 caagagctga gctacctgga tgagctgtct ggagatctct gtagagcaga atactagtct
     3361 ctaatttttt tagatttttt ttttttctag tagctactca gagagaactg cttagagaat
     3421 gaaatgaaca ttgctatttt agttgtgttg ttttgttttt ttttttttct agaaaatcca
     3481 aaaatatttt atagaagctt ctctgactct agtcagaaaa cccatgagct agccagagag
     3541 cttttggatt tttttttcct agcaagagaa agctgtctca agaagagaca gctgtctcaa
     3601 gcaaaagagc tgccttgagc agaaagctat ctctatcaga ctgcatagcc aagagctatc
     3661 tgcagaaagc tgtccagctg tctagactac aaggctgtca gcttgcaacc catcatatga
     3721 ctttgagttg tttctttcac cgctcccaga caccccttct cgcaggaacc tccctccaag
     3781 ccaaggctgg tcctgggcac cttgccacat ggtcttggct acagatgtgt gcaagacctg
     3841 taaggctata tttttcttct tgtgtgcagc tcctgcaata ggcctatcac acagtactca
     3901 cacagggcaa gggatctgat gagaacctcc tggggaaccc tcggggttca gctgatgctg
     3961 tattctgcaa tagtaattca tgtaatgtca ttgggtgtaa agtgttgtat aaaattcaag
     4021 cttccaattg agttgaaagt gaaaagcaat cttggaatgg atgacattaa tcctcatgca
     4081 agacaaattt ccagcttccc attgattcat aaagtgggtc atctgtgctt aactccattt
     4141 agttaacctg gttaatattt agacagaatt agccatttac gaactactgt gcaagttaaa
     4201 cagacaaata gaaaagtgaa atttcctaaa gaagattaaa cttttccttg catatataaa
     4261 ggcttgttga gtagtgcaga gggttaaata tggaagatcc tgtgggttat ctacagagtt
     4321 caccatggga agtgtaagag gtggaagcaa atggctttgg aaaaatcttc caagcacaca
     4381 acttcaactt ttaattttgt acaccatttc atcttaatct gtgtggcagt tgttttatat
     4441 ttaaaaagaa agaagtggtt ctcaatgaaa atcttgtatc tcaaggtttc atattaataa
     4501 ccctaacagg tatttacaca aggtgtcaca gtacttactg ggtaaacttt gggctttggt
     4561 ttctcaagga atggcctcat ttgagcaaaa cagagttttg aaatgaggga tttccctatg
     4621 gcgtaaagta ccatgatcac gttgccagct ggagtccagc tgggctggaa tgctctgctt
     4681 ttcattgtgt gttcctgcac aaagtagccc gtcttccact cgaagcctta agaggctgag
     4741 aaaatgagag ggccggataa catcactttt acaagacaaa gtggaggcag gaggccctag
     4801 atctttggca ggtccatcca agaaagggag tgtcacctct ggaatggaac aatgccggca
     4861 ctgttcttcc tgggccgcac gtggagagca cacagcacac cactaacact tctagagctc
     4921 aacgggaagc tcaaagggct gtctgatctc tatctatttt ttttcttgta gttcttgctt
     4981 atggctacca gccctacaaa ctgtcaacaa ctctgaagga tgctcttgca tctctgcctc
     5041 tctctttcat cagtacttca tgtgaatagg aatgtggcaa ataggagaga tttgggtttg
     5101 ctgttattat ttttgttgct gtgtatgcgt aattgcctgc catgtgggtg ctggtgcctg
     5161 acaccaatgg attaaaatgt aacttctgaa caactacctt ctaacaaaat aaaatagagt
     5221 agtcaa
//
