LOCUS       NM_019928               1249 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus kallikrein related-peptidase 4 (prostase, enamel
            matrix, prostate) (Klk4), mRNA.
ACCESSION   NM_019928
VERSION     NM_019928.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1249)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1249)
  AUTHORS   Chiba,Y., Yoshizaki,K., Sato,H., Ikeuchi,T., Rhodes,C., Chiba,M.,
            Saito,K., Nakamura,T., Iwamoto,T., Yamada,A., Yamada,Y. and
            Fukumoto,S.
  TITLE     Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes
            enamel hypomineralization in mice by alteration of the expression
            of kallikrein-related peptidase 4 (Klk4) during pH cycling process
  JOURNAL   FASEB J 37 (4), e22861 (2023)
   PUBMED   36929047
  REMARK    GeneRIF: Deficiency of G protein-coupled receptor Gpr111/Adgrf2
            causes enamel hypomineralization in mice by alteration of the
            expression of kallikrein-related peptidase 4 (Klk4) during pH
            cycling process.
REFERENCE   3  (bases 1 to 1249)
  AUTHORS   Li,J., Kou,M., Cui,M., Ruan,J. and Cheng,Z.
  TITLE     NaF reduces KLK4 expression by decreasing Foxo1/Runx2 expression in
            LS8 cells
  JOURNAL   Arch Oral Biol 133, 105311 (2022)
   PUBMED   34781073
  REMARK    GeneRIF: NaF reduces KLK4 expression by decreasing Foxo1/Runx2
            expression in LS8 cells.
REFERENCE   4  (bases 1 to 1249)
  AUTHORS   Fan,L., Ou,Y.J., Zhu,Y.X., Liang,Y.D., Zhou,Y. and Wang,Y.N.
  TITLE     Lif Deficiency Leads to Iron Transportation Dysfunction in
            Ameloblasts
  JOURNAL   J Dent Res 101 (1), 63-72 (2022)
   PUBMED   34034544
REFERENCE   5  (bases 1 to 1249)
  AUTHORS   Lee,D.J., Kim,H.Y., Lee,S.J. and Jung,H.S.
  TITLE     Spatiotemporal Changes in Transcriptome of Odontogenic and
            Non-odontogenic Regions in the Dental Arch of Mus musculus
  JOURNAL   Front Cell Dev Biol 9, 723326 (2021)
   PUBMED   34722506
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1249)
  AUTHORS   Borgono,C.A., Michael,I.P. and Diamandis,E.P.
  TITLE     Human tissue kallikreins: physiologic roles and applications in
            cancer
  JOURNAL   Mol Cancer Res 2 (5), 257-280 (2004)
   PUBMED   15192120
  REMARK    Review article
REFERENCE   7  (bases 1 to 1249)
  AUTHORS   Hu,J.C., Sun,X., Zhang,C., Liu,S., Bartlett,J.D. and Simmer,J.P.
  TITLE     Enamelysin and kallikrein-4 mRNA expression in developing mouse
            molars
  JOURNAL   Eur J Oral Sci 110 (4), 307-315 (2002)
   PUBMED   12206593
  REMARK    GeneRIF: expression of KLK4 correlates with the stage-associated
            changes in the digestion of enamel proteins
REFERENCE   8  (bases 1 to 1249)
  AUTHORS   Hu,J.C., Zhang,C., Sun,X., Yang,Y., Cao,X., Ryu,O. and Simmer,J.P.
  TITLE     Characterization of the mouse and human PRSS17 genes, their
            relationship to other serine proteases, and the expression of
            PRSS17 in developing mouse incisors
  JOURNAL   Gene 251 (1), 1-8 (2000)
   PUBMED   10863090
REFERENCE   9  (bases 1 to 1249)
  AUTHORS   Nguyen,H.V., Shull,G.E. and Melvin,J.E.
  TITLE     Muscarinic receptor-induced acidification in sublingual mucous
            acinar cells: loss of pH recovery in Na+-H+ exchanger-1 deficient
            mice
  JOURNAL   J Physiol 523 Pt 1 (Pt 1), 139-146 (2000)
   PUBMED   10673550
REFERENCE   10 (bases 1 to 1249)
  AUTHORS   Hu,J.C., Ryu,O.H., Chen,J.J., Uchida,T., Wakida,K., Murakami,C.,
            Jiang,H., Qian,Q., Zhang,C., Ottmers,V., Bartlett,J.D. and
            Simmer,J.P.
