LOCUS       NM_008456                862 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus kallikrein 1-related peptidase b5 (Klk1b5), mRNA.
ACCESSION   NM_008456
VERSION     NM_008456.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 862)
  AUTHORS   Li,S., Beedle,M.T., Herrera,G.B., Tam,K.K. and Winuthayanon,W.
  TITLE     Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in
            mice
  JOURNAL   Mol Reprod Dev 86 (6), 611-613 (2019)
   PUBMED   30957940
  REMARK    GeneRIF: Deletion of kallikrein 1b5 (Klk1b5) has no impact on
            fertility in mice.
REFERENCE   2  (bases 1 to 862)
  AUTHORS   Moreno-Moya,J.M., Franchi,N.A., Martinez-Escribano,S.,
            Martinez-Conejero,J.A., Bocca,S., Oehninger,S. and Horcajadas,J.A.
  TITLE     Transcriptome of early embryonic invasion at implantation sites in
            a murine model
  JOURNAL   Reprod Fertil Dev (2015) In press
   PUBMED   25940376
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 862)
  AUTHORS   Fischer,J., Wu,Z., Kantyka,T., Sperrhacke,M., Dimitrieva,O.,
            Koblyakova,Y., Ahrens,K., Graumann,N., Baurecht,H., Reiss,K.,
            Schroder,J.M., Proksch,E. and Meyer-Hoffert,U.
  TITLE     Characterization of Spink6 in mouse skin: the conserved inhibitor
            of kallikrein-related peptidases is reduced by barrier injury
  JOURNAL   J Invest Dermatol 134 (5), 1305-1312 (2014)
   PUBMED   24352040
REFERENCE   4  (bases 1 to 862)
  AUTHORS   Kriegel,A.J., Liu,Y., Cohen,B., Usa,K., Liu,Y. and Liang,M.
  TITLE     MiR-382 targeting of kallikrein 5 contributes to renal inner
            medullary interstitial fibrosis
  JOURNAL   Physiol Genomics 44 (4), 259-267 (2012)
   PUBMED   22202692
  REMARK    GeneRIF: Data support a completely novel mechanism in which miR-382
            targets kallikrein 5 and contributes to the development of renal
            inner medullary interstitial fibrosis.
REFERENCE   5  (bases 1 to 862)
  AUTHORS   Schwab,K.R., Patterson,L.T., Hartman,H.A., Song,N., Lang,R.A.,
            Lin,X. and Potter,S.S.
  TITLE     Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney
            development
  JOURNAL   BMC Biol 5, 15 (2007)
   PUBMED   17425782
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 862)
  AUTHORS   Ko,M.S., Wang,X., Horton,J.H., Hagen,M.D., Takahashi,N., Maezaki,Y.
            and Nadeau,J.H.
  TITLE     Genetic mapping of 40 cDNA clones on the mouse genome by PCR
  JOURNAL   Mamm Genome 5 (6), 349-355 (1994)
   PUBMED   8043949
REFERENCE   7  (bases 1 to 862)
  AUTHORS   Drinkwater,C.C. and Richards,R.I.
  TITLE     Sequence of the mouse glandular kallikrein gene, mGK-5
  JOURNAL   Nucleic Acids Res 15 (23), 10052 (1987)
   PUBMED   3502721
REFERENCE   8  (bases 1 to 862)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
REFERENCE   9  (bases 1 to 862)
  AUTHORS   van Leeuwen,B.H., Evans,B.A., Tregear,G.W. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Identification, structure, and
            expression of the renal kallikrein gene
  JOURNAL   J Biol Chem 261 (12), 5529-5535 (1986)
   PUBMED   3007510
REFERENCE   10 (bases 1 to 862)
  AUTHORS   Mason,A.J., Evans,B.A., Cox,D.R., Shine,J. and Richards,R.I.
  TITLE     Structure of mouse kallikrein gene family suggests a role in
            specific processing of biologically active peptides
  JOURNAL   Nature 303 (5915), 300-307 (1983)
   PUBMED   6602295
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124176.3.
