LOCUS       NM_011177               1165 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus kallikrein related-peptidase 6 (Klk6), transcript
            variant 1, mRNA.
ACCESSION   NM_011177
VERSION     NM_011177.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1165)
  AUTHORS   Georgieva,T.G., Darmoul,D., Chen,H., Cui,H., Rice,P.F.S.,
            Barton,J.K., Besselsen,D.G. and Ignatenko,N.A.
  TITLE     Kallikrein-Related Peptidase 6 Contributes to Murine Intestinal
            Tumorigenesis Driven by a Mutant Adenomatous polyposis coli Gene
  JOURNAL   Cancers (Basel) 16 (22), 3842 (2024)
   PUBMED   39594797
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1165)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1165)
  AUTHORS   Furube,E., Ohgidani,M. and Yoshida,S.
  TITLE     Systemic Inflammation Leads to Changes in the Intracellular
            Localization of KLK6 in Oligodendrocytes in Spinal Cord White
            Matter
  JOURNAL   Neurochem Res 48 (9), 2645-2659 (2023)
   PUBMED   37067738
  REMARK    GeneRIF: Systemic Inflammation Leads to Changes in the
            Intracellular Localization of KLK6 in Oligodendrocytes in Spinal
            Cord White Matter.
REFERENCE   4  (bases 1 to 1165)
  AUTHORS   Hwang,Y.S., Cho,H.J., Park,E.S., Lim,J., Yoon,H.R., Kim,J.T.,
            Yoon,S.R., Jung,H., Choe,Y.K., Kim,Y.H., Lee,C.H., Kwon,Y.T.,
            Kim,B.Y. and Lee,H.G.
  TITLE     KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by Regulating
            Cross-Talk between Tumor Cells and Macrophages
  JOURNAL   Cells 11 (24), 4101 (2022)
   PUBMED   36552865
  REMARK    GeneRIF: KLK6/PAR1 Axis Promotes Tumor Growth and Metastasis by
            Regulating Cross-Talk between Tumor Cells and Macrophages.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1165)
  AUTHORS   Yoon,H., Triplet,E.M., Simon,W.L., Choi,C.I., Kleppe,L.S., De
            Vita,E., Miller,A.K. and Scarisbrick,I.A.
  TITLE     Blocking Kallikrein 6 promotes developmental myelination
  JOURNAL   Glia 70 (3), 430-450 (2022)
   PUBMED   34626143
  REMARK    GeneRIF: Blocking Kallikrein 6 promotes developmental myelination.
REFERENCE   6  (bases 1 to 1165)
  AUTHORS   Sangorrin,M.P., Martone,C.B. and Sanchez,J.J.
  TITLE     Myofibril-bound serine protease and its endogenous inhibitor in
            mouse: extraction, partial characterization and effect on
            myofibrils
  JOURNAL   Comp Biochem Physiol B Biochem Mol Biol 131 (4), 713-723 (2002)
   PUBMED   11923084
REFERENCE   7  (bases 1 to 1165)
  AUTHORS   Breitenbach,U., Tuckermann,J.P., Gebhardt,C., Richter,K.H.,
            Furstenberger,G., Christofori,G. and Angel,P.
  TITLE     Keratinocyte-specific onset of serine protease BSSP expression in
            experimental carcinogenesis
  JOURNAL   J Invest Dermatol 117 (3), 634-640 (2001)
   PUBMED   11564170
REFERENCE   8  (bases 1 to 1165)
  AUTHORS   Matsui,H., Kimura,A., Yamashiki,N., Moriyama,A., Kaya,M.,
            Yoshida,I., Takagi,N. and Takahashi,T.
  TITLE     Molecular and biochemical characterization of a serine proteinase
            predominantly expressed in the medulla oblongata and cerebellar
            white matter of mouse brain
  JOURNAL   J Biol Chem 275 (15), 11050-11057 (2000)
   PUBMED   10753908
REFERENCE   9  (bases 1 to 1165)
  AUTHORS   Yamanaka,H., He,X., Matsumoto,K., Shiosaka,S. and Yoshida,S.
  TITLE     Protease M/neurosin mRNA is expressed in mature oligodendrocytes
  JOURNAL   Brain Res Mol Brain Res 71 (2), 217-224 (1999)
   PUBMED   10521576
REFERENCE   10 (bases 1 to 1165)
  AUTHORS   Meier,N., Dear,T.N. and Boehm,T.
  TITLE     A novel serine protease overexpressed in the hair follicles of nude
            mice
  JOURNAL   Biochem Biophys Res Commun 258 (2), 374-378 (1999)
   PUBMED   10329394
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC134858.6.
