LOCUS       NM_010643                899 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus kallikrein 1-related peptidase b24 (Klk1b24), mRNA.
ACCESSION   NM_010643 XM_001000656
VERSION     NM_010643.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 899)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 899)
  AUTHORS   Isbel,L., Srivastava,R., Oey,H., Spurling,A., Daxinger,L.,
            Puthalakath,H. and Whitelaw,E.
  TITLE     Trim33 Binds and Silences a Class of Young Endogenous Retroviruses
            in the Mouse Testis; a Novel Component of the Arms Race between
            Retrotransposons and the Host Genome
  JOURNAL   PLoS Genet 11 (12), e1005693 (2015)
   PUBMED   26624618
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 899)
  AUTHORS   Lundwall,A., Band,V., Blaber,M., Clements,J.A., Courty,Y.,
            Diamandis,E.P., Fritz,H., Lilja,H., Malm,J., Maltais,L.J.,
            Olsson,A.Y., Petraki,C., Scorilas,A., Sotiropoulou,G.,
            Stenman,U.H., Stephan,C., Talieri,M. and Yousef,G.M.
  TITLE     A comprehensive nomenclature for serine proteases with homology to
            tissue kallikreins
  JOURNAL   Biol Chem 387 (6), 637-641 (2006)
   PUBMED   16800724
REFERENCE   4  (bases 1 to 899)
  AUTHORS   Matsui,H., Takano,N. and Takahashi,T.
  TITLE     Characterization of mouse glandular kallikrein 24 expressed in
            testicular Leydig cells
  JOURNAL   Int J Biochem Cell Biol 37 (11), 2333-2343 (2005)
   PUBMED   15985384
  REMARK    GeneRIF: These results suggest that kallikrein 24 may play a role
            in the degradation of extracellular matrix proteins in the
            interstitial area surrounding the Leydig cells of the adult mouse
            testis.
REFERENCE   5  (bases 1 to 899)
  AUTHORS   Matsui,H., Takano,N., Moriyama,A. and Takahashi,T.
  TITLE     Single-chain tissue-type plasminogen activator is a substrate of
            mouse glandular kallikrein 24
  JOURNAL   Zoolog Sci 22 (10), 1105-1111 (2005)
   PUBMED   16286722
  REMARK    GeneRIF: mK24 may play a role in the degradation of extracellular
            matrix proteins in the interstitial area surrounding the Leydig
            cells of the adult mouse testis.
REFERENCE   6  (bases 1 to 899)
  AUTHORS   Olsson,A.Y., Lilja,H. and Lundwall,A.
  TITLE     Taxon-specific evolution of glandular kallikrein genes and
            identification of a progenitor of prostate-specific antigen
  JOURNAL   Genomics 84 (1), 147-156 (2004)
   PUBMED   15203212
REFERENCE   7  (bases 1 to 899)
  AUTHORS   Matsui,H., Moriyama,A. and Takahashi,T.
  TITLE     Cloning and characterization of mouse klk27, a novel tissue
            kallikrein expressed in testicular Leydig cells and exhibiting
            chymotrypsin-like specificity
  JOURNAL   Eur J Biochem 267 (23), 6858-6865 (2000)
   PUBMED   11082197
REFERENCE   8  (bases 1 to 899)
  AUTHORS   Evans,B.A., Drinkwater,C.C. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Structure and partial sequence
            analysis of the kallikrein gene locus
  JOURNAL   J Biol Chem 262 (17), 8027-8034 (1987)
   PUBMED   3036794
REFERENCE   9  (bases 1 to 899)
  AUTHORS   van Leeuwen,B.H., Evans,B.A., Tregear,G.W. and Richards,R.I.
  TITLE     Mouse glandular kallikrein genes. Identification, structure, and
            expression of the renal kallikrein gene
  JOURNAL   J Biol Chem 261 (12), 5529-5535 (1986)
   PUBMED   3007510
REFERENCE   10 (bases 1 to 899)
  AUTHORS   Mason,A.J., Evans,B.A., Cox,D.R., Shine,J. and Richards,R.I.
  TITLE     Structure of mouse kallikrein gene family suggests a role in
            specific processing of biologically active peptides
  JOURNAL   Nature 303 (5915), 300-307 (1983)
   PUBMED   6602295
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC146019.1 and AB039277.1.
            
            On Feb 24, 2016 this sequence version replaced NM_010643.1.