  TITLE     Localization of EMSP1 expression during tooth formation and cloning
            of mouse cDNA
  JOURNAL   J Dent Res 79 (1), 70-76 (2000)
   PUBMED   10690663
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087426.1 and BC100717.1.
            
            On Jun 5, 2018 this sequence version replaced NM_019928.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087426.1, BC100716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               AK087426.1         2-342
            342-1168            BC100717.1         302-1128
            1169-1249           AK087426.1         1174-1254
FEATURES             Location/Qualifiers
     source          1..1249
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.35 cM"
     gene            1..1249
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /note="kallikrein related-peptidase 4 (prostase, enamel
                     matrix, prostate)"
                     /db_xref="GeneID:56640"
                     /db_xref="MGI:MGI:1861379"
     exon            1..55
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            56..127
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..831
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /note="protease, serine 17 (enamel matrix, prostate);
                     kallikrein-like protein 1; enamel matrix serine proteinase
                     1; kallikrein-4"
                     /codon_start=1
                     /product="kallikrein-4 precursor"
                     /protein_id="NP_064312.1"
                     /db_xref="CCDS:CCDS21186.1"
                     /db_xref="GeneID:56640"
                     /db_xref="MGI:MGI:1861379"
                     /translation="MMVTARTPWGWFLGCLILEVTGASASSVSSRIIQGQDCSPHSQP
                     WQAALFSEDGFFCSGVLVHPQWVLSAAHCLQESYIVGLGLHNLKGSQEPGSRMLEAHL
                     SIQHPNFNDPSFANDLMLIKLNESVIESNTIRSIPVATQCPTPGDTCLVSGWGQLKNG
                     KLPSLLQCVNLSVASEETCRLLYDPVYHLSMFCAGGGQDQKDSCNGDSGGPIVCNRSL
                     QGLVSMGQGKCGQPGIPSVYTNLCKFTNWIQTIIQTN"
     exon            128..290
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            291..541
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            542..678
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     exon            679..1249
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1224..1229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /note="hexamer: AATAAA"
     polyA_site      1248
                     /gene="Klk4"
                     /gene_synonym="ESMP1; KLK-L1; Prss17; PSTS"
                     /note="major polyA site"
ORIGIN      
        1 aaccagctca gcttagctca gctcagccgc agaattcgga gcccagaagc agcaggagcc
       61 aacatgatgg tcactgcacg aaccccctgg ggctggttcc tggggtgcct catccttgag
      121 gtcacaggag cctccgcctc aagtgtcagc agccggatca tacaaggcca ggactgctcc
      181 ccacactcgc aaccctggca ggcggcactg ttctcagaag acggtttttt ctgctcggga
      241 gtcttggtgc atccgcagtg ggtgctgtca gcagcacatt gcttacagga gtcctacatc
      301 gtgggactgg gcctgcataa cctgaaaggc tcccaagagc ctggcagccg gatgttagag
      361 gcccacctct ccatccagca ccccaacttc aacgatcctt cttttgcaaa cgatctcatg
      421 ctcatcaaac tgaacgagtc agtgatagag tctaacacta tcaggagcat ccctgtggct
      481 acccaatgcc ccactcctgg agatacctgc ctagtctctg gttggggtca actaaagaat
      541 gggaaactgc ccagcctcct gcagtgtgtg aatctctcag tggcgtcaga ggagacttgc
      601 cggctgctgt atgaccctgt gtaccacctc agtatgttct gcgctggagg aggacaggac
      661 caaaaggact cctgcaatgg ggactctggg ggtcccatag tgtgcaacag atccctacaa
      721 gggctcgtgt ctatgggaca aggaaagtgt gggcagcctg gcataccaag tgtctacacc
      781 aatctctgca agttcactaa ctggatccag accatcattc agacaaacta gctatggact
      841 gactacaagg cccacatgaa gcctgctgag ggaacctgag actcaggatt gctcctagcc
      901 cttctccctc agatctacaa ggtcaggccc tagcctcctc cctcagactc acaagtccag
      961 actccaatct cctccctcag acccacaagt ccagactcca atttcctctc tcagatccaa
     1021 ggattcagac cacaataccc tctttcagat tcagggatcc atgccacaac ctcctccctg
     1081 gaacacagga gtggaaccca cctgcatttt cctctgtgtg cagtgtcctc tagtagccca
     1141 gtattgaccc agccttgcct ttgtcaccct taggcttgtt tcccccccca aacaccttat
     1201 gcctgtctcc tcagggatcc acaaataaaa gacctctcag ttctgtttg
//
