LOCUS       NM_008693                888 bp    mRNA    linear   ROD 16-OCT-2021
DEFINITION  Mus musculus kallikrein 1-related peptidase b3 (Klk1b3), mRNA.
ACCESSION   NM_008693
VERSION     NM_008693.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 888)
  AUTHORS   Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP,
            Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C,
            Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M and
            Yousef GM.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   2  (bases 1 to 888)
  AUTHORS   Olsson AY, Lilja H and Lundwall A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   3  (bases 1 to 888)
  AUTHORS   Guha U, Gomes WA, Samanta J, Gupta M, Rice FL and Kessler JA.
  TITLE     Target-derived BMP signaling limits sensory neuron number and the
            extent of peripheral innervation in vivo
  JOURNAL   Development 131 (5), 1175-1186 (2004)
   PUBMED   14973275
REFERENCE   4  (bases 1 to 888)
  AUTHORS   Moreno CR, Lantier F, Lantier I, Sarradin P and Elsen JM.
  TITLE     Detection of new quantitative trait Loci for susceptibility to
            transmissible spongiform encephalopathies in mice
  JOURNAL   Genetics 165 (4), 2085-2091 (2003)
   PUBMED   14704188
REFERENCE   5  (bases 1 to 888)
  AUTHORS   Fowlis GA, Fairchild S, Tomonari K and Simpson E.
  TITLE     Toward identification of minor histocompatibility antigens in mouse
            and man
  JOURNAL   Transplant Proc 24 (5), 1689-1691 (1992)
   PUBMED   1412798
REFERENCE   6  (bases 1 to 888)
  AUTHORS   Cornall RJ, Friedman JM and Todd JA.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   7  (bases 1 to 888)
  AUTHORS   Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL and
            Boon T.
  TITLE     Mapping of the genes encoding tum- transplantation antigens P91A,
            P35B, and P198
  JOURNAL   Immunogenetics 35 (5), 316-323 (1992)
   PUBMED   1348494
REFERENCE   8  (bases 1 to 888)
  AUTHORS   Evans,B.A. and Richards,R.I.
  TITLE     Genes for the alpha and gamma subunits of mouse nerve growth factor
            are contiguous
  JOURNAL   EMBO J 4 (1), 133-138 (1985)
   PUBMED   3848399
REFERENCE   9  (bases 1 to 888)
  AUTHORS   Ullrich,A., Gray,A., Wood,W.I., Hayflick,J. and Seeburg,P.H.
  TITLE     Isolation of a cDNA clone coding for the gamma-subunit of mouse
            nerve growth factor using a high-stringency selection procedure
  JOURNAL   DNA 3 (5), 387-392 (1984)
   PUBMED   6548955
REFERENCE   10 (bases 1 to 888)
  AUTHORS   Thomas,K.A., Baglan,N.C. and Bradshaw,R.A.
  TITLE     The amino acid sequence of the gamma-subunit of mouse submaxillary
            gland 7 S nerve growth factor
  JOURNAL   J Biol Chem 256 (17), 9156-9166 (1981)
   PUBMED   7263706
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC132657.1.
            
            On Feb 11, 2011 this sequence version replaced NM_008693.1.
