LOCUS       NM_010915                841 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus kallikrein 1-related pepidase b4 (Klk1b4), mRNA.
ACCESSION   NM_010915
VERSION     NM_010915.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 841)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 841)
  AUTHORS   Angelucci,F., Ricci,E., Padua,L., Sabino,A. and Tonali,P.A.
  TITLE     Music exposure differentially alters the levels of brain-derived
            neurotrophic factor and nerve growth factor in the mouse
            hypothalamus
  JOURNAL   Neurosci Lett 429 (2-3), 152-155 (2007)
   PUBMED   17980967
  REMARK    GeneRIF: Exposure to music in mice can influence neurotrophin
            production in the hypothalamus. Physiological effects of music
            might be in part mediated by modulation of neurotrophins.
REFERENCE   3  (bases 1 to 841)
  AUTHORS   Shoemaker,S.E., Sachs,H.H., Vaccariello,S.A. and Zigmond,R.E.
  TITLE     Reduction in nerve growth factor availability leads to a
            conditioning lesion-like effect in sympathetic neurons
  JOURNAL   J Neurobiol 66 (12), 1322-1337 (2006)
   PUBMED   16967509
  REMARK    GeneRIF: The results suggest that the decreased availability of NGF
            after axotomy is a sufficient stimulus to induce the conditioning
            lesion effect in sympathetic neurons.
REFERENCE   4  (bases 1 to 841)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   5  (bases 1 to 841)
  AUTHORS   Hansen-Algenstaedt,N., Algenstaedt,P., Schaefer,C., Hamann,A.,
            Wolfram,L., Cingoz,G., Kilic,N., Schwarzloh,B., Schroeder,M.,
            Joscheck,C., Wiesner,L., Ruther,W. and Ergun,S.
  TITLE     Neural driven angiogenesis by overexpression of nerve growth factor
  JOURNAL   Histochem Cell Biol 125 (6), 637-649 (2006)
   PUBMED   16315017
  REMARK    GeneRIF: We demonstrate that overexpression of nerve growth factor
            (NGF) in brown adipose tissue (BAT) of NGF-transgenic mice elevates
            both mRNA and protein levels of vascular endothelial growth factor
            (VEGF) and VEGF-receptors.
REFERENCE   6  (bases 1 to 841)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
REFERENCE   7  (bases 1 to 841)
  AUTHORS   van Leeuwen,B.H., Evans,B.A., Tregear,G.W. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Identification, structure, and
            expression of the renal kallikrein gene
  JOURNAL   J Biol Chem 261 (12), 5529-5535 (1986)
   PUBMED   3007510
REFERENCE   8  (bases 1 to 841)
  AUTHORS   Evans,B.A. and Richards,R.I.
  TITLE     Genes for the alpha and gamma subunits of mouse nerve growth factor
            are contiguous
  JOURNAL   EMBO J 4 (1), 133-138 (1985)
   PUBMED   3848399
REFERENCE   9  (bases 1 to 841)
  AUTHORS   Isackson,P.J., Ullrich,A. and Bradshaw,R.A.
  TITLE     Mouse 7S nerve growth factor: complete sequence of a cDNA coding
            for the alpha-subunit precursor and its relationship to serine
            proteases
  JOURNAL   Biochemistry 23 (25), 5997-6002 (1984)
   PUBMED   6395888
REFERENCE   10 (bases 1 to 841)
  AUTHORS   Mason,A.J., Evans,B.A., Cox,D.R., Shine,J. and Richards,R.I.
  TITLE     Structure of mouse kallikrein gene family suggests a role in
            specific processing of biologically active peptides
  JOURNAL   Nature 303 (5915), 300-307 (1983)
   PUBMED   6602295
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124176.3 and BF454440.1.
            
            On Feb 23, 2016 this sequence version replaced NM_010915.3.
