LOCUS       NM_010116                870 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus kallikrein 1-related peptidase b9 (Klk1b9), mRNA.
ACCESSION   NM_010116
VERSION     NM_010116.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 870)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   2  (bases 1 to 870)
  AUTHORS   Angata,T., Margulies,E.H., Green,E.D. and Varki,A.
  TITLE     Large-scale sequencing of the CD33-related Siglec gene cluster in
            five mammalian species reveals rapid evolution by multiple
            mechanisms
  JOURNAL   Proc Natl Acad Sci U S A 101 (36), 13251-13256 (2004)
   PUBMED   15331780
REFERENCE   3  (bases 1 to 870)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   4  (bases 1 to 870)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
REFERENCE   5  (bases 1 to 870)
  AUTHORS   Chan,C.S., Harvey,M.B. and Clements,J.A.
  TITLE     Temporal and tissue-specific expression of kallikrein (Klk) genes
            and identification of a novel Klk messenger ribonucleic acid
            transcript during early development in the mouse
  JOURNAL   Biol Reprod 61 (3), 621-628 (1999)
   PUBMED   10456837
REFERENCE   6  (bases 1 to 870)
  AUTHORS   Watson,M.L., Rao,J.K., Gilkeson,G.S., Ruiz,P., Eicher,E.M.,
            Pisetsky,D.S., Matsuzawa,A., Rochelle,J.M. and Seldin,M.F.
  TITLE     Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis
            gene to disease manifestations and renal disease-modifying loci
  JOURNAL   J Exp Med 176 (6), 1645-1656 (1992)
   PUBMED   1460423
REFERENCE   7  (bases 1 to 870)
  AUTHORS   Kim,W.S., Nakayama,K., Nakagawa,T., Kawamura,Y., Haraguchi,K. and
            Murakami,K.
  TITLE     Mouse submandibular gland prorenin-converting enzyme is a member of
            glandular kallikrein family
  JOURNAL   J Biol Chem 266 (29), 19283-19287 (1991)
   PUBMED   1918045
REFERENCE   8  (bases 1 to 870)
  AUTHORS   Saunders,A.M. and Seldin,M.F.
  TITLE     A molecular genetic linkage map of mouse chromosome 7
  JOURNAL   Genomics 8 (3), 525-535 (1990)
   PUBMED   1981054
REFERENCE   9  (bases 1 to 870)
  AUTHORS   Blaber,M., Isackson,P.J. and Bradshaw,R.A.
  TITLE     A complete cDNA sequence for the major epidermal growth factor
            binding protein in the male mouse submandibular gland
  JOURNAL   Biochemistry 26 (21), 6742-6749 (1987)
   PUBMED   3322386
REFERENCE   10 (bases 1 to 870)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M17962.1.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M17962.1, BC024624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..870
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.45 cM"
     gene            1..870
                     /gene="Klk1b9"
                     /gene_synonym="EGF-BP C; Egfbp-3; Egfbp3; KAL; kallikrein;
                     Klk9; mGk-9"
                     /note="kallikrein 1-related peptidase b9"
                     /db_xref="GeneID:13648"
                     /db_xref="MGI:MGI:95293"
     exon            1..82
                     /gene="Klk1b9"
                     /gene_synonym="EGF-BP C; Egfbp-3; Egfbp3; KAL; kallikrein;
                     Klk9; mGk-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..822
                     /gene="Klk1b9"
                     /gene_synonym="EGF-BP C; Egfbp-3; Egfbp3; KAL; kallikrein;
                     Klk9; mGk-9"
                     /EC_number="3.4.21.35"
                     /note="tissue kallikrein-9; glandular kallikrein K9;
                     epidermal growth factor-binding protein type C"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b9 preproprotein"
                     /protein_id="NP_034246.1"
                     /db_xref="CCDS:CCDS21191.1"
                     /db_xref="GeneID:13648"
                     /db_xref="MGI:MGI:95293"
                     /translation="MRFLILFLALSLGGIDAAPPVHSRIVGGFKCEKNSQPWHVAVYR
                     YNEYICGGVLLDANWVLTAAHCYYEENKVSLGKNNLYEEEPSAQHRLVSKSFLHPGYN
                     RSLHRNHIRHPEYDYSNDLMLLRLSKPADITDVVKPIALPTEEPKLGSTCLASGWGST
                     TPFKFQNAKDLQCVNLKLLPNEDCGKAHIEKVTDVMLCAGETDGGKDTCKGDSGGPLI
                     CDGVLQGITSWGFTPCGEPKKPGVYTKLIKFTSWIKDTMAKNL"
     exon            83..242
                     /gene="Klk1b9"
                     /gene_synonym="EGF-BP C; Egfbp-3; Egfbp3; KAL; kallikrein;
                     Klk9; mGk-9"
                     /inference="alignment:Splign:2.1.0"
     exon            243..529
                     /gene="Klk1b9"
                     /gene_synonym="EGF-BP C; Egfbp-3; Egfbp3; KAL; kallikrein;
                     Klk9; mGk-9"
                     /inference="alignment:Splign:2.1.0"
     exon            530..666
                     /gene="Klk1b9"
                     /gene_synonym="EGF-BP C; Egfbp-3; Egfbp3; KAL; kallikrein;
                     Klk9; mGk-9"
                     /inference="alignment:Splign:2.1.0"
     exon            667..870
                     /gene="Klk1b9"
                     /gene_synonym="EGF-BP C; Egfbp-3; Egfbp3; KAL; kallikrein;
                     Klk9; mGk-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      846..851
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b9"
                     /gene_synonym="EGF-BP C; Egfbp-3; Egfbp3; KAL; kallikrein;
                     Klk9; mGk-9"
     polyA_site      870
                     /gene="Klk1b9"
                     /gene_synonym="EGF-BP C; Egfbp-3; Egfbp3; KAL; kallikrein;
                     Klk9; mGk-9"
ORIGIN      
        1 aagctcactg cctgctgctc ctggacacct gttaccatga ggttcctgat cctgttccta
       61 gccctgtccc taggagggat tgatgctgca cctcctgtcc actctcgaat tgttggagga
      121 tttaaatgtg agaagaattc ccaaccctgg catgtggctg tgtaccgtta caacgaatat
      181 atatgcgggg gtgtcctgtt ggatgccaac tgggttctca cagctgccca ctgctattac
      241 gaagagaaca aggtttccct aggaaaaaac aacctatacg aagaggaacc ctctgctcag
      301 caccgattgg tcagcaaaag cttccttcac cctggctaca acaggagcct ccatagaaac
      361 cacatccgac atcctgagta tgactacagc aatgacctga tgctgctccg cctcagcaag
      421 cctgctgaca tcacagatgt tgtgaagccc atcgccctgc ctactgagga gcccaagctg
      481 gggagcacat gccttgcctc aggctggggc agcactacac ctttcaagtt ccaaaatgca
      541 aaagatctcc agtgtgtgaa cctcaagctc ctgcctaatg aggactgtgg caaagcccac
      601 atagagaagg tgacagatgt catgctgtgt gcaggagaga cagatggagg caaagacact
      661 tgcaagggag actcaggagg cccactgatc tgtgatggtg ttctccaagg tatcacatca
      721 tggggcttta ccccatgtgg tgaacccaaa aagccgggcg tctacaccaa acttattaag
      781 tttacctcct ggatcaaaga cactatggca aaaaacctct gagtgataca ctgtctgcct
      841 ttctcaataa aattcactat gcaacaaatg
//
