LOCUS       NM_026806               1239 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kallikrein related-peptidase 5 (Klk5), mRNA.
ACCESSION   NM_026806 XM_001001768 XM_001002786 XM_917001
VERSION     NM_026806.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1239)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1239)
  AUTHORS   Jackman,J.K., Stockwell,A., Choy,D.F., Xie,M.M., Lu,P., Jia,G.,
            Li,H., Abbas,A.R., Bronson,P.G., Lin,W.Y., Chiu,C.P.C., Maun,H.R.,
            Roose-Girma,M., Tam,L., Zhang,J., Modrusan,Z., Graham,R.R.,
            Behrens,T.W., White,S.R., Naureckas,T., Ober,C., Ferreira,M.,
            Sedlacek,R., Wu,J., Lee,W.P., Lazarus,R.A., Koerber,J.T.,
            Arron,J.R., Yaspan,B.L. and Yi,T.
  TITLE     Genome-wide association study identifies kallikrein 5 in type 2
            inflammation-low asthma
  JOURNAL   J Allergy Clin Immunol 150 (4), 972-978 (2022)
   PUBMED   35487308
REFERENCE   3  (bases 1 to 1239)
  AUTHORS   Zhou,S., Liu,S., Tian,G., Zhao,L., Wang,H., Li,Y., Shen,Y. and
            Han,L.
  TITLE     KLK5 is associated with the radioresistance, aggression, and
            progression of cervical cancer
  JOURNAL   Gynecol Oncol 166 (1), 138-147 (2022)
   PUBMED   35595569
  REMARK    GeneRIF: KLK5 is associated with the radioresistance, aggression,
            and progression of cervical cancer.
REFERENCE   4  (bases 1 to 1239)
  AUTHORS   Zingkou,E., Pampalakis,G. and Sotiropoulou,G.
  TITLE     Cathelicidin represents a new target for manipulation of skin
            inflammation in Netherton syndrome
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1866 (10), 165831 (2020)
   PUBMED   32442469
REFERENCE   5  (bases 1 to 1239)
  AUTHORS   Azouz,N.P., Klingler,A.M., Pathre,P., Besse,J.A.,
            Baruch-Morgenstern,N.B., Ballaban,A.Y., Osswald,G.A.,
            Brusilovsky,M., Habel,J.E., Caldwell,J.M., Ynga-Durand,M.A.,
            Abonia,P.J., Hu,Y.C., Wen,T. and Rothenberg,M.E.
  TITLE     Functional role of kallikrein 5 and proteinase-activated receptor 2
            in eosinophilic esophagitis
  JOURNAL   Sci Transl Med 12 (545) (2020)
   PUBMED   32461336
  REMARK    GeneRIF: Functional role of kallikrein 5 and proteinase-activated
            receptor 2 in eosinophilic esophagitis.
REFERENCE   6  (bases 1 to 1239)
  AUTHORS   Schwab,K.R., Patterson,L.T., Hartman,H.A., Song,N., Lang,R.A.,
            Lin,X. and Potter,S.S.
  TITLE     Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney
            development
  JOURNAL   BMC Biol 5, 15 (2007)
   PUBMED   17425782
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1239)
  AUTHORS   Rajapakse,S., Ogiwara,K., Yamano,N., Kimura,A., Hirata,K.,
            Takahashi,S. and Takahashi,T.
  TITLE     Characterization of mouse tissue kallikrein 5
  JOURNAL   Zoolog Sci 23 (11), 963-968 (2006)
   PUBMED   17189908
  REMARK    GeneRIF: The cloning and characteriazation of recombinant Klk5 is
            reported.
REFERENCE   8  (bases 1 to 1239)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   9  (bases 1 to 1239)
  AUTHORS   Borgono,C.A., Michael,I.P. and Diamandis,E.P.
  TITLE     Human tissue kallikreins: physiologic roles and applications in
            cancer
  JOURNAL   Mol Cancer Res 2 (5), 257-280 (2004)
   PUBMED   15192120
  REMARK    Review article
REFERENCE   10 (bases 1 to 1239)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK003996.1.