            
            On Feb 27, 2023 this sequence version replaced NM_011177.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All five variants encode the same protein.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus. The use of an alternative upstream start codon would
            result in a protein that is 7 aa longer.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y18723.1, BC031119.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC134858.6         15509-15763
            256-316             AC134858.6         16155-16215
            317-473             AC134858.6         16897-17053
            474-721             AC134858.6         18522-18769
            722-858             AC134858.6         19235-19371
            859-1165            AC134858.6         21587-21893
FEATURES             Location/Qualifiers
     source          1..1165
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.28 cM"
     gene            1..1165
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /note="kallikrein related-peptidase 6"
                     /db_xref="GeneID:19144"
                     /db_xref="MGI:MGI:1343166"
     exon            1..255
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1017
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /note="myofibril-bound protease; myelencephalon-specific
                     protease; brain serine protease; protease, serine, 18;
                     kallikrein 6; protease, serine, 9; protease M; kallikrein
                     29"
                     /codon_start=1
                     /product="kallikrein-6 precursor"
                     /protein_id="NP_035307.2"
                     /db_xref="CCDS:CCDS21184.2"
                     /db_xref="GeneID:19144"
                     /db_xref="MGI:MGI:1343166"
                     /translation="MPMKMLTMKMLALCLVLAKSAWSEEQEKVVHGGPCLKDSHPFQA
                     ALYTSGHLLCGGVLIDPQWVLTAAHCKKPNLQVILGKHNLRQTETFQRQISVDRTIVH
                     PRYNPETHDNDIMMVHLKNPVKFSKKIQPLPLKNDCSEENPNCQILGWGKMENGDFPD
                     TIQCADVHLVPREQCERAYPGKITQSMVCAGDMKEGNDSCQGDSGGPLVCGGRLRGLV
                     SWGDMPCGSKEKPGVYTDVCTHIRWIQNILRNKWL"
     exon            256..316
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /inference="alignment:Splign:2.1.0"
     exon            317..473
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /inference="alignment:Splign:2.1.0"
     exon            474..721
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /inference="alignment:Splign:2.1.0"
     exon            722..858
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1165
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /note="hexamer: AATAAA"
     polyA_site      1165
                     /gene="Klk6"
                     /gene_synonym="BSP; Bssp; Klk29; MSP; neurosin; Prss18;
                     Prss9"
                     /note="major polyA site"
ORIGIN      
        1 agagtccgcc tctctctggg aggccacaga gccaggaggg tttctggaga cagtctgcta
       61 cttgggaccc agcatccaag tgccccatat ttcatgcagg tcggatcata aggcagcctt
      121 ctgtcagtct gctctgcccc ttccctcgag gagcgccctg ccttgctgac tttctctgcc
      181 tctggcttcc tgtgataggt ggtgtcattc ccctccaacc tgagtgctgg caggtacact
      241 gctggccacc agcagatgcc catgaagatg ctgacaatga agatgctggc cctgtgcttg
      301 gttcttgcta aatcagcctg gtcggaggaa caggagaagg tggttcatgg aggcccgtgt
      361 ttgaaggact cccacccttt ccaggctgcc ctctacacct caggtcactt gctgtgtggt
      421 ggggtcctca ttgacccaca gtgggtgctg acagctgccc actgcaaaaa accgaatctg
      481 caggtgatct tggggaaaca caacctacgg caaacagaga ctttccaaag gcaaatctca
      541 gtggacagga ctattgtcca tccccgctac aaccctgaaa cccacgacaa tgacatcatg
      601 atggtgcatc tgaaaaatcc agtcaaattc tctaaaaaga tccagcctct gcccttgaag
      661 aatgactgct ctgaggagaa tcccaactgc cagatcctgg gctggggcaa gatggaaaat
      721 ggtgacttcc cagataccat tcagtgtgct gatgtccatc tggtgccccg ggagcagtgt
      781 gagcgtgcct accctggcaa gatcacccag agcatggtgt gcgcaggcga catgaaagaa
      841 ggcaacgatt cctgtcaggg tgattctgga ggtcccctag tatgtggggg tcgcctccga
      901 gggctcgtgt catggggtga catgccctgt ggatcaaagg agaagccagg agtttacacc
      961 gatgtctgca ctcatatcag atggatccaa aacatcctca gaaacaagtg gctgtgacat
     1021 gagacatcca gttctccccc acgacgcctc tgaccctcgc tggctccata ctctctctcc
     1081 ctgaagccct gccctgctct cagagccttc agatgtccag ctctgaccct ggtacttaat
     1141 aaatgtagtg acacagagca cagaa
//
