LOCUS       NM_020268                889 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus kallikrein 1-related peptidase b27 (Klk1b27), mRNA.
ACCESSION   NM_020268
VERSION     NM_020268.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 889)
  AUTHORS   Isbel,L., Srivastava,R., Oey,H., Spurling,A., Daxinger,L.,
            Puthalakath,H. and Whitelaw,E.
  TITLE     Trim33 Binds and Silences a Class of Young Endogenous Retroviruses
            in the Mouse Testis; a Novel Component of the Arms Race between
            Retrotransposons and the Host Genome
  JOURNAL   PLoS Genet 11 (12), e1005693 (2015)
   PUBMED   26624618
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 889)
  AUTHORS   Hu,S., Yao,G., Li,X., Chen,Z. and Sun,Y.
  TITLE     Androgen receptor binding sites identified in mouse testis
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 45 (9), 795-797 (2013)
   PUBMED   23838579
  REMARK    GeneRIF: Data indicate that androgen receptor (AR) regulation on
            Klk27, Rhox5, Eppin, and Cyp17 genes in adult mouse testis using
            chromatin immunoprecipitation (ChIP) assays.
REFERENCE   3  (bases 1 to 889)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   4  (bases 1 to 889)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   5  (bases 1 to 889)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
REFERENCE   6  (bases 1 to 889)
  AUTHORS   Matsui,H., Moriyama,A. and Takahashi,T.
  TITLE     Cloning and characterization of mouse klk27, a novel tissue
            kallikrein expressed in testicular Leydig cells and exhibiting
            chymotrypsin-like specificity
  JOURNAL   Eur J Biochem 267 (23), 6858-6865 (2000)
   PUBMED   11082197
REFERENCE   7  (bases 1 to 889)
  AUTHORS   Chan,C.S., Harvey,M.B. and Clements,J.A.
  TITLE     Temporal and tissue-specific expression of kallikrein (Klk) genes
            and identification of a novel Klk messenger ribonucleic acid
            transcript during early development in the mouse
  JOURNAL   Biol Reprod 61 (3), 621-628 (1999)
   PUBMED   10456837
REFERENCE   8  (bases 1 to 889)
  AUTHORS   Mason,A.J., Evans,B.A., Cox,D.R., Shine,J. and Richards,R.I.
  TITLE     Structure of mouse kallikrein gene family suggests a role in
            specific processing of biologically active peptides
  JOURNAL   Nature 303 (5915), 300-307 (1983)
   PUBMED   6602295
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC151051.2.
            
            On Jun 22, 2007 this sequence version replaced NM_020268.2.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, Feb 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB039275.1, BC132665.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC151051.2         142689-142785
            98-257              AC151051.2         144880-145039
            258-550             AC151051.2         146016-146308
            551-687             AC151051.2         146404-146540
            688-889             AC151051.2         146910-147111
FEATURES             Location/Qualifiers
     source          1..889
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.54 cM"
     gene            1..889
                     /gene="Klk1b27"
                     /gene_synonym="Gk27; Klk21l; Klk27; mGK-27"
                     /note="kallikrein 1-related peptidase b27"
                     /db_xref="GeneID:16619"
                     /db_xref="MGI:MGI:891980"
     exon            1..97
                     /gene="Klk1b27"
                     /gene_synonym="Gk27; Klk21l; Klk27; mGK-27"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..843
                     /gene="Klk1b27"
                     /gene_synonym="Gk27; Klk21l; Klk27; mGK-27"
                     /note="glandular kallikrein 27; tissue kallikrein 27;
                     glandular kallikrein K27"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b27
                     preproprotein"
                     /protein_id="NP_064664.1"
                     /db_xref="CCDS:CCDS21194.1"
                     /db_xref="GeneID:16619"
                     /db_xref="MGI:MGI:891980"
                     /translation="MRFLILFLALSLGGIDAAPPVQSRIIGGFKCKKNSQPWHVAVLR
                     SNKYICGGVLLDPNWVLTAAHCYGNDTSQHNVWLGKNKLFQREPSAQHRWVSKSFPHP
                     DYNMSLLNDHIPHPEDKSNDLMLLRLSKPADITDAVKPIDLPTEEPKLGSTCLASGWG
                     SITPTKYQIPNDLQCVFIKLLPNENCAKAYVHKVTDVMLCVGETGGGKGTCKGDSGGP
                     LICDGVLHGITSWGSIPCAKPNAPGVFTKLIKFTSWIKDTMAKNP"
     exon            98..257
                     /gene="Klk1b27"
                     /gene_synonym="Gk27; Klk21l; Klk27; mGK-27"
                     /inference="alignment:Splign:2.1.0"
     exon            258..550
                     /gene="Klk1b27"
                     /gene_synonym="Gk27; Klk21l; Klk27; mGK-27"
                     /inference="alignment:Splign:2.1.0"
     exon            551..687
                     /gene="Klk1b27"
                     /gene_synonym="Gk27; Klk21l; Klk27; mGK-27"
                     /inference="alignment:Splign:2.1.0"
     exon            688..889
                     /gene="Klk1b27"
                     /gene_synonym="Gk27; Klk21l; Klk27; mGK-27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      872..877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b27"
                     /gene_synonym="Gk27; Klk21l; Klk27; mGK-27"
                     /note="hexamer: AATACA"
     polyA_site      889
                     /gene="Klk1b27"
                     /gene_synonym="Gk27; Klk21l; Klk27; mGK-27"
                     /note="major polyA site"
ORIGIN      
        1 atcctcaaca gctccaagtt cactgcctgt ggaacctgga cacctgttac catgaggttc
       61 ctgatcctgt tccttgccct gtccctagga gggattgatg ctgcgcctcc tgtccagtct
      121 agaataattg gaggatttaa atgtaagaag aattctcaac cctggcatgt ggctgtgctc
      181 cgctccaaca aatatatatg cgggggagtc ctgttggacc ccaactgggt tctcacagct
      241 gcccactgct atggcaatga caccagccag cataatgttt ggctgggcaa aaacaagcta
      301 ttccaacgtg aaccctctgc tcagcaccga tgggtcagca aaagcttccc ccaccctgac
      361 tacaacatga gcctcctgaa tgaccacatc ccacatcctg aggacaagag caatgacctg
      421 atgctgctcc gtctcagcaa gcctgctgac atcacagatg ctgtgaagcc catcgacctg
      481 cccactgagg agcccaagct ggggagcaca tgcctagcct caggctgggg cagcattaca
      541 cccacaaaat accaaatccc aaatgatctt cagtgtgtgt tcatcaagct cctgcccaat
      601 gagaactgtg ccaaagccta cgtacataaa gtcacagatg tcatgctgtg tgtaggagag
      661 acgggtggag gcaaaggcac ttgcaagggt gactcaggag gcccactgat ctgtgatggt
      721 gttctccacg gtatcacatc atggggctct atcccatgcg ctaaacccaa tgcgccaggc
      781 gtcttcacaa aacttattaa gtttacctcc tggataaaag acactatggc aaaaaacccc
      841 tgagtgtcac attatctact gttctcaata aaatacacca tgaaacaaa
//
