LOCUS       NM_010644                877 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus kallikrein 1-related petidase b26 (Klk1b26), mRNA.
ACCESSION   NM_010644
VERSION     NM_010644.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 877)
  AUTHORS   Kurihara,K., Nakanishi,N. and Tomomura,A.
  TITLE     Interference of kallikrein 1b26 (klk1b26) translation by microRNA
            specifically expressed in female mouse submandibular glands: an
            additional mechanism for sexual dimorphism of klk1b26 protein in
            the glands
  JOURNAL   Biol Sex Differ 2, 13 (2011)
   PUBMED   22085651
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 877)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   3  (bases 1 to 877)
  AUTHORS   Itoh,S., Ding,B., Shishido,T., Lerner-Marmarosh,N., Wang,N.,
            Maekawa,N., Berk,B.C., Takeishi,Y., Yan,C., Blaxall,B.C. and Abe,J.
  TITLE     Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme
            in ischemic and diabetic myocardium
  JOURNAL   Circulation 113 (14), 1787-1798 (2006)
   PUBMED   16585392
REFERENCE   4  (bases 1 to 877)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   5  (bases 1 to 877)
  AUTHORS   Olsson,A.Y. and Lundwall,A.
  TITLE     Organization and evolution of the glandular kallikrein locus in Mus
            musculus
  JOURNAL   Biochem Biophys Res Commun 299 (2), 305-311 (2002)
   PUBMED   12437987
REFERENCE   6  (bases 1 to 877)
  AUTHORS   Kikkawa,Y., Yamanaka,N., Tada,J., Kanamori,N., Tsumura,K. and
            Hosoi,K.
  TITLE     Prorenin processing and restricted endoproteolysis by mouse tissue
            kallikrein family enzymes (mK1, mK9, mK13, and mK22)
  JOURNAL   Biochim Biophys Acta 1382 (1), 55-64 (1998)
   PUBMED   9507064
REFERENCE   7  (bases 1 to 877)
  AUTHORS   Kim,W.S., Nakayama,K. and Murakami,K.
  TITLE     The presence of two types of prorenin converting enzymes in the
            mouse submandibular gland
  JOURNAL   FEBS Lett 293 (1-2), 142-144 (1991)
   PUBMED   1959648
REFERENCE   8  (bases 1 to 877)
  AUTHORS   Lundgren,S., Ronne,H., Rask,L. and Peterson,P.A.
  TITLE     Sequence of an epidermal growth factor-binding protein
  JOURNAL   J Biol Chem 259 (12), 7780-7784 (1984)
   PUBMED   6330081
REFERENCE   9  (bases 1 to 877)
  AUTHORS   Richards,R.I., Catanzaro,D.F., Mason,A.J., Morris,B.J., Baxter,J.D.
            and Shine,J.
  TITLE     Mouse glandular kallikrein genes. Nucleotide sequence of cloned
            cDNA coding for a member of the kallikrein arginyl esteropeptidase
            group of serine proteases
  JOURNAL   J Biol Chem 257 (6), 2758-2761 (1982)
   PUBMED   6174512
REFERENCE   10 (bases 1 to 877)
  AUTHORS   Nordeen,S.K., Mason,A.J., Richards,R.I., Baxter,J.D. and Shine,J.
  TITLE     Mouse kallikrein arginyl-esteropeptidase genes: analysis of cloned
            cDNAs suggests rapid functional divergence from a common ancestral
            sequence
  JOURNAL   DNA 1 (3), 309-311 (1982)
   PUBMED   6926406
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from K01831.1 and AC134858.6.