            
            Summary: This gene encodes the gamma subunit of the 7S nerve growth
            factor (NGF) complex that is essential for the differentiation and
            survival of distinct populations of neurons in both the central and
            the peripheral nervous systems. The encoded protein is a glandular
            kallikrein-type serine protease that processes the beta subunit of
            NGF. This gene is present in a cluster of multiple related
            kallikrein-type protease genes on chromosome 7. [provided by
            RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132657.1, X01389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-888               BC132657.1         1-888
FEATURES             Location/Qualifiers
     source          1..888
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.71 cM"
     gene            1..888
                     /gene="Klk1b3"
                     /gene_synonym="gamma-NGF; mGk-3; Ngfg"
                     /note="kallikrein 1-related peptidase b3"
                     /db_xref="GeneID:18050"
                     /db_xref="MGI:MGI:97322"
     exon            1..102
                     /gene="Klk1b3"
                     /gene_synonym="gamma-NGF; mGk-3; Ngfg"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..842
                     /gene="Klk1b3"
                     /gene_synonym="gamma-NGF; mGk-3; Ngfg"
                     /EC_number="3.4.21.35"
                     /note="7S nerve growth factor gamma subunit; tissue
                     kallikrein-3; glandular kallikrein K3; 7S nerve growth
                     factor gamma chain"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b3 preproprotein"
                     /protein_id="NP_032719.1"
                     /db_xref="CCDS:CCDS21199.1"
                     /db_xref="GeneID:18050"
                     /db_xref="MGI:MGI:97322"
                     /translation="MWFLILFLALSLGGIDAAPPVQSRIVGGFKCEKNSQPWHVAVYR
                     YTQYLCGGVLLDPNWVLTAAHCYDDNYKVWLGKNNLFKDEPSAQHRFVSKAIPHPGFN
                     MSLMRKHIRFLEYDYSNDLMLLRLSKPADITDTVKPITLPTEEPKLGSTCLASGWGSI
                     TPTKFQFTDDLYCVNLKLLPNEDCAKAHIEKVTDAMLCAGEMDGGKDTCKGDSGGPLI
                     CDGVLQGITSWGHTPCGEPDMPGVYTKLNKFTSWIKDTMAKNP"
     exon            103..262
                     /gene="Klk1b3"
                     /gene_synonym="gamma-NGF; mGk-3; Ngfg"
                     /inference="alignment:Splign:2.1.0"
     exon            263..549
                     /gene="Klk1b3"
                     /gene_synonym="gamma-NGF; mGk-3; Ngfg"
                     /inference="alignment:Splign:2.1.0"
     exon            550..686
                     /gene="Klk1b3"
                     /gene_synonym="gamma-NGF; mGk-3; Ngfg"
                     /inference="alignment:Splign:2.1.0"
     exon            687..888
                     /gene="Klk1b3"
                     /gene_synonym="gamma-NGF; mGk-3; Ngfg"
                     /inference="alignment:Splign:2.1.0"
     regulatory      864..869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b3"
                     /gene_synonym="gamma-NGF; mGk-3; Ngfg"
     polyA_site      888
                     /gene="Klk1b3"
                     /gene_synonym="gamma-NGF; mGk-3; Ngfg"
ORIGIN      
        1 tgaggtgcct caacagctcc aagctcactg cctgcagctc ctggacacct gtcaccatgt
       61 ggttcctgat cctgttccta gccctgtccc taggagggat tgatgctgca cctcctgtcc
      121 agtctcgaat tgttggagga tttaaatgtg agaagaattc ccaaccctgg catgtggctg
      181 tgtaccgata cacccaatat ttatgcgggg gtgtcctgtt ggaccccaac tgggttctca
      241 cagctgccca ctgctatgac gacaactaca aggtttggct gggcaaaaac aacctattca
      301 aggatgaacc atctgctcag caccgatttg tcagcaaagc catccctcac cctggcttca
      361 acatgagcct catgaggaag cacatccgat tccttgagta tgactacagc aatgacctga
      421 tgctgctccg cctcagcaag cctgctgaca tcacagatac tgtgaagccc atcaccctgc
      481 ccactgagga gcccaagctg gggagcacat gcctagcctc aggctggggc agcattacac
      541 ccaccaaatt ccaattcaca gatgatctct actgtgtgaa cctcaagctc ctgcctaatg
      601 aggactgtgc caaagcccac atagagaagg tgacagatgc catgctgtgt gcaggagaga
      661 tggatggagg caaagacact tgcaagggtg actcaggagg cccactgatc tgtgatggtg
      721 ttctccaagg tatcacatca tggggccata ccccatgcgg tgaacctgat atgccaggcg
      781 tctacaccaa acttaataag tttacctcct ggataaaaga cactatggca aaaaacccct
      841 aagtatcaca actgtctgtt ctcaataaaa ggcaccatgc aacaaatg
//
