LOCUS       NM_011872               1923 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus kallikrein related-peptidase 7 (chymotryptic, stratum
            corneum) (Klk7), mRNA.
ACCESSION   NM_011872 XM_001001759
VERSION     NM_011872.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Guo,C.J., Mack,M.R., Oetjen,L.K., Trier,A.M., Council,M.L.,
            Pavel,A.B., Guttman-Yassky,E., Kim,B.S. and Liu,Q.
  TITLE     Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch
            Independently of Skin Inflammation
  JOURNAL   J Invest Dermatol 140 (6), 1244-1252 (2020)
   PUBMED   31883963
  REMARK    GeneRIF: Kallikrein 7 Promotes Atopic Dermatitis-Associated Itch
            Independently of Skin Inflammation.
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Kidana,K., Tatebe,T., Ito,K., Hara,N., Kakita,A., Saito,T.,
            Takatori,S., Ouchi,Y., Ikeuchi,T., Makino,M., Saido,T.C.,
            Akishita,M., Iwatsubo,T., Hori,Y. and Tomita,T.
  TITLE     Loss of kallikrein-related peptidase 7 exacerbates amyloid
            pathology in Alzheimer's disease model mice
  JOURNAL   EMBO Mol Med 10 (3) (2018)
   PUBMED   29311134
  REMARK    GeneRIF: KLK7 is an important enzyme in the degradation and
            clearance of deposited Amyloid beta species by astrocytes involved
            in the pathogenesis of Alzheimer's disease.
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Zieger,K., Weiner,J., Kunath,A., Gericke,M., Krause,K., Kern,M.,
            Stumvoll,M., Kloting,N., Bluher,M. and Heiker,J.T.
  TITLE     Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates
            metabolic consequences of high fat diet-induced obesity by
            counteracting adipose tissue inflammation in vivo
  JOURNAL   Cell Mol Life Sci 75 (4), 727-742 (2018)
   PUBMED   28932870
  REMARK    GeneRIF: A previously unrecognized role of KLK7 in adipose tissue
            with effects on whole body energy expenditure and insulin
            sensitivity.
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Kasparek,P., Ileninova,Z., Zbodakova,O., Kanchev,I., Benada,O.,
            Chalupsky,K., Brattsand,M., Beck,I.M. and Sedlacek,R.
  TITLE     KLK5 and KLK7 Ablation Fully Rescues Lethality of Netherton
            Syndrome-Like Phenotype
  JOURNAL   PLoS Genet 13 (1), e1006566 (2017)
   PUBMED   28095415
  REMARK    GeneRIF: Ablation of KLK7 is not sufficient to rescue the lethal
            effect of LEKTI-deficiency. Double deficiency of both KLK7 and KLK5
            completely rescues Netherton Syndrome-like phenotype.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Zhang,L., Ferreyros,M., Feng,W., Hupe,M., Crumrine,D.A., Chen,J.,
            Elias,P.M., Holleran,W.M., Niswander,L., Hohl,D., Williams,T.,
            Torchia,E.C. and Roop,D.R.
  TITLE     Defects in Stratum Corneum Desquamation Are the Predominant Effect
            of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin
            Ichthyosis
  JOURNAL   PLoS One 11 (8), e0161465 (2016)
   PUBMED   27551807
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1923)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
REFERENCE   7  (bases 1 to 1923)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   8  (bases 1 to 1923)
  AUTHORS   Borgono,C.A., Michael,I.P. and Diamandis,E.P.
  TITLE     Human tissue kallikreins: physiologic roles and applications in
            cancer
  JOURNAL   Mol Cancer Res 2 (5), 257-280 (2004)
   PUBMED   15192120
  REMARK    Review article
REFERENCE   9  (bases 1 to 1923)
  AUTHORS   Hansson,L., Backman,A., Ny,A., Edlund,M., Ekholm,E., Ekstrand
            Hammarstrom,B., Tornell,J., Wallbrandt,P., Wennbo,H. and Egelrud,T.
  TITLE     Epidermal overexpression of stratum corneum chymotryptic enzyme in
            mice: a model for chronic itchy dermatitis
  JOURNAL   J Invest Dermatol 118 (3), 444-449 (2002)
   PUBMED   11874483
REFERENCE   10 (bases 1 to 1923)
  AUTHORS   Backman,A., Stranden,P., Brattsand,M., Hansson,L. and Egelrud,T.
  TITLE     Molecular cloning and tissue expression of the murine analog to
            human stratum corneum chymotryptic enzyme
  JOURNAL   J Invest Dermatol 113 (2), 152-155 (1999)
   PUBMED   10469296
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC151989.4 and AK029477.1.