            
            Summary: This gene encodes the alpha subunit of the 7S nerve growth
            factor (NGF) complex that is essential for the differentiation and
            survival of distinct populations of neurons in both the central and
            the peripheral nervous systems. This gene is located in a cluster
            of several related kallikrein genes on chromosome 7. [provided by
            RefSeq, Feb 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC124176.3         142139-142155
            18-579              BF454440.1         1-562
            580-636             AC124176.3         145824-145880
            637-841             AC124176.3         146256-146460
FEATURES             Location/Qualifiers
     source          1..841
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.72 cM"
     gene            1..841
                     /gene="Klk1b4"
                     /gene_synonym="alpha-NGF; mGk-4; Ngfa"
                     /note="kallikrein 1-related pepidase b4"
                     /db_xref="GeneID:18048"
                     /db_xref="MGI:MGI:97320"
     exon            1..67
                     /gene="Klk1b4"
                     /gene_synonym="alpha-NGF; mGk-4; Ngfa"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..792
                     /gene="Klk1b4"
                     /gene_synonym="alpha-NGF; mGk-4; Ngfa"
                     /note="7S nerve growth factor alpha subunit; kallikrein
                     1-related peptidase-like b4; 7S nerve growth factor alpha
                     chain"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase-like b4
                     precursor"
                     /protein_id="NP_035045.2"
                     /db_xref="CCDS:CCDS21200.1"
                     /db_xref="GeneID:18048"
                     /db_xref="MGI:MGI:97320"
                     /translation="MWFLILFLALSLGGIDAAPPVQSQVDCENSQPWHVAVYRFNKYQ
                     CGGVLLDRNWVLTAAHCYNDKYQVWLGKNNFLEDEPSDQHRLVSKAIPHPDFNMSLLN
                     EHTPQPEDDYSNDLMLLRLSKPADITDVVKPITLPTEEPKLGSTCLASGWGSTTPIKF
                     KYPDDLQCVNLKLLPNEDCDKAHEMKVTDAMLCAGEMDGGSYTCEHDSGGPLICDGIL
                     QGITSWGPEPCGEPTEPSVYTKLIKFSSWIRETMANNP"
     exon            68..212
                     /gene="Klk1b4"
                     /gene_synonym="alpha-NGF; mGk-4; Ngfa"
                     /inference="alignment:Splign:2.1.0"
     exon            213..499
                     /gene="Klk1b4"
                     /gene_synonym="alpha-NGF; mGk-4; Ngfa"
                     /inference="alignment:Splign:2.1.0"
     exon            500..636
                     /gene="Klk1b4"
                     /gene_synonym="alpha-NGF; mGk-4; Ngfa"
                     /inference="alignment:Splign:2.1.0"
     exon            637..841
                     /gene="Klk1b4"
                     /gene_synonym="alpha-NGF; mGk-4; Ngfa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      816..821
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b4"
                     /gene_synonym="alpha-NGF; mGk-4; Ngfa"
                     /note="hexamer: AATAAA"
     polyA_site      838
                     /gene="Klk1b4"
                     /gene_synonym="alpha-NGF; mGk-4; Ngfa"
                     /note="major polyA site"
ORIGIN      
        1 agctcctgga cacctgttac catgtggttc ctgatcctgt tcctagccct gtccctagga
       61 gggattgatg ctgcacctcc tgtccagtct caagtggact gtgagaattc ccaaccctgg
      121 catgtggctg tgtaccgctt caacaaatat caatgcgggg gagtcctgtt ggaccgcaac
      181 tgggttctca cagctgccca ctgctataac gacaagtacc aggtttggct gggcaaaaac
      241 aactttttgg aggatgaacc ttctgaccaa caccggcttg tcagcaaagc catccctcac
      301 cctgacttca acatgagcct cctgaatgag cacaccccac aacctgagga cgactacagc
      361 aatgacctga tgctgctccg cctcagcaag cctgctgaca tcacagatgt tgtgaagccc
      421 atcaccctgc ccactgagga gcccaagctg gggagcacat gcctagcctc aggctggggc
      481 agcactacac ccatcaagtt caaatatcca gatgatctcc agtgtgtgaa cctcaagctc
      541 ctgcctaatg aggactgtga caaagcacat gaaatgaagg tgacagatgc catgctgtgt
      601 gcaggagaga tggatggtgg ctcatacact tgtgagcatg actcaggagg cccactgatc
      661 tgtgatggta ttctccaagg tatcacatca tggggccctg aaccatgtgg tgagcccact
      721 gagccaagtg tctacaccaa acttattaag ttcagctcct ggataagaga aactatggcg
      781 aataacccct gagtgtcaca ttgtcccctt ttctcaataa agcccaccat gcagcaaatg
      841 a
//