            
            On Sep 26, 2015 this sequence version replaced NM_010644.2.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            the peptidase S1 family of serine proteases. The kallikrein genes
            are present in a large gene cluster on chromosome 7. The encoded
            preproprotein is proteolytically processed to generate a mature
            protein product. Expression of this gene in the submandibular gland
            is sexually dimorphic likely due to both transcriptional and
            post-transcriptional regulation. This gene is thought to be
            distinct from the Egfbp2 gene (Gene ID: 13647), with which it
            shares 98% identity (PMIDs: 1959648, 9685728), however, it is not
            clear if both genes are present in all strains of mice. [provided
            by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: K01831.1, BC024688.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-869               K01831.1           1-869
            870-877             AC134858.6         207060-207067
FEATURES             Location/Qualifiers
     source          1..877
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.5 cM"
     gene            1..877
                     /gene="Klk1b26"
                     /gene_synonym="Egfbp2; Klk26; mGK-26; mGK26; PRECE-2"
                     /note="kallikrein 1-related petidase b26"
                     /db_xref="GeneID:16618"
                     /db_xref="MGI:MGI:891981"
     exon            1..88
                     /gene="Klk1b26"
                     /gene_synonym="Egfbp2; Klk26; mGK-26; mGK26; PRECE-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..828
                     /gene="Klk1b26"
                     /gene_synonym="Egfbp2; Klk26; mGK-26; mGK26; PRECE-2"
                     /EC_number="3.4.21.35"
                     /note="kallikrein 1-related peptidase b26; tissue
                     kallikrein 26; glandular kallikrein K26;
                     prorenin-converting enzyme 2; EGF-BP type B; kallikrein
                     1-related petidase b25"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b26
                     preproprotein"
                     /protein_id="NP_034774.1"
                     /db_xref="CCDS:CCDS39938.1"
                     /db_xref="GeneID:16618"
                     /db_xref="MGI:MGI:891981"
                     /translation="MWFLILFPALSLGGIDAAPPLQSRVVGGFNCEKNSQPWQVAVYY
                     QKEHICGGVLLDRNWVLTAAHCYVDQYEVWLGKNKLFQEEPSAQHRLVSKSFPHPGFN
                     MSLLMLQTTPPGADFSNDLMLLRLSKPADITDVVKPIALPTKEPKPGSTCLASGWGSI
                     TPTRWQKSDDLQCVFITLLPNENCAKVYLQKVTDVMLCAGEMGGGKDTCAGDSGGPLI
                     CDGILQGTTSNGPEPCGKPGVPAIYTNLIKFNSWIKDTMMKNA"
     exon            89..248
                     /gene="Klk1b26"
                     /gene_synonym="Egfbp2; Klk26; mGK-26; mGK26; PRECE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..535
                     /gene="Klk1b26"
                     /gene_synonym="Egfbp2; Klk26; mGK-26; mGK26; PRECE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            536..672
                     /gene="Klk1b26"
                     /gene_synonym="Egfbp2; Klk26; mGK-26; mGK26; PRECE-2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..877
                     /gene="Klk1b26"
                     /gene_synonym="Egfbp2; Klk26; mGK-26; mGK26; PRECE-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      852..857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b26"
                     /gene_synonym="Egfbp2; Klk26; mGK-26; mGK26; PRECE-2"
                     /note="hexamer: AATAAA"
     polyA_site      874
                     /gene="Klk1b26"
                     /gene_synonym="Egfbp2; Klk26; mGK-26; mGK26; PRECE-2"
                     /note="major polyA site"
ORIGIN      
        1 agctccaagc tcactgcctg cagttcctgg acacctgtta ccatgtggtt cctgatcctg
       61 ttcccagccc tgtccctagg agggattgat gctgcacctc ctctccagtc tcgggtggtt
      121 ggaggattta actgtgagaa gaattcccaa ccctggcagg tggctgtgta ctaccaaaag
      181 gaacacattt gtgggggtgt cctgttggac cgcaactggg ttctcacagc tgcccactgc
      241 tatgtcgacc agtatgaggt ttggctgggc aaaaacaagt tattccaaga ggaaccctct
      301 gctcagcacc gattggtcag caaaagcttc cctcaccctg gcttcaacat gagcctcctg
      361 atgcttcaaa caacacctcc tggggctgac ttcagcaatg acctgatgct gctccgcctc
      421 agcaagcctg ctgacatcac agatgttgtg aagcccatcg ccctgcccac aaaggagccc
      481 aagccgggga gcacatgcct agcctcaggc tggggcagca ttacacccac aagatggcaa
      541 aagtcagatg atcttcagtg tgtgttcatc acgctcctcc ccaatgagaa ctgtgccaaa
      601 gtctacctac agaaagtcac agatgtcatg ctgtgtgcag gagagatggg tggaggcaaa
      661 gacacttgtg cgggtgactc cggaggccca ctgatttgtg atggtattct ccaaggaacc
      721 acatcaaatg gccctgaacc atgcggtaaa cctggtgtac cagccatcta caccaacctt
      781 attaagttca actcctggat aaaagatact atgatgaaaa atgcctgagt gtcacattgt
      841 cccatgttct taataaagcc caccatgaag caaatga
//