            
            On Apr 5, 2007 this sequence version replaced NM_026806.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK003996.1, BC139475.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1239              AK003996.1         2-1240
FEATURES             Location/Qualifiers
     source          1..1239
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.3 cM"
     gene            1..1239
                     /gene="Klk5"
                     /gene_synonym="1110030O19Rik"
                     /note="kallikrein related-peptidase 5"
                     /db_xref="GeneID:68668"
                     /db_xref="MGI:MGI:1915918"
     exon            1..120
                     /gene="Klk5"
                     /gene_synonym="1110030O19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..929
                     /gene="Klk5"
                     /gene_synonym="1110030O19Rik"
                     /note="kallikrein 5"
                     /codon_start=1
                     /product="kallikrein-5 precursor"
                     /protein_id="NP_081082.1"
                     /db_xref="CCDS:CCDS21185.1"
                     /db_xref="GeneID:68668"
                     /db_xref="MGI:MGI:1915918"
                     /translation="MARTGHPWKWAMATLITTLVLGVSEPVLAGDVSSCDNPSGTEPS
                     GTNRDLSTDSKSGEDTRSDSSSRIVNGSDCQKDAQPWQGALLLGPNKLYCGAVLISPQ
                     WLLTAAHCRKPVFRIRLGHHSMSPVYESGQQMFQGIKSIPHPGYSHPGHSNDLMLIKM
                     NRKIRDSHSVKPVEIACDCATEGTRCMVSGWGTTSSSHNNFPKVLQCLNITVLSEERC
                     KNSYPGQIDKTMFCAGDEEGRDSCQGDSGGPVVCNGKLQGLVSWGDFPCAQRNRPGVY
                     TNLCEFVKWIKDTMNSN"
     exon            121..385
                     /gene="Klk5"
                     /gene_synonym="1110030O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            386..642
                     /gene="Klk5"
                     /gene_synonym="1110030O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            643..776
                     /gene="Klk5"
                     /gene_synonym="1110030O19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1239
                     /gene="Klk5"
                     /gene_synonym="1110030O19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1217..1222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk5"
                     /gene_synonym="1110030O19Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1234
                     /gene="Klk5"
                     /gene_synonym="1110030O19Rik"
                     /note="major polyA site"
ORIGIN      
        1 cagaaccact tagcctcgac ctttatttct taccaggtgc agcggtcatg gcgaggaccg
       61 gacacccctg gaaatgggca atggctaccc tgatcacaac cctggttctg ggggtctcag
      121 agcctgttct tgctggggat gtttcctctt gtgacaaccc ctctggaacc gaaccctctg
      181 ggaccaacag agacctcagc acggattcca agtctgggga ggacacccgt tcagatagca
      241 gctctcgaat tgtgaatggg tcagactgcc aaaaggatgc acagccatgg cagggcgccc
      301 tgcttctggg gcccaacaag ctgtactgtg gggctgtgct gatcagccca cagtggctgc
      361 tcacagcagc acactgcaga aagccagtgt tcagaatccg tctgggccac cattccatgt
      421 cacctgtcta tgagtctggg cagcagatgt tccagggaat caaatccatc ccccaccccg
      481 gttactccca ccctggccac tccaatgacc tcatgctcat caaaatgaac agaaaaatcc
      541 gtgactctca ctcagtgaag cccgtcgaaa ttgcttgtga ctgtgccacc gaggggacta
      601 ggtgcatggt gtctggctgg gggacaacga gcagcagcca caataacttc ccgaaagtcc
      661 tccagtgcct gaatattact gtgctcagtg aggagaggtg taaaaactcc tacccaggac
      721 agatagacaa gaccatgttc tgcgcaggtg atgaagaggg cagggactcc tgccagggtg
      781 attccggagg tcctgtggtc tgcaatggca agttacaggg ccttgtgtcc tggggtgatt
      841 tcccctgtgc tcagcggaac agaccaggtg tctacaccaa cctgtgtgag ttcgttaagt
      901 ggattaaaga caccatgaac tccaactaat gagccacacc aggaaccacg gaaccagtgc
      961 cacccaacgg caatgaggag cactgtccct ctctgagaat gctgaagata acttcagtct
     1021 ctccagaact tgctctatgt ttcttggcac caagatcacc atccctcaca gtggactgac
     1081 ccccgtttct atagccagac cctagggaca cttcctgaaa tgtctaaatt gtgttgaaac
     1141 ccatcactac ctatggaccc atccataaac ccagagttga gccttttctt cagccgtcac
     1201 ccagatttag acctcaaata aaaaacggga agaaccgtg
//