            
            Summary: This gene encodes a member of the kallikrein subfamily of
            serine proteases that are involved in diverse physiological
            functions such as skin desquamation, tooth enamel formation,
            seminal liquefaction, synaptic neural plasticity and brain
            function. The encoded preproprotein undergoes proteolytic cleavage
            of the activation peptide to generate the functional enzyme. This
            gene is located in a cluster of several related kallikrein genes on
            chromosome 7. [provided by RefSeq, Feb 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146015.1, BF540391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BC146019.1         1-27
            28-899              AB039277.1         1-872
FEATURES             Location/Qualifiers
     source          1..899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 28.7 cM"
     gene            1..899
                     /gene="Klk1b24"
                     /gene_synonym="Klk24; mGk-24"
                     /note="kallikrein 1-related peptidase b24"
                     /db_xref="GeneID:16617"
                     /db_xref="MGI:MGI:892021"
     exon            1..83
                     /gene="Klk1b24"
                     /gene_synonym="Klk24; mGk-24"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..829
                     /gene="Klk1b24"
                     /gene_synonym="Klk24; mGk-24"
                     /EC_number="3.4.21.35"
                     /note="tissue kallikrein 24; glandular kallikrein K24"
                     /codon_start=1
                     /product="kallikrein 1-related peptidase b24
                     preproprotein"
                     /protein_id="NP_034773.1"
                     /db_xref="CCDS:CCDS21198.1"
                     /db_xref="GeneID:16617"
                     /db_xref="MGI:MGI:892021"
                     /translation="MWFLILFLALSLGGIDAAPPVQSRVVGGFKCEKNSQPWHVAVFR
                     YNKYICGGVLLNPNWVLTAAHCYGNATSQYNVWLGKNKLFQREPSAQHRWVSKSFPHP
                     DYNMSLLNDDIPQPKDKSNDLMLLRLSEPADITDAVKPIDLPTEEPKLGSTCLASGWG
                     SITPTKWQKPNDLQCVFIKLLPNENCTKPYLHKVTDVMLCAGEMGGGKDTCAGDSGGP
                     LICDGILHGITSWGPVPCGKPNAPAIYTKLIKFASWIKDTMAKNP"
     exon            84..243
                     /gene="Klk1b24"
                     /gene_synonym="Klk24; mGk-24"
                     /inference="alignment:Splign:2.1.0"
     exon            244..536
                     /gene="Klk1b24"
                     /gene_synonym="Klk24; mGk-24"
                     /inference="alignment:Splign:2.1.0"
     exon            537..673
                     /gene="Klk1b24"
                     /gene_synonym="Klk24; mGk-24"
                     /inference="alignment:Splign:2.1.0"
     exon            674..875
                     /gene="Klk1b24"
                     /gene_synonym="Klk24; mGk-24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      853..858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Klk1b24"
                     /gene_synonym="Klk24; mGk-24"
                     /note="hexamer: AATAAA"
     polyA_site      875
                     /gene="Klk1b24"
                     /gene_synonym="Klk24; mGk-24"
                     /note="major polyA site"
ORIGIN      
        1 caagctcact gcctgctgct cctggacacc tgttaccatg tggttcctga tcctgttcct
       61 agccctgtcc ctaggaggga ttgatgctgc acctcctgtc cagtctcgtg tggttggagg
      121 attcaaatgt gagaagaatt cccaaccctg gcatgtggct gtgttccgct acaacaaata
      181 tatatgcggg ggagtcctgt tgaaccccaa ctgggttctc acagctgccc actgctatgg
      241 caatgccacc agccagtata atgtttggct gggcaaaaac aagctattcc aacgtgaacc
      301 ctctgctcag caccgatggg tcagcaaaag cttccctcac cctgactaca acatgagcct
      361 cctgaatgat gacatcccgc aacctaagga caagagcaat gacctgatgc tgctccgtct
      421 cagcgagcct gctgacatca cagatgctgt gaagcccatc gacctgccca ctgaggagcc
      481 caagctgggg agcacatgcc tagcctcagg ctggggcagc attacaccca cgaaatggca
      541 aaagccaaat gaccttcagt gtgtgttcat caagctcctg cccaatgaga actgtaccaa
      601 accctactta cataaagtca cagatgtcat gctgtgtgca ggagagatgg gtggaggcaa
      661 agacacttgt gcgggtgact caggaggccc actgatctgt gatggtattc tccacggtat
      721 cacatcatgg ggtcctgtcc catgtggtaa acccaatgcg ccggccatct acaccaaact
      781 tattaagttt gcctcctgga taaaagacac tatggccaaa aacccctgag tgtcacatta
      841 tctgctgttc tcaataaaat gcaccatgca acaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