            
            On May 3, 2016 this sequence version replaced NM_011872.2.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, May 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027823.1, AK029477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC151989.4         6707-6856           c
            151-1895            AK029477.1         1-1745
            1896-1923           AC151989.4         1763-1790           c
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.27 cM"
     gene            1..1923
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /note="kallikrein related-peptidase 7 (chymotryptic,
                     stratum corneum)"
                     /db_xref="GeneID:23993"
                     /db_xref="MGI:MGI:1346336"
     exon            1..200
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     exon            201..305
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     CDS             239..988
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /EC_number="3.4.21.117"
                     /note="kallikrein-7; thymopsin; serine protease 6; stratum
                     corneum chymotryptic enzyme; kallikrein 7 (chymotryptic,
                     stratum corneum); kallikrein-related peptidase 7"
                     /codon_start=1
                     /product="kallikrein-7 preproprotein"
                     /protein_id="NP_036002.1"
                     /db_xref="CCDS:CCDS21183.1"
                     /db_xref="GeneID:23993"
                     /db_xref="MGI:MGI:1346336"
                     /translation="MGVWLLSLITVLLSLALETAGQGERIIDGYKCKEGSHPWQVALL
                     KGNQLHCGGVLVDKYWVLTAAHCKMGQYQVQLGSDKIGDQSAQKIKATKSFRHPGYST
                     KTHVNDIMLVRLDEPVKMSSKVEAVQLPEHCEPPGTSCTVSGWGTTTSPDVTFPSDLM
                     CSDVKLISSRECKKVYKDLLGKTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQGLVSWG
                     TYPCGQPNDPGVYTQVCKYKRWVMETMKTHR"
     exon            306..447
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     exon            448..695
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     exon            696..832
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1923
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1581..1586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /note="hexamer: AATAAA"
     polyA_site      1602
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /note="major polyA site"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /note="hexamer: AATAAA"
     polyA_site      1923
                     /gene="Klk7"
                     /gene_synonym="Prss6; SCCE"
                     /note="major polyA site"
ORIGIN      
        1 ccaactgttg gggttgcctc agggatttca gataacccta tgctcaaagc agagggaagg
       61 cacccagaga cagctccacc tgtgccccag ggagctggag gcggtgcggg ggcaggggag
      121 gtataaaagg gccagcccta tagaaggctg gagacactgg tctccggatc aaggacagag
      181 cctcgccaag tcactcccag ctctctcatc tggcagtccc tgagccactg tcgccgagat
      241 gggagtctgg ctcctttccc tgataactgt gctgctgtct ttagccctgg aaaccgctgg
      301 acaaggagaa aggattatag atggctacaa atgtaaagaa ggctcgcacc catggcaggt
      361 ggctctgctc aaaggcaatc agcttcactg tggaggggtg ctggtggaca aatactgggt
      421 gctcacagca gcccactgca aaatgggtca gtaccaagta cagctgggca gtgataaaat
      481 aggggaccag agtgcccaga agatcaaggc tacaaagtca ttccggcacc ctggctactc
      541 cacaaagacc cacgtcaatg acatcatgct tgtgaggttg gatgagccag tcaagatgtc
      601 atccaaagtg gaggcagtcc agcttcctga acactgtgaa cccccaggga cgtcatgtac
      661 cgtctctgga tggggcacca caaccagccc agacgtgacc tttccctcgg atcttatgtg
      721 ctcggatgtg aagctcatct cctccaggga gtgcaagaag gtgtacaagg acctgctggg
      781 gaaaaccatg ctgtgtgctg gcattcctga ctctaagacc aacacgtgca atggtgactc
      841 aggggggccc ttggtgtgca acgacaccct ccaaggtctg gtgtcctggg gtacctaccc
      901 ttgtggccag cccaacgacc caggcgtcta cactcaagtc tgcaagtaca aacggtgggt
      961 gatggagacc atgaaaaccc atcgctaaca tgccaggagc cgagctgtga gcctttgagg
     1021 ttatgatcat ggagtaagga catcgtggca tccctgtaaa gtcctgcctg gctttacctt
     1081 tcctccagga catagccaaa cctcaacact aggttaagtt tataaaccaa tcagaacccc
     1141 agagacctaa aagcaaatca aggcaagaga ctaagaaacc tgagggctgt ggaagatgcc
     1201 agaaggctaa agctttccaa tacaagagcc agggattcct acagtccttt attggaaagt
     1261 ggttggtaac tgtgagacct tcatccactg ccttggactc aggtcatcca tttctgcaga
     1321 gttctttctc aaaaaaaaaa aaaaaaaaga ttgaaccaag tttggattca ttacagtact
     1381 tatcatagag gaagaaaaga atggaaacgg ttaacatgtt caaaatagta gattatttac
     1441 atgggagttg gactgctctc attatgaagt tgtgaagttg cttaaggtgt actgcttagc
     1501 cttatgcaag agagactgtt gttgtgtggt gtttaatggg gacgtgggct gaacatgcca
     1561 aatgaatact agtgagacag aataaaatct aagtgatatt gatgtgtgtg ctcataacct
     1621 ggaaggtaac gttggggaag ctgggagcca cgatggtgga gggaggagat ctatgaagaa
     1681 gagttggcta agaaattgta gctaggccag caagatggct cagtggataa aggtacttgc
     1741 tgccaatcct gacatggctt aagtttcatc tctagagcct acacagtgga agggaacaac
     1801 tgacgcacgc ttgttatcct ctgacctcca agtgtgctgg ggcacaagtg tccctgcaca
     1861 caaatatgga cgccaaacca gattaaaatg caaataaagt agtcttcatg tttttaactt
     1921 tta
//