            
            On Feb 23, 2016 this sequence version replaced NM_008456.3.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, Feb 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094281.1, BG870715.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AC124176.3         151180-151252
            74-233              AC124176.3         153158-153317
            234-520             AC124176.3         154316-154602
            521-657             AC124176.3         154697-154833
            658-862             AC124176.3         155205-155409
FEATURES             Location/Qualifiers
     source          1..862
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.73 cM"
     gene            1..862
                     /gene="Klk1b5"
                     /gene_synonym="kallikrein; Klk5; mGK-5"
                     /note="kallikrein 1-related peptidase b5"
                     /db_xref="GeneID:16622"
                     /db_xref="MGI:MGI:892020"
     exon            1..73
                     /gene="Klk1b5"
                     /gene_synonym="kallikrein; Klk5; mGK-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..813
                     /gene="Klk1b5"
                     /gene_synonym="kallikrein; Klk5; mGK-5"
                     /EC_number="3.4.21.35"
                     /note="tissue kallikrein-5; glandular kallikrein K5"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b5 preproprotein"
                     /protein_id="NP_032482.1"
                     /db_xref="CCDS:CCDS21201.1"
                     /db_xref="GeneID:16622"
                     /db_xref="MGI:MGI:892020"
                     /translation="MWFLILFLALSLGGIDAAPPVQSRIFGGFNCEKNSQPWQVAVYR
                     FTKYQCGGVLLNANWVLTAAHCHNDKYQVWLGKNNFFEDEPSAQHRLVSKAIPHPDFN
                     MSLLNEHTPQPEDDYSNDLMLLRLKKPADITDVVKPIDLPTEEPKLGSTCLASGWGSI
                     TPVIYEPADDLQCVNFKLLPNEDCVKAHIEKVTDVMLCAGDMDGGKDTCMGDSGGPLI
                     CDGVLHGITSWGPSPCGKPNVPGIYTKLIKFNSWIKDTIAKNA"
     exon            74..233
                     /gene="Klk1b5"
                     /gene_synonym="kallikrein; Klk5; mGK-5"
                     /inference="alignment:Splign:2.1.0"
     exon            234..520
                     /gene="Klk1b5"
                     /gene_synonym="kallikrein; Klk5; mGK-5"
                     /inference="alignment:Splign:2.1.0"
     exon            521..657
                     /gene="Klk1b5"
                     /gene_synonym="kallikrein; Klk5; mGK-5"
                     /inference="alignment:Splign:2.1.0"
     exon            658..862
                     /gene="Klk1b5"
                     /gene_synonym="kallikrein; Klk5; mGK-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      837..842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b5"
                     /gene_synonym="kallikrein; Klk5; mGK-5"
                     /note="hexamer: AATAAA"
     polyA_site      859
                     /gene="Klk1b5"
                     /gene_synonym="kallikrein; Klk5; mGK-5"
                     /note="major polyA site"
ORIGIN      
        1 gcctgcagct cctggacagc tgtcaccatg tggttcctga tcctgttcct agccctgtcc
       61 ctaggaggga ttgatgctgc acctcctgtc cagtctcgaa tttttggagg atttaactgt
      121 gagaagaact cccaaccctg gcaagtggct gtgtaccgct tcaccaaata tcaatgcggg
      181 ggagtcctgc tgaacgccaa ctgggttctc actgctgccc actgccataa tgacaagtac
      241 caggtttggc tgggcaaaaa caactttttt gaggatgaac cctctgccca acaccggctt
      301 gtcagcaaag ccatccctca ccctgacttc aacatgagcc tcctgaatga gcacacccca
      361 caacctgagg acgactacag caatgacctg atgctgctcc gcctcaaaaa gcctgctgac
      421 atcacagatg ttgtgaagcc catcgacctg cccactgagg agcccaagct ggggagcaca
      481 tgcctagcct caggctgggg cagcattaca cccgtcatat acgaacccgc agatgatctc
      541 cagtgtgtga acttcaagct cctgcctaat gaggactgtg tcaaagccca catagagaag
      601 gtgacagatg ttatgttgtg tgcaggagat atggatggag gcaaagacac ttgtatgggt
      661 gactcaggag gcccactgat ctgtgatggt gttctccacg gtatcacatc atggggccct
      721 agcccttgcg gtaaacccaa tgtgccaggt atctacacca aacttattaa gtttaactct
      781 tggataaaag acactatagc taaaaatgcc tgaatatcac attgtcccat gttctcaata
      841 aagcccacca tgcagcaaat ga
//
